ATE119538T1 - Industrieverfahren zur herstellung von vinblastinphosphonsäurederivaten. - Google Patents
Industrieverfahren zur herstellung von vinblastinphosphonsäurederivaten.Info
- Publication number
- ATE119538T1 ATE119538T1 AT91400619T AT91400619T ATE119538T1 AT E119538 T1 ATE119538 T1 AT E119538T1 AT 91400619 T AT91400619 T AT 91400619T AT 91400619 T AT91400619 T AT 91400619T AT E119538 T1 ATE119538 T1 AT E119538T1
- Authority
- AT
- Austria
- Prior art keywords
- vinblastinphosphonic
- producing
- acid derivatives
- industrial process
- amino
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 2
- -1 1-amino-2-methylpropyl diethyl phosphonate Chemical compound 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 238000005904 alkaline hydrolysis reaction Methods 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000009833 condensation Methods 0.000 abstract 1
- 230000005494 condensation Effects 0.000 abstract 1
- 239000012026 peptide coupling reagents Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- JXLYSJRDGCGARV-CFWMRBGOSA-N vinblastine Chemical compound C([C@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-CFWMRBGOSA-N 0.000 abstract 1
- 229960003048 vinblastine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Catalysts (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9101073A FR2672287B1 (fr) | 1991-01-31 | 1991-01-31 | Nouveau procede industriel de preparation du n-(desacetyl-o-4 vinblastinoyl-23) amino-1 methyl-2 propylphosphonate de diethyle (1s) et de ses sels. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE119538T1 true ATE119538T1 (de) | 1995-03-15 |
Family
ID=9409215
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT91400619T ATE119538T1 (de) | 1991-01-31 | 1991-03-07 | Industrieverfahren zur herstellung von vinblastinphosphonsäurederivaten. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5149812A (de) |
| EP (1) | EP0497065B1 (de) |
| JP (1) | JPH0730103B2 (de) |
| AT (1) | ATE119538T1 (de) |
| AU (1) | AU634639B2 (de) |
| CA (1) | CA2038976C (de) |
| DE (1) | DE69108000T2 (de) |
| DK (1) | DK0497065T3 (de) |
| ES (1) | ES2072562T3 (de) |
| FR (1) | FR2672287B1 (de) |
| IE (1) | IE66182B1 (de) |
| NZ (1) | NZ237546A (de) |
| PT (1) | PT97136A (de) |
| ZA (1) | ZA912226B (de) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8078420B2 (en) * | 2006-11-15 | 2011-12-13 | Miller Gary L | Raman spectrometry authentication |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2623504B1 (fr) * | 1987-11-25 | 1990-03-09 | Adir | Nouveaux derives n-(vinblastinoyl-23) d'acide amino-1 methylphosphonique, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2632643B1 (fr) * | 1988-06-10 | 1990-09-07 | Adir | Nouveau procede de preparation de derives n-(vinblastinoyl-23) d'acide amino-1 methylphosphonique |
-
1991
- 1991-01-31 FR FR9101073A patent/FR2672287B1/fr not_active Expired - Fee Related
- 1991-03-07 ES ES91400619T patent/ES2072562T3/es not_active Expired - Lifetime
- 1991-03-07 EP EP91400619A patent/EP0497065B1/de not_active Expired - Lifetime
- 1991-03-07 AT AT91400619T patent/ATE119538T1/de not_active IP Right Cessation
- 1991-03-07 DE DE69108000T patent/DE69108000T2/de not_active Expired - Fee Related
- 1991-03-07 DK DK91400619.2T patent/DK0497065T3/da active
- 1991-03-22 NZ NZ237546A patent/NZ237546A/en unknown
- 1991-03-25 US US07/674,653 patent/US5149812A/en not_active Expired - Fee Related
- 1991-03-25 ZA ZA912226A patent/ZA912226B/xx unknown
- 1991-03-25 JP JP3060015A patent/JPH0730103B2/ja not_active Expired - Lifetime
- 1991-03-25 AU AU73772/91A patent/AU634639B2/en not_active Ceased
- 1991-03-25 PT PT97136A patent/PT97136A/pt not_active Application Discontinuation
- 1991-03-25 IE IE97591A patent/IE66182B1/en not_active IP Right Cessation
- 1991-03-25 CA CA002038976A patent/CA2038976C/fr not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPH04247094A (ja) | 1992-09-03 |
| ES2072562T3 (es) | 1995-07-16 |
| DK0497065T3 (da) | 1995-07-24 |
| US5149812A (en) | 1992-09-22 |
| PT97136A (pt) | 1992-07-31 |
| EP0497065A1 (de) | 1992-08-05 |
| CA2038976A1 (fr) | 1992-08-01 |
| JPH0730103B2 (ja) | 1995-04-05 |
| AU7377291A (en) | 1992-08-13 |
| DE69108000D1 (de) | 1995-04-13 |
| IE910975A1 (en) | 1992-07-29 |
| NZ237546A (en) | 1992-04-28 |
| AU634639B2 (en) | 1993-02-25 |
| FR2672287A1 (fr) | 1992-08-07 |
| FR2672287B1 (fr) | 1994-07-22 |
| IE66182B1 (en) | 1993-12-13 |
| EP0497065B1 (de) | 1995-03-08 |
| CA2038976C (fr) | 1995-09-26 |
| ZA912226B (en) | 1991-12-24 |
| DE69108000T2 (de) | 1995-11-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |