ES2068294T3 - 2,3-dihidro-1-(piridinilamino)-indoles, un procedimiento para su preparacion y su uso como medicamentos. - Google Patents
2,3-dihidro-1-(piridinilamino)-indoles, un procedimiento para su preparacion y su uso como medicamentos.Info
- Publication number
- ES2068294T3 ES2068294T3 ES90114661T ES90114661T ES2068294T3 ES 2068294 T3 ES2068294 T3 ES 2068294T3 ES 90114661 T ES90114661 T ES 90114661T ES 90114661 T ES90114661 T ES 90114661T ES 2068294 T3 ES2068294 T3 ES 2068294T3
- Authority
- ES
- Spain
- Prior art keywords
- loweralkyl
- aryl
- indoles
- dihydro
- arylloweralkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003814 drug Substances 0.000 title 1
- -1 loweralkyl Chemical group 0.000 abstract 6
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 150000002431 hydrogen Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000006513 pyridinyl methyl group Chemical group 0.000 abstract 2
- 125000005301 thienylmethyl group Chemical group [H]C1=C([H])C([H])=C(S1)C([H])([H])* 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 229940035676 analgesics Drugs 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 229940125681 anticonvulsant agent Drugs 0.000 abstract 1
- 239000001961 anticonvulsive agent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- UPQBWVOMAKRBQF-UHFFFAOYSA-N n-pyridin-2-yl-2,3-dihydroindol-1-amine Chemical class C1CC2=CC=CC=C2N1NC1=CC=CC=N1 UPQBWVOMAKRBQF-UHFFFAOYSA-N 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
ESTA INVENCION ES RELTIVA A 2,3-DIHIDRO-1-(PIRIDINILAMINO)-INDOLOS DE LA FORMULA DONDE R1 ES HIDROGENO, ALQUILO INFERIOR, ARILO, ARILO ALQUILO INFERIOR, O HETEROARILO ALQUILO INFERIOR SELECCIONADO DEL GRUPO COMPUESTO POR PIRIDINILOMETILO, PIRIDINILOETILO, TIENILOMETILO, TIENILOETILO; R2 Y R3 SON INDEPENDIENTEMENTE HIDROGENO, ALQUILO INFERIOR, ARILO, ARILO ALQUILO INFERIOR, O HETEROARILO ALQUILO INFERIOR SELECCIONADO DEL GRUPO COMPUESTO POR PIRIDINILOMETILO, PIRIDINILOETILO, TIENILOMETILO, TIENILOETILO; O R2 Y R3 JUNTOS FORMAN UN ANILLO CICLOALCANO DE 4 A 6 CARBONOS O UN ARILO O HETEROCICLOALQUILO FUSIONADOS EN ESPIRAL; X E Y SON INDEPENDIENTEMENTE HIDROGENO, HALOGENO, HIDROXILO, ALQUILO INFERIOR, ALCOXILO INFERIOR, NITROGENO, AMINO O TRIFLUOROMETILO; M Y N SON INDEPENDIENTEMENTE ENTEROS DE 1 A 3. TAMBIEN ES RELATIVA A SUS SALES DE ADICION ACIDA FARMACEUTICAMENTE ACEPTABLES Y DONDE SON APROPIADAS LAS MEZCLAS OPTICAS, GEOMETRICAS Y ESTEREOISOMERAS Y RACEMICAS DE ELLAS Y A UN PROCESO PARA SU PREPARACION. LOS COMPUESTOS DE ESTA INVENCION PRESENTAN UTILIDAD COMO ANALGESICOS, ANTICONVULSIVOS, MEJORADORES DE MEMORIA Y PARA EL TRATAMIENTO DEL MAL DE ALZHEIMER.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38841589A | 1989-08-02 | 1989-08-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2068294T3 true ES2068294T3 (es) | 1995-04-16 |
