ATE116301T1 - Chinolinderivate, deren herstellung und verwendung. - Google Patents

Chinolinderivate, deren herstellung und verwendung.

Info

Publication number: ATE116301T1
Authority: AT; Austria
Prior art keywords: chem; production; quinoline derivatives; alkyl group; lower alkyl
Prior art date: 1989-10-06

Application number

AT90119128T

Other languages

English (en)

Inventor

Kanji Meguro

Hitoshi Ikeda

Original Assignee

Takeda Chemical Industries Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-10-06

Filing date

1990-10-05

Publication date

1995-01-15

1990-10-05 Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd

1995-01-15 Application granted granted Critical

1995-01-15 Publication of ATE116301T1 publication Critical patent/ATE116301T1/de

Links

SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical class N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 title 1
229940027991 antiseptic and disinfectant quinoline derivative Drugs 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 2
102000001494 Sterol O-Acyltransferase Human genes 0.000 abstract 1
108010054082 Sterol O-acyltransferase Proteins 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000002943 quinolinyl group Chemical class N1=C(C=CC2=CC=CC=C12)* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Obesity (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Diabetes (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Holo Graphy (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Measurement Of Radiation (AREA)
Quinoline Compounds (AREA)
Detergent Compositions (AREA)

AT90119128T 1989-10-06 1990-10-05 Chinolinderivate, deren herstellung und verwendung. ATE116301T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP26278289		1989-10-06
JP32229089		1989-12-11

Publications (1)

Publication Number	Publication Date
ATE116301T1 true ATE116301T1 (de)	1995-01-15

Family

ID=26545706

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90119128T ATE116301T1 (de)	1989-10-06	1990-10-05	Chinolinderivate, deren herstellung und verwendung.

Country Status (17)

Country	Link
US (1)	US5223513A (de)
EP (1)	EP0421456B1 (de)
KR (1)	KR910007883A (de)
CN (1)	CN1050715A (de)
AT (1)	ATE116301T1 (de)
AU (1)	AU629048B2 (de)
CA (1)	CA2026890C (de)
DE (1)	DE69015541T2 (de)
FI (1)	FI904915A7 (de)
HU (1)	HUT55364A (de)
IE (1)	IE903454A1 (de)
IL (1)	IL95839A (de)
NO (1)	NO904300L (de)
NZ (1)	NZ235582A (de)
PT (1)	PT95515A (de)
RU (1)	RU2001910C1 (de)
TW (1)	TW205037B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH03181465A (ja) *	1989-12-11	1991-08-07	Takeda Chem Ind Ltd	キノリン誘導体
WO1992019614A1 (en) *	1991-04-26	1992-11-12	Pfizer Inc.	4-aryl-3-(heteroarylureido)quinoline derivatives
JP2668163B2 (ja) *	1992-01-23	1997-10-27	ファイザーインク．	コレステロール血症および抗アテローム動脈硬化症薬としての４−アリール−３−（ヘテロアリールウレイド）−１，２−ジヒドロ−２−オキソ−キノリン誘導体
TW241258B (de) *	1992-04-15	1995-02-21	Takeda Pharm Industry Co Ltd
WO1993024458A1 (en) *	1992-05-28	1993-12-09	Pfizer Inc.	New n-aryl and n-heteroarylurea derivatives as inhibitors of acyl coenzyme a:cholesterol acyl transferase (acat)
EP0585913B1 (de) *	1992-09-04	1997-12-29	Takeda Chemical Industries, Ltd.	Kondensierte heterozyklische Verbindungen, deren Herstellung und Verwendung
US5565472A (en) *	1992-12-21	1996-10-15	Pfizer Inc.	4-aryl-3-(heteroarylureido)-1,2-dihydro-2-oxo-quinoline derivatives as antihypercholesterolemic and antiatherosclerotic agents
NZ264063A (en) *	1993-08-13	1995-11-27	Nihon Nohyaku Co Ltd	N-(2-phenylpyrid-3-yl)- and n-(4-phenylpyrimidin-5-yl)-n'-phenylurea derivatives and pharmaceutical compositions
TW263498B (de) *	1993-11-10	1995-11-21	Takeda Pharm Industry Co Ltd
US6133326A (en)	1994-08-31	2000-10-17	Pfizer Inc	Compositions and methods for decreasing sebum production
US5843957A (en) *	1995-05-19	1998-12-01	Sumitomo Pharmaceuticals Company, Ltd.	Naphthyridine derivatives
CA2301549A1 (en) *	1997-08-28	1999-03-04	Piyasena Hewawasam	4-aryl-3-aminoquinoline-2-one derivatives as potassium channel modulators
US6452008B2 (en)	1998-02-25	2002-09-17	Sumitomo Pharmaceuticals Company, Limited	Pyridone derivatives and process for preparing the same
WO1999043659A1 (en)	1998-02-25	1999-09-02	Sumitomo Pharmaceuticals Co., Ltd.	Pyridone derivatives and process for producing the same
EP1133474B1 (de) *	1998-12-04	2007-02-21	Bristol-Myers Squibb Company	3-substituierte-4-arylchinolin-2-on derivate als kaliumkanal- modulatoren
GEP20043286B (en) *	2000-02-02	2004-07-26	Warner Lambert Co	Dual Inhibitors of Cholesteryl Ester and Wax Ester Synthesis for Sebaceous Gland Disorders
US6852862B2 (en) *	2001-03-02	2005-02-08	Sumika Fine Chemicals Co., Ltd.	Process for producing quinoline-3-carboxylic acid compound
ATE316957T1 (de) *	2001-04-30	2006-02-15	Pfizer Prod Inc	Verbindungen verwendbar als zwischenprodukte für 4-aminochinolinderivate
CA2539760C (en) *	2003-09-23	2011-01-25	Merck & Co., Inc.	Quinoline potassium channel inhibitors
KR20140088194A (ko) *	2011-11-04	2014-07-09	에프. 호프만-라 로슈 아게	아릴-퀴놀린 유도체

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1216878B (de) *	1963-04-02	1966-05-18	Cassella Farbwerke Mainkur Ag	Verfahren zur Herstellung von coronargefaesserweiternden Derivaten des 7-Hydroxy-2-oxo-1, 2-dihydrochinolins
NO133758C (de) *	1970-04-04	1976-06-23	Takeda Chemical Industries Ltd
JPS555502B1 (de) *	1971-07-31	1980-02-07
US4530931A (en) *	1983-01-03	1985-07-23	Usv Pharmaceutical Corp.	8-Quinoline carbanilates for the inhibition of lipolysis
EP0166354B1 (de) *	1984-06-26	1992-08-05	Merck & Co. Inc.	Kondensierte Benzo-Laktam-Verbindungen und deren pharmazeutische Zusammensetzungen
IE892088L (en) *	1988-07-12	1990-01-12	William Henry Deryk Morris	Quinoline derivatives, their production and use

1990
- 1990-09-20 TW TW079107912A patent/TW205037B/zh active
- 1990-09-25 US US07/587,795 patent/US5223513A/en not_active Expired - Fee Related
- 1990-09-25 IE IE345490A patent/IE903454A1/en unknown
- 1990-09-28 IL IL9583990A patent/IL95839A/en not_active IP Right Cessation
- 1990-09-28 AU AU63707/90A patent/AU629048B2/en not_active Ceased
- 1990-10-03 NO NO90904300A patent/NO904300L/no unknown
- 1990-10-04 PT PT95515A patent/PT95515A/pt not_active Application Discontinuation
- 1990-10-04 CA CA002026890A patent/CA2026890C/en not_active Expired - Fee Related
- 1990-10-05 DE DE69015541T patent/DE69015541T2/de not_active Expired - Fee Related
- 1990-10-05 CN CN90108222A patent/CN1050715A/zh active Pending
- 1990-10-05 RU SU904831426A patent/RU2001910C1/ru active
- 1990-10-05 FI FI904915A patent/FI904915A7/fi not_active Application Discontinuation
- 1990-10-05 AT AT90119128T patent/ATE116301T1/de not_active IP Right Cessation
- 1990-10-05 NZ NZ235582A patent/NZ235582A/en unknown
- 1990-10-05 HU HU906360A patent/HUT55364A/hu unknown
- 1990-10-05 EP EP90119128A patent/EP0421456B1/de not_active Expired - Lifetime
- 1990-10-06 KR KR1019900015908A patent/KR910007883A/ko not_active Abandoned

Also Published As

Publication number	Publication date
HU906360D0 (en)	1991-04-29
CA2026890A1 (en)	1991-04-07
EP0421456A3 (en)	1991-05-29
NO904300D0 (no)	1990-10-03
EP0421456A2 (de)	1991-04-10
CN1050715A (zh)	1991-04-17
DE69015541T2 (de)	1995-06-01
NO904300L (no)	1991-04-08
HUT55364A (en)	1991-05-28
NZ235582A (en)	1992-03-26
US5223513A (en)	1993-06-29
FI904915A0 (fi)	1990-10-05
AU629048B2 (en)	1992-09-24
AU6370790A (en)	1991-04-11
IL95839A (en)	1995-03-15
TW205037B (de)	1993-05-01
IE903454A1 (en)	1991-04-10
RU2001910C1 (ru)	1993-10-30
EP0421456B1 (de)	1994-12-28
IL95839A0 (en)	1991-06-30
KR910007883A (ko)	1991-05-30
FI904915A7 (fi)	1991-04-07
PT95515A (pt)	1991-08-14
CA2026890C (en)	2001-09-18
DE69015541D1 (de)	1995-02-09
JPH03223254A (ja)	1991-10-02

Legal Events

Date	Code	Title	Description
1995-06-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE116301T1 (de)	1995-01-15	Chinolinderivate, deren herstellung und verwendung.
DE68920796D1 (de)	1995-03-09	Chinolinderivate, ihre Herstellung und Verwendung.
ZA93267B (en)	1993-08-23	Novel arylcyloakyl derivatives their production and their use
DE69104593D1 (de)	1994-11-17	Herstellung und Verwendung von N-Jodopropargyl-oxycarbonylaminosäure-Estern als antimicrobielle Mittel.
FI952101A0 (fi)	1995-05-03	Merkaptanfoerening
NO960239L (no)	1996-03-18	Kondenserte indanderivater og farmasöytisk akseptable salter derav
ES543153A0 (es)	1987-02-16	Metodo de preparar derivados de b-carbolin-3-oxadiazolilo
ATE158795T1 (de)	1997-10-15	Thiazolidindionderivate, ihre herstellung und anwendung
ATE89003T1 (de)	1993-05-15	Dioxaphosphorin-verbindungen und damit stabilisierte polyolefin-zusammensetzungen.
DE3853043D1 (de)	1995-03-23	Isochinolinderivate, ihre Herstellung und Verwendung.
ATE133672T1 (de)	1996-02-15	Thienopyridin-derivate, deren herstellung und verwendung
DE68918832D1 (de)	1994-11-17	Benzoxazepinderivate.
ES8604912A1 (es)	1986-02-16	Procedimiento de preparacion de nuevos derivados de (arilpi-peraziniletilaminoetoxi)-4 fenol
MY134476A (en)	2007-12-31	Aromatic compounds, their production processes and their compositions for the control of insect pests
DE3664467D1 (de)	1989-08-24	Pineapple ketone l'alkoxyalkyl derivatives