PT98959A - Processo de preparacao de compostos 6- ou 7-(2-imino-2-imidazolidina)-1,4-benzoxazinas e de composicoes farmaceuticas que os contem - Google Patents

Processo de preparacao de compostos 6- ou 7-(2-imino-2-imidazolidina)-1,4-benzoxazinas e de composicoes farmaceuticas que os contem

Info

Publication number
PT98959A
PT98959A PT98959A PT9895991A PT98959A PT 98959 A PT98959 A PT 98959A PT 98959 A PT98959 A PT 98959A PT 9895991 A PT9895991 A PT 9895991A PT 98959 A PT98959 A PT 98959A
Authority
PT
Portugal
Prior art keywords
carbons
lower alkyl
compounds
independently
benzoxazins
Prior art date
Application number
PT98959A
Other languages
English (en)
Other versions
PT98959B (pt
Inventor
Charles Gluchowski
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of PT98959A publication Critical patent/PT98959A/pt
Publication of PT98959B publication Critical patent/PT98959B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Neurology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Detergent Compositions (AREA)
  • Treating Waste Gases (AREA)
  • Cosmetics (AREA)
  • Preventing Corrosion Or Incrustation Of Metals (AREA)
PT98959A 1990-09-12 1991-09-12 Processo de preparacao de compostos 6- ou 7-(2-imino-2-imidazolidina)-1,4-benzoxazinas e de composicoes farmaceuticas que os contem PT98959B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/582,034 US5091528A (en) 1990-09-12 1990-09-12 6- or 7- (2-imino-2-imidazolidine)-1,4-benzoxazines as α adrenergic agents

Publications (2)

Publication Number Publication Date
PT98959A true PT98959A (pt) 1992-07-31
PT98959B PT98959B (pt) 1999-02-26

Family

ID=24327570

Family Applications (1)

Application Number Title Priority Date Filing Date
PT98959A PT98959B (pt) 1990-09-12 1991-09-12 Processo de preparacao de compostos 6- ou 7-(2-imino-2-imidazolidina)-1,4-benzoxazinas e de composicoes farmaceuticas que os contem

Country Status (17)

Country Link
US (1) US5091528A (pt)
EP (1) EP0548254B1 (pt)
JP (1) JP3096475B2 (pt)
AT (1) ATE180782T1 (pt)
AU (1) AU646098B2 (pt)
CA (1) CA2091440C (pt)
DE (1) DE69131295T2 (pt)
ES (1) ES2132093T3 (pt)
FI (1) FI94864C (pt)
HU (1) HU220671B1 (pt)
IE (1) IE913202A1 (pt)
IL (1) IL99345A (pt)
NO (1) NO303577B1 (pt)
NZ (1) NZ239580A (pt)
PT (1) PT98959B (pt)
WO (1) WO1992004345A1 (pt)
ZA (1) ZA917218B (pt)

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US5716952A (en) * 1992-03-18 1998-02-10 Allergan Method for reducing intraocular pressure in the mammalian eye by administration of muscarinic antagonists
US6077839A (en) * 1992-03-19 2000-06-20 Allergan Sales, Inc. Method for reducing intraocular pressure in the mammalian eye by administration of gamma aminobutyric acid (GABA) agonists
US5710288A (en) * 1993-04-21 1998-01-20 Allergan 1,3-benzodioxole and 1,2-dialkoxybenzene derivatives as ocular hypotensive agents
US5369127A (en) * 1993-04-21 1994-11-29 Allergan, Inc. 1,3-benzodioxole and 1,2-dialkoxybenzene derivatives as ocular hypotensive agents
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US5580892A (en) * 1993-10-22 1996-12-03 Allergan Method for using 2-(2-alkylphenylamino)-oxazolines as adrenergic agents
US5478858A (en) * 1993-12-17 1995-12-26 The Procter & Gamble Company 5-(2-imidazolinylamino) benzimidazole compounds useful as alpha-2 adrenoceptor agonists
CN1046718C (zh) * 1993-12-17 1999-11-24 普罗克特和甘保尔公司 用作α－2肾上腺素能受体兴奋剂的6－(2－亚咪唑烷基氨基)喹啉化合物
US5578607A (en) * 1993-12-17 1996-11-26 The Procter & Gamble Company 6-(2-imidazolinylamino)quinoline compounds useful as alpha-2 adrenoceptor agonists
US5576437A (en) * 1993-12-17 1996-11-19 The Procter & Gamble Company 7-(2-imidazolnylamino) quinoline compounds useful as alpha-2 adrenoceptor agonists
DE69425334T2 (de) * 1993-12-17 2001-02-08 The Procter & Gamble Company, Cincinnati 6-(2-imidazolinylamino) chinoxalin-verbindungen als alpha-2-adrenorezeptoragonisten
DE69521883T2 (de) * 1994-01-24 2002-04-04 Allergan Sales, Inc. Aromatische 2-amino-imidazolderivate als alpha 2a-adrenoceptor agonisten
AU2829395A (en) * 1994-06-16 1996-01-05 Allergan, Inc. Method for reducing intraocular pressure in the mammalian eye by administration of calcium chelators
DE69524223T2 (de) * 1994-07-11 2002-08-22 Allergan Sales, Inc. Bicyclische derivate mit starrer konformation und adamantane als alpha-2-adrenergische blockierende agenzien
US6150389A (en) 1994-07-11 2000-11-21 Allergan Sales, Inc. Comformationally rigid bicyclic and adamantane derivatives useful as α2 -adrenergic blocking agents
AU704972B2 (en) 1994-08-04 1999-05-13 H. Lundbeck A/S Novel benzimidazole derivatives
US6294563B1 (en) 1994-10-27 2001-09-25 Allergan Sales, Inc. Combinations of prostaglandins and brimonidine or derivatives thereof
AU715350B2 (en) * 1995-05-12 2000-01-20 Allergan, Inc. Aryl-imidazolines and aryl-imidazoles useful as alpha-2 adrenergic agonists without cardiovascular side effects
US6087361A (en) * 1995-05-12 2000-07-11 Allergan Sales, Inc. Aryl-imidazolines and aryl-imidazoles useful as α-2 adrenergic agonists without cardiovascular side effects
AU744018B2 (en) * 1995-05-12 2002-02-14 Allergan, Inc. Aryl-imidazolines and aryl-imidazoles useful as alpha-2 adrenergic agonists without cardiovascular side effects
US5914342A (en) * 1995-06-07 1999-06-22 The Procter & Gamble Company 2-imidazolinylamino heterocyclic compounds useful as alpha-2 adrenoceptor agonists
US5916900A (en) * 1995-06-29 1999-06-29 The Procter & Gamble Company 7-(2-imidazolinylamino)quinoline compounds useful as alpha-2 adrenoceptor agonists
US6350780B1 (en) 1995-07-28 2002-02-26 Allergan Sales, Inc. Methods and compositions for drug delivery
BR9713536A (pt) 1996-11-25 2000-11-07 Procter & Gamble Compostos heterocìclicos de guanidinila úteis como agonistas de adrenoceptores alfa-2
HUP9904215A3 (en) * 1996-11-25 2002-01-28 Procter & Gamble 2-imidazolinylaminoindole compounds useful as alpha-2 adrenoceptor agonists
US6172095B1 (en) 1996-11-25 2001-01-09 The Procter & Gamble Company Guanidinylamino heterocycle compounds useful as alpha-2 adrenoceptor agonists
AU5433898A (en) * 1996-11-25 1998-06-22 Procter & Gamble Company, The 2-imidazolinylaminobenzothiazole compounds useful as alpha-2 adrenoceptor agonists
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US6306877B1 (en) * 1999-08-09 2001-10-23 The Procter & Gamble Co. Guanidinylamino heterocycle compounds useful as alpha-2 adrenoceptor agonists
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ID24081A (id) * 1997-04-15 2000-07-06 Procter & Gamble Senyawa-senyawa 5-(2-imidazolinilamino) benzimidazol yang berguna sebagai agonis-agonis alfa-2-adrenoseptor
ATE271048T1 (de) 1997-11-24 2004-07-15 Procter & Gamble 5-(2-imidazolinylamino)-benzimidazol derivate, deren herstellung und deren verwendung als .alpha.-adrenoceptor agonisten mit verbesserter metabolischer stabilität
US6329369B1 (en) 1997-12-04 2001-12-11 Allergan Sales, Inc. Methods of treating pain and other conditions
US6841684B2 (en) 1997-12-04 2005-01-11 Allergan, Inc. Imidiazoles having reduced side effects
US6372712B1 (en) 1998-05-22 2002-04-16 The Board Of Trustees Of The Leland Stanford Jr. University Synthetic bifunctional molecules containing a drug moiety and presenter protein ligand
US7214687B2 (en) 1999-07-14 2007-05-08 Almirall Ag Quinuclidine derivatives and medicinal compositions containing the same
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Also Published As

Publication number Publication date
AU646098B2 (en) 1994-02-10
NO303577B1 (no) 1998-08-03
IE913202A1 (en) 1992-02-25
AU8643691A (en) 1992-03-30
NO930898L (no) 1993-05-10
JP3096475B2 (ja) 2000-10-10
HUT65587A (en) 1994-07-28
JPH06501004A (ja) 1994-01-27
NZ239580A (en) 1994-02-25
PT98959B (pt) 1999-02-26
WO1992004345A1 (en) 1992-03-19
HU9300695D0 (en) 1993-06-28
US5091528A (en) 1992-02-25
ZA917218B (en) 1992-06-24
EP0548254B1 (en) 1999-06-02
EP0548254A1 (en) 1993-06-30
NO930898D0 (no) 1993-03-11
DE69131295T2 (de) 2000-01-27
FI94864C (fi) 1995-11-10
DE69131295D1 (de) 1999-07-08
CA2091440A1 (en) 1992-03-13
ES2132093T3 (es) 1999-08-16
ATE180782T1 (de) 1999-06-15
HU220671B1 (hu) 2002-04-29
CA2091440C (en) 2003-11-11
FI94864B (fi) 1995-07-31
IL99345A (en) 1998-08-16
FI931095A0 (fi) 1993-03-11
IL99345A0 (en) 1992-07-15
FI931095A7 (fi) 1993-04-22

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Effective date: 19920327

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