ATE163012T1 - N-substituierte 4-pyrimidinamine und - pyrimidindiamine, verfahren zu ihrer herstellung und ihre anwendung als arzneimittel - Google Patents
N-substituierte 4-pyrimidinamine und - pyrimidindiamine, verfahren zu ihrer herstellung und ihre anwendung als arzneimittelInfo
- Publication number
- ATE163012T1 ATE163012T1 AT90116826T AT90116826T ATE163012T1 AT E163012 T1 ATE163012 T1 AT E163012T1 AT 90116826 T AT90116826 T AT 90116826T AT 90116826 T AT90116826 T AT 90116826T AT E163012 T1 ATE163012 T1 AT E163012T1
- Authority
- AT
- Austria
- Prior art keywords
- loweralkyl
- hydrogen
- pyrimidinamines
- aryl
- pyrimidindiamines
- Prior art date
Links
- 229940126601 medicinal product Drugs 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 150000002431 hydrogen Chemical group 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- -1 loweralkyl Chemical group 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000006883 memory enhancing effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/402,415 US4983608A (en) | 1989-09-05 | 1989-09-05 | N-substituted-4-pyrimidinamines and pyrimidinediamines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE163012T1 true ATE163012T1 (de) | 1998-02-15 |
Family
ID=23591798
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90116826T ATE163012T1 (de) | 1989-09-05 | 1990-09-01 | N-substituierte 4-pyrimidinamine und - pyrimidindiamine, verfahren zu ihrer herstellung und ihre anwendung als arzneimittel |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4983608A (de) |
| EP (1) | EP0417584B1 (de) |
| JP (1) | JPH07116181B2 (de) |
| KR (1) | KR0162641B1 (de) |
| AT (1) | ATE163012T1 (de) |
| AU (1) | AU626450B2 (de) |
| CA (1) | CA2024572C (de) |
| DE (1) | DE69032020T2 (de) |
| DK (1) | DK0417584T3 (de) |
| ES (1) | ES2112830T3 (de) |
| FI (1) | FI904327A7 (de) |
| GR (1) | GR3026318T3 (de) |
| IE (1) | IE903213A1 (de) |
| IL (1) | IL95568A (de) |
| NO (1) | NO903851L (de) |
| NZ (1) | NZ235145A (de) |
| PT (1) | PT95202B (de) |
| ZA (1) | ZA907033B (de) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5155098A (en) * | 1989-06-09 | 1992-10-13 | Hoechst-Roussel Pharmaceuticals Inc. | N-heteroaryl-purin-6-amines, and pharmaceutical compositions and methods employing them |
| US5214038A (en) * | 1991-04-15 | 1993-05-25 | Hoechst-Roussel Pharmaceuticals Inc. | 1-(pyrido[3,4-b]-1,4-oxazinyl-4-yl)-1H-indoles and intermediates for the preparation thereof |
| US5319096A (en) * | 1992-04-03 | 1994-06-07 | Hoechst-Roussel Pharmaceuticals Inc. | (1H-indol-1-yl)-2-(amino) acetamides and related (1H-indol-1-yl)-(aminoalkyl)amides, pharmaceutical composition and use |
| US5459274A (en) * | 1994-05-13 | 1995-10-17 | Hoechst-Roussel Pharmaceuticals Inc. | Preparation of N-alkyl-N-pyridinyl-1H-indol-1-amines |
| WO1997009325A1 (en) * | 1995-09-01 | 1997-03-13 | Signal Pharmaceuticals, Inc. | Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions |
| US5852028A (en) * | 1995-12-18 | 1998-12-22 | Signal Pharmaceuticals, Inc. | Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions |
| US5935966A (en) * | 1995-09-01 | 1999-08-10 | Signal Pharmaceuticals, Inc. | Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions |
| ZA989365B (en) | 1997-10-15 | 1999-04-15 | Boehringer Mannheim Pharm Corp | Preparation for treating alzheimer's disease |
| EA200000840A1 (ru) | 1998-02-17 | 2001-02-26 | Туларик, Инк. | Антивирусные производные пиримидина |
| ATE342892T1 (de) * | 1998-08-29 | 2006-11-15 | Astrazeneca Ab | Pyrimidine verbindungen |
| US6632820B1 (en) | 1998-08-29 | 2003-10-14 | Astrazeneca Ab | Pyrimidine compounds |
| GB9828511D0 (en) | 1998-12-24 | 1999-02-17 | Zeneca Ltd | Chemical compounds |
| GB9905075D0 (en) | 1999-03-06 | 1999-04-28 | Zeneca Ltd | Chemical compounds |
| GB9907658D0 (en) | 1999-04-06 | 1999-05-26 | Zeneca Ltd | Chemical compounds |
| GB9919778D0 (en) | 1999-08-21 | 1999-10-27 | Zeneca Ltd | Chemical compounds |
| MXPA02003436A (es) * | 1999-10-07 | 2002-08-20 | Amgen Inc | Inhibidores de triazina cinasa. |
| US6410726B1 (en) | 2000-01-12 | 2002-06-25 | Tularik Inc. | Arylsulfonic acid salts of pyrimidine-based antiviral |
| AU3704101A (en) * | 2000-02-17 | 2001-08-27 | Amgen Inc | Kinase inhibitors |
| GB0004890D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
| GB0004888D0 (en) * | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
| GB0004886D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
| GB0004887D0 (en) * | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
| GB0007371D0 (en) | 2000-03-28 | 2000-05-17 | Astrazeneca Uk Ltd | Chemical compounds |
| GB0016877D0 (en) | 2000-07-11 | 2000-08-30 | Astrazeneca Ab | Chemical compounds |
| GB0021726D0 (en) * | 2000-09-05 | 2000-10-18 | Astrazeneca Ab | Chemical compounds |
| GB0103926D0 (en) * | 2001-02-17 | 2001-04-04 | Astrazeneca Ab | Chemical compounds |
| GB0113041D0 (en) | 2001-05-30 | 2001-07-18 | Astrazeneca Ab | Chemical compounds |
| US7115617B2 (en) * | 2001-08-22 | 2006-10-03 | Amgen Inc. | Amino-substituted pyrimidinyl derivatives and methods of use |
| US6939874B2 (en) | 2001-08-22 | 2005-09-06 | Amgen Inc. | Substituted pyrimidinyl derivatives and methods of use |
| TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| GB0205693D0 (en) * | 2002-03-09 | 2002-04-24 | Astrazeneca Ab | Chemical compounds |
| US7442697B2 (en) * | 2002-03-09 | 2008-10-28 | Astrazeneca Ab | 4-imidazolyl substituted pyrimidine derivatives with CDK inhibitory activity |
| GB0205690D0 (en) * | 2002-03-09 | 2002-04-24 | Astrazeneca Ab | Chemical compounds |
| GB0205688D0 (en) * | 2002-03-09 | 2002-04-24 | Astrazeneca Ab | Chemical compounds |
| HRP20050089B1 (hr) | 2002-07-29 | 2015-06-19 | Rigel Pharmaceuticals | Upotreba 2,4 pirimidindiaminskog spoja za proizvodnju lijeka za lijeäśenje ili sprjeäśavanje autoimunosne bolesti |
| EP2316459B1 (de) | 2002-07-29 | 2013-11-06 | Rigel Pharmaceuticals, Inc. | 2,4-Pyrimidindiaminen zur Behandlung oder Vorbeugung von Autoimmunerkrankungen |
| US7109337B2 (en) * | 2002-12-20 | 2006-09-19 | Pfizer Inc | Pyrimidine derivatives for the treatment of abnormal cell growth |
| CA2529611C (en) * | 2002-12-20 | 2009-12-15 | Pfizer Products Inc. | Pyrimidine derivatives for the treatment of abnormal cell growth |
| UA80767C2 (en) * | 2002-12-20 | 2007-10-25 | Pfizer Prod Inc | Pyrimidine derivatives for the treatment of abnormal cell growth |
| GB0311276D0 (en) * | 2003-05-16 | 2003-06-18 | Astrazeneca Ab | Chemical compounds |
| GB0311274D0 (en) * | 2003-05-16 | 2003-06-18 | Astrazeneca Ab | Chemical compounds |
| WO2005012294A1 (en) | 2003-07-30 | 2005-02-10 | Rigel Pharmaceuticals, Inc. | 2,4-pyrimidinediamine compounds for use in the treatment or prevention of autoimmune diseases |
| TW200528101A (en) * | 2004-02-03 | 2005-09-01 | Astrazeneca Ab | Chemical compounds |
| JP2007537238A (ja) * | 2004-05-14 | 2007-12-20 | ファイザー・プロダクツ・インク | 異常細胞増殖の治療のためのピリミジン誘導体 |
| MXPA06011658A (es) * | 2004-05-14 | 2006-12-14 | Pfizer Prod Inc | Derivados de pirimidina para el tratamiento del crecimiento celular anormal. |
| US20060205945A1 (en) * | 2004-05-14 | 2006-09-14 | Pfizer Inc | Pyrimidine derivatives for the treatment of abnormal cell growth |
| JP2007537230A (ja) * | 2004-05-14 | 2007-12-20 | ファイザー・プロダクツ・インク | 異常細胞増殖の処置用のピリミジン誘導体 |
| JP2008511659A (ja) * | 2004-09-01 | 2008-04-17 | ライジェル ファーマシューティカルズ， インコーポレイテッド | ２，４−ピリミジンジアミン化合物の合成 |
| SI1814878T1 (sl) | 2004-11-24 | 2012-06-29 | Rigel Pharmaceuticals Inc | Spojine spiro-2,4-pirimidindiamina in njihova uporaba |
| MX2007007272A (es) * | 2004-12-17 | 2007-07-11 | Astrazeneca Ab | 4-(4-imidazol-4-il)pirimidin-2-ilamino)benzamidas como inhibidores de cdk. |
| EP1883302A4 (de) * | 2005-05-03 | 2009-05-20 | Rigel Pharmaceuticals Inc | Jak-kinase-hemmer und deren verwendung |
| JP4278172B2 (ja) * | 2005-07-30 | 2009-06-10 | アストラゼネカ アクチボラグ | 増殖性疾患の治療において使用するためのイミダゾリル−ピリミジン化合物 |
| AR056556A1 (es) * | 2005-09-30 | 2007-10-10 | Astrazeneca Ab | Imidazo(1,2-a)piridina con actividad antiproliferacion celular |
| TW200811169A (en) * | 2006-05-26 | 2008-03-01 | Astrazeneca Ab | Chemical compounds |
| KR20100015546A (ko) | 2007-04-13 | 2010-02-12 | 사노피-아벤티스 | Ｎ-아미노인돌의 전이 금속 촉매된 합성 |
| GB2553716B (en) * | 2015-04-17 | 2020-06-17 | Univ Holy Ghost Duquesne | Pyrrolopyrimidines as antitumor agents |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4792562A (en) * | 1985-12-04 | 1988-12-20 | Hoechst-Roussel Pharmaceuticals, Inc. | N-(pyrrol-1-yl)pyridinamines having memory enhancing activity |
| US4752610A (en) * | 1985-12-04 | 1988-06-21 | Hoechst-Roussel Pharmaceuticals Inc. | N-(pyrrol-1-yl)pyridinamines having memory enhancing properties |
| EP0287982B1 (de) * | 1987-04-24 | 1994-12-07 | Hoechst-Roussel Pharmaceuticals Incorporated | N-(Pyridinyl)-1H-indol-1-amine, Verfahren zu deren Herstellung und ihre Verwendung als Arzneimittel |
| US4806554A (en) * | 1988-01-11 | 1989-02-21 | Hoechst-Roussel Pharmaceuticals, Inc. | Pyrazol and indazolpyridinamines |
| US4868190A (en) * | 1988-12-27 | 1989-09-19 | Hoechst-Roussel Pharmaceuticals, Inc. | N-pyridinyl-9H-carbazol-9-amines |
-
1989
- 1989-09-05 US US07/402,415 patent/US4983608A/en not_active Expired - Lifetime
-
1990
- 1990-09-01 ES ES90116826T patent/ES2112830T3/es not_active Expired - Lifetime
- 1990-09-01 DE DE69032020T patent/DE69032020T2/de not_active Expired - Lifetime
- 1990-09-01 DK DK90116826T patent/DK0417584T3/da active
- 1990-09-01 EP EP90116826A patent/EP0417584B1/de not_active Expired - Lifetime
- 1990-09-01 AT AT90116826T patent/ATE163012T1/de not_active IP Right Cessation
- 1990-09-03 NZ NZ235145A patent/NZ235145A/en unknown
- 1990-09-03 IL IL9556890A patent/IL95568A/en unknown
- 1990-09-03 FI FI904327A patent/FI904327A7/fi not_active IP Right Cessation
- 1990-09-04 CA CA002024572A patent/CA2024572C/en not_active Expired - Lifetime
- 1990-09-04 AU AU62089/90A patent/AU626450B2/en not_active Ceased
- 1990-09-04 KR KR1019900013896A patent/KR0162641B1/ko not_active Expired - Lifetime
- 1990-09-04 PT PT95202A patent/PT95202B/pt not_active IP Right Cessation
- 1990-09-04 ZA ZA907033A patent/ZA907033B/xx unknown
- 1990-09-04 IE IE321390A patent/IE903213A1/en not_active IP Right Cessation
- 1990-09-04 NO NO90903851A patent/NO903851L/no unknown
- 1990-09-04 JP JP2232639A patent/JPH07116181B2/ja not_active Expired - Lifetime
-
1998
- 1998-03-11 GR GR980400509T patent/GR3026318T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69032020D1 (de) | 1998-03-12 |
| PT95202B (pt) | 1997-06-30 |
| CA2024572A1 (en) | 1991-03-06 |
| FI904327A0 (fi) | 1990-09-03 |
| KR0162641B1 (ko) | 1998-12-01 |
| JPH07116181B2 (ja) | 1995-12-13 |
| EP0417584B1 (de) | 1998-02-04 |
| DK0417584T3 (da) | 1998-09-23 |
| ZA907033B (en) | 1991-06-26 |
| GR3026318T3 (en) | 1998-06-30 |
| JPH0393784A (ja) | 1991-04-18 |
| CA2024572C (en) | 2000-09-26 |
| IL95568A (en) | 1995-01-24 |
| ES2112830T3 (es) | 1998-04-16 |
| DE69032020T2 (de) | 1998-07-09 |
| AU626450B2 (en) | 1992-07-30 |
| NO903851L (no) | 1991-03-06 |
| EP0417584A3 (en) | 1992-02-26 |
| AU6208990A (en) | 1991-03-14 |
| IL95568A0 (en) | 1991-06-30 |
| KR910006277A (ko) | 1991-04-29 |
| NZ235145A (en) | 1992-12-23 |
| US4983608A (en) | 1991-01-08 |
| PT95202A (pt) | 1991-05-22 |
| NO903851D0 (no) | 1990-09-04 |
| EP0417584A2 (de) | 1991-03-20 |
| IE903213A1 (en) | 1991-03-13 |
| FI904327A7 (fi) | 1991-03-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| EEFA | Change of the company name | ||
| EELA | Cancelled due to lapse of time |