ATE119938T1 - Produktion von menschlichen nervenwachstumsfaktoren. - Google Patents
Produktion von menschlichen nervenwachstumsfaktoren.Info
- Publication number
- ATE119938T1 ATE119938T1 AT90115815T AT90115815T ATE119938T1 AT E119938 T1 ATE119938 T1 AT E119938T1 AT 90115815 T AT90115815 T AT 90115815T AT 90115815 T AT90115815 T AT 90115815T AT E119938 T1 ATE119938 T1 AT E119938T1
- Authority
- AT
- Austria
- Prior art keywords
- cysteine residue
- human ngf
- animal cell
- production
- growth factors
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 108010025020 Nerve Growth Factor Proteins 0.000 title 1
- 102000007072 Nerve Growth Factors Human genes 0.000 title 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 abstract 7
- 101001111439 Homo sapiens Beta-nerve growth factor Proteins 0.000 abstract 5
- 102000046917 human NGF Human genes 0.000 abstract 5
- 210000004102 animal cell Anatomy 0.000 abstract 4
- 241000699802 Cricetulus griseus Species 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 229940126585 therapeutic drug Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/48—Nerve growth factor [NGF]
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP21298089 | 1989-08-21 | ||
| JP32819889 | 1989-12-20 | ||
| JP9625290 | 1990-04-13 | ||
| JP14739290 | 1990-06-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE119938T1 true ATE119938T1 (de) | 1995-04-15 |
Family
ID=27468414
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90115815T ATE119938T1 (de) | 1989-08-21 | 1990-08-17 | Produktion von menschlichen nervenwachstumsfaktoren. |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0414151B1 (de) |
| AT (1) | ATE119938T1 (de) |
| CA (1) | CA2023654A1 (de) |
| DE (1) | DE69017793T2 (de) |
| DK (1) | DK0414151T3 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5180820A (en) * | 1989-08-30 | 1993-01-19 | Barde Yves Alain | Brain-derived neurotrophic factor |
| US5389529A (en) * | 1991-06-12 | 1995-02-14 | Regeneron Pharmaceuticals, Inc. | Modified lamβ signal sequence and processes for producing recombinant neurotrophins |
| DE4139000A1 (de) * | 1991-11-27 | 1993-06-03 | Boehringer Mannheim Gmbh | Verfahren zur gentechnologischen herstellung von biologisch aktivem ss-ngf |
| US6291247B1 (en) | 1994-05-11 | 2001-09-18 | Queen's University At Kingston | Methods of screening for factors that disrupt neurotrophin conformation and reduce neurotrophin biological activity |
| AU729459B2 (en) | 1996-11-15 | 2001-02-01 | Genentech Inc. | Purification of neurotrophins |
| EP2586788B1 (de) | 2007-07-09 | 2017-11-29 | Genentech, Inc. | Verhindern der Disulfid-Bindungsreduktion während der rekombinanten Herstellung von Polypeptiden |
| JP2024527197A (ja) * | 2021-07-30 | 2024-07-23 | チェンドゥ ユノヴェル バイオファーマ カンパニー リミテッド． | 組換えｃｈｏ細胞、その構築方法、並びにそれを用いた検出システム及び方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK161152C (da) * | 1983-03-03 | 1991-11-11 | Genentech Inc | Polypeptid med egenskaber som human beta-nervevaekstfaktor og fremgangsmaade til fremstilling deraf, dna-isolat omfattende en sekvens som koder for polypeptidet, replicerbar udtrykkelsesvektor for dna-sekvensen, rekombinant vaertscelle transformeret med vektoren, farmaceutisk praeparat indeholdende polypeptidet og fremg. der omfatter anvendelsen af polypeptidet til fremst. af et farmaceutisk praeparat |
-
1990
- 1990-08-17 DK DK90115815.4T patent/DK0414151T3/da active
- 1990-08-17 EP EP90115815A patent/EP0414151B1/de not_active Expired - Lifetime
- 1990-08-17 AT AT90115815T patent/ATE119938T1/de not_active IP Right Cessation
- 1990-08-17 DE DE69017793T patent/DE69017793T2/de not_active Expired - Fee Related
- 1990-08-20 CA CA002023654A patent/CA2023654A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE69017793D1 (de) | 1995-04-20 |
| EP0414151B1 (de) | 1995-03-15 |
| DK0414151T3 (da) | 1995-05-22 |
| DE69017793T2 (de) | 1995-08-24 |
| CA2023654A1 (en) | 1991-02-22 |
| EP0414151A1 (de) | 1991-02-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties | ||
| EEWE | Authorization for restitution | ||
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |