ATE120543T1 - Vorrichtung und verfahren zur genauen, schnellen und einfachen durchführung eines prothrombin tests. - Google Patents

Vorrichtung und verfahren zur genauen, schnellen und einfachen durchführung eines prothrombin tests.

Info

Publication number
ATE120543T1
ATE120543T1 AT88903642T AT88903642T ATE120543T1 AT E120543 T1 ATE120543 T1 AT E120543T1 AT 88903642 T AT88903642 T AT 88903642T AT 88903642 T AT88903642 T AT 88903642T AT E120543 T1 ATE120543 T1 AT E120543T1
Authority
AT
Austria
Prior art keywords
quick
accurate
easy performance
prothrombin test
prothrombin
Prior art date
Application number
AT88903642T
Other languages
English (en)
Inventor
Bruce Oberhardt
Original Assignee
Cardiovascular Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cardiovascular Diagnostics Inc filed Critical Cardiovascular Diagnostics Inc
Application granted granted Critical
Publication of ATE120543T1 publication Critical patent/ATE120543T1/de

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/30—Mixers with shaking, oscillating, or vibrating mechanisms comprising a receptacle to only a part of which the shaking, oscillating, or vibrating movement is imparted
    • B01F31/31—Mixers with shaking, oscillating, or vibrating mechanisms comprising a receptacle to only a part of which the shaking, oscillating, or vibrating movement is imparted using receptacles with deformable parts, e.g. membranes, to which a motion is imparted
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5023—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures with a sample being transported to, and subsequently stored in an absorbent for analysis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/50—Mixing liquids with solids
    • B01F23/56—Mixing liquids with solids by introducing solids in liquids, e.g. dispersing or dissolving
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/7172—Feed mechanisms characterised by the means for feeding the components to the mixer using capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/4905—Determining clotting time of blood
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G01N33/525—Multi-layer analytical elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F21/00—Dissolving
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/23—Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0654—Lenses; Optical fibres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/069—Absorbents; Gels to retain a fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0825—Test strips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087—Multiple sequential chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1861—Means for temperature control using radiation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0655—Valves, specific forms thereof with moving parts pinch valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0694—Valves, specific forms thereof vents used to stop and induce flow, backpressure valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N2021/0346—Capillary cells; Microcells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00346—Heating or cooling arrangements
    • G01N2035/00435—Refrigerated reagent storage
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
    • G01N21/51—Scattering, i.e. diffuse reflection within a body or fluid inside a container, e.g. in an ampoule
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/066—Modifiable path; multiple paths in one sample
    • G01N2201/0668—Multiple paths; optimisable path length
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0098—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/805—Test papers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/969—Multiple layering of reactants
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/97—Test strip or test slide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/81—Tube, bottle, or dipstick

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Clinical Laboratory Science (AREA)
  • Immunology (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Ecology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
AT88903642T 1987-04-03 1988-04-01 Vorrichtung und verfahren zur genauen, schnellen und einfachen durchführung eines prothrombin tests. ATE120543T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/033,817 US4849340A (en) 1987-04-03 1987-04-03 Reaction system element and method for performing prothrombin time assay

Publications (1)

Publication Number Publication Date
ATE120543T1 true ATE120543T1 (de) 1995-04-15

Family

ID=21872614

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88903642T ATE120543T1 (de) 1987-04-03 1988-04-01 Vorrichtung und verfahren zur genauen, schnellen und einfachen durchführung eines prothrombin tests.

Country Status (8)

Country Link
US (4) US4849340A (de)
EP (1) EP0308494B1 (de)
JP (1) JP2736091B2 (de)
AT (1) ATE120543T1 (de)
AU (1) AU613623B2 (de)
CA (1) CA1310566C (de)
DE (1) DE3853457T2 (de)
WO (1) WO1988007666A1 (de)

