LU91225I2 - Plenaxis - Google Patents

Plenaxis

Info

Publication number
LU91225I2
LU91225I2 LU91225C LU91225C LU91225I2 LU 91225 I2 LU91225 I2 LU 91225I2 LU 91225 C LU91225 C LU 91225C LU 91225 C LU91225 C LU 91225C LU 91225 I2 LU91225 I2 LU 91225I2
Authority
LU
Luxembourg
Prior art keywords
moiety
peptide compound
lhrh
lhrh antagonist
hydrophilic
Prior art date
Application number
LU91225C
Other languages
English (en)
Original Assignee
Indiana Res & Technology Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23908180&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LU91225(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Indiana Res & Technology Corp filed Critical Indiana Res & Technology Corp
Publication of LU91225I2 publication Critical patent/LU91225I2/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/13—Luteinizing hormone-releasing hormone; related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
LU91225C 1995-06-07 2006-03-03 Plenaxis LU91225I2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/480,494 US5843901A (en) 1995-06-07 1995-06-07 LHRH antagonist peptides
PCT/US1996/009852 WO1996040757A2 (fr) 1995-06-07 1996-06-07 Peptides antagonistes de la lh-rh

Publications (1)

Publication Number Publication Date
LU91225I2 true LU91225I2 (fr) 2006-05-03

Family

ID=23908180

Family Applications (2)

Application Number Title Priority Date Filing Date
LU91225C LU91225I2 (fr) 1995-06-07 2006-03-03 Plenaxis
LU91857C LU91857I2 (fr) 1995-06-07 2011-08-22 Abarelix, optionnellement sous forme de sel pharmaceutiquement acceptable

Family Applications After (1)

Application Number Title Priority Date Filing Date
LU91857C LU91857I2 (fr) 1995-06-07 2011-08-22 Abarelix, optionnellement sous forme de sel pharmaceutiquement acceptable

Country Status (13)

Country Link
US (4) US5843901A (fr)
EP (2) EP0794961B1 (fr)
JP (3) JP4164125B2 (fr)
AT (2) ATE432941T1 (fr)
AU (1) AU715399B2 (fr)
CA (1) CA2219460C (fr)
DE (4) DE122006000012I2 (fr)
DK (2) DK0794961T3 (fr)
ES (2) ES2177789T3 (fr)
HK (1) HK1045161B (fr)
LU (2) LU91225I2 (fr)
PT (2) PT1188768E (fr)
WO (1) WO1996040757A2 (fr)

