ATE120190T1 - 5-fluor-2,4,6-pyrimidinthiaminderivate zur verhinderung des haarsausfalls. - Google Patents

5-fluor-2,4,6-pyrimidinthiaminderivate zur verhinderung des haarsausfalls.

Info

Publication number: ATE120190T1
Authority: AT; Austria
Prior art keywords: pyrimidinthiamine; fluorine; derivatives; minoxidil; hair loss
Prior art date: 1990-11-14

Application number

AT91917952T

Other languages

English (en)

Inventor

Heinrich Josef Schostarez

Original Assignee

Upjohn Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-11-14

Filing date

1991-09-20

Publication date

1995-04-15

1991-09-20 Application filed by Upjohn Co filed Critical Upjohn Co

1995-04-15 Application granted granted Critical

1995-04-15 Publication of ATE120190T1 publication Critical patent/ATE120190T1/de

Links

201000004384 Alopecia Diseases 0.000 title 1
208000024963 hair loss Diseases 0.000 title 1
230000003676 hair loss Effects 0.000 title 1
229960003632 minoxidil Drugs 0.000 abstract 3
ZFMITUMMTDLWHR-UHFFFAOYSA-N Minoxidil Chemical compound NC1=[N+]([O-])C(N)=CC(N2CCCCC2)=N1 ZFMITUMMTDLWHR-UHFFFAOYSA-N 0.000 abstract 2
208000024172 Cardiovascular disease Diseases 0.000 abstract 1
230000003247 decreasing effect Effects 0.000 abstract 1
230000003779 hair growth Effects 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/50—Three nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Dermatology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Birds (AREA)
Epidemiology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Cosmetics (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Developing Agents For Electrophotography (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)

AT91917952T 1990-11-14 1991-09-20 5-fluor-2,4,6-pyrimidinthiaminderivate zur verhinderung des haarsausfalls. ATE120190T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US61269590A	1990-11-14	1990-11-14

Publications (1)

Publication Number	Publication Date
ATE120190T1 true ATE120190T1 (de)	1995-04-15

Family

ID=24454264

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91917952T ATE120190T1 (de)	1990-11-14	1991-09-20	5-fluor-2,4,6-pyrimidinthiaminderivate zur verhinderung des haarsausfalls.

Country Status (10)

Country	Link
US (1)	US5373012A (de)
EP (1)	EP0557301B1 (de)
JP (1)	JPH06501947A (de)
AT (1)	ATE120190T1 (de)
AU (1)	AU651630B2 (de)
CA (1)	CA2092811A1 (de)
DE (1)	DE69108402T2 (de)
DK (1)	DK0557301T3 (de)
ES (1)	ES2070513T3 (de)
WO (1)	WO1992008705A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7914814B2 (en)	1997-09-17	2011-03-29	Strategic Science & Technologies, Llc	Topical delivery of arginine of cause beneficial effects
US7629384B2 (en)	1997-09-17	2009-12-08	Strategic Science & Technologies, Llc	Topical delivery of L-arginine to cause beneficial effects
EP1737429B1 (de)	2004-04-19	2013-07-17	Strategic Science & Technologies, LLC	Transdermale abgabe von vorteilhaften substanzen, beeinflusst von einer umgebung mit hoher ionenstärke
US9226909B2 (en)	2004-04-19	2016-01-05	Strategic Science & Technologies, Llc	Beneficial effects of increasing local blood flow
US11684624B2 (en)	2009-06-24	2023-06-27	Strategic Science & Technologies, Llc	Treatment of erectile dysfunction and other indications
EP2445493A1 (de)	2009-06-24	2012-05-02	Strategic Science & Technologies, LLC	Topische zusammensetzung mit naproxen
US12138268B2 (en)	2009-06-24	2024-11-12	Strategic Science & Technologies, Llc	Treatment of erectile dysfunction and other indications
CN102481275B (zh)	2009-06-24	2014-07-23	战略科学技术有限公司	含有布洛芬的表面组合物
US9463158B2 (en)	2009-06-24	2016-10-11	Strategic Science & Technologies, Llc	Treatment of erectile dysfunction and other indications
US9289495B2 (en)	2010-12-29	2016-03-22	Strategic Science & Technologies, Llc	Systems and methods for treatment of allergies and other indications
CZ305457B6 (cs)	2011-02-28	2015-09-30	Ústav organické chemie a biochemie, Akademie věd ČR v. v. i.	Pyrimidinové sloučeniny inhibující tvorbu oxidu dusnatého a prostaglandinu E2, způsob výroby a použití
HU230149B1 (hu) *	2012-11-21	2015-09-28	Richter Gedeon Nyrt.	Új eljárás triklór-pirimidin-amin származékok előállítására
ES2952159T3 (es) *	2014-10-29	2023-10-27	Samson Clinical Pty Ltd	Minoxidil oral para el tratamiento de alopecia areata
CN109485608B (zh) *	2018-12-24	2020-09-22	大连大学	一种4,6-二氯-5-氟-2-氨基嘧啶工业化生产方法
WO2024262969A1 (ko) *	2023-06-20	2024-12-26	주식회사 아이코어바이오	탈모 치료 성분이 고정화된 신규한 구조를 가지는 화합물 및 이의 제조 방법

