ES2072138T3 - N-(mercaptoalquil) amidas. - Google Patents

N-(mercaptoalquil) amidas.

Info

Publication number
ES2072138T3
ES2072138T3 ES92901485T ES92901485T ES2072138T3 ES 2072138 T3 ES2072138 T3 ES 2072138T3 ES 92901485 T ES92901485 T ES 92901485T ES 92901485 T ES92901485 T ES 92901485T ES 2072138 T3 ES2072138 T3 ES 2072138T3
Authority
ES
Spain
Prior art keywords
lower alkyl
aryl
alkyl
hydrogen
heteroaryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92901485T
Other languages
English (en)
Inventor
Bernard R Neustadt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ES2072138T3 publication Critical patent/ES2072138T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/40—Y being a hydrogen or a carbon atom
    • C07C323/42—Y being a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/30—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms, not being part of nitro or nitroso groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

SE DESCRIBEN NUEVAS AMIDAS N-(MERCAPTOALQUILO) DE LA FORMULA (I), EN LA QUE R1 ES ALQUILO INFERIOR, ALQUILO CICLO INFERIOR, ARILO O HETEROARILO; R2 ES (COR3)-ARILO, HETEROARILO, (COR3)ARILO SUSTITUIDO O HETEROARILO SUSTITUIDO, EN DONDE LOS SUSTITUYENTES SON 1-3 SUSTITUYENTES SELECCIONADOS DEL GRUPO COMPUESTO DE CARBOXI, ALCOXICARBONILO, ALQUILO INFERIOR, HIDROXI, ALCOXI INFERIOR, ALQUILO CICLO INFERIOR, CIANO, TRIFLUOROMETILO,FENILO, FENOXI Y FENILTIO; R3 ES -OR4 O N-R4R5; R4 Y R5 ESTAN SELECCIONADOS DE MODO INDEPENDIENTE DEL GRUPO COMPUESTO DE HIDROGENO, ALQUILO INFERIOR, HIDROXI ALQUILO INFERIOR,ALCOXI INFERIOR ALQUILO INFERIOR Y ARILO ALQUILO INFERIOR, O R4 Y R5 JUNTOS CON EL NITROGENO AL CUAL ESTA UNIDOS FORMAN UN ANILLO DE 5, 6 O 7 MIEMBROS; Q ES HIDROGENO O R6CO-; R6 ES HIDROGENO, ALQUILO INFERIOR O ARILO; Y M ES 1 O 2; Y LAS SALES FARMACEUTICAMENTE ACEPTABLES DE ELLOS UTILES EN EL TRATAMIENTO DE TRASTORNOS CARCIOVASCULARES, NEFROTOXICIDAD Y CONDICIONES DOLOROSAS, ASI COMO COMBINACIONES DE N(MERCAPTOALQUILO)AMIDAS Y FACTORES NATRIURETICOS ATRIALES O ANGIOTENSORES QUE CONVIERTEN INHIBIDORES ENZIMATICOS, UTILES PARA TRATAR LOS TRASTORNOS CARDIOVASCULARES.
ES92901485T 1990-12-21 1991-12-19 N-(mercaptoalquil) amidas. Expired - Lifetime ES2072138T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/633,696 US5232920A (en) 1990-12-21 1990-12-21 N-(mercaptoalkyl)amides

Publications (1)

Publication Number Publication Date
ES2072138T3 true ES2072138T3 (es) 1995-07-01

Family

ID=24540737

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92901485T Expired - Lifetime ES2072138T3 (es) 1990-12-21 1991-12-19 N-(mercaptoalquil) amidas.

Country Status (15)

Country Link
US (1) US5232920A (es)
EP (1) EP0563153B1 (es)
JP (1) JP2511625B2 (es)
AT (1) ATE119879T1 (es)
AU (1) AU9104691A (es)
DE (1) DE69108262T2 (es)
DK (1) DK0563153T3 (es)
ES (1) ES2072138T3 (es)
IE (1) IE73256B1 (es)
IL (1) IL100427A0 (es)
NZ (1) NZ241063A (es)
PT (1) PT99861A (es)
TW (1) TW199139B (es)
WO (1) WO1992011235A1 (es)
ZA (1) ZA9110014B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5177064A (en) * 1990-07-13 1993-01-05 University Of Florida Targeted drug delivery via phosphonate derivatives
US5552397A (en) * 1992-05-18 1996-09-03 E. R. Squibb & Sons, Inc. Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase
US5654294A (en) * 1993-05-13 1997-08-05 Bristol-Myers Squibb Spiro lactam dual action inhibitors
US5508272A (en) * 1993-06-15 1996-04-16 Bristol-Myers Squibb Company Compounds containing a fused bicycle ring and processes therefor
US5362727A (en) * 1993-07-26 1994-11-08 Bristol-Myers Squibb Substituted azepino[2,1-a]isoquinoline compounds
US5462964A (en) * 1993-10-20 1995-10-31 The Du Pont Merck Pharmaceutical Company Dipeptide boronic acid inhibitors of trypsin-like enzymes
US5616775A (en) * 1994-05-05 1997-04-01 Bristol-Myers Squibb Co. Process for preparing homocystein analogs useful as intermediates for compounds containing a fused bicyclic ring
US5587375A (en) * 1995-02-17 1996-12-24 Bristol-Myers Squibb Company Azepinone compounds useful in the inhibition of ACE and NEP
US5877313A (en) * 1995-05-17 1999-03-02 Bristol-Myers Squibb Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP
US5635504A (en) * 1995-06-07 1997-06-03 Bristol-Myers Squibb Co. Diazepine containing dual action inhibitors
US5650408A (en) * 1995-06-07 1997-07-22 Karanewsky; Donald S. Thiazolo benzazepine containing dual action inhibitors
EP3282937A4 (en) * 2015-04-14 2018-11-21 Nueon Inc. Method and apparatus for determining markers of health by analysis of blood

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4256761A (en) * 1979-07-13 1981-03-17 Usv Pharmaceutical Corporation Antihypertensive amides
US4820729A (en) * 1981-03-30 1989-04-11 Rorer Pharmaceutical Corporation N-substituted-amido-amino acids
US4470973A (en) * 1982-07-19 1984-09-11 E. R. Squibb & Sons, Inc. Substituted peptide compounds
ZA852359B (en) * 1984-04-02 1985-11-27 Squibb & Sons Inc Enkephalinase inhibitors
FR2589468B1 (fr) * 1985-07-30 1987-12-31 Roussel Uclaf Nouveaux derives du 2-acylamino ethanethiol 2-substitue, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
US4740499A (en) * 1986-07-28 1988-04-26 Monsanto Company Method of enhancing the bioactivity of atrial peptides

Also Published As

Publication number Publication date
PT99861A (pt) 1992-12-31
ZA9110014B (en) 1992-08-26
EP0563153B1 (en) 1995-03-15
US5232920A (en) 1993-08-03
JP2511625B2 (ja) 1996-07-03
EP0563153A1 (en) 1993-10-06
NZ241063A (en) 1995-04-27
ATE119879T1 (de) 1995-04-15
TW199139B (es) 1993-02-01
IL100427A0 (en) 1992-09-06
WO1992011235A1 (en) 1992-07-09
JPH05509331A (ja) 1993-12-22
DE69108262T2 (de) 1995-07-06
DE69108262D1 (de) 1995-04-20
DK0563153T3 (da) 1995-05-29
IE73256B1 (en) 1997-05-21
AU9104691A (en) 1992-07-22
IE914487A1 (en) 1992-07-01

Similar Documents

Publication Publication Date Title
DK0563153T3 (da) N-(mercaptoalkyl)amider
NZ324007A (en) Quinazoline derivatives susbtituted by a phenyl and medicaments
AP1687A (en) Therapeutic biaryl derivatives.
AU7578894A (en) Methods for inhibiting smooth muscle cell proliferation and restinosis
NZ331613A (en) Piperazinyl or piperidinyl substituted 1,2,3,4-tetrahydronaphthalene derivatives
IE831564L (en) N-substituted imidazoles
NO996108L (no) 9-oksinerytromycinderivater
DE69808326D1 (de) Azetidinonderivate zur behandlung von hcmv entzündungen
AU6148696A (en) Methods of inhibiting pneumocystis carinii pneumonia and compounds useful therefor
AU8445591A (en) N-(mercaptoalkyl)ureas and carbamates
NO971261D0 (no) Kinoksalin-derivater nyttige innen terapi
MXPA03011032A (es) Activadores de derivados de oxazol/tiazol del receptor hppar-alfa.
DE602004007181D1 (de) 2,4,6-tris(4'aminobenzaldineopentylmalonat)-s-triazin, dieser enthaltenden Sonnenschutzzusammensetzungen und dessen Verwendungen
AP2002002595A0 (en) Heterocyclic amide derivatives.
ATE295172T1 (de) Propylaxe und behandlung der arzneimittel induzierten nierenstörungen
DE69001710D1 (de) Merkaptoacylaminosaeure.
AP2001002356A0 (en) Tricyclic analgesics.
EP0372410A3 (en) Use of heterocyclic amides to inhibit tumor metastasis
ES2069893T3 (es) Derivados de disulfuros de mercaptoacilaminoacidos.
ATE239707T1 (de) 2-phenylpyridine-derivate und verfahren zu deren herstellung
TH19278A (th) อนุพันธ์ของ 5-อิมิโน-2-อิมิแดโซลีน ซึ่งมีฤทธิ์ฆ่าเชื้อรา

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 563153

Country of ref document: ES