DK0443471T3 - 2-Deoxy-2-methylidencytidin-dihydrat, fremgangsmåder til fremstilling heraf, samt præparater - Google Patents

2-Deoxy-2-methylidencytidin-dihydrat, fremgangsmåder til fremstilling heraf, samt præparater

Info

Publication number: DK0443471T3
Authority: DK; Denmark
Prior art keywords: deoxy; preparations; processes; preparation; methylidenecytidine
Prior art date: 1990-02-19

Application number

DK91102225.9T

Other languages

English (en)

Inventor

Atsushi Sakai

Toshiyuki Shibata

Takayuki Ogawa

Shinji Sakata

Takanori Miyashita

Kazuhiko Kondo

Original Assignee

Yoshitomi Pharmaceutical

Yamasa Shoyu Kk

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-02-19

Filing date

1991-02-16

Publication date

1995-06-26

1991-02-16 Application filed by Yoshitomi Pharmaceutical, Yamasa Shoyu Kk filed Critical Yoshitomi Pharmaceutical

1995-06-26 Application granted granted Critical

1995-06-26 Publication of DK0443471T3 publication Critical patent/DK0443471T3/da

Links

238000000034 method Methods 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title 2
PULHLIOPJXPGJN-BWVDBABLSA-N 4-amino-1-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)-3-methylideneoxolan-2-yl]pyrimidin-2-one Chemical compound O=C1N=C(N)C=CN1[C@H]1C(=C)[C@H](O)[C@@H](CO)O1 PULHLIOPJXPGJN-BWVDBABLSA-N 0.000 abstract 2
150000001720 carbohydrates Chemical class 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Molecular Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Biochemistry (AREA)
Oil, Petroleum & Natural Gas (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Dermatology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

DK91102225.9T 1990-02-19 1991-02-16 2-Deoxy-2-methylidencytidin-dihydrat, fremgangsmåder til fremstilling heraf, samt præparater DK0443471T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP2037695A JPH0615557B2 (ja)	1990-02-19	1990-02-19	２’―デオキシ―２’―メチリデンシチジンの２水和物結晶

Publications (1)

Publication Number	Publication Date
DK0443471T3 true DK0443471T3 (da)	1995-06-26

Family

ID=12504690

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91102225.9T DK0443471T3 (da)	1990-02-19	1991-02-16	2-Deoxy-2-methylidencytidin-dihydrat, fremgangsmåder til fremstilling heraf, samt præparater

Country Status (9)

Country	Link
US (2)	US5183882A (da)
EP (1)	EP0443471B1 (da)
JP (1)	JPH0615557B2 (da)
KR (2)	KR960010947B1 (da)
AT (1)	ATE118012T1 (da)
CA (1)	CA2036507C (da)
DE (1)	DE69107098T2 (da)
DK (1)	DK0443471T3 (da)
ES (1)	ES2067780T3 (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5401726A (en) *	1988-08-25	1995-03-28	Yoshitomi Pharaceutical Industries, Ltd.	2'methylidenepyrimidine nucleoside compounds, their use and method for production thereof
JPH0615557B2 (ja) *	1990-02-19	1994-03-02	ヤマサ醤油株式会社	２’―デオキシ―２’―メチリデンシチジンの２水和物結晶
US5589587A (en) *	1992-05-12	1996-12-31	Merrell Pharmaceuticals Inc.	Process for the preparation of ribonucleotide reductase inhibitors
CA2168843C (en) *	1993-08-19	2004-10-19	Raymond Cvetovich	Thermodynamically stable crystal form of 4"-deoxy-4"-epi-methylamino avermectin b1a/b1b benzoic acid salt and processes for its preparation
ATE186732T1 (de) *	1994-01-07	1999-12-15	Merrell Pharma Inc	(e)-2'-deoxy-2'-(fluormethylen)cytidin-monohydr t
US5811408A (en) *	1994-07-12	1998-09-22	Yamasa Corporation	2'-deoxy-2'-(substituted or unsubstituted)methylidene-4'-thionucleosides
US5665711A (en) *	1995-12-12	1997-09-09	Yoshitomi Pharmaceutical Industries, Ltd.	Antitumor composition for oral administration
EP2106788A1 (en) *	2008-04-04	2009-10-07	Ipsen Pharma	Liquid and freeze dried formulations

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1988007049A1 (fr) *	1987-03-19	1988-09-22	Yamasa Shoyu Kabushiki Kaisha	Derives de nucleosides de 2'-alkylidene pyrimidine, procede de preparation et utilisation de ces composes
JPS63258818A (ja) *	1987-04-16	1988-10-26	Yoshitomi Pharmaceut Ind Ltd	制ガン剤
EP0373485B1 (en) *	1988-12-07	1995-05-31	Yamasa Shoyu Co., Ltd.	Pyrimidine 2'-methylidene nucleoside compounds
JPH0615557B2 (ja) *	1990-02-19	1994-03-02	ヤマサ醤油株式会社	２’―デオキシ―２’―メチリデンシチジンの２水和物結晶