Families Citing this family (110)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL117175A (en) * 1995-02-20 2005-11-20 Sankyo Co Osteoclastogenesis inhibitory factor protein
US5843901A (en) 1995-06-07 1998-12-01 Advanced Research & Technology Institute LHRH antagonist peptides
US5780435A (en) * 1995-12-15 1998-07-14 Praecis Pharmaceuticals Incorporated Methods for treating prostate cancer with LHRH-R antagonists
US5968895A (en) 1996-12-11 1999-10-19 Praecis Pharmaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
DE69740107D1 (de) 1996-12-23 2011-03-10 Immunex Corp Rezeptor aktivator von nf-kappa b, rezeptor is mitglied der tnf rezeptor superfamilie
US5925730A (en) 1997-04-11 1999-07-20 Ferring Bv GnRH antagonists
ES2263204T5 (es) * 1997-04-15 2013-10-14 Daiichi Sankyo Company, Limited Nueva proteína y proceso para producir la misma
ES2284203T5 (es) 1997-04-16 2016-03-11 Amgen Inc. Proteínas de unión a osteoprotegerina y sus receptores
US6316408B1 (en) * 1997-04-16 2001-11-13 Amgen Inc. Methods of use for osetoprotegerin binding protein receptors
CN1307481A (zh) * 1998-04-27 2001-08-08 普雷西斯药品公司 用于治疗热潮红和男子女性型乳房的方法
US6217844B1 (en) * 1998-04-27 2001-04-17 Praecis Pharmaceuticals, Inc. Methods for detecting lesions in dense breast tissue using LHRH antagonists
US6191115B1 (en) * 1998-08-12 2001-02-20 Abbott Laboratories C-terminus modified heptapeptide LHRH analogs
US6455499B1 (en) * 1999-02-23 2002-09-24 Indiana University Foundation Methods for treating disorders associated with LHRH activity
US6703367B1 (en) * 1999-04-27 2004-03-09 Praecis Pharmaceuticals Inc. Methods for treating hot flashes and gynaecomastia
IL147970A0 (en) * 1999-08-09 2002-09-12 Tripep Ab Pharmaceutical compositions containing tripeptides
IL142900A0 (en) * 1999-09-03 2002-04-21 Amgen Inc Compositions and methods for the prevention or treatment of cancer and bone loss associated with cancer
US20030103978A1 (en) 2000-02-23 2003-06-05 Amgen Inc. Selective binding agents of osteoprotegerin binding protein
US7109171B2 (en) 2000-02-28 2006-09-19 Praecis Pharmaceuticals Inc. Methods for treating FSH related conditions with GnRH antagonists
AU2001267872A1 (en) * 2000-06-30 2002-01-14 Suntory Limited Novel gonadotropin-releasing hormone, precursor peptides thereof and genes encoding the same
US6598784B2 (en) * 2000-12-20 2003-07-29 Meadwestvaco Packaging Syatens, Llc Beverage carton with strap type carrying handle
WO2002056903A2 (fr) * 2001-01-17 2002-07-25 Praecis Pharmaceuticals Inc. Methodes pour traiter des etats lies aux hormones au moyen d'une combinaison d'antagonistes de la lhrh et de modulateurs selectifs des recepteurs des oestrogenes
MX368013B (es) 2001-02-19 2019-09-13 Novartis Ag Tratamiento de cáncer.
CA2444867C (fr) 2001-05-16 2010-08-17 Novartis Ag Combinaison comprenant n-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2pyrimidine-amine et agent chimiotherapeutique
WO2003000156A1 (fr) 2001-06-22 2003-01-03 Southern Biosystems, Inc. Implants coaxiaux a liberation prolongee d'ordre 0
EP2295081B1 (fr) 2001-06-26 2018-10-31 Amgen Inc. Anticorps OPGL
US6593455B2 (en) * 2001-08-24 2003-07-15 Tripep Ab Tripeptide amides that block viral infectivity and methods of use thereof
GB0128510D0 (en) * 2001-11-28 2002-01-23 Novartis Ag Organic compounds
US7718776B2 (en) 2002-04-05 2010-05-18 Amgen Inc. Human anti-OPGL neutralizing antibodies as selective OPGL pathway inhibitors
PT1505959E (pt) 2002-05-16 2009-02-05 Novartis Ag Utilização de agentes de ligação do receptor edg em cancro
US6861236B2 (en) 2002-05-24 2005-03-01 Applied Nanosystems B.V. Export and modification of (poly)peptides in the lantibiotic way
CN101791409A (zh) 2003-04-22 2010-08-04 研究及应用科学协会股份有限公司 肽载体
GB0320806D0 (en) 2003-09-05 2003-10-08 Astrazeneca Ab Therapeutic treatment
JP4407322B2 (ja) * 2004-03-09 2010-02-03 味の素株式会社 ペプチドの製造方法
DK2253614T3 (da) 2004-04-07 2013-01-07 Novartis Ag IAP-inhibitorer
GB0512324D0 (en) 2005-06-16 2005-07-27 Novartis Ag Organic compounds
MX2007008781A (es) 2005-01-21 2007-09-11 Astex Therapeutics Ltd Compuestos farmaceuticos.
GB0510390D0 (en) 2005-05-20 2005-06-29 Novartis Ag Organic compounds
US20080255149A1 (en) 2005-09-27 2008-10-16 Novartis Ag Carboxyamine Compounds and Methods of Use Thereof
US20070106271A1 (en) * 2005-11-09 2007-05-10 Searete Llc, A Limited Liability Corporation Remote control of substance delivery system
GB0605120D0 (en) 2006-03-14 2006-04-26 Novartis Ag Organic Compounds
NZ572299A (en) 2006-05-09 2010-07-30 Novartis Ag Combination comprising a substituted 3,5-diphenyl-1,2,4-triazole and a platinum compound and use thereof
WO2008037477A1 (fr) 2006-09-29 2008-04-03 Novartis Ag PYRAZOLOPYRIMIDINES UTILISÉES COMME INHIBITEURS DES LIPIDES KINASES Pl3K
WO2008044041A1 (fr) 2006-10-12 2008-04-17 Astex Therapeutics Limited Combinaisons pharmaceutiques
EP2073807A1 (fr) 2006-10-12 2009-07-01 Astex Therapeutics Limited Combinaisons pharmaceutiques
US20100069458A1 (en) 2007-02-15 2010-03-18 Peter Wisdom Atadja Combination of lbh589 with other therapeutic agents for treating cancer
AU2009228765B2 (en) 2008-03-24 2012-05-31 Novartis Ag Arylsulfonamide-based matrix metalloprotease inhibitors
GEP20125708B (en) 2008-03-26 2012-12-10 Novartis Ag Hydroxamate-based inhibitors of deacetylases b
MA32934B1 (fr) * 2008-11-28 2012-01-02 Novartis Ag Combinaisons inhibitrices hsp90
WO2010083617A1 (fr) 2009-01-21 2010-07-29 Oncalis Ag Pyrazolopyrimidines en tant qu'inhibiteurs de protéines kinases
EP2379099A1 (fr) 2009-01-22 2011-10-26 Maatschap Interne Geneeskunde Rijnstate Méthode de traitement prophylactique ou thérapeutique des bouffées vasomotrices
PL2391366T3 (pl) 2009-01-29 2013-04-30 Novartis Ag Podstawione benzimidazole do leczenia gwiaździaków
WO2010149755A1 (fr) 2009-06-26 2010-12-29 Novartis Ag Dérivés d'imidazolidin-2-one 1,3-disubstitués en tant qu'inhibiteurs de cyp 17
US8389526B2 (en) 2009-08-07 2013-03-05 Novartis Ag 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives
EA201200260A1 (ru) 2009-08-12 2012-09-28 Новартис Аг Гетероциклические гидразоны и их применение для лечения рака и воспаления
CA2771432A1 (fr) 2009-08-20 2011-02-24 Novartis Ag Composes d'oximes heterocycliques
IN2012DN01693A (fr) 2009-08-26 2015-06-05 Novartis Ag
CN102596963A (zh) 2009-09-10 2012-07-18 诺瓦提斯公司 二环杂芳基的醚衍生物
AU2010317167B2 (en) 2009-11-04 2012-11-29 Novartis Ag Heterocyclic sulfonamide derivatives useful as MEK inhibitors
WO2011064211A1 (fr) 2009-11-25 2011-06-03 Novartis Ag Dérivés hétérocycliques d'hétéroaryles bicycliques à 6 cycles benzéniques accolés de benzène contenant de l'oxygène
EA201200823A1 (ru) 2009-12-08 2013-02-28 Новартис Аг Гетероциклические производные сульфонамидов
US8440693B2 (en) 2009-12-22 2013-05-14 Novartis Ag Substituted isoquinolinones and quinazolinones
CU24130B1 (es) 2009-12-22 2015-09-29 Novartis Ag Isoquinolinonas y quinazolinonas sustituidas
UA112517C2 (uk) 2010-07-06 2016-09-26 Новартіс Аг Тетрагідропіридопіримідинові похідні
SG177783A1 (en) 2010-07-09 2012-02-28 Smart Communications Inc Content provision system and method
JP2013537210A (ja) 2010-09-16 2013-09-30 ノバルティス アーゲー １７α−ヒドロキシラーゼ／Ｃ１７，２０−リアーゼ阻害剤
EP2673277A1 (fr) 2011-02-10 2013-12-18 Novartis AG Composés de [1, 2, 4]triazolo [4, 3 -b]pyridazine en tant qu'inhibiteurs de la tyrosine kinase c-met
JP2014507465A (ja) 2011-03-08 2014-03-27 ノバルティス アーゲー フルオロフェニル二環式ヘテロアリール化合物
US9029399B2 (en) 2011-04-28 2015-05-12 Novartis Ag 17α-hydroxylase/C17,20-lyase inhibitors
EA201391820A1 (ru) 2011-06-09 2014-12-30 Новартис Аг Гетероциклические сульфонамидные производные
WO2012175520A1 (fr) 2011-06-20 2012-12-27 Novartis Ag Dérivés d'isoquinolinone substitués par un hydroxy
US8859586B2 (en) 2011-06-20 2014-10-14 Novartis Ag Cyclohexyl isoquinolinone compounds
KR20140025530A (ko) 2011-06-27 2014-03-04 노파르티스 아게 테트라히드로-피리도-피리미딘 유도체의 고체 형태 및 염
CA2848809A1 (fr) 2011-09-15 2013-03-21 Novartis Ag 3-(quinolin-6-ylthio)-[1,2,4]triazolo[4,3-a]pyradines substituees en position 6 a activite tyrosine kinase
WO2013080141A1 (fr) 2011-11-29 2013-06-06 Novartis Ag Composés pyrazolopyrrolidine
JO3398B1 (ar) 2011-12-22 2019-10-20 Novartis Ag مشتقات 2،3- ثانى هيدرو- بنزو[1,4] أوكسازين والمركبات المتعلقة بها كمثبطات كيناز فسفواينوسيتيد-3 (pi3k) لمعالجة على سبيل المثال التهاب المفاصل الروماتيدي
EP2794594A1 (fr) 2011-12-22 2014-10-29 Novartis AG Dérivés quinoline
BR112014015308A8 (pt) 2011-12-23 2017-06-13 Novartis Ag compostos para inibição da interação de bcl2 com contrapartes de ligação
EP2794592A1 (fr) 2011-12-23 2014-10-29 Novartis AG Composés inhibiteurs de l'interaction entre bcl2 et des partenaires de liaison
EP2794591A1 (fr) 2011-12-23 2014-10-29 Novartis AG Composés inhibiteurs de l'interaction entre bcl2 et des partenaires de liaison
WO2013096051A1 (fr) 2011-12-23 2013-06-27 Novartis Ag Composés pour inhiber l'interaction de bcl-2 avec des partenaires de liaison
US9126980B2 (en) 2011-12-23 2015-09-08 Novartis Ag Compounds for inhibiting the interaction of BCL2 with binding partners
UY34591A (es) 2012-01-26 2013-09-02 Novartis Ag Compuestos de imidazopirrolidinona
EP2831090A4 (fr) * 2012-03-26 2015-11-11 Univ California Préparation de polypeptides, de peptides et de protéines fonctionnalisés par alkylation de groupes thioéther
