ATE119903T1 - Interphenylen-7-oxabicycloheptyl substituierte heterocyclische amid-prostaglandin-analoge, geeignet bei der behandlung von thrombotischen und vasopastischen leiden. - Google Patents

Interphenylen-7-oxabicycloheptyl substituierte heterocyclische amid-prostaglandin-analoge, geeignet bei der behandlung von thrombotischen und vasopastischen leiden.

Info

Publication number: ATE119903T1
Authority: AT; Austria
Prior art keywords: aralkyl; aryl; interphenylene; thrombotic; lower alkyl
Prior art date: 1989-04-03

Application number

AT90303537T

Other languages

English (en)

Inventor

Raj Narain Misra

Original Assignee

Squibb & Sons Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-04-03

Filing date

1990-04-02

Publication date

1995-04-15

1990-04-02 Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc

1995-04-15 Application granted granted Critical

1995-04-15 Publication of ATE119903T1 publication Critical patent/ATE119903T1/de

Links

230000001732 thrombotic effect Effects 0.000 title abstract 2
150000001408 amides Chemical class 0.000 title 1
229940006138 antiglaucoma drug and miotics prostaglandin analogues Drugs 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 6
125000003710 aryl alkyl group Chemical group 0.000 abstract 4
125000003118 aryl group Chemical group 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 3
-1 5-tetrazolyl Chemical group 0.000 abstract 2
125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 2
125000000753 cycloalkyl group Chemical group 0.000 abstract 2
DYWAPFDKPAHSED-UHFFFAOYSA-N 2-cycloheptyloxepane Chemical group C1CCCCCC1C1OCCCCC1 DYWAPFDKPAHSED-UHFFFAOYSA-N 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
125000003368 amide group Chemical group 0.000 abstract 1
125000003435 aroyl group Chemical group 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
125000005343 heterocyclic alkyl group Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 1
239000002184 metal Substances 0.000 abstract 1
150000003180 prostaglandins Chemical class 0.000 abstract 1
230000002455 vasospastic effect Effects 0.000 abstract 1
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 1
229920002554 vinyl polymer Polymers 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
- C07C17/16—Preparation of halogenated hydrocarbons by replacement by halogens of hydroxyl groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
- C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Diabetes (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT90303537T 1989-04-03 1990-04-02 Interphenylen-7-oxabicycloheptyl substituierte heterocyclische amid-prostaglandin-analoge, geeignet bei der behandlung von thrombotischen und vasopastischen leiden. ATE119903T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US33407089A	1989-04-03	1989-04-03

Publications (1)

Publication Number	Publication Date
ATE119903T1 true ATE119903T1 (de)	1995-04-15

Family

ID=23305449

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90303537T ATE119903T1 (de)	1989-04-03	1990-04-02	Interphenylen-7-oxabicycloheptyl substituierte heterocyclische amid-prostaglandin-analoge, geeignet bei der behandlung von thrombotischen und vasopastischen leiden.

Country Status (28)

Country	Link
EP (1)	EP0391652B1 (de)
JP (1)	JP2989213B2 (de)
KR (1)	KR0160508B1 (de)
CN (1)	CN1028529C (de)
AT (1)	ATE119903T1 (de)
AU (1)	AU632797B2 (de)
CA (1)	CA2012267C (de)
CY (1)	CY1851A (de)
CZ (1)	CZ285656B6 (de)
DD (1)	DD293353A5 (de)
DE (1)	DE69017735T2 (de)
DK (1)	DK0391652T3 (de)
EG (1)	EG19080A (de)
ES (1)	ES2069682T3 (de)
FI (1)	FI97543C (de)
HK (1)	HK110495A (de)
HU (2)	HUT54368A (de)
IE (1)	IE67274B1 (de)
IL (1)	IL93771A (de)
MX (1)	MX20132A (de)
MY (1)	MY106245A (de)
NO (1)	NO177425C (de)
NZ (1)	NZ232897A (de)
PL (1)	PL164345B1 (de)
PT (1)	PT93641B (de)
RU (1)	RU2059618C1 (de)
SK (1)	SK158290A3 (de)
ZA (1)	ZA902559B (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ233600A (en) *	1989-06-12	1992-10-28	Squibb & Sons Inc	7-oxabicyclo(2.2.1)heptane imidazole prostaglandin analogs and pharmaceutical compositions
US4977174A (en) *	1989-06-12	1990-12-11	E. R. Squibb & Sons, Inc.	7-oxabicycloheptane imidazole prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease
ZA911453B (en) *	1990-03-19	1991-11-27	Squibb & Sons Inc	Method of protecting against and/or treating ulcerative gastrointestinal conditions using a thromoboxane,a2 receptor antagonist and combination useful in preventing and/or treating ulcers and/or inflammation
US5290799A (en) *	1990-09-19	1994-03-01	E. R. Squibb & Sons, Inc.	7-oxabicycloheptyl substituted heterocyclic thioamide prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease
US5550248A (en) *	1990-11-29	1996-08-27	E.R. Squibb & Sons, Inc.	Substituted stryl heterocyclic amido prostaglandin analogs
US5135939A (en) *	1991-01-28	1992-08-04	E. R. Squibb & Sons, Inc.	Heterocyclic ketone prostaglandin analogs
US5238951A (en) *	1991-02-01	1993-08-24	E. R. Squibb & Sons, Inc.	Heterocyclic amido prostaglandin analogs
IE920039A1 (en) *	1991-02-01	1992-08-12	Squibb & Sons Inc	Heterocyclic amido prostaglandin analogs
US5158967A (en) *	1991-06-12	1992-10-27	E. R. Squibb & Sons, Inc.	7-oxabicycloheptyl substituted heterocyclic amide prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease
US5162352A (en) *	1991-08-22	1992-11-10	E. R. Squibb & Sons, Inc.	7-oxabicycloheptyl substituted heterocyclic amide prostaglandin analogs
CA2081679A1 (en) *	1991-11-27	1993-05-28	Raj N. Misra	Gem-dialkyl-7-oxabicycloheptyl substituted heterocyclic amide prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease
US5281716A (en) *	1992-06-18	1994-01-25	Bristol-Myers Squibb Company	Method for preparing 7-oxabicycloheptyl substituted oxazole amide prostaglandin analog intermediates useful in the preparation of anti-thrombotic and anti-vasospastic compounds
US5399725A (en) *	1993-05-27	1995-03-21	Bristol-Myers Squibb Co.	7-oxabicycloheptane carboxylic acid prostaglandin analog intermediates useful in the preparation of anti-thrombotic and anti-vasospastic compounds and method for preparing same
US5539126A (en) *	1994-04-20	1996-07-23	Bristol-Myers Squibb Company	Method for preparing homochiral maleimide intermediates, via silylation techniques
US5849766A (en) *	1996-05-31	1998-12-15	Eli Lilly And Company	Carbamoyl substituted heterocycles
US5849922A (en) *	1996-05-31	1998-12-15	Eli Lilly And Company	Preparation of substituted alkenoic acids
US5856584A (en) *	1997-08-06	1999-01-05	The Nutrasweet Company	Preparation of 3,3-dimethylbutyraldehyde by oxidation of 3, 3-dimethylbutanol
US5905175A (en) *	1998-05-20	1999-05-18	The Nutrasweet Company	Synthesis and purification of 3,3-dimethylbutyraldehyde via oxidation of 1-chloro-3,3-dimethylbutane with dimethyl sulfoxide
US6511999B2 (en)	2000-09-14	2003-01-28	Allergan, Inc.	Interheteroaryl 7-oxabicyclic [2.2.1]heptane oxazoles as prostaglandin F2α antagonists
US6369089B1 (en)	2000-09-14	2002-04-09	Allergan Sales, Inc.	Interheteroaryl 7-oxabicyclic [2.2.1]heptane oxazoles as prostaglandin F2α antagonists
US6407250B1 (en)	2000-09-14	2002-06-18	Allergan Sales, Inc.	Interphenylene 7-oxabicyclic [2.2.1] heptane oxazoles as prostaglandin F2a antagonists
FR2838437B1 (fr) *	2002-04-11	2004-06-04	Aventis Pharma Sa	Procedes de preparation de combretastatines
US7045634B2 (en)	2003-09-05	2006-05-16	Allergan, Inc.	Prostamide receptor antagonists
WO2010114997A1 (en)	2009-04-02	2010-10-07	Allergan, Inc.	Prostaglandin e receptor antagonists
AU2012258780A1 (en) *	2011-05-25	2013-12-19	Allergan, Inc.	Fatty acid amide hydrolase inhibitors for treating pain

