ATE88507T1 - Diagnostische probe zum nachweis von praedisposition fuer diabetes typ 1. - Google Patents
Diagnostische probe zum nachweis von praedisposition fuer diabetes typ 1.Info
- Publication number
- ATE88507T1 ATE88507T1 AT88310163T AT88310163T ATE88507T1 AT E88507 T1 ATE88507 T1 AT E88507T1 AT 88310163 T AT88310163 T AT 88310163T AT 88310163 T AT88310163 T AT 88310163T AT E88507 T1 ATE88507 T1 AT E88507T1
- Authority
- AT
- Austria
- Prior art keywords
- diabetes
- type
- diagnostic sample
- probe
- thymine
- Prior art date
Links
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 title 1
- RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical group CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 abstract 4
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 abstract 2
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical group O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 abstract 2
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 abstract 2
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 abstract 2
- 239000000523 sample Substances 0.000 abstract 2
- 229940113082 thymine Drugs 0.000 abstract 2
- 229930024421 Adenine Natural products 0.000 abstract 1
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 abstract 1
- 238000009007 Diagnostic Kit Methods 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108020005187 Oligonucleotide Probes Proteins 0.000 abstract 1
- 229960000643 adenine Drugs 0.000 abstract 1
- 229960002685 biotin Drugs 0.000 abstract 1
- 235000020958 biotin Nutrition 0.000 abstract 1
- 239000011616 biotin Substances 0.000 abstract 1
- 229940104302 cytosine Drugs 0.000 abstract 1
- 239000003599 detergent Substances 0.000 abstract 1
- 239000003550 marker Substances 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 239000002751 oligonucleotide probe Substances 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 108091008146 restriction endonucleases Proteins 0.000 abstract 1
- 229940035893 uracil Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/172—Haplotypes
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/114,559 US5039606A (en) | 1987-10-29 | 1987-10-29 | Diagnostic probe for diabetes type I predisposition |
| EP88310163A EP0314500B1 (de) | 1987-10-29 | 1988-10-28 | Diagnostische Probe zum Nachweis von Prädisposition für Diabetes Typ 1 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE88507T1 true ATE88507T1 (de) | 1993-05-15 |
Family
ID=22355999
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT88310163T ATE88507T1 (de) | 1987-10-29 | 1988-10-28 | Diagnostische probe zum nachweis von praedisposition fuer diabetes typ 1. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5039606A (de) |
| EP (1) | EP0314500B1 (de) |
| JP (1) | JP2975023B2 (de) |
| AT (1) | ATE88507T1 (de) |
| AU (1) | AU612418B2 (de) |
| CA (1) | CA1299506C (de) |
| DE (1) | DE3880434T2 (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1284931C (en) * | 1986-03-13 | 1991-06-18 | Henry A. Erlich | Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids |
| US5604099A (en) * | 1986-03-13 | 1997-02-18 | Hoffmann-La Roche Inc. | Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids |
| US6194561B1 (en) | 1986-03-13 | 2001-02-27 | Roche Molecular Systems, Inc. | Characterization and detection of sequences associated with autoimmune diseases |
| US5340935A (en) * | 1990-01-05 | 1994-08-23 | Dana-Farber Cancer Institute, Inc. | DNAS encoding proteins active in lymphocyte-medicated cytotoxicity |
| US5079343A (en) * | 1990-01-05 | 1992-01-07 | Dana-Farber Cancer Institute, Inc. | Intracellular antigen found in subpopulation of cd8+ t lymphocytes and monoclonal antibody reactive with same |
| WO1992011389A1 (en) * | 1990-12-21 | 1992-07-09 | F. Hoffmann-La Roche Ag | Hla dqbeta dna typing |
| DE4114365A1 (de) * | 1991-05-02 | 1992-11-05 | Max Planck Gesellschaft | Verfahren zur diagnose von nicht-insulin-abhaengigem diabetes mellitus |
| DE4224738A1 (de) * | 1992-07-27 | 1994-02-03 | Engler Blum Gabriele | Verfahren zur Analyse molekularer organischer Strukturen |
| DE9402109U1 (de) * | 1994-02-09 | 1994-03-31 | Maartens Kleinmetaal B.V., Haarlem | Rotationsschneidwerkzeug |
| US5763591A (en) * | 1996-03-25 | 1998-06-09 | Cedars-Sinai Medical Center | Polynucleic acid sequences that are functionally associated with the development of autoimmune disease |
| FR2749308B1 (fr) * | 1996-06-03 | 1998-07-24 | Bio Merieux | Sondes nucleotidiques et procede pour determiner le typage hla dqb1 |
| GB9621129D0 (en) | 1996-10-10 | 1996-11-27 | Duff Gordon W | Detecting genetic predisposition to sight-threatening diabetic retinopathy |
| US20050032077A1 (en) * | 1998-03-10 | 2005-02-10 | Duff Gordon W. | Detecting genetic predisposition to sight-threatening diabetic retinopathy |
| US6852493B2 (en) | 1999-05-14 | 2005-02-08 | Iris Biotechnologies, Inc. | Magnetic field enhanced hybridization of target molecules to immobilized probes |
| ATE232560T1 (de) * | 1999-05-27 | 2003-02-15 | Iris Biotechnologies Inc | Verfahren für die erhöhung der hybridisierungsrate von nukleinsäuren |
| WO2008016988A1 (en) * | 2006-08-01 | 2008-02-07 | Gen-Probe Incorporated | Methods of nonspecific target capture of nucleic acids |
| EP2279411A4 (de) * | 2008-04-09 | 2011-09-21 | Pacific Northwest Res Inst | Screening-verfahren für die genetische prädisposition für diabetes vom typ i |
| WO2011083477A1 (en) * | 2010-01-10 | 2011-07-14 | New Diabetic Solutions | Immuno-tolerance formulations |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3687064T2 (de) * | 1985-06-14 | 1993-11-11 | Bristol Myers Squibb Co | Verfahren zur identifizierung von mit gesteigerter diabetesgefahr assoziierten allelen. |
| CA1284931C (en) * | 1986-03-13 | 1991-06-18 | Henry A. Erlich | Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids |
| WO1988002999A1 (en) * | 1986-10-22 | 1988-05-05 | Prize Frize, Inc. | Apparatus and method for preparing fried potato products |
-
1987
- 1987-10-29 US US07/114,559 patent/US5039606A/en not_active Expired - Fee Related
-
1988
- 1988-10-21 AU AU24109/88A patent/AU612418B2/en not_active Ceased
- 1988-10-28 EP EP88310163A patent/EP0314500B1/de not_active Expired - Lifetime
- 1988-10-28 JP JP63272857A patent/JP2975023B2/ja not_active Expired - Lifetime
- 1988-10-28 AT AT88310163T patent/ATE88507T1/de not_active IP Right Cessation
- 1988-10-28 DE DE8888310163T patent/DE3880434T2/de not_active Expired - Fee Related
- 1988-10-28 CA CA000581575A patent/CA1299506C/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA1299506C (en) | 1992-04-28 |
| EP0314500A3 (en) | 1989-07-26 |
| DE3880434T2 (de) | 1993-09-02 |
| JP2975023B2 (ja) | 1999-11-10 |
| AU2410988A (en) | 1989-05-04 |
| AU612418B2 (en) | 1991-07-11 |
| JPH02500A (ja) | 1990-01-05 |
| DE3880434D1 (de) | 1993-05-27 |
| EP0314500A2 (de) | 1989-05-03 |
| US5039606A (en) | 1991-08-13 |
| EP0314500B1 (de) | 1993-04-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |