ATE120191T1 - Makrocyclische chelatisierungsmittel und daraus hergestellte chelate. - Google Patents

Makrocyclische chelatisierungsmittel und daraus hergestellte chelate.

Info

Publication number: ATE120191T1
Authority: AT; Austria
Prior art keywords: group; alkyl; alkoxyhydroxyalkyl; alkoxyalkyl; hydroxyalkyl
Prior art date: 1987-12-24

Application number

AT88121087T

Other languages

English (en)

Inventor

Ernst Felder

Carlo Musu

Luciano Fumagalli

Fulvio Uggeri

Original Assignee

Bracco Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-12-24

Filing date

1988-12-16

Publication date

1995-04-15

1988-12-16 Application filed by Bracco Spa filed Critical Bracco Spa

1995-04-15 Application granted granted Critical

1995-04-15 Publication of ATE120191T1 publication Critical patent/ATE120191T1/de

Links

239000002738 chelating agent Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 6
125000004183 alkoxy alkyl group Chemical group 0.000 abstract 4
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 4
QBPPRVHXOZRESW-UHFFFAOYSA-N 1,4,7,10-tetraazacyclododecane Chemical class C1CNCCNCCNCCN1 QBPPRVHXOZRESW-UHFFFAOYSA-N 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
239000000032 diagnostic agent Substances 0.000 abstract 1
229940039227 diagnostic agent Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Epidemiology (AREA)
Radiology & Medical Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Cosmetics (AREA)
Detergent Compositions (AREA)
Investigating Or Analysing Biological Materials (AREA)

AT88121087T 1987-12-24 1988-12-16 Makrocyclische chelatisierungsmittel und daraus hergestellte chelate. ATE120191T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT23217/87A IT1224416B (it)	1987-12-24	1987-12-24	Chelanti macrociclici e loro chelati

Publications (1)

Publication Number	Publication Date
ATE120191T1 true ATE120191T1 (de)	1995-04-15

Family

ID=11204998

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88121087T ATE120191T1 (de)	1987-12-24	1988-12-16	Makrocyclische chelatisierungsmittel und daraus hergestellte chelate.

Country Status (14)

Country	Link
EP (2)	EP0440606A1 (de)
JP (1)	JP2744920B2 (de)
KR (1)	KR900700467A (de)
AT (1)	ATE120191T1 (de)
DE (1)	DE3853415T2 (de)
ES (1)	ES2070845T3 (de)
IE (1)	IE67551B1 (de)
IL (1)	IL88762A (de)
IT (1)	IT1224416B (de)
MX (1)	MX9203262A (de)
NZ (1)	NZ227421A (de)
PH (1)	PH26255A (de)
WO (1)	WO1989005802A1 (de)
ZA (1)	ZA889597B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2833766B2 (ja) *	1987-07-16	1998-12-09	ニユコメド・アクシエセルカペト	アミノポリカルボン酸およびその誘導体
DE4001655A1 (de)	1990-01-18	1991-07-25	Schering Ag	6-ring enthaltende makrocyclische tetraaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
US6039931A (en) *	1989-06-30	2000-03-21	Schering Aktiengesellschaft	Derivatized DTPA complexes, pharmaceutical agents containing these compounds, their use, and processes for their production
US5695739A (en) *	1989-06-30	1997-12-09	Schering Aktiengesellschaft	Derivatized DTPA complexes, pharmaceutical agents containing these compounds, their use, and processes for their production
DE4009119A1 (de) *	1990-03-19	1991-09-26	Schering Ag	1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
US5162109A (en) *	1990-09-13	1992-11-10	Mallinckrodt Medical, Inc.	Magnetic resonance imaging agents
DE4035760A1 (de) *	1990-11-08	1992-05-14	Schering Ag	Mono-n-substituierte 1,4,7,10-tetraazacyclododecan-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
US6875864B2 (en)	1991-08-01	2005-04-05	Bracco International B.V.	Aminocarboxylate ligands having substituted aromatic amide moieties
AU663572B2 (en) *	1992-03-27	1995-10-12	Nihon Medi-Physics Co., Ltd.	Tetraazacyclododecane derivative and its use
US5310535A (en) *	1992-04-24	1994-05-10	The Dow Chemical Company	Carboxamide modified polyamine chelators and radioactive complexes thereof for conjugation to antibodies
EP0588229A3 (en) *	1992-09-12	1994-06-15	Hoechst Ag	Macrocyclic chelating agents for the preparation of technetium or rhenium complexes
WO1995001346A1 (en) *	1993-06-30	1995-01-12	Akzo Nobel N.V.	Chelating compounds
JP3878208B2 (ja) *	1994-04-08	2007-02-07	ブラッコインターナショナルベスローテンフェンノートシャップ	芳香族アミド化合物およびそれらのキレート
US6693190B1 (en)	1994-05-11	2004-02-17	Bracco International B.V.	Enhanced relaxivity monomeric and multimeric compounds
IT1274038B (it) *	1994-07-29	1997-07-14	Bracco Spa	Chelanti macrociclici loro chelati e relativi usi in campo diagnostico
US5672335A (en) *	1994-11-30	1997-09-30	Schering Aktiengesellschaft	Use of metal complexes as liver and gallbladder X-ray diagnostic agents
DE19507820A1 (de) *	1995-02-21	1996-08-22	Schering Ag	Neuartig substituierte DTPA-Derivate, deren Metallkomplexe, diese Komplexe enthaltende pharmazeutische Mittel, deren Verwendung in der Diagnostik, sowie Verfahren zur Herstellung der Komplexe und Mittel
IT1291624B1 (it) *	1997-04-18	1999-01-11	Bracco Spa	Chelati complessi di metalli paramagnetici a bassa tossicita'
IT1293777B1 (it) *	1997-07-25	1999-03-10	Bracco Spa	Processo per la preparazione di tetraazamacrocicli
IT1293778B1 (it) *	1997-07-25	1999-03-10	Bracco Spa	1,4,7,10-tetraazabiciclo(8.2.2.)tetradecan-2 one, sua preparazione e suo uso per la preparazione di tetraazamacrocicli
DE19744004C1 (de) *	1997-09-26	1999-07-22	Schering Ag	Lipophile Metall-Komplexe für Nekrose und Infarkt-Imaging
US6495118B1 (en)	1997-09-26	2002-12-17	Schering Aktiengesellschaft	Lipophilic metal complexes for necrosis and infarction imaging
IT1297035B1 (it) *	1997-12-30	1999-08-03	Bracco Spa	Derivati dell'acido 1,4,7,10-tetraazaciclododecan-1,4-diacetico
IT1297034B1 (it)	1997-12-30	1999-08-03	Bracco Spa	Acido 1,4,7,10-tetraazaciclododecan-1,4-diacetico

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL194579C (nl) *	1983-01-21	2002-08-05	Schering Ag	Diagnostisch middel.
DE3316703A1 (de) *	1983-05-04	1984-11-08	Schering AG, 1000 Berlin und 4709 Bergkamen	Orales kontrastmittel fuer die kernspintomographie und dessen herstellung
US4639365A (en) *	1984-10-18	1987-01-27	The Board Of Regents, The University Of Texas System	Gadolinium chelates as NMR contrast agents
EP0232751B1 (de) *	1986-01-23	1991-09-11	E.R. Squibb & Sons, Inc.	1-Substituiertes-4,7,10-triscarboxymethyl-1,4,7,10-tetraazacyclododecan und Analoga
FR2596992B1 (fr) *	1986-04-11	1988-12-16	Guerbet Sa	Sel de lysine du complexe gadolinium-dota et ses applications au diagnostic
DE3625417C2 (de) *	1986-07-28	1998-10-08	Schering Ag	Tetraazacyclododecan-Derivate
EP0281474B2 (de) *	1987-02-28	2006-05-24	Sumitomo Electric Industries Limited	Verfahren zur Herstellung eines Oxid-Verbindungssupraleiterfadens
EP0503746B1 (de) *	1987-03-13	1997-05-14	Kabushiki Kaisha Toshiba	Supraleitender Draht und Verfahren zu seiner Herstellung

1987
- 1987-12-24 IT IT23217/87A patent/IT1224416B/it active
1988
- 1988-12-16 ES ES88121087T patent/ES2070845T3/es not_active Expired - Lifetime
- 1988-12-16 EP EP89900817A patent/EP0440606A1/de active Pending
- 1988-12-16 DE DE3853415T patent/DE3853415T2/de not_active Expired - Lifetime
- 1988-12-16 AT AT88121087T patent/ATE120191T1/de not_active IP Right Cessation
- 1988-12-16 EP EP88121087A patent/EP0325762B1/de not_active Expired - Lifetime
- 1988-12-16 WO PCT/EP1988/001166 patent/WO1989005802A1/en not_active Ceased
- 1988-12-16 JP JP1500736A patent/JP2744920B2/ja not_active Expired - Lifetime
- 1988-12-20 NZ NZ227421A patent/NZ227421A/xx unknown
- 1988-12-22 PH PH37968A patent/PH26255A/en unknown
- 1988-12-22 IE IE384488A patent/IE67551B1/en not_active IP Right Cessation
- 1988-12-22 IL IL8876288A patent/IL88762A/en not_active IP Right Cessation
- 1988-12-22 ZA ZA889597A patent/ZA889597B/xx unknown
1989
- 1989-08-25 KR KR1019890701612A patent/KR900700467A/ko not_active Withdrawn
1992
- 1992-06-24 MX MX9203262A patent/MX9203262A/es unknown

Also Published As

Publication number	Publication date
EP0325762B1 (de)	1995-03-22
EP0440606A1 (de)	1991-08-14
JP2744920B2 (ja)	1998-04-28
DE3853415T2 (de)	1995-08-31
KR900700467A (ko)	1990-08-13
ZA889597B (en)	1989-09-27
IT8723217A0 (it)	1987-12-24
IE67551B1 (en)	1996-04-17
IE883844L (en)	1989-06-24
EP0325762A1 (de)	1989-08-02
JPH03501848A (ja)	1991-04-25
NZ227421A (en)	1990-10-26
IL88762A0 (en)	1989-07-31
DE3853415D1 (de)	1995-04-27
PH26255A (en)	1992-04-01
WO1989005802A1 (en)	1989-06-29
IL88762A (en)	1995-07-31
IT1224416B (it)	1990-10-04
MX9203262A (es)	1992-07-01
ES2070845T3 (es)	1995-06-16

Legal Events

Date	Code	Title	Description
1995-09-15	UEP	Publication of translation of european patent specification
1999-09-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE120191T1 (de)	1995-04-15	Makrocyclische chelatisierungsmittel und daraus hergestellte chelate.
ATE275134T1 (de)	2004-09-15	4-oxo-1,4-dihydro-3-chinolincarboxamide als antivirale mittel
TR200002606T2 (tr)	2001-01-22	Benzen-sülfonamit türevleri ve ilaç olarak kullanımları.
DE3867572D1 (de)	1992-02-20	Benzothiazol-derivat und es als aktiven bestandteil enthaltendes antirheumatisches mittel.
NO922145L (no)	1992-12-01	Nedbrytbare chelateringsmidler med sulfonatgrupper, samt anvendelser av og formuleringer med disse
IL97403A0 (en)	1992-06-21	3,5-di-tertiarybutyl-4-hydroxyphenylmethylene derivatives of 2-substituted thiazolidinones,oxazolidinones,and imidazolidinones and pharmaceutical compositions containing them
ATE21894T1 (de)	1986-09-15	Neue 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihrer verwendung in arzneimitteln.
DE69420564D1 (de)	1999-10-14	Immunsuppressive und antiallergische verbindungen; z.b. n-(3-oxohexanoyl)-homoserinlacton
ATE156816T1 (de)	1997-08-15	Multiwirkstoffresistenz-umkehrende mittel
NO932607D0 (no)	1993-07-19	Piperidinderivater og anvendelse av disse
ATE155465T1 (de)	1997-08-15	Phenoxy- oder phenoxyalkyl-piperidine als antivirale mittel
DK0447324T3 (da)	1996-04-29	2,4-pyrimidindionderivater og lægemidler indeholdende disse
ATE67199T1 (de)	1991-09-15	Benzoxazin-derivate und verfahren zu ihrer herstellung.
DK0573318T3 (da)	1999-10-11	4-phenylcarbamoyl-3-isoxazolcarboxylsyreforbindelser, fremgangsmåde til deres fremstilling, farmaceutiske præparater med in
ES2106058T3 (es)	1997-11-01	Derivados de benzamida.
ES2098285T3 (es)	1997-05-01	Derivados de halogenoalquil-azolilo.
ATE119523T1 (de)	1995-03-15	Isochinolinderivate und ihre salze als proteasehemmer.
DE60237652D1 (de)	2010-10-21	Variolinderivate und ihre Verwendung als Cytostatika
DE3851449D1 (de)	1994-10-20	Cephalosporinderivate, Verfahren zu ihrer Herstellung und antibakterielle Mittel.
FI824298A0 (fi)	1982-12-14	N,n-disubstituerade alkenamider och fenylalkenamider, deras framstaellningsfoerfaranden och anvaendning som laekemedel
NO894184D0 (no)	1989-10-20	Alkylestere av 2- 4-(2-piperidino-etoksy)-benzoyl -benzosyre med forgrenet kjede, fremgangsmaater for fremstilling derav og deres anvendelse som spasmolyttiske midler.
ATE1585T1 (de)	1982-10-15	Clavulansaeurederivate, ihre herstellung und sie enthaltende pharmazeutische praeparate.
ECSP951529A (es)	1997-05-16	Compuestos farmaceuticos