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4652576A (en) *	1985-10-18	1987-03-24	E. R. Squibb & Sons, Inc.	7-oxabicycloheptane substituted amide-carbamate prostaglandin analogs
US4663337A (en) *	1986-04-18	1987-05-05	E. R. Squibb & Sons, Inc.	7-oxabicycloheptane substituted amides useful in the treatment of thrombotic disease
NZ231962A (en) *	1988-12-23	1992-10-28	Squibb & Sons Inc	7-oxabicycloheptane derivatives as prostaglandin analogs; medicaments
NZ233600A (en) *	1989-06-12	1992-10-28	Squibb & Sons Inc	7-oxabicyclo(2.2.1)heptane imidazole prostaglandin analogs and pharmaceutical compositions

1990
- 1990-03-13 NZ NZ232897A patent/NZ232897A/xx unknown
- 1990-03-15 CA CA002012267A patent/CA2012267C/en not_active Expired - Lifetime
- 1990-03-16 IL IL9377190A patent/IL93771A/en not_active IP Right Cessation
- 1990-03-19 MY MYPI90000427A patent/MY106245A/en unknown
- 1990-03-21 AU AU52064/90A patent/AU632797B2/en not_active Ceased
- 1990-03-26 IE IE109590A patent/IE67274B1/en not_active IP Right Cessation
- 1990-03-30 CZ CS901582A patent/CZ285656B6/cs not_active IP Right Cessation
- 1990-03-30 MX MX2013290A patent/MX20132A/es unknown
- 1990-03-30 SK SK1582-90A patent/SK158290A3/sk unknown
- 1990-04-02 KR KR1019900004487A patent/KR0160508B1/ko not_active Expired - Fee Related
- 1990-04-02 DE DE69017735T patent/DE69017735T2/de not_active Expired - Fee Related
- 1990-04-02 NO NO901494A patent/NO177425C/no unknown
- 1990-04-02 EP EP90303537A patent/EP0391652B1/de not_active Expired - Lifetime
- 1990-04-02 PT PT93641A patent/PT93641B/pt not_active IP Right Cessation
- 1990-04-02 ES ES90303537T patent/ES2069682T3/es not_active Expired - Lifetime
- 1990-04-02 HU HU902048A patent/HUT54368A/hu unknown
- 1990-04-02 FI FI901645A patent/FI97543C/fi not_active IP Right Cessation
- 1990-04-02 DK DK90303537.6T patent/DK0391652T3/da active
- 1990-04-02 AT AT90303537T patent/ATE119903T1/de not_active IP Right Cessation
- 1990-04-03 EG EG20890A patent/EG19080A/xx active
- 1990-04-03 DD DD90339392A patent/DD293353A5/de not_active IP Right Cessation
- 1990-04-03 PL PL90284600A patent/PL164345B1/pl unknown
- 1990-04-03 CN CN90101837A patent/CN1028529C/zh not_active Expired - Lifetime
- 1990-04-03 ZA ZA902559A patent/ZA902559B/xx unknown
- 1990-04-03 JP JP2090070A patent/JP2989213B2/ja not_active Expired - Fee Related
1992
- 1992-01-14 RU SU925010525A patent/RU2059618C1/ru not_active IP Right Cessation
1994
- 1994-12-15 HU HU94P/P00057P patent/HU210713A9/hu unknown
1995
- 1995-07-06 HK HK110495A patent/HK110495A/en not_active IP Right Cessation
1996
- 1996-03-08 CY CY185196A patent/CY1851A/xx unknown

Also Published As

Publication number	Publication date
CA2012267C (en)	2001-02-27
EP0391652A1 (de)	1990-10-10
IE67274B1 (en)	1996-03-20
DE69017735D1 (de)	1995-04-20
IE901095L (en)	1990-10-03
SK278865B6 (sk)	1998-04-08
IL93771A0 (en)	1990-12-23
EG19080A (en)	1994-07-30
CZ285656B6 (cs)	1999-10-13
HK110495A (en)	1995-07-14
NO177425C (no)	1995-09-20
CZ158290A3 (cs)	1999-06-16
PL284600A1 (en)	1991-01-14
HU9002048D0 (en)	1990-08-28
MX20132A (es)	1994-01-31
DE69017735T2 (de)	1995-08-17
HUT54368A (en)	1991-02-28
JP2989213B2 (ja)	1999-12-13
RU2059618C1 (ru)	1996-05-10
JPH02289579A (ja)	1990-11-29
DK0391652T3 (da)	1995-04-03
MY106245A (en)	1995-04-29
KR0160508B1 (ko)	1998-12-01
PL164345B1 (pl)	1994-07-29
IL93771A (en)	1995-06-29
EP0391652B1 (de)	1995-03-15
NO901494L (no)	1990-10-04
FI97543B (fi)	1996-09-30
CN1028529C (zh)	1995-05-24
NO177425B (no)	1995-06-06
FI901645A0 (fi)	1990-04-02
HU210713A9 (en)	1995-06-28
NO901494D0 (no)	1990-04-02
SK158290A3 (en)	1998-04-08
ES2069682T3 (es)	1995-05-16
ZA902559B (en)	1991-01-30
FI97543C (fi)	1997-01-10
KR900016197A (ko)	1990-11-12
AU5206490A (en)	1990-10-04
CA2012267A1 (en)	1990-10-03
PT93641A (pt)	1990-11-20
CY1851A (en)	1996-03-08
DD293353A5 (de)	1991-08-29
AU632797B2 (en)	1993-01-14
CN1046163A (zh)	1990-10-17
NZ232897A (en)	1992-12-23
PT93641B (pt)	1996-06-28

Legal Events

Date	Code	Title	Description
1995-08-15	UEP	Publication of translation of european patent specification
2009-01-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
AU632797B2 (en)	1993-01-14	Interphenylene 7-oxabicycloheptyl substituted heterocyclic amide prostaglandin analogs useful in the treatment of thrombotic and vasopastic disease
ATE135363T1 (de)	1996-03-15	Nucleoside zur verwendung für die therapie
DE69329887D1 (de)	2001-03-01	Thienobenzodiazepinderivate zur Behandlung von Störungen des Zentralnervensystems
DE68912459D1 (de)	1994-03-03	Verwendung von Thromboxan-A2-Rezeptorantagonisten zur Herstellung einer pharmazeutischen Zusammensetzung zur Behandlung von Hautkrankheiten.
ATE65402T1 (de)	1991-08-15	Ifosfamid-mesna-lyophilisat und verfahren zu dessen herstellung.
ES2141787T3 (es)	2000-04-01	Derivados de la 1,2,3,4-tetrahidro-9-acridinamina.
ATE142496T1 (de)	1996-09-15	Verwendung von n-butyl-deoxynojirimycin zur behandlung von herpes
DE59008170D1 (de)	1995-02-16	Verfahren zur Herstellung mikronisierter bioabbaubarer Partikel.
CA2097317A1 (en)	1992-06-15	Antiallergic piperdinyl benzimidazoles
DE69110713D1 (de)	1995-08-03	7-Oxabicycloheptan-imidazol-prostaglandin-Analoge, verwendbar bei der Behandlung von thrombotischen und vasospastischen Erkrankungen.
ATE83480T1 (de)	1993-01-15	Cyclisches peptid, seine herstellung und seine verwendung zur behandlung von cardiovasculaeren stoerungen.
ATE145911T1 (de)	1996-12-15	Inositol-phosphat-analog als kalzium- antagonistische substanz
IT1223395B (it)	1990-09-19	Composti ad attivita' cardiovascolare
DE59010504D1 (de)	1996-10-24	Typisierung humaner Rhinoviren
HUT56559A (en)	1991-09-30	Process for producing ascorbinic acid derivatives and pharma
DE69327077D1 (de)	1999-12-30	Carbamoylpyrrolidon-Derivate zur Behandlung von Depressionen und cerebrovasculären Störungen
DE3887426D1 (de)	1994-03-10	Eperisone als Hypotonikum.
ATE112284T1 (de)	1994-10-15	Exo-3'-4'-o-benzyliden-3''-demethylchartreusin und seine salze.
ATE100311T1 (de)	1994-02-15	Verwendung von retinoiden.
DE69026991D1 (de)	1996-06-20	Phospholipide zur Behandlung der multiplen Sklerose
DE69127367D1 (de)	1997-09-25	Aluminium-Kalium-Sulfat enthaltende Creme und Verfahren zur Herstellung