ATE119541T1 - Verfahren zur herstellung von nucleosiden und ihre analogen. - Google Patents

Verfahren zur herstellung von nucleosiden und ihre analogen.

Info

Publication number: ATE119541T1
Authority: AT; Austria
Prior art keywords: nucleoside; analogues; cyclonucleoside; cytarabine; amine
Prior art date: 1990-03-13

Application number

AT91906244T

Other languages

English (en)

Inventor

Khashayar Karimian

Original Assignee

Acic Canada Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-03-13

Filing date

1991-03-13

Publication date

1995-03-15

1990-03-13 Priority claimed from CA 2012094 external-priority patent/CA2012094C/en

1990-03-13 Priority claimed from CA 2012093 external-priority patent/CA2012093C/en

1991-03-13 Application filed by Acic Canada Inc filed Critical Acic Canada Inc

1995-03-15 Application granted granted Critical

1995-03-15 Publication of ATE119541T1 publication Critical patent/ATE119541T1/de

Links

239000002777 nucleoside Substances 0.000 title abstract 3
238000004519 manufacturing process Methods 0.000 title abstract 2
-1 cytarabine Chemical class 0.000 abstract 3
UHDGCWIWMRVCDJ-CCXZUQQUSA-N Cytarabine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-CCXZUQQUSA-N 0.000 abstract 2
150000001412 amines Chemical class 0.000 abstract 2
229960000684 cytarabine Drugs 0.000 abstract 2
230000000118 anti-neoplastic effect Effects 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1
239000003443 antiviral agent Substances 0.000 abstract 1
239000003125 aqueous solvent Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229940127073 nucleoside analogue Drugs 0.000 abstract 1
150000003833 nucleoside derivatives Chemical class 0.000 abstract 1
239000002243 precursor Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Life Sciences & Earth Sciences (AREA)
Saccharide Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT91906244T 1990-03-13 1991-03-13 Verfahren zur herstellung von nucleosiden und ihre analogen. ATE119541T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CA 2012094 CA2012094C (en)	1990-03-13	1990-03-13	Process for producing cytarabine and analogues thereof
CA 2012093 CA2012093C (en)	1990-03-13	1990-03-13	Process for producing 2,2'-cyclocytidine and analogues thereof

Publications (1)

Publication Number	Publication Date
ATE119541T1 true ATE119541T1 (de)	1995-03-15

Family

ID=25674007

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91906244T ATE119541T1 (de)	1990-03-13	1991-03-13	Verfahren zur herstellung von nucleosiden und ihre analogen.

Country Status (8)

Country	Link
US (1)	US5610292A (de)
EP (1)	EP0521923B1 (de)
AT (1)	ATE119541T1 (de)
AU (1)	AU7473791A (de)
BR (1)	BR9106158A (de)
DE (1)	DE69108014T2 (de)
HU (1)	HUT61566A (de)
WO (1)	WO1991013900A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH10501809A (ja) *	1994-06-22	1998-02-17	ネクスターファーマスーティカルズ，インコーポレイテッド	分子内求核置換による公知および新規２′−ヌクレオシドの新規製造方法
IT1277425B1 (it)	1995-08-03	1997-11-10	Pro Bio Sint Srl	Metodo per la preparazione della 1-b-d-arabinofuranosilcitosina
EP2319854B1 (de)	1997-01-08	2016-11-30	Sigma-Aldrich Co. LLC	Biokonjugation von Makromolekülen
US7427678B2 (en)	1998-01-08	2008-09-23	Sigma-Aldrich Co.	Method for immobilizing oligonucleotides employing the cycloaddition bioconjugation method
WO2001079248A1 (fr) *	2000-04-13	2001-10-25	Mitsui Chemicals, Inc.	Procede de preparation de derives de cytidine
CA2450073C (en)	2001-07-25	2017-08-29	Biomarin Pharmaceutical Inc.	Compositions and methods for modulating blood-brain barrier transport
WO2003062452A2 (en)	2002-01-23	2003-07-31	Proligo, Llc	Methods for the integrated synthesis and purification of oligonucleotides
EP1585755B1 (de)	2002-12-31	2015-08-05	Sigma-Aldrich Co. LLC	Verfahren und zusammenstellungen für die tandem-synthese von zwei oder mehr oligonukleotiden auf einen festen träger
WO2005026186A1 (de) *	2003-09-12	2005-03-24	Max-Delbrück-Centrum für Molekulare Medizin	Β-l-nucleoside und ihre verwendung als pharmazeutische mittel zur behandlung viraler erkrankungen
CN1300326C (zh) *	2004-12-22	2007-02-14	华南理工大学	酶催化制备阿糖胞苷酯的方法
EP2671508B1 (de)	2005-04-28	2020-09-16	Proteus Digital Health, Inc.	Pharma-Informatiksystem
JP2010503710A (ja)	2006-09-18	2010-02-04	ラプトールファーマシューティカルインコーポレイテッド	受容体関連タンパク質（ｒａｐ）結合体の投与による肝障害の処置
US8404830B2 (en)	2007-07-17	2013-03-26	Somalogic, Inc.	Method for generating aptamers with improved off-rates
WO2009114325A2 (en)	2008-03-03	2009-09-17	Tosk, Incorporated	Methotrexate adjuvants to reduce toxicity and methods for using the same
ES2919563T3 (es)	2009-02-20	2022-07-27	Enhanx Biopharm Inc	Sistema de administración de medicamentos a base de glutatión
KR20180114970A (ko)	2009-05-06	2018-10-19	라보라토리 스킨 케어, 인크.	활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
NZ602618A (en)	2010-04-12	2013-12-20	Somalogic Inc	Aptamers to beta-ngf and their use in treating beta-ngf mediated diseases and disorders
US20120077778A1 (en)	2010-09-29	2012-03-29	Andrea Bourdelais	Ladder-Frame Polyether Conjugates
CA2928207C (en)	2013-11-21	2020-09-15	Somalogic, Inc.	Cytidine-5-carboxamide modified nucleotide compositions and methods related thereto
US11446303B2 (en)	2019-06-21	2022-09-20	Tosk, Inc.	Uridine phosphorylase (UPase) inhibitors for treatment of liver conditions

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4652554A (en) *	1982-02-22	1987-03-24	St. Jude Children's Research Hospital	Nitro-substituted 1-β-D-arabinofuranosylcytosines
DE69111438T2 (de) *	1990-03-13	1996-01-04	Acic Canada Inc	2,3'-o-cyclocytidine und verfahren zu deren herstellung.

1991
- 1991-03-13 AT AT91906244T patent/ATE119541T1/de not_active IP Right Cessation
- 1991-03-13 DE DE69108014T patent/DE69108014T2/de not_active Expired - Fee Related
- 1991-03-13 AU AU74737/91A patent/AU7473791A/en not_active Abandoned
- 1991-03-13 HU HU9202906A patent/HUT61566A/hu unknown
- 1991-03-13 EP EP91906244A patent/EP0521923B1/de not_active Expired - Lifetime
- 1991-03-13 BR BR919106158A patent/BR9106158A/pt not_active Application Discontinuation
- 1991-03-13 WO PCT/CA1991/000077 patent/WO1991013900A1/en not_active Ceased
1994
- 1994-09-27 US US08/313,579 patent/US5610292A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE69108014D1 (de)	1995-04-13
EP0521923A1 (de)	1993-01-13
US5610292A (en)	1997-03-11
EP0521923B1 (de)	1995-03-08
DE69108014T2 (de)	1995-07-06
HU9202906D0 (en)	1992-11-30
HUT61566A (en)	1993-01-28
WO1991013900A1 (en)	1991-09-19
BR9106158A (pt)	1993-03-16
AU7473791A (en)	1991-10-10

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Legal Events

Date	Code	Title	Description
1995-09-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties