ATE117988T1 - Disulfidderivate von mercapto-acyl-aminsäuren. - Google Patents

Disulfidderivate von mercapto-acyl-aminsäuren.

Info

Publication number: ATE117988T1
Authority: AT; Austria
Prior art keywords: lower alkyl; aryl; heteroaryl; alkyl; mercapto
Prior art date: 1990-05-17

Application number

AT91911546T

Other languages

English (en)

Inventor

Martin F Haslanger

Bernard R Neustadt

Elizabeth M Smith

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-05-17

Filing date

1991-05-15

Publication date

1995-02-15

1991-05-15 Application filed by Schering Corp filed Critical Schering Corp

1995-02-15 Application granted granted Critical

1995-02-15 Publication of ATE117988T1 publication Critical patent/ATE117988T1/de

Links

150000002019 disulfides Chemical class 0.000 title abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 10
125000003118 aryl group Chemical group 0.000 abstract 5
125000003545 alkoxy group Chemical group 0.000 abstract 4
125000001072 heteroaryl group Chemical group 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
208000024172 Cardiovascular disease Diseases 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 2
125000004414 alkyl thio group Chemical group 0.000 abstract 2
150000002431 hydrogen Chemical class 0.000 abstract 2
125000003396 thiol group Chemical class [H]S* 0.000 abstract 2
239000005541 ACE inhibitor Substances 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 abstract 1
229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 abstract 1
125000004659 aryl alkyl thio group Chemical group 0.000 abstract 1
125000002102 aryl alkyloxo group Chemical group 0.000 abstract 1
230000001746 atrial effect Effects 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
239000002833 natriuretic agent Substances 0.000 abstract 1
IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Neurology (AREA)
Hematology (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
Neurosurgery (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT91911546T 1990-05-17 1991-05-15 Disulfidderivate von mercapto-acyl-aminsäuren. ATE117988T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US52537090A	1990-05-17	1990-05-17

Publications (1)

Publication Number	Publication Date
ATE117988T1 true ATE117988T1 (de)	1995-02-15

Family

ID=24092967

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91911546T ATE117988T1 (de)	1990-05-17	1991-05-15	Disulfidderivate von mercapto-acyl-aminsäuren.

Country Status (14)

Country	Link
EP (1)	EP0528997B1 (de)
JP (1)	JPH06102648B2 (de)
AT (1)	ATE117988T1 (de)
AU (1)	AU7957291A (de)
DE (1)	DE69107207T2 (de)
DK (1)	DK0528997T3 (de)
ES (1)	ES2069893T3 (de)
GR (1)	GR3015801T3 (de)
IE (1)	IE911666A1 (de)
IL (1)	IL98149A0 (de)
NZ (1)	NZ238154A (de)
PT (1)	PT97669A (de)
WO (1)	WO1991017980A1 (de)
ZA (1)	ZA913685B (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ334898A (en) *	1996-10-23	2000-09-29	Warner Lambert Co	Substituted gamma aminobutyric acids as pharamceutical agents

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4173704A (en) *	1976-05-10	1979-11-06	E. R. Squibb & Sons, Inc.	Dithio aminoacid derivatives
US4053651A (en) *	1976-05-10	1977-10-11	E. R. Squibb & Sons, Inc.	Compounds and method for alleviating angiotensin related hypertension
CH637374A5 (en) *	1977-12-02	1983-07-29	Squibb & Sons Inc	Substituted amino acids
US4329495A (en) *	1981-05-18	1982-05-11	Pfizer Inc.	Enkephalinase enzyme inhibiting compounds
DE3467754D1 (de) *	1983-10-03	1988-01-07	Squibb & Sons Inc	Enkephalinase inhibitors
JPS60136554A (ja) *	1983-10-03	1985-07-20	イ−・ア−ル・スクイブ・アンド・サンズ・インコ−ポレイテッド	エンケフアリナ−ゼ抑制剤
FR2556721B1 (fr) *	1983-12-14	1986-05-16	Roussel Uclaf	Nouveaux derives de o-mercaptopropanamide d'o amino-acides, leur procede de preparation, leur application comme medicaments et les compositions les renfermant
DE3814374A1 (de) *	1988-04-28	1989-11-09	Joerg Schwarzbich	Kugelraste

1991
- 1991-05-15 PT PT97669A patent/PT97669A/pt not_active Application Discontinuation
- 1991-05-15 DE DE69107207T patent/DE69107207T2/de not_active Expired - Fee Related
- 1991-05-15 EP EP91911546A patent/EP0528997B1/de not_active Expired - Lifetime
- 1991-05-15 IL IL98149A patent/IL98149A0/xx unknown
- 1991-05-15 IE IE166691A patent/IE911666A1/en unknown
- 1991-05-15 ES ES91911546T patent/ES2069893T3/es not_active Expired - Lifetime
- 1991-05-15 DK DK91911546.9T patent/DK0528997T3/da active
- 1991-05-15 ZA ZA913685A patent/ZA913685B/xx unknown
- 1991-05-15 AU AU79572/91A patent/AU7957291A/en not_active Abandoned
- 1991-05-15 NZ NZ238154A patent/NZ238154A/xx unknown
- 1991-05-15 AT AT91911546T patent/ATE117988T1/de active
- 1991-05-15 WO PCT/US1991/003251 patent/WO1991017980A1/en not_active Ceased
- 1991-05-15 JP JP3510190A patent/JPH06102648B2/ja not_active Expired - Lifetime
1995
- 1995-04-17 GR GR950400931T patent/GR3015801T3/el unknown

Also Published As

Publication number	Publication date
EP0528997B1 (de)	1995-02-01
NZ238154A (en)	1993-07-27
AU7957291A (en)	1991-12-10
JPH05502038A (ja)	1993-04-15
JPH06102648B2 (ja)	1994-12-14
IL98149A0 (en)	1992-06-21
WO1991017980A1 (en)	1991-11-28
EP0528997A1 (de)	1993-03-03
DE69107207D1 (de)	1995-03-16
GR3015801T3 (en)	1995-07-31
ES2069893T3 (es)	1995-05-16
DK0528997T3 (da)	1995-04-24
PT97669A (pt)	1992-02-28
IE911666A1 (en)	1991-11-20
ZA913685B (en)	1992-02-26
DE69107207T2 (de)	1995-06-29

Publication	Publication Date	Title
HUT65618A (en)	1994-07-28	Process for producing benzylidene-carbamoyl-2-pyrrolidone, -4-oxazolidinone, -4-thiazolidinone and -3-isothiazolidinone analogues
ATE90107T1 (de)	1993-06-15	Peptide mit collagenase hemmender wirkung.
DE59000151D1 (de)	1992-07-16	Verfahren zur bekaempfung von pilzen ausserhalb des menschlichen oder tierischen koerpers.
ES8606341A1 (es)	1986-04-16	Un procedimiento para la preparacion de pirazolo piridinas.
ES2052714T3 (es)	1994-07-16	Un proceso para la preparacion de un compuesto denominado "cornexistina".
TR199801474T2 (xx)	1998-10-21	2, 4-Diamino-1, 3, 5-Triazin, �retim y�ntemleri.
DE3771558D1 (de)	1991-08-29	Von substituierten phenyl-2-acrylsaeuren abgeleitete sulfide.
DK0392560T3 (da)	1996-01-29	Diaminoethylenforbindelser
LV10619A (lv)	1995-04-20	Arstniecibas lidzekli
ES2072138T3 (es)	1995-07-01	N-(mercaptoalquil) amidas.
DK0528997T3 (da)	1995-04-24	Disulfidderivater af mercaptoacylaminosyrer
DK0393441T3 (da)	1993-09-27	Mercapto-acylaminosyrer
AU5082779A (en)	1980-03-20	Substituted bis-benzimidazolyl compounds and their use in treating protozoal or virus diseases
EA199700106A1 (ru)	1997-12-30	Замещенные 2-фенилпиридины в качестве гербицидов
ATE330933T1 (de)	2006-07-15	Verfahren zur herstellung von optisch aktiven amino-alkoholen
ES2053061T3 (es)	1994-07-16	Derivado de aminobutanol y procedimiento para la preparacion de 3-pirrolidinol a partir de dicho derivado.
DK18186A (da)	1986-07-17	Aminoacrylsyre-derivater, deres fremstilling og anvendelse, samt vedfremstillingen anvendelige mellemprodukter og fremstillingderaf
DE3850240D1 (de)	1994-07-21	Verfahren zur Herstellung von O-Carboxyarylimidazolinone.
DK434689A (da)	1989-09-01	Fremgangsmaade til fremstilling af 4-amino-5-dialkoxymethylpyrimidinderivater