ATE118012T1 - 2'-deoxy-2'-methylidenecytidin-dihydrat, verfahren zu ihrer herstellung und mischmaterial. - Google Patents

2'-deoxy-2'-methylidenecytidin-dihydrat, verfahren zu ihrer herstellung und mischmaterial.

Info

Publication number: ATE118012T1
Authority: AT; Austria
Prior art keywords: deoxy; production; mixing material; methylidenecytidine; dihydrate
Prior art date: 1990-02-19

Application number

AT91102225T

Other languages

English (en)

Inventor

Atsushi Sakai

Toshiyuki Shibata

Takayuki Ogawa

Shinji Sakata

Takanori Miyashita

Kazuhiko Kondo

Original Assignee

Yoshitomi Pharmaceutical

Yamasa Shoyu Kk

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-02-19

Filing date

1991-02-16

Publication date

1995-02-15

1991-02-16 Application filed by Yoshitomi Pharmaceutical, Yamasa Shoyu Kk filed Critical Yoshitomi Pharmaceutical

1995-02-15 Application granted granted Critical

1995-02-15 Publication of ATE118012T1 publication Critical patent/ATE118012T1/de

Links

238000004519 manufacturing process Methods 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
XTYUGPDATYNDMJ-YPMAUOMFSA-N 4-amino-1-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)-3-methylideneoxolan-2-yl]pyrimidin-2-one;dihydrate Chemical compound O.O.O=C1N=C(N)C=CN1[C@H]1C(=C)[C@H](O)[C@@H](CO)O1 XTYUGPDATYNDMJ-YPMAUOMFSA-N 0.000 title 1
PULHLIOPJXPGJN-BWVDBABLSA-N 4-amino-1-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)-3-methylideneoxolan-2-yl]pyrimidin-2-one Chemical compound O=C1N=C(N)C=CN1[C@H]1C(=C)[C@H](O)[C@@H](CO)O1 PULHLIOPJXPGJN-BWVDBABLSA-N 0.000 abstract 2
150000001720 carbohydrates Chemical class 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Molecular Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Biochemistry (AREA)
Oil, Petroleum & Natural Gas (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Dermatology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Virology (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

AT91102225T 1990-02-19 1991-02-16 2'-deoxy-2'-methylidenecytidin-dihydrat, verfahren zu ihrer herstellung und mischmaterial. ATE118012T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP2037695A JPH0615557B2 (ja)	1990-02-19	1990-02-19	２’―デオキシ―２’―メチリデンシチジンの２水和物結晶

Publications (1)

Publication Number	Publication Date
ATE118012T1 true ATE118012T1 (de)	1995-02-15

Family

ID=12504690

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91102225T ATE118012T1 (de)	1990-02-19	1991-02-16	2'-deoxy-2'-methylidenecytidin-dihydrat, verfahren zu ihrer herstellung und mischmaterial.

Country Status (9)

Country	Link
US (2)	US5183882A (de)
EP (1)	EP0443471B1 (de)
JP (1)	JPH0615557B2 (de)
KR (2)	KR960010947B1 (de)
AT (1)	ATE118012T1 (de)
CA (1)	CA2036507C (de)
DE (1)	DE69107098T2 (de)
DK (1)	DK0443471T3 (de)
ES (1)	ES2067780T3 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5401726A (en) *	1988-08-25	1995-03-28	Yoshitomi Pharaceutical Industries, Ltd.	2'methylidenepyrimidine nucleoside compounds, their use and method for production thereof
JPH0615557B2 (ja) *	1990-02-19	1994-03-02	ヤマサ醤油株式会社	２’―デオキシ―２’―メチリデンシチジンの２水和物結晶
US5589587A (en) *	1992-05-12	1996-12-31	Merrell Pharmaceuticals Inc.	Process for the preparation of ribonucleotide reductase inhibitors
DK0714400T3 (da) *	1993-08-19	2000-04-10	Merck & Co Inc	Termodynamisk stabil krystalform af 4''-deoxy-4''-epi-methylaminoavermectin B1a/B1b-benzoesyresalt og fremgangsmåder til de
ATE186732T1 (de) *	1994-01-07	1999-12-15	Merrell Pharma Inc	(e)-2'-deoxy-2'-(fluormethylen)cytidin-monohydr t
EP0770621A4 (de) *	1994-07-12	1998-01-28	Yamasa Corp	2'-deoxy-2'(substituiertes oder unsubstituiertes methylidene)-4-thionukleosid
US5665711A (en) *	1995-12-12	1997-09-09	Yoshitomi Pharmaceutical Industries, Ltd.	Antitumor composition for oral administration
EP2106788A1 (de) *	2008-04-04	2009-10-07	Ipsen Pharma	Flüssige und lyophilisierte Formulierungen

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5047520A (en) *	1987-03-19	1991-09-10	Yamasa Shoyu Kabushiki Kaisha	2'-alkylidenepyrimidine nucleoside derivatives, process for production thereof, and uses thereof
JPS63258818A (ja) *	1987-04-16	1988-10-26	Yoshitomi Pharmaceut Ind Ltd	制ガン剤
DE68922899T2 (de) *	1988-12-07	1995-10-12	Yamasa Shoyu Kk	Verbindungen von Pyrimidin 2'-Methylidin Nukleosiden.
JPH0615557B2 (ja) *	1990-02-19	1994-03-02	ヤマサ醤油株式会社	２’―デオキシ―２’―メチリデンシチジンの２水和物結晶

1990
- 1990-02-19 JP JP2037695A patent/JPH0615557B2/ja not_active Expired - Lifetime
1991
- 1991-02-16 EP EP91102225A patent/EP0443471B1/de not_active Expired - Lifetime
- 1991-02-16 AT AT91102225T patent/ATE118012T1/de not_active IP Right Cessation
- 1991-02-16 DK DK91102225.9T patent/DK0443471T3/da active
- 1991-02-16 ES ES91102225T patent/ES2067780T3/es not_active Expired - Lifetime
- 1991-02-16 DE DE69107098T patent/DE69107098T2/de not_active Expired - Fee Related
- 1991-02-18 CA CA002036507A patent/CA2036507C/en not_active Expired - Fee Related
- 1991-02-19 US US07/656,824 patent/US5183882A/en not_active Expired - Fee Related
- 1991-02-19 KR KR1019910002636A patent/KR960010947B1/ko not_active Expired - Lifetime
1992
- 1992-10-09 US US07/959,267 patent/US5412089A/en not_active Expired - Lifetime
1996
- 1996-05-21 KR KR1019960017263A patent/KR0174212B1/ko not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US5183882A (en)	1993-02-02
KR960010947B1 (ko)	1996-08-14
EP0443471B1 (de)	1995-02-01
KR910021351A (ko)	1991-12-20
JPH0615557B2 (ja)	1994-03-02
EP0443471A1 (de)	1991-08-28
DE69107098T2 (de)	1995-06-29
US5412089A (en)	1995-05-02
DK0443471T3 (da)	1995-06-26
CA2036507A1 (en)	1991-08-20
KR0174212B1 (ko)	1999-02-01
JPH03240794A (ja)	1991-10-28
KR970005016A (ko)	1997-01-29
DE69107098D1 (de)	1995-03-16
CA2036507C (en)	1996-09-10
ES2067780T3 (es)	1995-04-01

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Legal Events

Date	Code	Title	Description
1995-06-15	UEP	Publication of translation of european patent specification
2001-11-15	REN	Ceased due to non-payment of the annual fee