ATE115954T1 - Substituierte zyklobutendion-verbindungen. - Google Patents

Substituierte zyklobutendion-verbindungen.

Info

Publication number: ATE115954T1
Authority: AT; Austria
Prior art keywords: alkyl; hydrogen; group; cyano; nitro
Prior art date: 1989-10-30

Application number

AT90311721T

Other languages

English (en)

Inventor

Geoffrey Smith Kline Bee Stemp

Pinnacles

Gordon Burrell

Original Assignee

Beecham Group Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-10-30

Filing date

1990-10-25

Publication date

1995-01-15

1990-10-25 Application filed by Beecham Group Plc filed Critical Beecham Group Plc

1995-01-15 Application granted granted Critical

1995-01-15 Publication of ATE115954T1 publication Critical patent/ATE115954T1/de

Links

RGBVWCQARBEPPW-UHFFFAOYSA-N cyclobut-3-ene-1,2-dione Chemical class O=C1C=CC1=O RGBVWCQARBEPPW-UHFFFAOYSA-N 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 10
239000001257 hydrogen Substances 0.000 abstract 10
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 9
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 8
125000004093 cyano group Chemical group *C#N 0.000 abstract 4
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 4
229910052760 oxygen Inorganic materials 0.000 abstract 4
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
125000001475 halogen functional group Chemical group 0.000 abstract 3
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
125000004448 alkyl carbonyl group Chemical group 0.000 abstract 2
229910052799 carbon Inorganic materials 0.000 abstract 2
125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 abstract 2
125000004356 hydroxy functional group Chemical group O* 0.000 abstract 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
229910052717 sulfur Inorganic materials 0.000 abstract 2
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 1
125000006625 (C3-C8) cycloalkyloxy group Chemical group 0.000 abstract 1
FZENGILVLUJGJX-NSCUHMNNSA-N (E)-acetaldehyde oxime Chemical compound C\C=N\O FZENGILVLUJGJX-NSCUHMNNSA-N 0.000 abstract 1
125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
125000001494 2-propynyl group Chemical group [H]C#CC([H])([H])* 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
229910004679 ONO2 Inorganic materials 0.000 abstract 1
125000004423 acyloxy group Chemical group 0.000 abstract 1
125000005236 alkanoylamino group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000001589 carboacyl group Chemical group 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000006310 cycloalkyl amino group Chemical group 0.000 abstract 1
125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
JKFAIQOWCVVSKC-UHFFFAOYSA-N furazan Chemical compound C=1C=NON=1 JKFAIQOWCVVSKC-UHFFFAOYSA-N 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
125000000716 hydrazinylidene group Chemical group [*]=NN([H])[H] 0.000 abstract 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
125000001893 nitrooxy group Chemical group [O-][N+](=O)O* 0.000 abstract 1
125000005004 perfluoroethyl group Chemical group FC(F)(F)C(F)(F)* 0.000 abstract 1
-1 polymethylene Polymers 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
150000003852 triazoles Chemical class 0.000 abstract 1
125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Cosmetics (AREA)
Silicon Polymers (AREA)
Fuel-Injection Apparatus (AREA)
Optical Head (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyrane Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

AT90311721T 1989-10-30 1990-10-25 Substituierte zyklobutendion-verbindungen. ATE115954T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB898924373A GB8924373D0 (en)	1989-10-30	1989-10-30	Novel compounds

Publications (1)

Publication Number	Publication Date
ATE115954T1 true ATE115954T1 (de)	1995-01-15

Family

ID=10665385

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90311721T ATE115954T1 (de)	1989-10-30	1990-10-25	Substituierte zyklobutendion-verbindungen.

Country Status (12)

Country	Link
US (1)	US5147866A (de)
EP (1)	EP0426379B1 (de)
JP (1)	JPH03151374A (de)
KR (1)	KR910007908A (de)
AT (1)	ATE115954T1 (de)
AU (1)	AU625427B2 (de)
CA (1)	CA2028668A1 (de)
DE (1)	DE69015322T2 (de)
GB (1)	GB8924373D0 (de)
IE (1)	IE903868A1 (de)
PT (1)	PT95730A (de)
ZA (1)	ZA908594B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0430621A3 (en) *	1989-11-29	1992-03-04	Beecham Group P.L.C.	Process for the preparation of chiral 3,4-epoxy benzopyrans
US5206252A (en) *	1992-05-08	1993-04-27	American Home Products Corporation	Thiadiazolyl-amino derivatives of benzopyrans and indanes
NZ254112A (en) *	1992-07-10	1997-06-24	Boots Co Plc	Dioxocyclobutene derivatives; compounds, preparation and pharmaceutical compositions
CA2130078A1 (en) *	1993-09-16	1995-03-17	Jonas A. Gylys	Antimigraine cyclobutenedione derivatives of indolylalkyl-pyridinyl and pyrimidinylpiperazines
US5382592A (en) *	1993-09-16	1995-01-17	Bristol-Myers Squibb Company	Antimigraine cyclobutenedione derivatives of tryptamines
US5521188A (en) *	1993-09-16	1996-05-28	Bristol-Myers Squibb Company	Antimigraine cyclobutenedione derivatives of indolylalkyl-pyridinyl and pyrimidinylpiperazines
US5506252A (en) *	1993-11-17	1996-04-09	American Home Products Corporation	Substituted N-heteroaryl and N-aryl-1,2-diaminocyclobutene-3,4-diones
US5354763A (en) *	1993-11-17	1994-10-11	American Home Products Corporation	Substituted N-heteroaryl and N-aryl-1,2-diaminocyclobutene-3,4-diones
US5500442A (en) *	1994-06-10	1996-03-19	American Home Products Corporation	Cyclobut-3-ene-1,2-dione derivatives as smooth muscle relaxants
US5482942A (en) *	1994-06-28	1996-01-09	American Home Products Corporation	(3,4-dioxocyclobuten-1-yl)chromene, indene, and dihydronaphthalenone derivatives as smooth muscle relaxants
US5466712A (en) *	1994-11-04	1995-11-14	American Home Products Corporation	Substituted n-aryl-1,2-diaminocyclobutene-3,4-diones
EP0796243B1 (de) *	1994-11-16	1999-01-27	American Home Products Corporation	Diaminocyclobuten-3,4-dione
US5464867A (en) *	1994-11-16	1995-11-07	American Home Products Corporation	Diaminocyclobutene-3,4-diones
US5872139A (en) *	1996-06-17	1999-02-16	American Home Products Corporation	Heterocyclymethylamino derivatives of cyclobutene-3,4-diones
US5763474A (en) *	1996-07-17	1998-06-09	American Home Products Corporation	Substituted N-arylmethylamino derivatives of cyclobutene-3,4-diones
US5750574A (en) *	1996-07-17	1998-05-12	American Home Products Corporation	Fluorinated N-arylmethylamino derivatives of cyclobutene-3,4-diones
US5846999A (en) *	1996-07-17	1998-12-08	American Home Products Corporation	Substituted N-arylmethylamino derivatives of cyclobutene-3,4-diones
US5780505A (en) *	1996-07-17	1998-07-14	American Home Products Corporation	Substituted N-arylmethylamino derivatives of cyclobutene-3, 4-diones
US5840764A (en) *	1997-01-30	1998-11-24	American Home Products Corporation	Substituted hydroxy-anilino derivatives of cyclobutene-3,4-diones
HUP9701865A3 (en) *	1997-11-06	2000-01-28	Egyt Gyogyszervegyeszeti Gyar	Pyrano[3,2-c]pyridine derivatives and pharmaceutical compositons containing them, process for the preparation and use thereof
AU2005316739A1 (en) *	2004-12-13	2006-06-22	Galileo Pharmaceuticals, Inc.	Spiro derivatives as lipoxygenase inhibitors

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1495526A (en) *	1974-05-31	1977-12-21	Beecham Group Ltd	Chroman derivatives
US4391815A (en) *	1976-04-02	1983-07-05	Beecham Group Limited	Cyanobenzano[b]pyrans
DE3064286D1 (en) *	1979-09-28	1983-08-25	Beecham Group Plc	Chromanol derivatives, a process for their preparation and a pharmaceutical composition comprising them
DE3064285D1 (en) *	1979-09-28	1983-08-25	Beecham Group Plc	Chromanol derivatives, a process for their preparation and a pharmaceutical composition comprising them
EP0076075B1 (de) *	1981-09-25	1986-11-20	Beecham Group Plc	Benzopyran-Verbindungen mit pharmazeutischer Wirkung
DE3364145D1 (de) *	1982-04-08	1986-07-24	Beecham Group Plc	Antihypertensive benzopyranols
EP0107423B1 (de) *	1982-10-19	1986-07-23	Beecham Group Plc	Chromanen und Chromenen
DE3475786D1 (de) *	1983-09-01	1989-02-02	Beecham Group Plc	Chromanol derivatives
GB8414987D0 (en) *	1984-06-12	1984-07-18	Beecham Group Plc	Active compounds
US4612309A (en) *	1984-10-23	1986-09-16	William H. Rorer, Inc.	Antisecretory bicyclic benzo-oxy heterocyclic ethers and thioethers
EP0205292B1 (de) *	1985-06-08	1991-11-06	Beecham Group Plc	Pyrano[3,2-c]pyridinderivate, Verfahren und Zwischenprodukte zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
GB8521857D0 (en) *	1985-09-03	1985-10-09	Beecham Group Plc	Active compounds
PT84806B (pt) *	1986-05-03	1989-12-29	Beecham Group Plc	Processo para a preparacao de benzopiranos
DE3835011A1 (de) *	1988-10-14	1990-04-19	Merck Patent Gmbh	Chromanderivate
DE3881714D1 (de) *	1987-02-04	1993-07-22	Hoechst Ag	Alkylsubstituierte n-benzopyranyllactame, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen.
DE3703227A1 (de) *	1987-02-04	1988-08-18	Hoechst Ag	Substituierte 3,4-dihydro-2h-benzopyrane, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen
FR2615191B1 (fr) *	1987-05-16	1991-01-11	Sandoz Sa	Nouveaux benzo(b)pyrannes et pyrannopyridines, leur preparation et leur utilisation comme medicaments
IL88035A0 (en) *	1987-10-27	1989-06-30	American Home Prod	Benzopyran derivatives,their preparation and pharmaceutical compositions containing them
CA1308108C (en) *	1987-10-27	1992-09-29	Dominick A. Quagliato	Antihypertensive benzopyran derivatives
DK691488A (da) *	1987-12-14	1989-06-15	Beecham Group Plc	Hidtil ukendte forbindelser
JPH0699439B2 (ja) *	1988-02-03	1994-12-07	日産化学工業株式会社	ピラノベンゾオキサジアゾール誘導体
US5021432A (en) *	1988-04-26	1991-06-04	Yoshitomi Pharmaceutical Industries, Ltd.	Benzopyran compound and its pharmaceutical use

1989
- 1989-10-30 GB GB898924373A patent/GB8924373D0/en active Pending
1990
- 1990-10-25 DE DE69015322T patent/DE69015322T2/de not_active Expired - Fee Related
- 1990-10-25 AT AT90311721T patent/ATE115954T1/de not_active IP Right Cessation
- 1990-10-25 EP EP90311721A patent/EP0426379B1/de not_active Expired - Lifetime
- 1990-10-26 ZA ZA908594A patent/ZA908594B/xx unknown
- 1990-10-26 CA CA002028668A patent/CA2028668A1/en not_active Abandoned
- 1990-10-26 IE IE386890A patent/IE903868A1/en unknown
- 1990-10-29 AU AU65544/90A patent/AU625427B2/en not_active Ceased
- 1990-10-29 PT PT95730A patent/PT95730A/pt not_active Application Discontinuation
- 1990-10-29 KR KR1019900017376A patent/KR910007908A/ko not_active Withdrawn
- 1990-10-29 US US07/604,874 patent/US5147866A/en not_active Expired - Fee Related
- 1990-10-30 JP JP2293499A patent/JPH03151374A/ja active Pending

Also Published As

Publication number	Publication date
ZA908594B (en)	1992-02-26
AU6554490A (en)	1991-05-02
DE69015322T2 (de)	1995-05-18
AU625427B2 (en)	1992-07-09
IE903868A1 (en)	1991-05-08
EP0426379A2 (de)	1991-05-08
GB8924373D0 (en)	1989-12-20
CA2028668A1 (en)	1991-05-01
EP0426379A3 (en)	1991-11-06
JPH03151374A (ja)	1991-06-27
US5147866A (en)	1992-09-15
KR910007908A (ko)	1991-05-30
EP0426379B1 (de)	1994-12-21
DE69015322D1 (de)	1995-02-02
PT95730A (pt)	1991-09-13

Legal Events

Date	Code	Title	Description
1995-06-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE115954T1 (de)	1995-01-15	Substituierte zyklobutendion-verbindungen.
GR3020915T3 (en)	1996-11-30	Benzopyran derivatives with antihypertensive activity
HU0003413D0 (en)	2000-08-25	New pyridine compounds, a process for their preparation and pharmaceutical compositions containing them
ES519491A0 (es)	1984-04-01	Un metodo para preparar compuesto de piridilo.
AU581324B2 (en)	1989-02-16	Substituted 6-phenyl-4,5-dihydro pyradazin-3-ones
ES8503333A1 (es)	1985-02-16	Un metodo de preparar derivados de 4-quinolona
AU628568B2 (en)	1992-09-17	0 or 3 linked (1,2,4-triazole) and (heteroaryl or indanol) derivatives
DK657389A (da)	1990-06-24	Benzopyran-, tetrahydronaphthalen-, pyranopyridin- og indanderivater
DK115686D0 (da)	1986-03-13	Fremgangsmaade til fremstilling af thienoimidazolderivater
BR8802065A (pt)	1988-11-29	Composto,processo para a preparacao de um composto,composicao herbicida e processo para combater o crescimento de plantas indesejaveis num local
AU2002364411A1 (en)	2003-06-17	Propanolaminomethyltetralines, their preparation and pharmaceutical composition comprising same