1990
- 1990-02-19 JP JP2037695A patent/JPH0615557B2/ja not_active Expired - Lifetime
1991
- 1991-02-16 DK DK91102225.9T patent/DK0443471T3/da active
- 1991-02-16 DE DE69107098T patent/DE69107098T2/de not_active Expired - Fee Related
- 1991-02-16 AT AT91102225T patent/ATE118012T1/de not_active IP Right Cessation
- 1991-02-16 ES ES91102225T patent/ES2067780T3/es not_active Expired - Lifetime
- 1991-02-16 EP EP91102225A patent/EP0443471B1/en not_active Expired - Lifetime
- 1991-02-18 CA CA002036507A patent/CA2036507C/en not_active Expired - Fee Related
- 1991-02-19 KR KR1019910002636A patent/KR960010947B1/ko not_active Expired - Lifetime
- 1991-02-19 US US07/656,824 patent/US5183882A/en not_active Expired - Fee Related
1992
- 1992-10-09 US US07/959,267 patent/US5412089A/en not_active Expired - Lifetime
1996
- 1996-05-21 KR KR1019960017263A patent/KR0174212B1/ko not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JPH0615557B2 (ja)	1994-03-02
CA2036507C (en)	1996-09-10
EP0443471A1 (en)	1991-08-28
JPH03240794A (ja)	1991-10-28
US5412089A (en)	1995-05-02
DE69107098T2 (de)	1995-06-29
ES2067780T3 (es)	1995-04-01
KR0174212B1 (ko)	1999-02-01
EP0443471B1 (en)	1995-02-01
CA2036507A1 (en)	1991-08-20
ATE118012T1 (de)	1995-02-15
KR910021351A (ko)	1991-12-20
DE69107098D1 (de)	1995-03-16
KR960010947B1 (ko)	1996-08-14
KR970005016A (ko)	1997-01-29
US5183882A (en)	1993-02-02

Publication	Publication Date	Title
DK502888D0 (da)	1988-09-09	Anvendelse af azithromycin og derivater deraf til fremstilling af antiprotozoale laegemidler
FI883596A7 (fi)	1989-02-05	Epipodofyllotoxinglukosid-4' -fosfatderivat.
DZ1270A1 (fr)	2004-09-13	Dérivés de fluorocytidine.
DE3853922D1 (de)	1995-07-06	Aminosäurederivate als Amphotere.
OA06063A (fr)	1981-06-30	Dérivés de l'anthelmintique C-076.
DK631688D0 (da)	1988-11-11	2',3'-dideoxy-2'-fluornucleosider, fremstillingen deraf samt praeparater indeholdende samme
DE3776261D1 (de)	1992-03-05	Naehrstoffzusammensetzung.
DK0443471T3 (da)	1995-06-26	2-Deoxy-2-methylidencytidin-dihydrat, fremgangsmåder til fremstilling heraf, samt præparater
ZA892284B (en)	1990-02-28	Novel fluorophosphonate nucleotide derivatives
NO882849L (no)	1989-01-02	3',4'-dinitrogensubstituerte epipodofyllotoksinglukosidderivater.
DK218388A (da)	1988-04-21	Aktivt princip isoleret fra hajvaev
FR2653771B1 (fr)	1994-09-23	Procede de preparation de l'azt (azido-3'-desoxy-3'-thymidine) et de composes apparentes.
DE3783937D1 (de)	1993-03-18	1,4-naphthochinonderivate enthaltende rodentizide zusammensetzungen.
DE3789032D1 (de)	1994-03-24	Mechanismus zur Einstellung eines Ausgangsgliedes.
OA06102A (fr)	1981-06-30	Compositions à base de dérivés d'acides - isocyanocarboxyliques, destinées à influencer la croissance des végétaux.
DE3881406D1 (de)	1993-07-08	Cycloalkan(1,2-c:4,3-c')dipyrazole.
DE3880088D1 (de)	1993-05-13	Ethylierte avermectine.
SE7701506L (sv)	1977-08-14	Antihypertensiva medel
ES2004489A4 (es)	1989-01-16	Gametocidas de piridina.
IL96299A0 (en)	1991-08-16	Glutaric acid derivatives and preparations thereof
FI880081A7 (fi)	1988-07-13	2,1-bensotiazepin-2,2-dioxid-5 -karboxylsyraderivat.
DK161888A (da)	1988-09-27	Trioxabicyclo (2.2.2) octanderivater
FI875169A7 (fi)	1988-05-26	Cykloalka-(b)-pyrazolo-(3,4-d) -pyridin-3-onderivat.
ES551865A0 (es)	1987-04-16	Procedimiento para la preparacion de derivados de 5'-o-(glicosilureidosulfonil) uridina.
JPS53124293A (en)	1978-10-30	Novel adenosine derivatives