ATE118686T1 - Biologisch wirksame polymere arzneistoffderivate. - Google Patents
Biologisch wirksame polymere arzneistoffderivate.Info
- Publication number
- ATE118686T1 ATE118686T1 AT90910711T AT90910711T ATE118686T1 AT E118686 T1 ATE118686 T1 AT E118686T1 AT 90910711 T AT90910711 T AT 90910711T AT 90910711 T AT90910711 T AT 90910711T AT E118686 T1 ATE118686 T1 AT E118686T1
- Authority
- AT
- Austria
- Prior art keywords
- biologically effective
- polymeric drug
- drug derivatives
- combined
- adjacent
- Prior art date
Links
- 239000003118 drug derivative Substances 0.000 title 1
- 239000003814 drug Substances 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 108010016626 Dipeptides Proteins 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003640 drug residue Substances 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB898918009A GB8918009D0 (en) | 1989-08-07 | 1989-08-07 | New biologically active drug polymer derivatives and method for preparing same |
| GB898919618A GB8919618D0 (en) | 1989-08-30 | 1989-08-30 | New biologically active drug polymer derivatives and method for preparing same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE118686T1 true ATE118686T1 (de) | 1995-03-15 |
Family
ID=26295714
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90910711T ATE118686T1 (de) | 1989-08-07 | 1990-07-26 | Biologisch wirksame polymere arzneistoffderivate. |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0437563B1 (de) |
| JP (1) | JP2662311B2 (de) |
| AT (1) | ATE118686T1 (de) |
| CA (1) | CA2038935C (de) |
| DE (1) | DE69017180T2 (de) |
| DK (1) | DK0437563T3 (de) |
| ES (1) | ES2069082T3 (de) |
| WO (1) | WO1991001758A1 (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5880131A (en) * | 1993-10-20 | 1999-03-09 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
| US5951974A (en) * | 1993-11-10 | 1999-09-14 | Enzon, Inc. | Interferon polymer conjugates |
| HUT75533A (en) * | 1993-11-10 | 1997-05-28 | Schering Corp | Improved interferon polymer conjugates |
| US5738846A (en) * | 1994-11-10 | 1998-04-14 | Enzon, Inc. | Interferon polymer conjugates and process for preparing the same |
| DE19514087A1 (de) * | 1995-04-13 | 1996-10-17 | Deutsches Krebsforsch | Konjugat aus einem Wirkstoff, einem Polyether und ggfs. einem nicht als körperfremd angesehenen, nativen Protein |
| AU5893796A (en) * | 1995-06-07 | 1996-12-30 | Novo Nordisk A/S | Modification of polypeptides |
| AU5893696A (en) * | 1995-06-07 | 1996-12-30 | Novo Nordisk A/S | Modification of polypeptides |
| GB9812550D0 (en) * | 1998-06-11 | 1998-08-05 | Aepact Ltd | Tumour therapy and imaging |
| EP1008355A1 (de) | 1998-12-08 | 2000-06-14 | Debio Recherche Pharmaceutique S.A. | Verfahren zur Identifizierung der Bindungsstellen eines Polymeren an Makromolekülen mit Markierungsbindung von Aminosäuren |
| US6309633B1 (en) * | 1999-06-19 | 2001-10-30 | Nobex Corporation | Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same |
| GB0202906D0 (en) | 2002-02-07 | 2002-03-27 | Univ London | Prevention of myocardial damage |
| WO2004099245A1 (de) * | 2003-05-05 | 2004-11-18 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Stabilisiertes interferon-ϝ |
| JP2008505853A (ja) | 2004-04-13 | 2008-02-28 | クインテセンス バイオサイエンシーズ インコーポレーティッド | 細胞傷害性薬剤としての非天然のリボヌクレアーゼ複合体 |
| JP4877225B2 (ja) * | 2005-02-18 | 2012-02-15 | 日油株式会社 | ポリオキシアルキレン誘導体 |
| US8840882B2 (en) | 2006-06-23 | 2014-09-23 | Quintessence Biosciences, Inc. | Modified ribonucleases |
| WO2008010991A2 (en) | 2006-07-17 | 2008-01-24 | Quintessence Biosciences, Inc. | Methods and compositions for the treatment of cancer |
| WO2009120358A1 (en) * | 2008-03-27 | 2009-10-01 | Nektar Therapeutics | Oligomer-nitrogenous base conjugates |
| BRPI0920743A2 (pt) | 2008-10-01 | 2016-09-20 | Quintessence Biosciences Inc | ribonucleases terapeuticas |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4609546A (en) * | 1982-06-24 | 1986-09-02 | Japan Chemical Research Co., Ltd. | Long-acting composition |
| JPS60176586A (ja) * | 1984-02-21 | 1985-09-10 | Sanwa Kagaku Kenkyusho:Kk | 新規な修飾ウロキナ−ゼ、その製法並びにこれを含有する血栓溶解剤 |
| EP0229108B1 (de) * | 1985-06-26 | 1990-12-27 | Cetus Corporation | Solubilisierung von proteinen für pharmazeutische zusammensetzungen mittels polymerkonjugierung |
| CA1283046C (en) * | 1986-05-29 | 1991-04-16 | Nandini Katre | Tumor necrosis factor formulation |
| DK468388A (da) * | 1987-08-21 | 1989-02-22 | Wellcome Found | Kompleks af polyethylenglycol og vaevplasminogen-aktivator, fremgangsmaade til dets fremstilling og farmaceutiske kompositioner indeholdende komplekset |
-
1990
- 1990-07-26 DK DK90910711.2T patent/DK0437563T3/da active
- 1990-07-26 WO PCT/EP1990/001261 patent/WO1991001758A1/en not_active Ceased
- 1990-07-26 ES ES90910711T patent/ES2069082T3/es not_active Expired - Lifetime
- 1990-07-26 AT AT90910711T patent/ATE118686T1/de not_active IP Right Cessation
- 1990-07-26 JP JP2510696A patent/JP2662311B2/ja not_active Expired - Fee Related
- 1990-07-26 EP EP90910711A patent/EP0437563B1/de not_active Expired - Lifetime
- 1990-07-26 CA CA002038935A patent/CA2038935C/en not_active Expired - Fee Related
- 1990-07-26 DE DE69017180T patent/DE69017180T2/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69017180T2 (de) | 1995-07-20 |
| DE69017180D1 (de) | 1995-03-30 |
| ES2069082T3 (es) | 1995-05-01 |
| WO1991001758A1 (en) | 1991-02-21 |
| EP0437563A1 (de) | 1991-07-24 |
| CA2038935A1 (en) | 1991-02-08 |
| DK0437563T3 (da) | 1995-05-29 |
| EP0437563B1 (de) | 1995-02-22 |
| CA2038935C (en) | 1998-12-08 |
| JPH04501121A (ja) | 1992-02-27 |
| JP2662311B2 (ja) | 1997-10-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REN | Ceased due to non-payment of the annual fee |