EP2855483B1 (fr) 2012-05-24 2017-10-25 Novartis AG Composés pyrrolopyrrolidinones
EP2861256B1 (fr) 2012-06-15 2019-10-23 The Brigham and Women's Hospital, Inc. Compositions pour le traitement du cancer et leurs procédés de préparation
DK2903968T3 (en) 2012-10-02 2017-01-30 Gilead Sciences Inc INHIBITORS OF HISTON DEMETHYLASES
TW201422625A (zh) 2012-11-26 2014-06-16 Novartis Ag 二氫－吡啶并－□衍生物之固體形式
WO2014115077A1 (fr) 2013-01-22 2014-07-31 Novartis Ag Composés de purinone substitués
US9556180B2 (en) 2013-01-22 2017-01-31 Novartis Ag Pyrazolo[3,4-d]pyrimidinone compounds as inhibitors of the P53/MDM2 interaction
WO2014128612A1 (fr) 2013-02-20 2014-08-28 Novartis Ag Dérivés de quinazolin-4-one
PE20151667A1 (es) 2013-02-27 2015-11-27 Epitherapeutics Aps Inhibidores de histona desmetilasas
US20150018376A1 (en) 2013-05-17 2015-01-15 Novartis Ag Pyrimidin-4-yl)oxy)-1h-indole-1-carboxamide derivatives and use thereof
UY35675A (es) 2013-07-24 2015-02-27 Novartis Ag Derivados sustituidos de quinazolin-4-ona
US9227969B2 (en) 2013-08-14 2016-01-05 Novartis Ag Compounds and compositions as inhibitors of MEK
WO2015022663A1 (fr) 2013-08-14 2015-02-19 Novartis Ag Composés et compositions utiles comme inhibiteurs de mek
WO2015022664A1 (fr) 2013-08-14 2015-02-19 Novartis Ag Composés et compositions utiles comme inhibiteurs de mek
KR20160060100A (ko) 2013-09-22 2016-05-27 칼리토르 사이언시즈, 엘엘씨 치환된 아미노피리미딘 화합물 및 이용 방법
BR112016012141A2 (pt) 2014-01-15 2017-08-08 Novartis Ag "combinações farmacêuticas, uso das mesmas, e embalagem comercial"
WO2015148867A1 (fr) 2014-03-28 2015-10-01 Calitor Sciences, Llc Composés hétéroaryle substitués et procédés d'utilisation
CA2943824A1 (fr) 2014-03-31 2015-10-08 Gilead Sciences, Inc. Inhibiteurs d'histones demethylases
BR112016022499A2 (pt) 2014-04-03 2017-08-15 Invictus Oncology Pvt Ltd Produtos terapêuticos combinatórios supramoleculares
SG11201701182VA (en) 2014-08-27 2017-03-30 Gilead Sciences Inc Compounds and methods for inhibiting histone demethylases
WO2016154120A1 (fr) 2015-03-20 2016-09-29 The Regents Of The University Of California Polypeptides, peptides et protéines fonctionnalisé(e)s par alkylation de groupes thioéther via des réactions d'ouverture de cycle
EP3124495A1 (fr) 2015-07-31 2017-02-01 Centre National de la Recherche Scientifique (C.N.R.S.) Dérivés de polypeptides de type élastine et leurs utilisations
JP2018527362A (ja) 2015-09-11 2018-09-20 サンシャイン・レイク・ファーマ・カンパニー・リミテッドＳｕｎｓｈｉｎｅ Ｌａｋｅ Ｐｈａｒｍａ Ｃｏ．，Ｌｔｄ． 置換されたヘテロアリール化合物および使用方法
WO2017189860A1 (fr) 2016-04-27 2017-11-02 The Regents Of The University Of California Préparation de résidus fonctionnels d'homocystéine dans des polypeptides et des peptides
WO2019099311A1 (fr) 2017-11-19 2019-05-23 Sunshine Lake Pharma Co., Ltd. Composés hétéroaryle substitués et leurs méthodes d'utilisation
US11602534B2 (en) 2017-12-21 2023-03-14 Hefei Institutes Of Physical Science, Chinese Academy Of Sciences Pyrimidine derivative kinase inhibitors
KR102737185B1 (ko) 2018-01-20 2024-12-05 선샤인 레이크 파르마 컴퍼니 리미티드 치환된 아미노피리미딘 화합물 및 이의 사용 방법
CN109926430A (zh) * 2018-11-19 2019-06-25 云南省环境科学研究院(中国昆明高原湖泊国际研究中心) 一种重金属废渣还原造锍熔炼处置的方法

Family Cites Families (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3787385A (en) * 1971-05-17 1974-01-22 K Folkers Synthetically produced tetrapeptide having the activity of the luteinizing hormone releasing hormone
US3974135A (en) * 1971-06-24 1976-08-10 Karl Folkers Synthetic decapeptide having the activity of the luteinizing hormone releasing hormone and method for producing the same
US3953416A (en) * 1971-12-20 1976-04-27 Karl Folkers Synthetic decapeptide having the activity of the luteinizing hormone releasing hormone and method for manufacturing the same
JPS5257177A (en) * 1975-10-29 1977-05-11 Parke Davis & Co Production of novel nonapeptide
BE847761A (fr) * 1975-10-29 1977-02-14 Nouveaux octapeptides et procedes pour les produire,
DE2617646C2 (de) * 1976-04-22 1986-07-31 Hoechst Ag, 6230 Frankfurt Nonapeptid-amide und Decapeptid-amide mit Gonadoliberin-Wirkung, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Präparate
US4215038A (en) * 1978-10-16 1980-07-29 The Salk Institute For Biological Studies Peptides which inhibit gonadal function
US4307083A (en) * 1978-10-16 1981-12-22 The Salk Institute For Biological Studies LRF Antagonists
US4244946A (en) * 1979-06-11 1981-01-13 The Salk Institute For Biological Studies Water-soluble peptides affecting gonadal function
US4292313A (en) * 1980-04-15 1981-09-29 The Salk Institute For Biological Studies LRF Antagonists
US4409208A (en) * 1980-04-15 1983-10-11 The Salk Institute For Biological Studies GnRH antagonists
US4377574A (en) * 1980-06-26 1983-03-22 The Salk Institute For Biological Studies Contraceptive treatment of male mammals
US4386074A (en) * 1980-08-29 1983-05-31 The Salk Institute For Biological Studies LRF Antagonists
US4419347A (en) * 1980-10-06 1983-12-06 Syntex (U.S.A.) Inc. Nonapeptide and decapeptide analogs of LHRH, useful as LHRH antagonists
US4341767A (en) * 1980-10-06 1982-07-27 Syntex Inc. Nonapeptide and decapeptide analogs of LHRH, useful as LHRH antagonists
US4489061A (en) * 1981-06-12 1984-12-18 The Salk Institute For Biological Studies Treatment of male mammals
US4481190A (en) * 1982-12-21 1984-11-06 Syntex (U.S.A.) Inc. Nonapeptide and decapeptide analogs of LHRH useful as LHRH antagonists
US4581169A (en) * 1982-12-21 1986-04-08 Syntex (U.S.A.) Inc. Nona-peptide and deca-peptide analogs of LHRH, useful as LHRH antagonists
US4667014A (en) * 1983-03-07 1987-05-19 Syntex (U.S.A.) Inc. Nonapeptide and decapeptide analogs of LHRH, useful as LHRH antagonists
US4444759A (en) * 1982-07-26 1984-04-24 The Salk Institute For Biological Studies GnRH Antagonists II
US4619914A (en) * 1983-03-10 1986-10-28 The Salk Institute For Biological Studies GNRH antagonists IIIB
US4504414A (en) * 1983-03-28 1985-03-12 Board Of Regents, The University Of Texas System Synthetic pyridyl-alanyl decapeptides having antiovulatory activity
DE3467173D1 (en) * 1983-08-16 1987-12-10 Akzo Nv Lh- rh antagonists
US4547370A (en) * 1983-11-29 1985-10-15 The Salk Institute For Biological Studies GnRH Antagonists
US4569927A (en) * 1984-02-23 1986-02-11 The Salk Institute For Biological Studies GnRH Antagonists IV
US4652550A (en) * 1984-05-21 1987-03-24 The Salk Institute For Biological Studies GnRH antagonists VII
US4647653A (en) * 1984-08-23 1987-03-03 Tulane Educational Fund Therapeutic peptides
US4565804A (en) * 1984-09-07 1986-01-21 The Salk Institute For Biological Studies GnRH Antagonists VI
US4690916A (en) * 1984-11-13 1987-09-01 Syntex (U.S.A.) Inc. Nona and decapeptide analogs of LHRH useful as LHRH antagonists
US4740500A (en) * 1985-01-31 1988-04-26 The Salk Institute For Biological Studies GnRH antagonists VIII
US4659691A (en) * 1985-02-08 1987-04-21 Merck & Co., Inc. Novel cyclic Hexapeptide LHRH antagonists
US4677193A (en) * 1985-02-22 1987-06-30 The Salk Institute For Biological Studies Peptides containing an aliphatic-aromatic ketone side chain
US5003011A (en) * 1985-04-09 1991-03-26 The Administrators Of The Tulane Educational Fund Therapeutic decapeptides
US4866160A (en) * 1985-04-09 1989-09-12 The Administrators Of The Tulane Educational Fund Therapeutic decapeptides
US5073624A (en) * 1985-04-09 1991-12-17 Administrators Of The Tulane Educational Fund Therapeutic decapeptides
US4642332A (en) * 1985-04-26 1987-02-10 The Board Of Regents, The University Of Texas System Effective hormonal peptides: D-3-Pal6 -LHRH
US4656247A (en) * 1985-04-26 1987-04-07 Board Of Regents, The University Of Texas System Effective hormonal peptides: D-3-QA1 6-LHRH
US4661472A (en) * 1985-05-09 1987-04-28 The Salk Institute For Biological Studies GnRH antagonists IX
US4721775A (en) * 1985-08-26 1988-01-26 Board Of Regents, The University Of Texas System Effective peptides related to the luteinizing hormone releasing hormone from L-amino acids
US4705778A (en) * 1985-10-22 1987-11-10 Sri International Orally active LHRH analogs
US5182205A (en) * 1986-11-27 1993-01-26 Hoffmann-La Roche Inc. Nucleotide sequences which are selectively expressed in pre-B cells and probes therefor
US4801577A (en) * 1987-02-05 1989-01-31 Syntex (U.S.A.) Inc. Nonapeptide and decapeptide analogs of LHRH useful as LHRH antagonists
US4851385A (en) * 1987-07-15 1989-07-25 Indiana University Foundation LHRH antagonist analogs having low histamine-release activity
US4800191A (en) * 1987-07-17 1989-01-24 Schally Andrew Victor LHRH antagonists
US4935491A (en) * 1987-08-24 1990-06-19 Board Of Regents, The University Of Texas System Effective antagonists of the luteinizing hormone releasing hormone which release negligible histamine
US5300492A (en) * 1988-02-10 1994-04-05 Tap Pharmaceuticals LHRH analogs
US5140009A (en) * 1988-02-10 1992-08-18 Tap Pharmaceuticals, Inc. Octapeptide LHRH antagonists
US5110904A (en) * 1989-08-07 1992-05-05 Abbott Laboratories Lhrh analogs
DE68928278T2 (de) * 1988-02-10 1998-03-12 Tap Pharmaceuticals Inc Lhrh-analog
DK163689A (da) * 1988-04-08 1989-10-30 Sandoz Ag Peptidderivater
US4992421A (en) * 1988-04-19 1991-02-12 Abbott Laboratories Luteinizing hormone releasing hormone antagonist
US5258492A (en) * 1988-10-21 1993-11-02 The Administrators Of The Tulane Educational Fund LHRH analogues with cytotoxic moieties at the sixth position
US5171835A (en) * 1988-10-21 1992-12-15 The Administrators Of The Tulane Educational Fund LHRH antagonists
US5296468A (en) * 1989-10-30 1994-03-22 The Salk Institute For Biological Studies GnRH analogs
US5169932A (en) * 1989-10-30 1992-12-08 The Salk Institute For Biological Studies Gnrh analogs
US5352796A (en) * 1989-10-30 1994-10-04 The Salk Institute For Biological Studies Amino acids useful in making GnRH analogs
US5064939A (en) * 1990-02-06 1991-11-12 The Salk Institute For Biological Studies Cyclic gnrh antagonists
US5180711A (en) * 1990-06-14 1993-01-19 Applied Research Systems Ars Holding N.V. Combined treatment with gnrh antagonist and gnrh to control gonadotropin levels in mammals
CN1036343C (zh) * 1990-11-10 1997-11-05 天津市计划生育研究所 新促黄体生成素释放激素拮抗类似物的制备方法
IL101074A (en) * 1991-03-14 1997-09-30 Salk Inst For Biological Studi GnRH ANALOGS AND THEIR PREPARATION
US5340585A (en) * 1991-04-12 1994-08-23 University Of Southern California Method and formulations for use in treating benign gynecological disorders
DE69214818T2 (de) * 1991-04-25 1997-02-27 Romano S.-Cergue Deghenghi LHRH-Antagonisten
DE4117507A1 (de) * 1991-05-24 1992-11-26 Schering Ag Verfahren zur herstellung von n(pfeil hoch)6(pfeil hoch)-substituierten lysin-derivaten
US5480969A (en) * 1992-09-15 1996-01-02 The Administrators Of The Tulane Educational Fund Antagonists of LHRH
US5371070A (en) * 1992-11-09 1994-12-06 The Salk Institute For Biological Studies Bicyclic GnRH antagonists and a method for regulating the secretion of gonadotropins
JPH08504209A (ja) * 1992-12-04 1996-05-07 アボツト・ラボラトリーズ ６位修飾デカペプチドｌｈｒｈ拮抗薬
CA2136079A1 (fr) * 1992-12-18 1994-07-07 Fortuna Haviv Antagonistes de lhrh presentant des residus aminoacyle modifies en position 5 et 6
JPH08510260A (ja) * 1993-05-20 1996-10-29 バイオテック・オーストラリア・プロプライエタリー・リミテッド Ｌｈｒｈ拮抗剤
DE4320201A1 (de) * 1993-06-18 1995-01-12 Asta Medica Ag Verwendung von Cetrorelix und weiteren Nona- und Dekapeptiden zur Herstellung eines Arzneimittels zur Bekämpfung von Aids und zur Wachstumsstimulation
US5413990A (en) * 1993-08-06 1995-05-09 Tap Pharmaceuticals Inc. N-terminus modified analogs of LHRH
US5502035A (en) * 1993-08-06 1996-03-26 Tap Holdings Inc. N-terminus modified analogs of LHRH
US5508383A (en) * 1994-03-09 1996-04-16 Tap Holdings Inc. Cyclic peptide LHRH antagonists
US5506207A (en) * 1994-03-18 1996-04-09 The Salk Institute For Biological Studies GNRH antagonists XIII
US5516759A (en) * 1994-12-08 1996-05-14 Tap Holdings Inc. LHRH antagonists having lactam groups at the N-terminus
US5843901A (en) * 1995-06-07 1998-12-01 Advanced Research & Technology Institute LHRH antagonist peptides
US5780435A (en) * 1995-12-15 1998-07-14 Praecis Pharmaceuticals Incorporated Methods for treating prostate cancer with LHRH-R antagonists

Also Published As

Publication number Publication date
US20030040482A1 (en) 2003-02-27
ATE432941T1 (de) 2009-06-15
AU715399B2 (en) 2000-02-03
EP1188768A2 (fr) 2002-03-20
DK0794961T3 (da) 2002-10-21
HK1045161A1 (en) 2002-11-15
US7071165B2 (en) 2006-07-04
EP1188768B1 (fr) 2009-06-03
WO1996040757A3 (fr) 1997-02-20
EP1188768A3 (fr) 2002-10-23
EP0794961A2 (fr) 1997-09-17
HK1045161B (en) 2009-12-24
US20030181385A1 (en) 2003-09-25
DE69535963D1 (de) 2009-07-16
EP0794961B1 (fr) 2002-08-28
CA2219460C (fr) 2009-04-14
JP2009040793A (ja) 2009-02-26
DE69623254T2 (de) 2002-12-19
PT1188768E (pt) 2009-08-13
ATE222924T1 (de) 2002-09-15
US5843901A (en) 1998-12-01
JPH11507374A (ja) 1999-06-29
US20020115615A1 (en) 2002-08-22
DK1188768T3 (da) 2009-09-21
ES2326861T3 (es) 2009-10-21
AU6168096A (en) 1996-12-30
LU91857I2 (fr) 2011-10-24
ES2177789T3 (es) 2002-12-16
CA2219460A1 (fr) 1996-12-19
DE69623254D1 (de) 2002-10-02
WO1996040757A2 (fr) 1996-12-19
PT794961E (pt) 2003-01-31
US6423686B1 (en) 2002-07-23
JP2007302695A (ja) 2007-11-22
DE122006000012I2 (de) 2010-02-04
DE122006000012I1 (de) 2006-06-29
JP4164125B2 (ja) 2008-10-08

Similar Documents

Publication Publication Date Title
LU91225I2 (fr) Plenaxis
DK0528312T3 (da) Cykliske peptider og anvendelse deraf
DK0966297T4 (da) Regulering af gastrointestinal motilitet
LV10720A (lv) Peptidi un farmaceitiska kompozicija uz to bazes
SE8903042L (sv) Pharmaceutical compositions comprising cyklosporins
ATE108662T1 (de) Antimikrobielle peptide, zusammensetzungen, die diese enthalten, und verwendungen daraus.
ATE331037T1 (de) Isoliertes frpb nukleinsäuremolekül und entsprechende impfstoff
FI903971A0 (fi) Peptid med bradykinin antagonistverkan.
BG97123A (bg) Производни на човешка, стимулирана от жлъчните соли, липаза и фармацевтични състави на тяхна основа
DK482185D0 (da) Peptider, deres fremstilling og anvendelse som laegemidler
ATE69556T1 (de) Cyclopeptide als resorptionsfoerderer bei applikation auf die schleimhaeute.
NZ231636A (en) Anticoagulant peptides analogus to hirudins' active site
DE69002881D1 (de) Peptide und deren Benutzung.
DK1612555T3 (da) Kryptiske peptider til anvendelse til at inducere immunologisk tolerance
ATE46347T1 (de) Immunostimulierende peptide.
ES2091571T3 (es) Nuevos derivados peptidicos activos en los procesos de adhesion celular, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
IT8720701A0 (it) Composizioni farmaceutiche adattivita' immunomodulante.
IT8719949A0 (it) Composizioni farmaceutiche adattivita' immunomodulante.
IT8847610A0 (it) Composizioni farmaceutiche adattivita' antiprolattinica
TH35998A (th) Lh-rh เป็ปไทด์ อะนาล็อก ประโยชน์ของสิ่งเหล่านั้นและองค์ประกอบทางเภสัชกรรมซึ่งประกอบด้วยสิ่งเหล่านั้น