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3382247A (en) *	1965-11-01	1968-05-07	Upjohn Co	6-amino-1, 2-dihydro-1-hydroxy-2-imino-4-phenoxypyrimidines
US3464987A (en) *	1966-02-21	1969-09-02	Upjohn Co	1,2-dihydro-1-hydroxy-2-imino-6-(lower alkyl)pyrimidines
US3644364A (en) *	1970-03-31	1972-02-22	Upjohn Co	Compounds and process
US4596812A (en) *	1976-05-24	1986-06-24	The Upjohn Company	Methods and solutions for treating male pattern alopecia
US4139619A (en) *	1976-05-24	1979-02-13	The Upjohn Company	6-Amino-4-(substituted amino)-1,2-dihydro-1-hydroxy-2-iminopyrimidine, topical compositions and process for hair growth
US4287338A (en) *	1980-03-10	1981-09-01	The Upjohn Company	Sulfooxy-pyrimidinium, -pyridinium, and -triazinium hydroxide inner salts
LU86695A1 (fr) *	1986-12-01	1988-07-14	Oreal	Nouveaux derives de piperazinyl-1 pyrimidine,leur preparation et leur application en therapeutique et cosmetique
BG94957A (bg) *	1990-08-10	1993-12-24	Ciba - Geigy Ag	Пиримидинови производни и средство за борба срещу вредители по растенията

1991
- 1991-09-20 AU AU87206/91A patent/AU651630B2/en not_active Ceased
- 1991-09-20 CA CA002092811A patent/CA2092811A1/en not_active Abandoned
- 1991-09-20 DK DK91917952.3T patent/DK0557301T3/da active
- 1991-09-20 AT AT91917952T patent/ATE120190T1/de active
- 1991-09-20 WO PCT/US1991/006728 patent/WO1992008705A1/en not_active Ceased
- 1991-09-20 JP JP3516732A patent/JPH06501947A/ja active Pending
- 1991-09-20 DE DE69108402T patent/DE69108402T2/de not_active Expired - Fee Related
- 1991-09-20 EP EP91917952A patent/EP0557301B1/de not_active Expired - Lifetime
- 1991-09-20 ES ES91917952T patent/ES2070513T3/es not_active Expired - Lifetime
1993
- 1993-05-10 US US08/059,552 patent/US5373012A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AU8720691A (en)	1992-06-11
AU651630B2 (en)	1994-07-28
US5373012A (en)	1994-12-13
DK0557301T3 (da)	1995-07-24
DE69108402D1 (de)	1995-04-27
EP0557301A1 (de)	1993-09-01
JPH06501947A (ja)	1994-03-03
WO1992008705A1 (en)	1992-05-29
ES2070513T3 (es)	1995-06-01
DE69108402T2 (de)	1995-10-05
EP0557301B1 (de)	1995-03-22
CA2092811A1 (en)	1992-05-15

Publication	Publication Date	Title
ATE120190T1 (de)	1995-04-15	5-fluor-2,4,6-pyrimidinthiaminderivate zur verhinderung des haarsausfalls.
BG103003A (en)	1999-09-30	Substituted 3,5-diphenyl-1,2,4-triazoles and their use as pharmaceutical chelateforming means with a metal
MY121294A (en)	2006-01-28	Novel hexanoic acid derivatives.
BG104812A (en)	2001-06-29	New dihydropyrimidines
NO20075065L (no)	1999-02-25	Anvendelse av isoflavonforbindelser til a behandle hjertesykdom
TR200000059T2 (tr)	2000-06-21	Piridin türevleri
CA2245142A1 (en)	1997-08-07	New phenanthridines
ATE250576T1 (de)	2003-10-15	Substituierte pyrrolylverbindungen zur behandlung von entzündungen
ZA988158B (en)	1999-03-08	Sulfinic acid derivatives and their preparation and use
HRP930239A2 (en)	1996-06-30	Anti-inflamatory 4-aminophenol derivatives
ZA914889B (en)	1993-02-24	Method of treating alopecia
CY2431B1 (en)	2004-11-12	Novel phenanthridines substituted in the 6 position.
RU92016277A (ru)	1995-10-27	Микробиоциды
DK1077941T3 (da)	2009-12-07	Forbindelser med væksthormonfrigörende egenskaber
UA32588C2 (uk)	2001-02-15	Склад для інгібування нітрифікації аміачного азоту
MX9700470A (es)	1998-05-31	Uso de triacetato de glicerilo para tratar onicomicosis.
ATE242220T1 (de)	2003-06-15	Benzimidazolderivate mit dopaminerger wirkung
IL126235A (en)	2003-02-12	Compounds with growth hormone releasing properties, pharmaceutical compositions comprising them and their use
MD502G2 (ro)	1996-11-30	Derivaţi noi ai adenozinei, procedee de preparare a lor, compoziţii farmaceutice ce le conţin
HUT66153A (en)	1994-09-28	Pharmaceutical compositions which can be used for preventing and treating of chemotherapy-induced alopecia
ES2157961T3 (es)	2001-09-01	Inhibicion del hirsutismo y la alopecia en mujeres.
DK0703916T3 (da)	2002-12-02	14-Substituerede marcfortiner og derivater, der kan anvendes som antispirant-midler
DK100785A (da)	1985-09-08	Midler til stimulering af haarvaekst
ES2179848T3 (es)	2003-02-01	Composicion dermocosmetica antifungica.
TW225993B (en)	1994-07-01	A composition prevention hair loss and promoting hair growth and its usage