Families Citing this family (380)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5144139A (en) * 1985-08-05 1992-09-01 Biotrack, Inc. Capillary flow device
US5140161A (en) * 1985-08-05 1992-08-18 Biotrack Capillary flow device
US5164598A (en) * 1985-08-05 1992-11-17 Biotrack Capillary flow device
US5204525A (en) * 1985-08-05 1993-04-20 Biotrack Capillary flow device
US4935346A (en) 1986-08-13 1990-06-19 Lifescan, Inc. Minimum procedure system for the determination of analytes
US4918025A (en) * 1987-03-03 1990-04-17 Pb Diagnostic Systems, Inc. Self contained immunoassay element
US4849340A (en) * 1987-04-03 1989-07-18 Cardiovascular Diagnostics, Inc. Reaction system element and method for performing prothrombin time assay
US5110727A (en) * 1987-04-03 1992-05-05 Cardiovascular Diagnostics, Inc. Method for performing coagulation assays accurately, rapidly and simply, using dry chemical reagents and paramagnetic particles
USD501678S1 (en) * 1987-04-03 2005-02-08 Cardiovascular Diagnostics, Inc. Assay card for an assay chamber
US5209904A (en) * 1987-12-23 1993-05-11 Abbott Laboratories Agglutination reaction device utilizing selectively impregnated porous material
US5779976A (en) * 1988-11-03 1998-07-14 Igen International, Inc. Apparatus for improved luminescence assays
US5114350A (en) * 1989-03-08 1992-05-19 Cholestech Corporation Controlled-volume assay apparatus
US4957582A (en) * 1989-03-16 1990-09-18 Eastman Kodak Company Capillary transport zone coated with adhesive
IE940110L (en) * 1989-03-23 1990-09-23 Bunce Roger A Liquid transfer devices
US5039617A (en) * 1989-04-20 1991-08-13 Biotrack, Inc. Capillary flow device and method for measuring activated partial thromboplastin time
EP0397424A3 (de) * 1989-05-08 1991-08-21 Biotrack, Inc. Mehrfachanalysesystem
US5147609A (en) * 1989-05-19 1992-09-15 Pb Diagnostic Systems, Inc. Assay element
IT1230744B (it) * 1989-07-07 1991-10-29 Instrumentation Lab Spa Metodo per la determinazione della attivita' funzionale della proteina s nel plasma umano.
JPH0810193B2 (ja) * 1989-08-21 1996-01-31 富士写真フイルム株式会社 生化学分析方法における点着異常判定方法
US5104812A (en) * 1989-11-27 1992-04-14 Syntex (U.S.A.) Inc. Device and method for interrupting capillary flow
US5622870A (en) * 1989-11-27 1997-04-22 Behringwerke Ag Device and method for completing a fluidic circuit
US5068181A (en) * 1989-12-01 1991-11-26 Akzo N.V. Method of monitoring reagent delivery in a scanning spectrophotometer
US5646046A (en) * 1989-12-01 1997-07-08 Akzo Nobel N.V. Method and instrument for automatically performing analysis relating to thrombosis and hemostasis
US5110724A (en) * 1990-04-02 1992-05-05 Cholestech Corporation Multi-analyte assay device
US4986964A (en) * 1990-04-19 1991-01-22 Center For Innovative Technology Clot retractometer
WO1991018276A1 (en) * 1990-05-22 1991-11-28 Kelly Kenneth A Microassay strip device for immunoassay
TW221493B (de) * 1990-07-10 1994-03-01 Cardiovascular Diagnostics Inc
DE69126142T2 (de) * 1990-09-26 1997-09-11 Akers Lab Inc Verbessertes bestimmungsverfahren für liganden
ZA92803B (en) 1991-02-06 1992-11-25 Igen Inc Method and apparatus for magnetic microparticulate based luminescene asay including plurality of magnets
EP0501796A3 (en) * 1991-03-01 1993-10-06 Biotrack, Inc. Capillary stop-flow junction having improved stability against accidental fluid flow
US5207984A (en) * 1991-03-11 1993-05-04 Miles Inc. Blood sample collection and test device
US5998220A (en) 1991-05-29 1999-12-07 Beckman Coulter, Inc. Opposable-element assay devices, kits, and methods employing them
US6168956B1 (en) 1991-05-29 2001-01-02 Beckman Coulter, Inc. Multiple component chromatographic assay device
US5877028A (en) 1991-05-29 1999-03-02 Smithkline Diagnostics, Inc. Immunochromatographic assay device
BE1005090A5 (fr) * 1991-06-25 1993-04-13 Saliva Diagnostic Systems Inc Dispositif d'echantillonnage et systeme d'adequation d'echantillon.
US5540888A (en) * 1991-11-11 1996-07-30 British Technology Group Limited Liquid transfer assay devices
JP3382632B2 (ja) * 1992-03-13 2003-03-04 オリンパス光学工業株式会社 生体関連物質の測定方法およびそれに用いる反応容器
US5443959A (en) * 1992-09-09 1995-08-22 Tokuyama Corporation Method of assaying fibrinogen, dry reagent therefor, and process for the preparation thereof
US5344754A (en) * 1993-01-13 1994-09-06 Avocet Medical, Inc. Assay timed by electrical resistance change and test strip
JPH08507148A (ja) * 1993-02-17 1996-07-30 カーディオヴァスキュラー ダイアグノスティクス，インク． 固相化学カスケードイムノアッセイおよびアフィニティアッセイ
US5512492A (en) * 1993-05-18 1996-04-30 University Of Utah Research Foundation Waveguide immunosensor with coating chemistry providing enhanced sensitivity
US5670329A (en) * 1993-05-28 1997-09-23 Cardiovascular Diagnostics, Inc. Method and analytical system for performing fibrinogen assays accurately, rapidly and simply using a rotating magnetic field
US6521187B1 (en) 1996-05-31 2003-02-18 Packard Instrument Company Dispensing liquid drops onto porous brittle substrates
US6203759B1 (en) 1996-05-31 2001-03-20 Packard Instrument Company Microvolume liquid handling system
US6537817B1 (en) 1993-05-31 2003-03-25 Packard Instrument Company Piezoelectric-drop-on-demand technology
DE4323672A1 (de) * 1993-07-15 1995-01-19 Boehringer Mannheim Gmbh Vorrichtung zur gleichzeitigen Bestimmung von Analyten
US5522255A (en) * 1993-08-31 1996-06-04 Boehringer Mannheim Corporation Fluid dose, flow and coagulation sensor for medical instrument
US5841023A (en) * 1993-08-31 1998-11-24 Boehringer Mannheim Corporation Magnet for medical instrument
WO1995006430A1 (en) * 1993-08-31 1995-03-09 Boehringer Mannheim Corporation Analog heater control for medical instrument
EP0720439A4 (de) * 1993-08-31 1997-09-24 Boehringer Mannheim Corp Stromversorgungssteuerung und kontrolle für medizinisches instrument
US5526111A (en) * 1993-08-31 1996-06-11 Boehringer Mannheim Corporation Method and apparatus for calculating a coagulation characteristic of a sample of blood a blood fraction or a control
ES2220914T3 (es) * 1993-08-31 2004-12-16 Roche Diagnostics Corporation Reactivo y metodo para su suso.
US5478751A (en) * 1993-12-29 1995-12-26 Abbott Laboratories Self-venting immunodiagnositic devices and methods of performing assays
US5582907A (en) * 1994-07-28 1996-12-10 Pall Corporation Melt-blown fibrous web
AU3276895A (en) * 1994-07-28 1996-02-22 Pall Corporation Fibrous web and process of preparing same
GB9416002D0 (en) * 1994-08-08 1994-09-28 Univ Cranfield Fluid transport device
US5504011A (en) * 1994-10-21 1996-04-02 International Technidyne Corporation Portable test apparatus and associated method of performing a blood coagulation test
JP3388060B2 (ja) * 1994-11-25 2003-03-17 日本碍子株式会社 流体の特性測定用素子及び流体の特性測定装置
AU689143B2 (en) * 1994-12-02 1998-03-26 Cardiovascular Diagnostics, Inc. Improved method and analytical system for performing fibrinogen assays accurately, rapidly and simply
US5508521A (en) * 1994-12-05 1996-04-16 Cardiovascular Diagnostics Inc. Method and apparatus for detecting liquid presence on a reflecting surface using modulated light
US5814565A (en) * 1995-02-23 1998-09-29 University Of Utah Research Foundation Integrated optic waveguide immunosensor
DE19512710A1 (de) * 1995-04-10 1996-10-17 Behringwerke Ag Biosensor
DE19523061A1 (de) * 1995-06-24 1997-01-02 Boehringer Mannheim Gmbh Element und System zum Sammeln, Transportieren und Lagern von zu analysierendem Probenmaterial
US20020022261A1 (en) * 1995-06-29 2002-02-21 Anderson Rolfe C. Miniaturized genetic analysis systems and methods
US5863502A (en) * 1996-01-24 1999-01-26 Sarnoff Corporation Parallel reaction cassette and associated devices
CA2248185A1 (en) * 1996-03-19 1997-09-25 University Of Utah Research Foundation Lens and associatable flow cell
US20020090644A1 (en) * 1999-05-21 2002-07-11 Weigl Bernhard H. Microscale diffusion immunoassay
US6541213B1 (en) 1996-03-29 2003-04-01 University Of Washington Microscale diffusion immunoassay
US5942443A (en) * 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
EP1249354A1 (de) * 1996-06-14 2002-10-16 Minnesota Mining And Manufacturing Company Anzeigeeinheit und Verfahren zum Anzeigen von Bildern
US20060000722A1 (en) * 1996-06-28 2006-01-05 Caliper Life Sciences, Inc. High throughput screening assay systems in microscale fluidic devices
CN1173776C (zh) * 1996-06-28 2004-11-03 卡钳技术有限公司 在微规模流体性设备里的高通过量的筛选分析系统
US5945345A (en) * 1996-08-27 1999-08-31 Metrika, Inc. Device for preventing assay interference using silver or lead to remove the interferant
US5832165A (en) 1996-08-28 1998-11-03 University Of Utah Research Foundation Composite waveguide for solid phase binding assays
CA2266930C (en) * 1996-09-24 2007-11-27 Case Western Reserve University Device for optical and electrochemical measurements in microliter size samples
US7153651B1 (en) * 1996-10-31 2006-12-26 Inverness Medical - Biostar, Inc. Flow-through optical assay devices providing laminar flow of fluid samples, and methods of construction thereof
US6703247B1 (en) 1996-12-23 2004-03-09 American Registry Of Pathology Apparatus and methods for efficient processing of biological samples on slides
WO1998038487A2 (en) 1997-02-28 1998-09-03 Cepheid Heat exchanging, optically interrogated chemical reaction assembly
US6150174A (en) * 1997-03-05 2000-11-21 Diametrics Medical, Inc. Method for measurement of whole blood coagulation parameters
US6052224A (en) * 1997-03-21 2000-04-18 Northern Edge Associates Microscope slide system and method of use
US5910288A (en) * 1997-07-10 1999-06-08 Hewlett-Packard Company Method and apparatus for mixing a thin film of fluid
US6066243A (en) * 1997-07-22 2000-05-23 Diametrics Medical, Inc. Portable immediate response medical analyzer having multiple testing modules
US6061128A (en) * 1997-09-04 2000-05-09 Avocet Medical, Inc. Verification device for optical clinical assay systems
US6222619B1 (en) * 1997-09-18 2001-04-24 University Of Utah Research Foundation Diagnostic device and method
EP1018012A4 (de) * 1997-09-26 2002-10-09 Univ Washington Simultan ablaufende partikeltrennung und chemische reaktion
DE19753849A1 (de) * 1997-12-04 1999-06-10 Roche Diagnostics Gmbh Analytisches Testelement mit sich verjüngendem Kapillarkanal
US5908786A (en) * 1997-12-12 1999-06-01 Akzo Nobel, N.V. Blood coagulation monitoring device with liquid crystal and gradient heater
SE9800070D0 (sv) * 1998-01-14 1998-01-14 Hemocue Ab Blandningsmetod
SE520341C2 (sv) * 1998-01-14 2003-06-24 Hemocue Ab Metod och förfarande för blandning i ett tunt vätskeskick
US5975153A (en) * 1998-02-13 1999-11-02 Roche Diagnostics Corporation Capillary fill test device with improved fluid delivery
SE9800590D0 (sv) 1998-02-26 1998-02-26 Global Hemostasis Inst Mgr Ab Determination of polymerization/coagulation in a fluid
US6200531B1 (en) * 1998-05-11 2001-03-13 Igen International, Inc. Apparatus for carrying out electrochemiluminescence test measurements
US6312888B1 (en) 1998-06-10 2001-11-06 Abbott Laboratories Diagnostic assay for a sample of biological fluid
US6165795A (en) * 1998-06-25 2000-12-26 Cardiovascular Diagnostics, Inc. Methods for performing fibrinogen assays using dry chemical reagents containing ecarin and magnetic particles
US6830934B1 (en) * 1999-06-15 2004-12-14 Lifescan, Inc. Microdroplet dispensing for a medical diagnostic device
US6084660A (en) * 1998-07-20 2000-07-04 Lifescan, Inc. Initiation of an analytical measurement in blood
US6521182B1 (en) * 1998-07-20 2003-02-18 Lifescan, Inc. Fluidic device for medical diagnostics
CA2338246A1 (en) * 1998-07-21 2000-02-03 Arcturus Engineering, Inc. Fluidic extraction of microdissected samples
US6132685A (en) * 1998-08-10 2000-10-17 Caliper Technologies Corporation High throughput microfluidic systems and methods
US6186659B1 (en) * 1998-08-21 2001-02-13 Agilent Technologies Inc. Apparatus and method for mixing a film of fluid
US6482306B1 (en) 1998-09-22 2002-11-19 University Of Washington Meso- and microfluidic continuous flow and stopped flow electroösmotic mixer
US6498497B1 (en) * 1998-10-14 2002-12-24 Caliper Technologies Corp. Microfluidic controller and detector system with self-calibration
JP2002533695A (ja) * 1998-12-23 2002-10-08 アメリカン・レジストリー・オブ・パソロジー スライド上で生物学的試料を効率的に処理する装置および方法
US20060216744A1 (en) * 1998-12-23 2006-09-28 American Registry Of Pathology Armed Forces Institute Of Pathology Apparatus and methods for efficient processing of biological samples on slides
FR2792333B1 (fr) * 1999-04-14 2003-01-24 Labonord Dispositif de depot de cellules sur une plaque d'analyse
US20020019062A1 (en) * 1999-06-18 2002-02-14 Peter Lea Assay devices
US6258593B1 (en) 1999-06-30 2001-07-10 Agilent Technologies Inc. Apparatus for conducting chemical or biochemical reactions on a solid surface within an enclosed chamber
US6645359B1 (en) * 2000-10-06 2003-11-11 Roche Diagnostics Corporation Biosensor
US6743399B1 (en) 1999-10-08 2004-06-01 Micronics, Inc. Pumpless microfluidics
US6136549A (en) * 1999-10-15 2000-10-24 Feistel; Christopher C. systems and methods for performing magnetic chromatography assays
US6319719B1 (en) 1999-10-28 2001-11-20 Roche Diagnostics Corporation Capillary hematocrit separation structure and method
US6629057B2 (en) 1999-11-05 2003-09-30 Beckman Coulter, Inc. Comprehensive verification systems and methods for analyzer-read clinical assays
US6338969B1 (en) * 1999-11-15 2002-01-15 Bayer Corporation Assay test system for regulating temperature
US6458326B1 (en) 1999-11-24 2002-10-01 Home Diagnostics, Inc. Protective test strip platform
JP2001159618A (ja) * 1999-12-03 2001-06-12 Matsushita Electric Ind Co Ltd バイオセンサ
WO2001048461A1 (de) * 1999-12-24 2001-07-05 Roche Diagnostics Gmbh Testelement-analysesystem
FR2803225B1 (fr) * 1999-12-29 2002-06-14 Biomerieux Sa Appareil d'analyse a compartiment reactionnel a geometrie variable, procede de mixage et de guidage de liquides
US6562210B1 (en) * 1999-12-30 2003-05-13 Roche Diagnostics Corporation Cell for electrochemical anaylsis of a sample
DE10002500A1 (de) * 2000-01-21 2001-07-26 Univ Albert Ludwigs Freiburg Kapillarkraftmischer
US6451264B1 (en) * 2000-01-28 2002-09-17 Roche Diagnostics Corporation Fluid flow control in curved capillary channels
US6406672B1 (en) 2000-01-28 2002-06-18 Roche Diagnostics Plasma retention structure providing internal flow
DE10005203A1 (de) * 2000-02-05 2001-08-16 Bayerische Motoren Werke Ag Vermessungsvorrichtung zum Abbilden und Aufzeichnen eines dreidimensionalen Objekts
US6323040B1 (en) * 2000-02-15 2001-11-27 Ryan S. Raz System for biological specimen preparation
US6402704B1 (en) * 2000-04-18 2002-06-11 Sonexxus Incorporated Prothrombin test apparatus for home use
JP2003532891A (ja) * 2000-05-09 2003-11-05 ファーマネティクス インコーポレーテッド 血小板機能アッセイ及びその試薬
US6557427B2 (en) * 2000-05-24 2003-05-06 Micronics, Inc. Capillaries for fluid movement within microfluidic channels
US7255833B2 (en) * 2000-07-25 2007-08-14 Cepheid Apparatus and reaction vessel for controlling the temperature of a sample
EP1305607A1 (de) * 2000-07-31 2003-05-02 Lifescan, Inc. Verfahren und vorrichtung zur detektion der präsenz eines fluids auf einem teststreifen
WO2002033407A1 (en) * 2000-10-17 2002-04-25 Abbott Laboratories Diagnostic assay for a sample of biological fluid
GB0028647D0 (en) * 2000-11-24 2001-01-10 Nextgen Sciences Ltd Apparatus for chemical assays
US6620310B1 (en) * 2000-12-13 2003-09-16 Lifescan, Inc. Electrochemical coagulation assay and device
US7144495B2 (en) * 2000-12-13 2006-12-05 Lifescan, Inc. Electrochemical test strip with an integrated micro-needle and associated methods
ES2232407T3 (es) * 2000-12-28 2005-06-01 F. Hoffmann-La Roche Ag Metodo para el procesado de una muestra de acido nucleico mediante la oscilacion de un segmento de una pared de un cartucho, un sistema y un cartucho para realizar dicho metodo.
DE10101576B4 (de) * 2001-01-15 2016-02-18 Presens Precision Sensing Gmbh Optischer Sensor und Sensorfeld
US6525330B2 (en) 2001-02-28 2003-02-25 Home Diagnostics, Inc. Method of strip insertion detection
US6562625B2 (en) 2001-02-28 2003-05-13 Home Diagnostics, Inc. Distinguishing test types through spectral analysis
US6541266B2 (en) 2001-02-28 2003-04-01 Home Diagnostics, Inc. Method for determining concentration of an analyte in a test strip
WO2002072264A1 (en) * 2001-03-09 2002-09-19 Biomicro Systems, Inc. Method and system for microfluidic interfacing to arrays
CN100437114C (zh) * 2001-04-12 2008-11-26 爱科来株式会社 样品分析装置
US6759009B2 (en) * 2001-05-04 2004-07-06 Portascience Incorporated Method and device for clotting time assay
US20030211551A1 (en) * 2001-05-09 2003-11-13 Mahan Donald E Platelet function assay and reagent therefor
WO2002093169A1 (en) * 2001-05-17 2002-11-21 Bayer Healthcare Llc Assay test system for regulating temperature
US7473398B2 (en) 2001-05-25 2009-01-06 Roche Diagnostics Operations, Inc. Biosensor
EP1404218A4 (de) * 2001-06-12 2008-11-19 Pelikan Technologies Inc Thermischer sensor für die fluiddetektion
US7402282B2 (en) 2001-07-20 2008-07-22 Ortho-Clinical Diagnostics, Inc. Auxiliary sample supply for a clinical analyzer
JP4282477B2 (ja) * 2001-07-27 2009-06-24 アークレイ株式会社 分析用具
US6678542B2 (en) 2001-08-16 2004-01-13 Optiscan Biomedical Corp. Calibrator configured for use with noninvasive analyte-concentration monitor and employing traditional measurements
DE10140699A1 (de) * 2001-08-24 2003-03-13 Roche Diagnostics Gmbh Anordnung und Verfahren zur Untersuchung der Fließfähigkeit einer physiologischen Flüssigprobe
US6902904B2 (en) 2001-08-27 2005-06-07 Pharmanetics Incorporated Coagulation assay reagents containing lanthanides
