ATE117688T1 - Heterozyklische amine mit zns-wirksamkeit. - Google Patents
Heterozyklische amine mit zns-wirksamkeit.Info
- Publication number
- ATE117688T1 ATE117688T1 AT90908816T AT90908816T ATE117688T1 AT E117688 T1 ATE117688 T1 AT E117688T1 AT 90908816 T AT90908816 T AT 90908816T AT 90908816 T AT90908816 T AT 90908816T AT E117688 T1 ATE117688 T1 AT E117688T1
- Authority
- AT
- Austria
- Prior art keywords
- compounds
- alkyl
- heterocyclic amine
- cns activity
- hydrogen
- Prior art date
Links
- 150000001412 amines Chemical class 0.000 title 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 abstract 1
- UUFQTNFCRMXOAE-UHFFFAOYSA-N 1-methylmethylene Chemical compound C[CH] UUFQTNFCRMXOAE-UHFFFAOYSA-N 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 101100167062 Caenorhabditis elegans chch-3 gene Proteins 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 230000036772 blood pressure Effects 0.000 abstract 1
- YDVJBLJCSLVMSY-UHFFFAOYSA-N carbamoyl cyanide Chemical group NC(=O)C#N YDVJBLJCSLVMSY-UHFFFAOYSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- -1 cyclic amine Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/40—Nitrogen atoms attached in position 8
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/06—Peri-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36437489A | 1989-06-09 | 1989-06-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE117688T1 true ATE117688T1 (de) | 1995-02-15 |
Family
ID=23434241
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90908816T ATE117688T1 (de) | 1989-06-09 | 1990-05-15 | Heterozyklische amine mit zns-wirksamkeit. |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0480939B1 (de) |
| JP (1) | JP2955358B2 (de) |
| KR (1) | KR0167346B1 (de) |
| AT (1) | ATE117688T1 (de) |
| AU (1) | AU626427B2 (de) |
| CA (1) | CA2051697C (de) |
| DE (1) | DE69016430T2 (de) |
| DK (1) | DK0480939T3 (de) |
| ES (1) | ES2067744T3 (de) |
| FI (2) | FI96310C (de) |
| HK (1) | HK65397A (de) |
| HU (2) | HU210264B (de) |
| NO (1) | NO301421B1 (de) |
| RU (1) | RU2023712C1 (de) |
| WO (1) | WO1990015058A1 (de) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05117276A (ja) * | 1991-10-23 | 1993-05-14 | Sumitomo Pharmaceut Co Ltd | 新規な３環性キノキサリンジオン誘導体 |
| TW260660B (de) * | 1993-04-22 | 1995-10-21 | Sumitomo Pharma | |
| DE4314593A1 (de) * | 1993-04-28 | 1994-11-03 | Schering Ag | Pyrido(1,2,3-de)chinoxalinderivate, Verfahren zu deren Herstellung und ihre Verwendung von Arzneimitteln |
| ATE159943T1 (de) * | 1993-07-27 | 1997-11-15 | Upjohn Co | Heterozyclische amine mit zns-wirksamkeit |
| FR2719843B1 (fr) * | 1994-05-10 | 1996-06-07 | Synthelabo | Dérivés de 5,6-dihydro-4h-imidazo [2',1':2,3] imidazo-[4,5,1-ij] quinoléine et de 4,5-dihydroimidazo [1,2-a] pyrrolo-[1,2,3-cd] benzimidazole, leur préparation et leur application en thérapeutique. |
| EP0705834A1 (de) * | 1994-07-27 | 1996-04-10 | Ciba-Geigy Ag | Azaaliphatisch Überbrückte Chinoxalin-2,3-dione |
| EP0705835A1 (de) * | 1994-09-01 | 1996-04-10 | Ciba-Geigy Ag | Oxa- oder thiaaliphatisch überbrückte Chinoxalin-2,3-dione |
| GB9514464D0 (en) * | 1995-07-14 | 1995-09-13 | Glaxo Lab Sa | Medicaments |
| CZ39598A3 (cs) * | 1995-08-10 | 1998-06-17 | Bayer Aktiengesellschaft | Halogenbenzimidazoly, způsob jejich výroby, meziprodukty pro jejich výrobu, mikrobicidní prostředky tyto látky obsahující a jejich použití |
| FR2760237B1 (fr) * | 1997-02-28 | 1999-04-16 | Rhone Poulenc Rorer Sa | Thiazolobenzoheterocycles, leur preparation et les medicaments les contenant |
| US6288075B1 (en) | 1998-02-26 | 2001-09-11 | Rhone-Poulenc Rorer S.A. | Thiazolo[5,4,3-ij]quinolines, preparation and medicines containing the same |
| FR2766487B1 (fr) * | 1997-07-28 | 1999-08-27 | Rhone Poulenc Rorer Sa | Thiazolobenzoheterocycles, leur preparation et les medicaments les contenant |
| US6197339B1 (en) * | 1997-09-30 | 2001-03-06 | Pharmacia & Upjohn Company | Sustained release tablet formulation to treat Parkinson's disease |
| US6455564B1 (en) * | 1999-01-06 | 2002-09-24 | Pharmacia & Upjohn Company | Method of treating sexual disturbances |
| US6355802B1 (en) * | 1999-02-05 | 2002-03-12 | Pharmacia & Upjohn Company | Process to prepare (5R)-(methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]-quinolin-2(1h)-one |
| US7074927B2 (en) | 1999-05-13 | 2006-07-11 | Pharmacia & Upjohn Company | Heterocyclic amines having central nervous system activity |
| DE19954707A1 (de) * | 1999-11-13 | 2001-05-17 | Merck Patent Gmbh | Imidazolverbindungen als Phosphodiesterase VII-Hemmer |
| GB0008939D0 (en) * | 2000-04-11 | 2000-05-31 | Glaxo Group Ltd | Process for preparing substituted benzimidazole compounds |
| CN1450898A (zh) | 2000-04-21 | 2003-10-22 | 法玛西雅厄普约翰美国公司 | 用于治疗纤维肌痛和慢性疲劳综合症的化合物 |
| AR033520A1 (es) * | 2000-04-27 | 2003-12-26 | Upjohn Co | (5r)-(metilamino) -5,6-dihidro-4h-imidazo[4,5,1-ij] quinolin-2(1h)-tiona |
| MXPA03001472A (es) * | 2000-08-16 | 2003-06-06 | Upjohn Co | Compuestos para el tratamiento de trastornos adictivos. |
| US6759405B2 (en) | 2000-11-03 | 2004-07-06 | Wyeth | Cycloocta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives |
| AR031202A1 (es) | 2000-11-03 | 2003-09-10 | Wyeth Corp | Ciclopenta(b) (1,4)diazepino(6,7,1-hi) indoles y derivados |
| AR031199A1 (es) | 2000-11-03 | 2003-09-10 | Wyeth Corp | Ciclohepta/b//1,4/diacepino/6,7,1-hi/indoles y derivados |
| US6541513B2 (en) * | 2001-02-27 | 2003-04-01 | Ortho-Mcneil Pharmaceutical, Inc. | Carbamate compounds for use in preventing or treating psychotic disorders |
| FR2825705B1 (fr) * | 2001-06-08 | 2005-05-20 | Aventis Pharma Sa | Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens |
| FR2835186B1 (fr) | 2002-01-28 | 2006-10-20 | Aventis Pharma Sa | Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases |
| TW200307540A (en) | 2002-04-25 | 2003-12-16 | Wyeth Corp | [1, 4]Diazocino[7, 8, 1-hi] indole derivatives as antipsychotic and antiobesity agents |
| TWI312781B (en) | 2002-04-25 | 2009-08-01 | [1,4]diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents | |
| TW200307682A (en) * | 2002-04-25 | 2003-12-16 | Wyeth Corp | 1,2,3,4,7,8-Hexahydro-6H-[1,4]diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents |
| AR040683A1 (es) * | 2002-07-25 | 2005-04-13 | Pharmacia Corp | Composicion de tabletas de liberacion sostenida que comprende un agonista de los receptores de la dopamina |
| US20050226926A1 (en) | 2002-07-25 | 2005-10-13 | Pfizer Inc | Sustained-release tablet composition of pramipexole |
| US20070196481A1 (en) * | 2002-07-25 | 2007-08-23 | Amidon Gregory E | Sustained-release tablet composition |
| FR2844273B1 (fr) | 2002-09-05 | 2008-04-04 | Aventis Pharma Sa | Nouveaux composes heterocycliques, procede et intermediaires de preparation et utilisation comme medicament, notamment comme inhibiteurs de beta-lactamases et anti-bacteriens. |
| PL376452A1 (en) * | 2002-10-25 | 2005-12-27 | Pharmacia & Upjohn Company Llc | Use of heterocyclic amine-type compounds as neuroprotective agents |
| US7262297B2 (en) * | 2003-05-15 | 2007-08-28 | Hoffmann-La Roche Inc. | Diaminopyrroloquinazolines compounds as protein tyrosine phosphatase inhibitors |
| AU2004261283B2 (en) * | 2003-07-31 | 2008-05-01 | Irm, Llc | Bicyclic compounds and compositions as PDF inhibitors |
| US20050250803A1 (en) * | 2003-11-26 | 2005-11-10 | Pfizer Inc | Combination of dopamine agonists and monoamine reuptake inhibitors |
| UA93608C2 (ru) | 2004-08-13 | 2011-02-25 | Берингер Ингельхайм Интернациональ Гмбх | композициЯ таблетки пролонгированного высвобождения, которая содержит прамипексол или его фармацевтически приемлемую соль, СПОСОБ EE ИЗГОТОВЛЕНИЯ И EE ПРИМЕНЕНИЕ |
| CN101022788B (zh) | 2004-08-13 | 2010-11-10 | 贝林格尔·英格海姆国际有限公司 | 包含普拉克索或其可药用盐的延长释放小球制剂、其制备方法及其用途 |
| TW200635926A (en) * | 2004-11-05 | 2006-10-16 | Wyeth Corp | Metabolites of ceratin [1,4]diazepino[6,7,1-ij]quinoline derivatives and methods of preparation and use thereof |
| GT200500317A (es) | 2004-11-05 | 2006-10-27 | Proceso para preparar compuestos de quinolina y productos obtenidos de los mismos | |
| AR053902A1 (es) | 2005-06-14 | 2007-05-23 | Schering Corp | Inhibidores de aspartil proteasa heterociclicos macrociclicos |
| AR054849A1 (es) | 2005-07-26 | 2007-07-18 | Wyeth Corp | Diazepinoquinolinas, sintesis de las mismas, e intermediarios para obtenerlas |
| AR092568A1 (es) | 2012-09-14 | 2015-04-22 | Abbvie Deutschland | Derivados triciclicos de quinolinas y de quinoxalinas |
| US20140080813A1 (en) | 2012-09-14 | 2014-03-20 | AbbVie Deutschland GmbH & Co. KG | Tricyclic quinoline and quinoxaline derivatives |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU3563389A (en) * | 1988-05-09 | 1989-11-29 | Upjohn Company, The | Anxiolytic/anti-depressant 2,3-dihydro-1h-phenalen-2-amines |
-
1990
- 1990-05-15 KR KR1019910701790A patent/KR0167346B1/ko not_active Expired - Fee Related
- 1990-05-15 AT AT90908816T patent/ATE117688T1/de not_active IP Right Cessation
- 1990-05-15 JP JP2508489A patent/JP2955358B2/ja not_active Expired - Fee Related
- 1990-05-15 HU HU905216A patent/HU210264B/hu not_active IP Right Cessation
- 1990-05-15 DE DE69016430T patent/DE69016430T2/de not_active Expired - Fee Related
- 1990-05-15 ES ES90908816T patent/ES2067744T3/es not_active Expired - Lifetime
- 1990-05-15 CA CA002051697A patent/CA2051697C/en not_active Expired - Fee Related
- 1990-05-15 EP EP90908816A patent/EP0480939B1/de not_active Expired - Lifetime
- 1990-05-15 DK DK90908816.3T patent/DK0480939T3/da active
- 1990-05-15 AU AU57438/90A patent/AU626427B2/en not_active Ceased
- 1990-05-15 WO PCT/US1990/002621 patent/WO1990015058A1/en not_active Ceased
-
1991
- 1991-12-04 FI FI915715A patent/FI96310C/fi active
- 1991-12-06 RU SU915010471A patent/RU2023712C1/ru not_active IP Right Cessation
- 1991-12-06 NO NO914827A patent/NO301421B1/no unknown
-
1994
- 1994-10-07 FI FI944704A patent/FI96687C/fi active
-
1995
- 1995-06-30 HU HU95P/P00660P patent/HU211702A9/hu unknown
-
1997
- 1997-05-15 HK HK65397A patent/HK65397A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO1990015058A1 (en) | 1990-12-13 |
| RU2023712C1 (ru) | 1994-11-30 |
| HUT60269A (en) | 1992-08-28 |
| AU5743890A (en) | 1991-01-07 |
| FI96687C (fi) | 1996-08-12 |
| HU905216D0 (en) | 1992-02-28 |
| NO914827D0 (no) | 1991-12-06 |
| FI96310C (fi) | 1996-06-10 |
| FI96310B (fi) | 1996-02-29 |
| ES2067744T3 (es) | 1995-04-01 |
| NO301421B1 (no) | 1997-10-27 |
| HU211702A9 (en) | 1995-12-28 |
| AU626427B2 (en) | 1992-07-30 |
| FI944704A0 (fi) | 1994-10-07 |
| DE69016430T2 (de) | 1995-06-01 |
| HK65397A (en) | 1997-05-23 |
| HU210264B (en) | 1995-03-28 |
| FI915715A0 (fi) | 1991-12-04 |
| EP0480939A1 (de) | 1992-04-22 |
| EP0480939B1 (de) | 1995-01-25 |
| JP2955358B2 (ja) | 1999-10-04 |
| NO914827L (no) | 1992-02-07 |
| KR920701204A (ko) | 1992-08-11 |
| JPH04506071A (ja) | 1992-10-22 |
| CA2051697A1 (en) | 1990-12-10 |
| DE69016430D1 (de) | 1995-03-09 |
| FI944704L (fi) | 1994-10-07 |
| FI96687B (fi) | 1996-04-30 |
| CA2051697C (en) | 1996-10-08 |
| DK0480939T3 (da) | 1995-07-10 |
| KR0167346B1 (ko) | 1999-01-15 |
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