Family
ID=23534038
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES90114661T Expired - Lifetime ES2068294T3 (es) | 1989-08-02 | 1990-07-31 | 2,3-dihidro-1-(piridinilamino)-indoles, un procedimiento para su preparacion y su uso como medicamentos. |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0415103B1 (es) |
| JP (1) | JPH0674266B2 (es) |
| KR (1) | KR0164595B1 (es) |
| AT (1) | ATE118002T1 (es) |
| AU (1) | AU628201B2 (es) |
| CA (1) | CA2022488C (es) |
| DE (1) | DE69016531T2 (es) |
| DK (1) | DK0415103T3 (es) |
| ES (1) | ES2068294T3 (es) |
| FI (1) | FI95466C (es) |
| GR (1) | GR3015228T3 (es) |
| IE (1) | IE66601B1 (es) |
| IL (1) | IL95251A (es) |
| NO (1) | NO176398C (es) |
| NZ (1) | NZ234726A (es) |
| PT (1) | PT94880B (es) |
| ZA (1) | ZA906048B (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4868190A (en) * | 1988-12-27 | 1989-09-19 | Hoechst-Roussel Pharmaceuticals, Inc. | N-pyridinyl-9H-carbazol-9-amines |
| US5214038A (en) * | 1991-04-15 | 1993-05-25 | Hoechst-Roussel Pharmaceuticals Inc. | 1-(pyrido[3,4-b]-1,4-oxazinyl-4-yl)-1H-indoles and intermediates for the preparation thereof |
| US5202319A (en) * | 1991-09-23 | 1993-04-13 | Hoechst-Roussel Pharmaceuticals Inc. | Substituted 3-amino-2,3,4,5-tetrahydro-1-aryloxy-3-benzazepines |
| US5459274A (en) * | 1994-05-13 | 1995-10-17 | Hoechst-Roussel Pharmaceuticals Inc. | Preparation of N-alkyl-N-pyridinyl-1H-indol-1-amines |
| US6100276A (en) * | 1996-04-12 | 2000-08-08 | Aventis Pharmaceuticals Inc. | Isatin derivatives as acetylcholinesterase inhibitors and analgesics |
| KR20000062358A (ko) * | 1996-12-27 | 2000-10-25 | 게리 디. 스트리트, 스티븐 엘. 네스비트 | 알츠하이머병 및 울병 치료용 ｎ-(피리디닐아미노)이소인돌린 |
| GB0119435D0 (en) | 2001-02-15 | 2001-10-03 | Aventis Pharm Prod Inc | Method of treating of demyelinating diseases or conditions |
| KR20230062158A (ko) | 2021-10-29 | 2023-05-09 | 대우조선해양 주식회사 | 극지용 선박의 발전기 엔진의 외기 흡입구조 및 상기 외기 흡입구조를 포함하는 극지용 선박 |
| KR20230062160A (ko) | 2021-10-29 | 2023-05-09 | 대우조선해양 주식회사 | 극지용 선박의 공조 시스템 및 상기 극지용 선박의 외기 흡입구조 |
| KR20230062159A (ko) | 2021-10-29 | 2023-05-09 | 대우조선해양 주식회사 | 극지용 선박의 발전기 엔진의 외기 흡입구조 및 상기 외기 흡입구조를 포함하는 극지용 선박 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE115143T1 (de) * | 1987-04-24 | 1994-12-15 | Hoechst Roussel Pharma | N-(pyridinyl)-1h-indol-1-amine, verfahren zu deren herstellung und ihre verwendung als arzneimittel. |
| US4868190A (en) * | 1988-12-27 | 1989-09-19 | Hoechst-Roussel Pharmaceuticals, Inc. | N-pyridinyl-9H-carbazol-9-amines |
| US4983615A (en) * | 1989-06-28 | 1991-01-08 | Hoechst-Roussel Pharmaceuticals Inc. | Heteroarylamino- and heteroaryloxypyridinamine compounds which are useful in treating skin disorders |
-
1990
- 1990-07-31 DK DK90114661.3T patent/DK0415103T3/da active
- 1990-07-31 ES ES90114661T patent/ES2068294T3/es not_active Expired - Lifetime
- 1990-07-31 AT AT90114661T patent/ATE118002T1/de not_active IP Right Cessation
- 1990-07-31 NZ NZ234726A patent/NZ234726A/en unknown
- 1990-07-31 FI FI903820A patent/FI95466C/fi not_active IP Right Cessation
- 1990-07-31 IL IL9525190A patent/IL95251A/en not_active IP Right Cessation
- 1990-07-31 EP EP90114661A patent/EP0415103B1/en not_active Expired - Lifetime
- 1990-07-31 DE DE69016531T patent/DE69016531T2/de not_active Expired - Fee Related
- 1990-08-01 NO NO903390A patent/NO176398C/no unknown
- 1990-08-01 KR KR1019900011817A patent/KR0164595B1/ko not_active Expired - Fee Related
- 1990-08-01 JP JP2202619A patent/JPH0674266B2/ja not_active Expired - Fee Related
- 1990-08-01 CA CA002022488A patent/CA2022488C/en not_active Expired - Fee Related
- 1990-08-01 IE IE278890A patent/IE66601B1/en not_active IP Right Cessation
- 1990-08-01 PT PT94880A patent/PT94880B/pt not_active IP Right Cessation
- 1990-08-01 AU AU60003/90A patent/AU628201B2/en not_active Ceased
- 1990-08-01 ZA ZA906048A patent/ZA906048B/xx unknown
-
1995
- 1995-02-28 GR GR950400433T patent/GR3015228T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU6000390A (en) | 1991-02-07 |
| DE69016531D1 (de) | 1995-03-16 |
| ZA906048B (en) | 1991-05-29 |
| NO176398C (no) | 1995-03-29 |
| KR0164595B1 (ko) | 1999-01-15 |
| DK0415103T3 (da) | 1995-06-19 |
| FI95466C (fi) | 1996-02-12 |
| NO903390L (no) | 1991-02-04 |
| EP0415103B1 (en) | 1995-02-01 |
| GR3015228T3 (en) | 1995-05-31 |
| NO903390D0 (no) | 1990-08-01 |
| IE902788A1 (en) | 1991-02-27 |
| PT94880A (pt) | 1991-04-18 |
| PT94880B (pt) | 1997-12-31 |
| FI903820A0 (fi) | 1990-07-31 |
| NO176398B (no) | 1994-12-19 |
| AU628201B2 (en) | 1992-09-10 |
| DE69016531T2 (de) | 1995-07-06 |
| CA2022488C (en) | 2000-11-07 |
| CA2022488A1 (en) | 1991-02-03 |
| IL95251A (en) | 1996-08-04 |
| IE66601B1 (en) | 1996-01-24 |
| EP0415103A1 (en) | 1991-03-06 |
| IL95251A0 (en) | 1991-06-10 |
| FI95466B (fi) | 1995-10-31 |
| ATE118002T1 (de) | 1995-02-15 |
| NZ234726A (en) | 1992-01-29 |
| KR910004598A (ko) | 1991-03-29 |
| JPH0674266B2 (ja) | 1994-09-21 |
| JPH03118378A (ja) | 1991-05-20 |
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| ZA907033B (en) | N-substituted-4-pyrimidinamines an pyrimidindiamines,a process for their preparation and their use as medicaments | |
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| ES2068294T3 (es) | 2,3-dihidro-1-(piridinilamino)-indoles, un procedimiento para su preparacion y su uso como medicamentos. | |
| DK0413191T3 (da) | 1-(Pyridinylamino)-2-pyrrolidinoner, fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler | |
| PT92234A (pt) | Processo para a preparacao de 1,2,3,4-tetraidro-1,9-acridinodiaminas |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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