FR2829576B1 (fr) * 2001-09-12 2003-10-31 Bio Merieux Procede et dispositif d'isolement et/ou determination d'un analyte
US7517499B2 (en) 2001-09-28 2009-04-14 Ibidi Gmbh Flow chamber
DE10148210B4 (de) * 2001-09-28 2005-09-15 Ibidi Gmbh Flusskammer
DE10151778A1 (de) * 2001-10-19 2003-05-08 Philips Corp Intellectual Pty Verfahren zur Ermittlung der räumlichen Verteilung magnetischer Partikel
US7050157B2 (en) * 2001-11-08 2006-05-23 Optiscan Biomedical Corp. Reagent-less whole-blood glucose meter
US6989891B2 (en) * 2001-11-08 2006-01-24 Optiscan Biomedical Corporation Device and method for in vitro determination of analyte concentrations within body fluids
US6680177B2 (en) * 2001-12-07 2004-01-20 Cardiovascular Diagnostics, Inc. Low molecular weight heparin assay, system and reagent therefor
ATE389177T1 (de) * 2001-12-21 2008-03-15 Ge Healthcare Bio Sciences Ab Immobilisierung von bindungsstoffen
JP2005519593A (ja) 2002-01-18 2005-07-07 ユニバーシティ オブ ユタ リサーチ ファウンデーション 平面導波路を使用する１塩基多型の検出法
US7004928B2 (en) 2002-02-08 2006-02-28 Rosedale Medical, Inc. Autonomous, ambulatory analyte monitor or drug delivery device
JP3892743B2 (ja) * 2002-03-01 2007-03-14 日本碍子株式会社 反応セルおよびその使用方法
US20060134713A1 (en) 2002-03-21 2006-06-22 Lifescan, Inc. Biosensor apparatus and methods of use
WO2003083489A1 (en) 2002-03-25 2003-10-09 Vector Ii, Inc. System for performing blood coagulation assays and measuring blood clotting times
US7524462B2 (en) * 2002-03-29 2009-04-28 Agilent Technologies, Inc. Capillary flow for a heterogenous assay in a micro-channel environment
DE60207196T2 (de) * 2002-04-09 2006-07-20 Cholestech Corp., Hayward Verfahren und Vorrichtung zur Quantifizierung von Lipoprotein-Cholesterol hoher Dichte
US7115421B2 (en) * 2002-04-17 2006-10-03 Biosafe Medical Technologies, Inc. Method and device for measurement of hematocrit
DE10219154A1 (de) * 2002-04-29 2003-11-20 Siemens Ag Verfahren zur Überwachung der Verfügbarkeit von Verbindungen in MPLS-Netzen
WO2003093836A1 (fr) * 2002-04-30 2003-11-13 Arkray, Inc. Instrument d'analyse, procede d'analyse d'echantillon et dispositif d'analyse utilisant un tel instrument, procede de formation d'ouverture dans l'instrument
JPWO2003093834A1 (ja) * 2002-04-30 2005-09-08 アークレイ株式会社 分析用具
US7285425B2 (en) * 2002-05-14 2007-10-23 Siemens Medical Solutions Diagnostics Assay test system for regulating temperature
US6958132B2 (en) * 2002-05-31 2005-10-25 The Regents Of The University Of California Systems and methods for optical actuation of microfluidics based on opto-electrowetting
US7919308B2 (en) * 2002-06-14 2011-04-05 Agilent Technologies, Inc. Form in place gaskets for assays
AUPS309002A0 (en) 2002-06-20 2002-07-11 Vision Biosystems Limited A covertile for a substrate
JP2005530183A (ja) * 2002-06-20 2005-10-06 バイオヴェリス コーポレイション エレクトロケミルミネッセンス・フローセル及びフローセル部品
US6939450B2 (en) * 2002-10-08 2005-09-06 Abbott Laboratories Device having a flow channel
JP3746756B2 (ja) * 2002-10-22 2006-02-15 株式会社日立製作所 溶液攪拌装置、溶液攪拌方法
US7126676B2 (en) * 2002-11-07 2006-10-24 Frank Anthony Greco Spectral analysis of light scattered from clotting blood
US20060110283A1 (en) * 2002-11-12 2006-05-25 Inverness Medical Switzerland Gmbh Photometric determination of coagulation time in undiluted whole blood
EP1419818B1 (de) * 2002-11-14 2013-10-30 Boehringer Ingelheim microParts GmbH Vorrichtung zum schrittweisen Transport von Flüssigkeit unter Ausnutzung von Kapillarkräften
US20040101439A1 (en) * 2002-11-21 2004-05-27 Fusco Adam J Biological and chemical reaction devices and methods of manufacture
US7053783B2 (en) 2002-12-18 2006-05-30 Biovigilant Systems, Inc. Pathogen detector system and method
US6983177B2 (en) * 2003-01-06 2006-01-03 Optiscan Biomedical Corporation Layered spectroscopic sample element with microporous membrane
US20040132168A1 (en) * 2003-01-06 2004-07-08 Peter Rule Sample element for reagentless whole blood glucose meter
US20040131088A1 (en) * 2003-01-08 2004-07-08 Adtran, Inc. Shared T1/E1 signaling bit processor
CA2518667C (en) 2003-03-14 2011-07-19 The Trustees Of Columbia University In The City Of New York Systems and methods of blood-based therapies having a microfluidic membraneless exchange device
US20060076295A1 (en) 2004-03-15 2006-04-13 The Trustees Of Columbia University In The City Of New York Systems and methods of blood-based therapies having a microfluidic membraneless exchange device
CA2519628C (en) * 2003-03-24 2020-06-09 Intuity Medical, Inc. Analyte concentration detection devices and methods
CA2522755A1 (en) * 2003-04-16 2004-11-04 Drexel University Acoustic blood analyzer for assessing blood properties
GB0313015D0 (en) * 2003-06-06 2003-07-09 Hall Effect Technologies Ltd Method and device for analysing a liquid
EP1666136B1 (de) * 2003-07-24 2008-10-15 AOGAKI, Ryoichi Mikroreaktor mit magnetischer barriere
USD530826S1 (en) * 2003-08-12 2006-10-24 Idexx Laboratories, Inc. Chemical reagent test slide
US7588733B2 (en) 2003-12-04 2009-09-15 Idexx Laboratories, Inc. Retaining clip for reagent test slides
KR100639776B1 (ko) * 2004-01-05 2006-10-27 바이오메드포토닉스 주식회사 측방 유동 정량 검정 방법 및 이를 위한 스트립과 레이저유발 표면형광 검출 장치 및 소형 스캐너
EP1711590B1 (de) * 2004-01-08 2016-12-14 Dako Denmark A/S Vorrichtung und verfahren zur bearbeitung biologischer proben und reservoir dafür
TWI258586B (en) * 2004-01-13 2006-07-21 Neupro Technology Co Ltd Immunochemical detection device
US7439069B2 (en) * 2004-02-27 2008-10-21 Nippoldt Douglas D Blood coagulation test cartridge, system, and method
US7422905B2 (en) * 2004-02-27 2008-09-09 Medtronic, Inc. Blood coagulation test cartridge, system, and method
AU2004318179B2 (en) * 2004-03-05 2009-07-23 Egomedical Swiss Ag Analyte test system for determining the concentration of an analyte in a physiological fluid
US7399637B2 (en) * 2004-04-19 2008-07-15 Medtronic, Inc. Blood coagulation test cartridge, system, and method
WO2005103663A1 (ja) * 2004-04-23 2005-11-03 Arkray, Inc. 分析用具およびその製造方法
WO2005111580A1 (en) * 2004-05-07 2005-11-24 Optiscan Biomedical Corporation Sample element with fringing-reduction capabilities
US20060002817A1 (en) * 2004-06-30 2006-01-05 Sebastian Bohm Flow modulation devices
US20060001551A1 (en) * 2004-06-30 2006-01-05 Ulrich Kraft Analyte monitoring system with wireless alarm
US8343074B2 (en) * 2004-06-30 2013-01-01 Lifescan Scotland Limited Fluid handling devices
US20060000709A1 (en) * 2004-06-30 2006-01-05 Sebastian Bohm Methods for modulation of flow in a flow pathway
US20060019406A1 (en) * 2004-07-23 2006-01-26 Ning Wei Lateral flow device for the detection of large pathogens
EP1784912A4 (de) * 2004-07-30 2012-03-14 Biovigilant Systems Inc Pathogen- und partikeldetektorsystem und -verfahren
ES2334671T3 (es) 2004-08-13 2010-03-15 Egomedical Technologies Ag Sistema de ensayo de analitos para determinar la concentracion de un analito en un fluido fisiologico o acuoso.
ATE369562T1 (de) * 2004-09-09 2007-08-15 Analyticon Biotechnologies Ag Lateralflussmessvorrichtung und messverfahren für analyten
WO2006036592A1 (en) * 2004-09-23 2006-04-06 University Of Washington Microscale diffusion immunoassay utilizing multivalent reactants
US20060068500A1 (en) * 2004-09-28 2006-03-30 Kimberly-Clark Worldwide, Inc. Detecting yeast infections using a lateral flow assay
US20060078471A1 (en) * 2004-10-12 2006-04-13 Witty Thomas R Apparatus and method for a precision flow assay
ES2303014T3 (es) 2004-11-25 2008-08-01 F. Hoffmann-La Roche Ag Dispositivo para el analisis de muestras.
US20060134387A1 (en) * 2004-12-20 2006-06-22 William Gottermeier Multilayer article formed by adhesive ablation
AT502915B1 (de) * 2004-12-23 2008-01-15 Hoffmann La Roche Vorrichtung zur thermostatisierung einer messzelle in einem analysator und messzelle, welche in einen analysator austauschbar einsetzbar ist
US20070144976A1 (en) * 2004-12-24 2007-06-28 Matthias Franzreb Micro-reactor
US20060195058A1 (en) 2005-02-14 2006-08-31 Gable Jennifer H Methods and apparatus for extracting and analyzing a bodily fluid
US20070103678A1 (en) * 2005-02-14 2007-05-10 Sterling Bernhard B Analyte detection system with interferent identification and correction
US8936755B2 (en) 2005-03-02 2015-01-20 Optiscan Biomedical Corporation Bodily fluid composition analyzer with disposable cassette
JP4586130B2 (ja) * 2005-02-22 2010-11-24 丸石化成株式会社 検体液採取器具
US7189522B2 (en) 2005-03-11 2007-03-13 Chembio Diagnostic Systems, Inc. Dual path immunoassay device
WO2006098804A2 (en) * 2005-03-11 2006-09-21 Chembio Diagnostic Systems, Inc. Dual path immunoassay device
EP1866646A1 (de) * 2005-03-29 2007-12-19 Inverness Medical Switzerland GmbH Hybride vorrichtung
CA2517299A1 (en) * 2005-08-26 2007-02-26 Chromedx Inc. Hollow needle assembly
US7740804B2 (en) * 2005-04-12 2010-06-22 Chromedx Inc. Spectroscopic sample holder
US8206650B2 (en) * 2005-04-12 2012-06-26 Chromedx Inc. Joint-diagnostic spectroscopic and biosensor meter
CA2507323A1 (en) * 2005-05-13 2006-11-13 Chromedx Inc. Diagnostic whole blood and plasma apparatus
US20100245803A1 (en) * 2005-04-12 2010-09-30 Chromedx Inc. Blood sample holder for spectroscopic analysis
KR101311815B1 (ko) 2005-06-03 2013-10-22 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템 단일 패러데이 전극에서의 전기발생 화학발광 및 전기화학
US20060281187A1 (en) 2005-06-13 2006-12-14 Rosedale Medical, Inc. Analyte detection devices and methods with hematocrit/volume correction and feedback control
JPWO2006137334A1 (ja) * 2005-06-23 2009-01-15 アークレイ株式会社 分析用具
CN101223560B (zh) * 2005-07-15 2012-12-12 百维吉伦特系统有限公司 病原体和颗粒的检测器系统和方法
ATE460664T1 (de) * 2005-08-31 2010-03-15 Egomedical Technologies Ag Gerinnungstestsystem
DE602005026588D1 (de) * 2005-08-31 2011-04-07 Egomedical Technologies Ag Analytentestsystem unter verwendung nichtenzymatischer analytenerkennungselemente
JP5232003B2 (ja) 2005-09-30 2013-07-10 インテュイティ メディカル インコーポレイテッド 多部分体液試料採取及び分析カートリッジ
US8801631B2 (en) 2005-09-30 2014-08-12 Intuity Medical, Inc. Devices and methods for facilitating fluid transport
US9561001B2 (en) 2005-10-06 2017-02-07 Optiscan Biomedical Corporation Fluid handling cassette system for body fluid analyzer
US8153444B2 (en) * 2005-10-13 2012-04-10 Auric Enterprises, Llc Immuno gold lateral flow assay
US7344893B2 (en) * 2005-10-13 2008-03-18 Auric Enterprises, Llc Immuno-gold lateral flow assay
US8075852B2 (en) * 2005-11-02 2011-12-13 Affymetrix, Inc. System and method for bubble removal
US9056291B2 (en) 2005-11-30 2015-06-16 Micronics, Inc. Microfluidic reactor system
US7763453B2 (en) 2005-11-30 2010-07-27 Micronics, Inc. Microfluidic mixing and analytic apparatus
WO2007075919A2 (en) * 2005-12-22 2007-07-05 Honeywell International Inc. Portable sample analyzer system
JP5028804B2 (ja) * 2006-01-19 2012-09-19 ソニー株式会社 機能デバイス
GB2438669A (en) * 2006-03-07 2007-12-05 Inverness Medical Switzerland Sensing apparatus having a pair of coils and an oscillating member
EP2005168A4 (de) * 2006-03-09 2009-05-20 Biosite Inc Verfahren und zusammensetzung zur diagnose von krankheiten der aorta
US20080261261A1 (en) * 2006-03-31 2008-10-23 Kmg2 Sensors Corporation System/unit and method employing a plurality of magnetoelastic sensor elements for automatically quantifying parameters of whole blood and platelet-rich plasma
US7837941B2 (en) 2006-04-07 2010-11-23 Agamatrix, Inc. Method and apparatus for monitoring alteration of flow characteristics in a liquid sample
CA2652173A1 (en) 2006-05-22 2007-11-29 Edward F. Leonard Systems and methods of microfluidic membraneless exchange using filtration of extraction fluid outlet streams
GB0611701D0 (en) * 2006-06-14 2006-07-26 Biochrom Ltd Analytical apparatus
AU2007265628B2 (en) 2006-06-23 2012-12-06 Revvity Health Sciences, Inc. Methods and devices for microfluidic point-of-care immunoassays
EP2034318B1 (de) 2006-06-26 2013-09-04 Nippon Telegraph and Telephone Corporation Durchflusszelle und verfahren zur herstellung davon
CN101627305B (zh) * 2006-07-17 2015-03-04 通用生物感测器有限公司 磁性粒子移动性的电化学侦测
US7749775B2 (en) * 2006-10-03 2010-07-06 Jonathan Scott Maher Immunoassay test device and method of use
US7384798B2 (en) * 2006-10-31 2008-06-10 Hewlett-Packard Development Company, L.P. Method of detecting analytes in a microfluidic sample and a system for performing the same
US20080101987A1 (en) * 2006-10-31 2008-05-01 Selwayan Saini Analytical test strip with electroluminescent lamp
US20080101986A1 (en) * 2006-10-31 2008-05-01 Selwayan Saini Analytical test strip with electroluminescent module
RU2487338C2 (ru) * 2006-12-12 2013-07-10 Конинклейке Филипс Электроникс Н.В. Микроэлектронное сенсорное устройство для обнаружения частиц-меток
WO2008071218A1 (en) * 2006-12-14 2008-06-19 Egomedical Swiss Ag Monitoring device
EP2126587B1 (de) * 2007-01-09 2010-09-29 Cholestech Corporation Vorrichtung und verfahren zur messung des ldl-assoziierten cholesterols
WO2008092470A1 (en) * 2007-01-29 2008-08-07 Egomedical Swiss Ag Resealeable container for storing moisture sensitive test elements
EP2140276A1 (de) * 2007-05-02 2010-01-06 Siemens Healthcare Diagnostics Inc. Piezoausgabe einer diagnoseflüssigkeit auf eine reagensoberfläche
WO2008137212A1 (en) * 2007-05-02 2008-11-13 Siemens Healthcare Diagnostics Inc. Piezo dispensing of a diagnostic liquid into microfluidic devices
US8597190B2 (en) 2007-05-18 2013-12-03 Optiscan Biomedical Corporation Monitoring systems and methods with fast initialization
WO2009029561A2 (en) * 2007-08-24 2009-03-05 Advanced Liquid Logic, Inc. Bead manipulations on a droplet actuator
JP5112441B2 (ja) * 2007-09-04 2013-01-09 パナソニック株式会社 血液分析素子とそれを用いた血液分析装置
WO2009057024A1 (en) 2007-10-29 2009-05-07 Koninklijke Philips Electronics N. V. Frustrated total internal reflection biosensor cartridge
KR100886914B1 (ko) * 2007-11-01 2009-03-09 주식회사 아이센스 혈액 분석 장치용 카트리지 및 이를 이용한 혈액 분석 장치
US8339608B2 (en) * 2007-11-05 2012-12-25 Koninklijke Philips Electronics N.V. Method for detecting redispersion of beads
JP2011504591A (ja) * 2007-11-26 2011-02-10 アトノミックス アクティーゼルスカブ 信号対ノイズ比を増すための手段および方法を備える、統合型分離および検出カートリッジ
US8628976B2 (en) * 2007-12-03 2014-01-14 Azbil BioVigilant, Inc. Method for the detection of biologic particle contamination
EP2249899A4 (de) 2008-02-04 2011-05-11 Univ Columbia Fluidtrennvorrichtungen, -systeme und -verfahren
WO2009109997A1 (en) * 2008-03-07 2009-09-11 Advanced Microdevices Pvt Ltd Method and device for particle removal and droplet preparation for qualitative and quantitative bioanalysis
SE533103C2 (sv) * 2008-04-01 2010-06-29 Tommy Forsell Blodviskositetsanalys
WO2009145920A1 (en) 2008-05-30 2009-12-03 Intuity Medical, Inc. Body fluid sampling device -- sampling site interface
US10383556B2 (en) 2008-06-06 2019-08-20 Intuity Medical, Inc. Medical diagnostic devices and methods
JP5642066B2 (ja) 2008-06-06 2014-12-17 インテュイティ メディカル インコーポレイテッド 体液の試料内に含まれている検体の存在または濃度を決定する検定を行う方法および装置
US20100022916A1 (en) 2008-07-24 2010-01-28 Javanbakhsh Esfandiari Method and Apparatus for Collecting and Preparing Biological Samples for Testing
CN102131737B (zh) * 2008-08-21 2014-03-19 西门子医疗保健诊断公司 用于尿沉渣分析的多层载玻片
KR101311020B1 (ko) 2008-11-07 2013-09-25 에프. 호프만-라 로슈 아게 광도계 반응 필름용 세립 충전물질
US9040285B2 (en) 2008-12-18 2015-05-26 Koninklijkle Philips N.V. Sensing device for sensing a fluid
US8177141B2 (en) * 2008-12-19 2012-05-15 Zodiac Pool Systems, Inc. Laminar deck jet
US8042748B2 (en) * 2008-12-19 2011-10-25 Zodiac Pool Systems, Inc. Surface disruptor for laminar jet fountain
US8448499B2 (en) 2008-12-23 2013-05-28 C A Casyso Ag Cartridge device for a measuring system for measuring viscoelastic characteristics of a sample liquid, a corresponding measuring system, and a corresponding method
US8331751B2 (en) 2009-03-02 2012-12-11 mBio Diagnositcs, Inc. Planar optical waveguide with core of low-index-of-refraction interrogation medium
US8300993B2 (en) * 2009-03-02 2012-10-30 Mbio Diagnostics, Inc. Waveguide with integrated lens
US9658222B2 (en) 2009-03-02 2017-05-23 Mbio Diagnostics, Inc. Planar waveguide based cartridges and associated methods for detecting target analyte
US9212995B2 (en) 2009-03-02 2015-12-15 Mbio Diagnostics, Inc. System and method for detecting multiple molecules in one assay
CA2752715C (en) 2009-04-14 2018-05-01 Arie R. Van Doorn Hifu induced cavitation with reduced power threshold
BRPI1012522B1 (pt) 2009-04-15 2019-11-26 Biocartis N V sistema ótico de multiplexação e método para detectar componentes de amostra em pelo menos duas câmaras de amostra diferentes
WO2010118542A1 (en) 2009-04-15 2010-10-21 Biocartis Sa Protection of bioanalytical sample chambers
EP2421649B1 (de) 2009-04-23 2018-01-24 Dublin City University Lateralstrom-assayvorrichtung zur überwachung von koagulation und verfahren dafür
EP2427270B1 (de) 2009-05-06 2015-04-01 Biocartis NV Vorrichtung zum schneiden eines probenträgers
AU2010257118B2 (en) 2009-06-04 2014-08-28 Lockheed Martin Corporation Multiple-sample microfluidic chip for DNA analysis
NZ597699A (en) * 2009-07-20 2014-04-30 Univ Monash Three-dimensional microfluidic systems
US9554742B2 (en) 2009-07-20 2017-01-31 Optiscan Biomedical Corporation Fluid analysis system
EP2456355B1 (de) 2009-07-20 2016-09-14 Optiscan Biomedical Corporation Einstellbarer steckverbinder und totraumreduzierung dafür
EP2492665A1 (de) * 2009-10-19 2012-08-29 Tokyo Institute of Technology Biosensor mit magnetischen mikropartikeln
US9498791B2 (en) 2009-11-13 2016-11-22 Ventana Medical Systems, Inc. Opposables and automated specimen processing systems with opposables
EP2499500B1 (de) 2009-11-13 2020-12-30 Ventana Medical Systems, Inc. Dünnschichtverarbeitungsvorrichtungen für einstellbare volumenanpassung
US10746752B2 (en) 2009-11-13 2020-08-18 Ventana Medical Systems, Inc. Opposables and automated specimen processing systems with opposables
EP3106871B1 (de) 2009-11-30 2021-10-27 Intuity Medical, Inc. Verfahren zum verifizieren der genauigkeit des betriebs einer analyt-überwachungsvorrichtung
WO2011073866A1 (en) * 2009-12-18 2011-06-23 Koninklijke Philips Electronics N.V. Substance determining apparatus
WO2011094577A2 (en) 2010-01-29 2011-08-04 Micronics, Inc. Sample-to-answer microfluidic cartridge
DK2555704T3 (da) 2010-04-08 2019-08-05 Hemosonics Llc Visning af hæmostatiske parametre
WO2011156522A1 (en) 2010-06-09 2011-12-15 Optiscan Biomedical Corporation Measuring analytes in a fluid sample drawn from a patient
EP2584964B1 (de) 2010-06-25 2021-08-04 Intuity Medical, Inc. Analytüberwachungsvorrichtungen
WO2012001127A1 (en) 2010-06-30 2012-01-05 Csem Centre Suisse D'electronique Et De Microtechnique Sa Recherche Et Developpement Pipette tip, pipette system and method for performing analysis with the pipette tip and system
US20130114076A1 (en) * 2010-07-09 2013-05-09 Koninklijke Philips Electronics N.V. Cartridge with large-scale manufacturing design
US9329175B2 (en) 2010-08-05 2016-05-03 Abbott Point Of Care Inc. Oscillating immunoassay method and device
US11402375B2 (en) 2010-08-05 2022-08-02 Abbott Point Of Care Inc. Magnetic immunosensor with trench configuration and method of use
WO2012019104A1 (en) 2010-08-05 2012-02-09 Abbott Point Of Care Inc. Immunoassay method and device with magnetically susceptible bead capture
EP2601526B1 (de) 2010-08-05 2016-12-21 Abbott Point Of Care, Inc. Magnetischer immunsensor und anwendungsverfahren dafür
GB201014316D0 (en) 2010-08-27 2010-10-13 Univ Dublin City A agglutination assay method and device
TW201217783A (en) 2010-09-15 2012-05-01 Mbio Diagnostics Inc System and method for detecting multiple molecules in one assay
WO2012045753A1 (de) * 2010-10-07 2012-04-12 Boehringer Ingelheim Microparts Gmbh Mikrofluidische plattform
AU2011315951B2 (en) 2010-10-15 2015-03-19 Lockheed Martin Corporation Micro fluidic optic design
US9522396B2 (en) 2010-12-29 2016-12-20 S.D. Sight Diagnostics Ltd. Apparatus and method for automatic detection of pathogens
US8603835B2 (en) 2011-02-10 2013-12-10 Chembio Diagnostic Systems, Inc. Reduced step dual path immunoassay device and method
DK2676136T3 (da) 2011-02-15 2021-03-15 Hemosonics Llc Indretninger, systemer og fremgangsmåder til vurdering af hæmostase
WO2012127050A2 (de) * 2011-03-24 2012-09-27 Boehringer Ingelheim Microparts Gmbh Vorrichtung und verfahren zur filtration von blut
WO2012159021A2 (en) 2011-05-19 2012-11-22 Hemosonics, Llc Portable hemostasis analyzer
EP2726852B1 (de) * 2011-06-30 2020-11-25 Koninklijke Philips N.V. Mehrfache untersuchungen einer probe
EP2729784A4 (de) 2011-07-06 2015-05-13 Optiscan Biomedical Corp Messzelle für flüssigkeitsanalysesystem
USD698926S1 (en) * 2011-07-14 2014-02-04 Verathon Inc. Electrical connector tab
EP3750480B1 (de) 2011-08-03 2022-02-02 Intuity Medical, Inc. Vorrichtung zur entnahme von körperflüssigkeiten
CN104136123B (zh) 2012-01-09 2017-03-01 精密公司 微流体反应器系统
US9588113B2 (en) 2012-02-22 2017-03-07 Church & Dwight Co., Inc. Methods for electronic analyte assaying
US9322054B2 (en) 2012-02-22 2016-04-26 Lockheed Martin Corporation Microfluidic cartridge
WO2014085804A1 (en) 2012-11-30 2014-06-05 The University Of North Carolina At Chapel Hill Methods, systems, and computer readable media for determining physical properties of a specimen in a portable point of care diagnostic device
JP2016509206A (ja) 2012-12-21 2016-03-24 マイクロニクス， インコーポレイテッド 携帯型蛍光検出システムおよびマイクロアッセイカートリッジ
US10518262B2 (en) 2012-12-21 2019-12-31 Perkinelmer Health Sciences, Inc. Low elasticity films for microfluidic use
WO2014100732A1 (en) 2012-12-21 2014-06-26 Micronics, Inc. Fluidic circuits and related manufacturing methods
WO2014129292A1 (ja) * 2013-02-22 2014-08-28 株式会社 日立ハイテクノロジーズ 生体分析デバイスおよび生体分子分析装置
USD728120S1 (en) 2013-03-15 2015-04-28 Ventana Medical Systems, Inc. Arcuate member for moving liquids along a microscope slide
CA2911303C (en) 2013-05-07 2021-02-16 Micronics, Inc. Methods for preparation of nucleic acid-containing samples using clay minerals and alkaline solutions
WO2014182844A1 (en) 2013-05-07 2014-11-13 Micronics, Inc. Microfluidic devices and methods for performing serum separation and blood cross-matching
CN105189784B (zh) 2013-05-07 2020-06-30 珀金埃尔默健康科学有限公司 用于制备和分析核酸的装置
EP3869257B1 (de) 2013-05-23 2024-05-08 S.D. Sight Diagnostics Ltd. Verfahren und system zur bildgebung einer zellprobe
US10729386B2 (en) 2013-06-21 2020-08-04 Intuity Medical, Inc. Analyte monitoring system with audible feedback
IL227276A0 (en) 2013-07-01 2014-03-06 Parasight Ltd A method and system for preparing a monolayer of cells, particularly suitable for diagnosis
US10082500B2 (en) 2013-08-22 2018-09-25 Franz Baudenbacher Device and method for detecting a target analyte
US10831013B2 (en) 2013-08-26 2020-11-10 S.D. Sight Diagnostics Ltd. Digital microscopy systems, methods and computer program products
KR20150039051A (ko) * 2013-10-01 2015-04-09 삼성전자주식회사 혈액으로부터 혈장 또는 혈청을 분리하는 혈액 필터 장치 및 그의 용도
WO2015095239A1 (en) 2013-12-18 2015-06-25 Optiscan Biomedical Corporation Systems and methods for detecting leaks
ES2906853T3 (es) 2014-04-02 2022-04-20 Chembio Diagnostic Systems Inc Inmunoensayo que utiliza conjugado de atrapamiento
EP3134553B1 (de) 2014-04-24 2019-08-21 Lucira Health, Inc. Kolorimetrische detektion von nukleinsäureamplifikation
US10073091B2 (en) * 2014-08-08 2018-09-11 Ortho-Clinical Diagnostics, Inc. Lateral flow assay device
CN107077732B (zh) 2014-08-27 2020-11-24 思迪赛特诊断有限公司 用于对数字显微镜计算聚焦变化的系统及方法
US10539579B2 (en) 2014-09-29 2020-01-21 C A Casyso Gmbh Blood testing system and method
US10816559B2 (en) 2014-09-29 2020-10-27 Ca Casyso Ag Blood testing system and method
US10175225B2 (en) 2014-09-29 2019-01-08 C A Casyso Ag Blood testing system and method
US20160116466A1 (en) 2014-10-27 2016-04-28 Chembio Diagnostic Systems, Inc. Rapid Screening Assay for Qualitative Detection of Multiple Febrile Illnesses
EP3859425B1 (de) 2015-09-17 2024-04-17 S.D. Sight Diagnostics Ltd. Verfahren und vorrichtung zur detektion einer entität in einer körperprobe
CN105628747B (zh) * 2015-12-18 2019-03-22 上海奥普生物医药有限公司 凝血时间测试分析装置及其测试分析方法
JP6891191B2 (ja) * 2016-03-14 2021-06-18 ルシラ ヘルス インコーポレイテッド 光学的性質を改変するための装置および方法
EP3429752A4 (de) 2016-03-14 2019-10-30 Lucira Health, Inc. Systeme und verfahren zur durchführung von biologischen tests
CA3214851A1 (en) 2016-03-14 2017-09-21 Lucira Health, Inc. Devices and methods for biological assay sample preparation and delivery
DK3429543T3 (da) 2016-03-14 2025-01-27 Pfizer Selektivt ventilerede biologiske analyseanordninger og tilhørende fremgangsmåder
US11733150B2 (en) 2016-03-30 2023-08-22 S.D. Sight Diagnostics Ltd. Distinguishing between blood sample components
US11307196B2 (en) 2016-05-11 2022-04-19 S.D. Sight Diagnostics Ltd. Sample carrier for optical measurements
AU2017263807B2 (en) 2016-05-11 2023-02-02 S.D. Sight Diagnostics Ltd Performing optical measurements on a sample
KR101865055B1 (ko) * 2016-09-02 2018-06-08 (주)지엠에스바이오 혈당 측정용 스트립
US10172401B1 (en) * 2016-12-17 2019-01-08 Simple Texan Llc Backing plate for magnetic attachment
JP6941939B2 (ja) 2016-12-22 2021-09-29 リンテック株式会社 検査部材、および検査部材の製造方法
US11080848B2 (en) 2017-04-06 2021-08-03 Lucira Health, Inc. Image-based disease diagnostics using a mobile device
JP7432500B2 (ja) 2017-04-20 2024-02-16 ヘモソニックス エル・エル・シー 止血機能の分析のための使い捨てシステム
JP7046166B2 (ja) 2017-09-14 2022-04-01 ルシラ ヘルス インコーポレイテッド 電子読み出しを用いる多重化バイオアッセイデバイス
EP3710810B1 (de) 2017-11-14 2023-09-06 S.D. Sight Diagnostics Ltd. Probenträger für optische messungen
GB2569344A (en) * 2017-12-14 2019-06-19 Randox Laboratories Ltd Fluidic card assembly
USD910200S1 (en) 2018-12-21 2021-02-09 Lucira Health, Inc. Test tube
CN211905402U (zh) * 2019-11-22 2020-11-10 京东方科技集团股份有限公司 检测芯片及检测系统
CN110681297B (zh) * 2019-11-25 2023-05-30 徐州蓝湖信息科技有限公司 一种化工试剂制备扩散加速器
CN115349085A (zh) 2020-03-24 2022-11-15 前沿诊疗股份有限公司 用于常规化学、免疫分析和核酸检测的临床分光光度计
WO2021216764A1 (en) * 2020-04-24 2021-10-28 Leavitt Medical, Inc. D/B/A Lumea Focal plane spacers for microscope slides and related systems and methods
USD953561S1 (en) 2020-05-05 2022-05-31 Lucira Health, Inc. Diagnostic device with LED display
USD962470S1 (en) 2020-06-03 2022-08-30 Lucira Health, Inc. Assay device with LCD display
US11554371B2 (en) * 2020-12-30 2023-01-17 International Business Machines Corporation Precise fluid input control for point-of-care devices
EP4317988A4 (de) * 2021-03-24 2024-09-18 FUJIFILM Corporation Kartusche und immunochromatographische detektionsvorrichtung
KR102674118B1 (ko) * 2021-07-08 2024-06-12 (주)옵토레인 Pcr 모듈
GB2622895B (en) * 2022-12-23 2025-01-22 Flexotronix Ltd Housing

Family Cites Families (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US27866A (en) * 1860-04-10 Improved mode of securing metal hoops on cotton-bales
US2616796A (en) * 1950-11-25 1952-11-04 Fred J Schilling Apparatus for determining a coagulation factor of blood samples
US3233975A (en) * 1962-03-05 1966-02-08 Ames Lab Tek Inc Prothrombin reaction chamber
GB1088421A (en) * 1964-01-07 1967-10-25 Harshaw Chemicals Ltd A method and apparatus for depositing a coating on the internal walls of capillary or smallbore tubes
US3395210A (en) * 1964-02-07 1968-07-30 Warner Lambert Pharmaceutical Lyophilized diagnostic reagent for the determination of blood coagulation factors
DE1617732C2 (de) * 1966-03-01 1972-12-21 Promoveo-Sobioda & Cie, Seyssinet (Frankreich) Vorrichtung zur Untersuchung lebender Zellen von Mikroorganismen
US3450501A (en) * 1966-03-28 1969-06-17 Bruce J Oberhardt Prothrombin time determination
US3520659A (en) * 1967-10-20 1970-07-14 Xerox Corp Method and apparatus for use in determining prothrombin time of a blood sample
US3635678A (en) * 1969-06-13 1972-01-18 Baxter Laboratories Inc Clot-timing system and method
BE759811A (fr) 1969-12-04 1971-06-03 Technicon Instr Appareil de determination automatique des vitesses de coagulation, agglutination ou floculation de liquides, et agent renforcateur de reactionutilisable avec cet appareil
US3695842A (en) * 1970-03-12 1972-10-03 Intern Technidyne Corp Method and system for analyzing a liquid
US3691017A (en) * 1970-05-06 1972-09-12 Worthington Bio Chem Corp Means and method for chemical analysis
US3672351A (en) * 1970-08-17 1972-06-27 Richard W Ubersax Disposable blood test device
BE792113A (fr) * 1971-12-13 1973-05-30 Technicon Instr Melangeur de liquides contenant des particules magnetiques
US3861197A (en) * 1973-06-29 1975-01-21 Technicon Instr Method and apparatus for determining the viscosity of a liquid sample
US3880714A (en) * 1973-07-18 1975-04-29 Warner Lambert Co Diagnostic reagent
SE380100B (de) * 1974-02-07 1975-10-27 Monega Anstalt
US3918908A (en) * 1974-05-17 1975-11-11 Geomet Method for prothrombin testing
SE399768B (sv) * 1975-09-29 1978-02-27 Lilja Jan E Kyvett for provtagning, blandning av, provet med ett reagensmedel och direkt utforande av, serskilt optisk, analys av det med reagensmedlet blandade provet
US4097237A (en) * 1977-03-04 1978-06-27 Technicon Instruments Corporation Determination of cells in blood
US4176973A (en) * 1977-07-29 1979-12-04 Gregory Stephen A Stenotype tape marking attachment
JPS5469497A (en) * 1977-11-12 1979-06-04 Kyoto Daiichi Kagaku Kk Method and device for measuring blood solidification time
US4344438A (en) * 1978-08-02 1982-08-17 The United States Of America As Represented By The Department Of Health, Education And Welfare Optical sensor of plasma constituents
US4233029A (en) * 1978-10-25 1980-11-11 Eastman Kodak Company Liquid transport device and method
US4302313A (en) * 1979-07-23 1981-11-24 Eastman Kodak Company Electrode-containing device with capillary transport between electrodes
US4310399A (en) * 1979-07-23 1982-01-12 Eastman Kodak Company Liquid transport device containing means for delaying capillary flow
US4321057A (en) * 1979-09-20 1982-03-23 Buckles Richard G Method for quantitative analysis using optical fibers
US4323536A (en) * 1980-02-06 1982-04-06 Eastman Kodak Company Multi-analyte test device
US4413407A (en) * 1980-03-10 1983-11-08 Eastman Kodak Company Method for forming an electrode-containing device with capillary transport between electrodes
DE3029579C2 (de) * 1980-08-05 1985-12-12 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren und Mittel zur Abtrennung von Plasma oder Serum aus Vollblut
US4366241A (en) * 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
US4426451A (en) * 1981-01-28 1984-01-17 Eastman Kodak Company Multi-zoned reaction vessel having pressure-actuatable control means between zones
US4340669A (en) * 1981-02-12 1982-07-20 Miles Laboratories, Inc. System for the determination of glucose in fluids
US4391905A (en) * 1981-02-12 1983-07-05 Miles Laboratories, Inc. System for the determination of glucose in fluids
US4391906A (en) * 1981-02-12 1983-07-05 Miles Laboratories, Inc. System for the determination of glucose in fluids
US4473457A (en) * 1982-03-29 1984-09-25 Eastman Kodak Company Liquid transport device providing diversion of capillary flow into a non-vented second zone
DE3233809A1 (de) * 1982-09-11 1984-03-15 Boehringer Mannheim Gmbh, 6800 Mannheim Kuevette zur bestimmung chemischer verbindungen in fluessigkeiten
DE3247608A1 (de) * 1982-12-23 1984-07-05 Boehringer Mannheim Gmbh, 6800 Mannheim Teststreifen
US4558014A (en) * 1983-06-13 1985-12-10 Myron J. Block Assay apparatus and methods
IT1196349B (it) * 1983-12-02 1988-11-16 Vertrik Bioteknik Ab Dispositivo per le analisi chimiche ed impiego di esso
US4654127A (en) * 1984-04-11 1987-03-31 Sentech Medical Corporation Self-calibrating single-use sensing device for clinical chemistry and method of use
US4978503A (en) * 1984-06-13 1990-12-18 Ares-Serono Research & Development Limited Partnership Devices for use in chemical test procedures
US4596695A (en) * 1984-09-10 1986-06-24 Cottingham Hugh V Agglutinographic reaction chamber
US4826759A (en) * 1984-10-04 1989-05-02 Bio-Metric Systems, Inc. Field assay for ligands
FR2580407B1 (fr) * 1985-04-11 1987-06-26 Vieillard Didier Procede et appareil pour la mesure de la coagulation du plasma sanguin
US4678757A (en) * 1985-04-11 1987-07-07 Smithkline Diagnostics, Inc. Device and method for whole blood separation and analysis
DE3523439A1 (de) * 1985-06-29 1987-01-08 Boehringer Mannheim Gmbh Testtraeger
DE3523969A1 (de) * 1985-07-04 1987-01-08 Boehringer Mannheim Gmbh Gerinnungsneutrale, hydrophile glasfasern
US4756884A (en) * 1985-08-05 1988-07-12 Biotrack, Inc. Capillary flow device
US4963498A (en) * 1985-08-05 1990-10-16 Biotrack Capillary flow device
US4682895A (en) * 1985-08-06 1987-07-28 Texas A&M University Fiber optic probe for quantification of colorimetric reactions
US4761381A (en) * 1985-09-18 1988-08-02 Miles Inc. Volume metering capillary gap device for applying a liquid sample onto a reactive surface
US4712460A (en) * 1985-11-18 1987-12-15 Biotrack, Inc. Integrated drug dosage form and metering system
DE3616496A1 (de) * 1986-05-16 1987-11-19 Boehringer Mannheim Gmbh Analyseelement zur bestimmung von gerinnungsparametern
US4731330A (en) * 1986-07-01 1988-03-15 Biotrack, Inc. Whole blood control sample
US4753776A (en) * 1986-10-29 1988-06-28 Biotrack, Inc. Blood separation device comprising a filter and a capillary flow pathway exiting the filter
US4789629A (en) * 1986-11-24 1988-12-06 Smithkline Beckman Corporation Method and device for collecting and testing for fecal occult blood
US4849340A (en) * 1987-04-03 1989-07-18 Cardiovascular Diagnostics, Inc. Reaction system element and method for performing prothrombin time assay
US4912034A (en) * 1987-09-21 1990-03-27 Biogenex Laboratories Immunoassay test device and method
US4999163A (en) * 1987-10-29 1991-03-12 Hygeia Sciences, Inc. Disposable, pre-packaged device for conducting immunoassay procedures
US4818677A (en) * 1987-12-03 1989-04-04 Monoclonal Antibodies, Inc. Membrane assay using focused sample application

Also Published As

Publication number Publication date
US5658723A (en) 1997-08-19
JP2736091B2 (ja) 1998-04-02
JPH01502797A (ja) 1989-09-28
DE3853457D1 (de) 1995-05-04
EP0308494A1 (de) 1989-03-29
US6197494B1 (en) 2001-03-06
AU1591888A (en) 1988-11-02
AU613623B2 (en) 1991-08-08
US20020119486A1 (en) 2002-08-29
US4849340A (en) 1989-07-18
WO1988007666A1 (en) 1988-10-06
EP0308494B1 (de) 1995-03-29
DE3853457T2 (de) 1995-10-26
CA1310566C (en) 1992-11-24
EP0308494A4 (de) 1990-07-04

Similar Documents

Publication Publication Date Title
DE3853457D1 (de) Vorrichtung und verfahren zur genauen, schnellen und einfachen durchführung eines prothrombin tests.
IT1068124B (it) Vaschetta di campionatura per analisi chimiche
DE69507019D1 (de) Speicheltestverfahren und vorrichtung
ES433418A1 (es) Un sistema de ensayos para la determinacion de constituyen-tes quimicos en un fluido.
IT1116284B (it) Dispositivo automatico e reagente per analisi di campioni fluidi,particolarmente per prove di immunizzatione
ATE31822T1 (de) Testvorrichtung.
DE69429770D1 (de) Verfahren und analytisches system zur genauen schnellen und einfachen ausführung von fibrinogen-assays
ATE55833T1 (de) Vorrichtung zum analysieren einer fluessigen probe.
ES443619A1 (es) Aparato de ensayo para analizar una pluralidad de muestras liquidas.
GB1494232A (en) Method of preparing measuring liquids
ES2128321T3 (es) Ensayos de fibrinogeno que usan reactivos quimicos que contienen particulas magneticas.
DE60112017D1 (de) Verfahren, Reagenz, Messkartusche und Vorrichtung zur Fibrinogenbestimmung
ES8507181A1 (es) Un metodo para la determinacion de un polinucleotido
ES481441A1 (es) Un metodo de una sola inmersion, para la preparacion de un dispositivo de ensayo, para determinar la presencia de urobilinogeno.
JPS5748658A (en) Immunologic measuring method and reagent for measurement
ES540545A0 (es) Un metodo para la preparacion de un instrumento de ensayo para determinar la presencia de un ion en una muestra acuosaa ensayar
FR2303290A1 (fr) Detecteur a reactif, son procede de preparation et son application a l'analyse chimique et biochimique
FR2319903A1 (fr) Procede et appareillage pour effectuer des analyses chimiques et cliniques
NL7512875A (en) Rapid measurement of coagulation rates - using uniform bore reaction tube contg. lyophilised reagents to which blood sample is added
IT1086777B (it) Procedimento per la preparazione di soluzioni titolate

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties