ATE120543T1 - Vorrichtung und verfahren zur genauen, schnellen und einfachen durchführung eines prothrombin tests. - Google Patents

Vorrichtung und verfahren zur genauen, schnellen und einfachen durchführung eines prothrombin tests.

Info

Publication number
ATE120543T1
ATE120543T1 AT88903642T AT88903642T ATE120543T1 AT E120543 T1 ATE120543 T1 AT E120543T1 AT 88903642 T AT88903642 T AT 88903642T AT 88903642 T AT88903642 T AT 88903642T AT E120543 T1 ATE120543 T1 AT E120543T1
Authority
AT
Austria
Prior art keywords
quick
accurate
easy performance
prothrombin test
prothrombin
Prior art date
Application number
AT88903642T
Other languages
English (en)
Inventor
Bruce Oberhardt
Original Assignee
Cardiovascular Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cardiovascular Diagnostics Inc filed Critical Cardiovascular Diagnostics Inc
Application granted granted Critical
Publication of ATE120543T1 publication Critical patent/ATE120543T1/de

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/30Mixers with shaking, oscillating, or vibrating mechanisms comprising a receptacle to only a part of which the shaking, oscillating, or vibrating movement is imparted
    • B01F31/31Mixers with shaking, oscillating, or vibrating mechanisms comprising a receptacle to only a part of which the shaking, oscillating, or vibrating movement is imparted using receptacles with deformable parts, e.g. membranes, to which a motion is imparted
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5023Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures with a sample being transported to, and subsequently stored in an absorbent for analysis
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/50Mixing liquids with solids
    • B01F23/56Mixing liquids with solids by introducing solids in liquids, e.g. dispersing or dissolving
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30Micromixers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71Feed mechanisms
    • B01F35/717Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/7172Feed mechanisms characterised by the means for feeding the components to the mixer using capillary forces
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483Physical analysis of biological material
    • G01N33/487Physical analysis of biological material of liquid biological material
    • G01N33/49Blood
    • G01N33/4905Determining clotting time of blood
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G01N33/525Multi-layer analytical elements
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F21/00Dissolving
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/23Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40Mixing liquids with liquids; Emulsifying
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00Mixers with shaking, oscillating, or vibrating mechanisms
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/06Auxiliary integrated devices, integrated components
    • B01L2300/0627Sensor or part of a sensor is integrated
    • B01L2300/0654Lenses; Optical fibres
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/06Auxiliary integrated devices, integrated components
    • B01L2300/069Absorbents; Gels to retain a fluid
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0809Geometry, shape and general structure rectangular shaped
    • B01L2300/0825Test strips
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087Multiple sequential chambers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0887Laminated structure
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/18Means for temperature control
    • B01L2300/1805Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1827Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/18Means for temperature control
    • B01L2300/1861Means for temperature control using radiation
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406Moving fluids with specific forces or mechanical means specific forces capillary forces
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/06Valves, specific forms thereof
    • B01L2400/0633Valves, specific forms thereof with moving parts
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/06Valves, specific forms thereof
    • B01L2400/0633Valves, specific forms thereof with moving parts
    • B01L2400/0655Valves, specific forms thereof with moving parts pinch valves
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/06Valves, specific forms thereof
    • B01L2400/0694Valves, specific forms thereof vents used to stop and induce flow, backpressure valves
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03Cuvette constructions
    • G01N2021/0346Capillary cells; Microcells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00346Heating or cooling arrangements
    • G01N2035/00435Refrigerated reagent storage
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47Scattering, i.e. diffuse reflection
    • G01N21/49Scattering, i.e. diffuse reflection within a body or fluid
    • G01N21/51Scattering, i.e. diffuse reflection within a body or fluid inside a container, e.g. in an ampoule
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • G01N21/648Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/78Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00Features of devices classified in G01N21/00
    • G01N2201/06Illumination; Optics
    • G01N2201/066Modifiable path; multiple paths in one sample
    • G01N2201/0668Multiple paths; optimisable path length
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0098Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/805Test papers
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/81Packaged device or kit
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/969Multiple layering of reactants
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/97Test strip or test slide
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/975Kit
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/807Apparatus included in process claim, e.g. physical support structures
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/807Apparatus included in process claim, e.g. physical support structures
    • Y10S436/81Tube, bottle, or dipstick

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Ecology (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
AT88903642T 1987-04-03 1988-04-01 Vorrichtung und verfahren zur genauen, schnellen und einfachen durchführung eines prothrombin tests. ATE120543T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/033,817 US4849340A (en) 1987-04-03 1987-04-03 Reaction system element and method for performing prothrombin time assay

Publications (1)

Publication Number Publication Date
ATE120543T1 true ATE120543T1 (de) 1995-04-15

Family

ID=21872614

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88903642T ATE120543T1 (de) 1987-04-03 1988-04-01 Vorrichtung und verfahren zur genauen, schnellen und einfachen durchführung eines prothrombin tests.

Country Status (8)

Country Link
US (4) US4849340A (de)
EP (1) EP0308494B1 (de)
JP (1) JP2736091B2 (de)
AT (1) ATE120543T1 (de)
AU (1) AU613623B2 (de)
CA (1) CA1310566C (de)
DE (1) DE3853457T2 (de)
WO (1) WO1988007666A1 (de)

Families Citing this family (381)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5144139A (en) * 1985-08-05 1992-09-01 Biotrack, Inc. Capillary flow device
US5204525A (en) * 1985-08-05 1993-04-20 Biotrack Capillary flow device
US5164598A (en) * 1985-08-05 1992-11-17 Biotrack Capillary flow device
US5140161A (en) * 1985-08-05 1992-08-18 Biotrack Capillary flow device
US4935346A (en) 1986-08-13 1990-06-19 Lifescan, Inc. Minimum procedure system for the determination of analytes
US4918025A (en) * 1987-03-03 1990-04-17 Pb Diagnostic Systems, Inc. Self contained immunoassay element
US4849340A (en) * 1987-04-03 1989-07-18 Cardiovascular Diagnostics, Inc. Reaction system element and method for performing prothrombin time assay
US5110727A (en) * 1987-04-03 1992-05-05 Cardiovascular Diagnostics, Inc. Method for performing coagulation assays accurately, rapidly and simply, using dry chemical reagents and paramagnetic particles
USD501678S1 (en) * 1987-04-03 2005-02-08 Cardiovascular Diagnostics, Inc. Assay card for an assay chamber
US5209904A (en) * 1987-12-23 1993-05-11 Abbott Laboratories Agglutination reaction device utilizing selectively impregnated porous material
US5779976A (en) * 1988-11-03 1998-07-14 Igen International, Inc. Apparatus for improved luminescence assays
US5114350A (en) * 1989-03-08 1992-05-19 Cholestech Corporation Controlled-volume assay apparatus
US4957582A (en) * 1989-03-16 1990-09-18 Eastman Kodak Company Capillary transport zone coated with adhesive
IE940110L (en) * 1989-03-23 1990-09-23 Bunce Roger A Liquid transfer devices
US5039617A (en) * 1989-04-20 1991-08-13 Biotrack, Inc. Capillary flow device and method for measuring activated partial thromboplastin time
EP0397424A3 (de) * 1989-05-08 1991-08-21 Biotrack, Inc. Mehrfachanalysesystem
US5147609A (en) * 1989-05-19 1992-09-15 Pb Diagnostic Systems, Inc. Assay element
IT1230744B (it) * 1989-07-07 1991-10-29 Instrumentation Lab Spa Metodo per la determinazione della attivita' funzionale della proteina s nel plasma umano.
JPH0810193B2 (ja) * 1989-08-21 1996-01-31 富士写真フイルム株式会社 生化学分析方法における点着異常判定方法
US5622870A (en) * 1989-11-27 1997-04-22 Behringwerke Ag Device and method for completing a fluidic circuit
US5104812A (en) * 1989-11-27 1992-04-14 Syntex (U.S.A.) Inc. Device and method for interrupting capillary flow
US5068181A (en) * 1989-12-01 1991-11-26 Akzo N.V. Method of monitoring reagent delivery in a scanning spectrophotometer
US5646046A (en) * 1989-12-01 1997-07-08 Akzo Nobel N.V. Method and instrument for automatically performing analysis relating to thrombosis and hemostasis
US5110724A (en) * 1990-04-02 1992-05-05 Cholestech Corporation Multi-analyte assay device
US4986964A (en) * 1990-04-19 1991-01-22 Center For Innovative Technology Clot retractometer
WO1991018276A1 (en) * 1990-05-22 1991-11-28 Kelly Kenneth A Microassay strip device for immunoassay
TW221493B (de) * 1990-07-10 1994-03-01 Cardiovascular Diagnostics Inc
WO1992005440A1 (en) * 1990-09-26 1992-04-02 Akers Research Corporation Improved ligand assay
ZA92803B (en) 1991-02-06 1992-11-25 Igen Inc Method and apparatus for magnetic microparticulate based luminescene asay including plurality of magnets
EP0501796A3 (en) * 1991-03-01 1993-10-06 Biotrack, Inc. Capillary stop-flow junction having improved stability against accidental fluid flow
US5207984A (en) * 1991-03-11 1993-05-04 Miles Inc. Blood sample collection and test device
US5998220A (en) 1991-05-29 1999-12-07 Beckman Coulter, Inc. Opposable-element assay devices, kits, and methods employing them
US5877028A (en) 1991-05-29 1999-03-02 Smithkline Diagnostics, Inc. Immunochromatographic assay device
US6168956B1 (en) 1991-05-29 2001-01-02 Beckman Coulter, Inc. Multiple component chromatographic assay device
BE1005090A5 (fr) * 1991-06-25 1993-04-13 Saliva Diagnostic Systems Inc Dispositif d'echantillonnage et systeme d'adequation d'echantillon.
US5540888A (en) * 1991-11-11 1996-07-30 British Technology Group Limited Liquid transfer assay devices
JP3382632B2 (ja) * 1992-03-13 2003-03-04 オリンパス光学工業株式会社 生体関連物質の測定方法およびそれに用いる反応容器
US5443959A (en) * 1992-09-09 1995-08-22 Tokuyama Corporation Method of assaying fibrinogen, dry reagent therefor, and process for the preparation thereof
US5344754A (en) * 1993-01-13 1994-09-06 Avocet Medical, Inc. Assay timed by electrical resistance change and test strip
EP0685069A4 (de) * 1993-02-17 2002-01-23 Cardiovascular Diagnostics Inc Immunoassay und affinitätstest auf der grundlage einer trockenchemischen kaskade
US5512492A (en) * 1993-05-18 1996-04-30 University Of Utah Research Foundation Waveguide immunosensor with coating chemistry providing enhanced sensitivity
US5670329A (en) * 1993-05-28 1997-09-23 Cardiovascular Diagnostics, Inc. Method and analytical system for performing fibrinogen assays accurately, rapidly and simply using a rotating magnetic field
US6537817B1 (en) 1993-05-31 2003-03-25 Packard Instrument Company Piezoelectric-drop-on-demand technology
US6521187B1 (en) 1996-05-31 2003-02-18 Packard Instrument Company Dispensing liquid drops onto porous brittle substrates
US6203759B1 (en) 1996-05-31 2001-03-20 Packard Instrument Company Microvolume liquid handling system
DE4323672A1 (de) * 1993-07-15 1995-01-19 Boehringer Mannheim Gmbh Vorrichtung zur gleichzeitigen Bestimmung von Analyten
EP0720439A4 (de) * 1993-08-31 1997-09-24 Boehringer Mannheim Corp Stromversorgungssteuerung und kontrolle für medizinisches instrument
US5841023A (en) * 1993-08-31 1998-11-24 Boehringer Mannheim Corporation Magnet for medical instrument
CA2168966C (en) * 1993-08-31 2007-07-31 George R. Lennert Analog heater control for medical instrument
US5526111A (en) * 1993-08-31 1996-06-11 Boehringer Mannheim Corporation Method and apparatus for calculating a coagulation characteristic of a sample of blood a blood fraction or a control
DE69433776T2 (de) * 1993-08-31 2005-05-25 Roche Diagnostics Corp., Indianapolis Reagenz und verfahren für seine anwendung
US5522255A (en) * 1993-08-31 1996-06-04 Boehringer Mannheim Corporation Fluid dose, flow and coagulation sensor for medical instrument
US5478751A (en) * 1993-12-29 1995-12-26 Abbott Laboratories Self-venting immunodiagnositic devices and methods of performing assays
US5582907A (en) * 1994-07-28 1996-12-10 Pall Corporation Melt-blown fibrous web
WO1996003194A1 (en) * 1994-07-28 1996-02-08 Pall Corporation Fibrous web and process of preparing same
GB9416002D0 (en) * 1994-08-08 1994-09-28 Univ Cranfield Fluid transport device
US5504011A (en) * 1994-10-21 1996-04-02 International Technidyne Corporation Portable test apparatus and associated method of performing a blood coagulation test
JP3388060B2 (ja) * 1994-11-25 2003-03-17 日本碍子株式会社 流体の特性測定用素子及び流体の特性測定装置
AU689143B2 (en) * 1994-12-02 1998-03-26 Cardiovascular Diagnostics, Inc. Improved method and analytical system for performing fibrinogen assays accurately, rapidly and simply
US5508521A (en) * 1994-12-05 1996-04-16 Cardiovascular Diagnostics Inc. Method and apparatus for detecting liquid presence on a reflecting surface using modulated light
US5814565A (en) * 1995-02-23 1998-09-29 University Of Utah Research Foundation Integrated optic waveguide immunosensor
DE19512710A1 (de) * 1995-04-10 1996-10-17 Behringwerke Ag Biosensor
DE19523061A1 (de) * 1995-06-24 1997-01-02 Boehringer Mannheim Gmbh Element und System zum Sammeln, Transportieren und Lagern von zu analysierendem Probenmaterial
US20020022261A1 (en) * 1995-06-29 2002-02-21 Anderson Rolfe C. Miniaturized genetic analysis systems and methods
US5863502A (en) * 1996-01-24 1999-01-26 Sarnoff Corporation Parallel reaction cassette and associated devices
US6108463A (en) * 1996-03-19 2000-08-22 University Of Utah Research Foundation Lens and associatable flow cell
US6541213B1 (en) 1996-03-29 2003-04-01 University Of Washington Microscale diffusion immunoassay
US20020090644A1 (en) * 1999-05-21 2002-07-11 Weigl Bernhard H. Microscale diffusion immunoassay
US5942443A (en) * 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
WO1997047481A1 (en) * 1996-06-14 1997-12-18 Minnesota Mining And Manufacturing Company Display unit and methods of displaying an image
CN1173776C (zh) 1996-06-28 2004-11-03 卡钳技术有限公司 在微规模流体性设备里的高通过量的筛选分析系统
US20060000722A1 (en) * 1996-06-28 2006-01-05 Caliper Life Sciences, Inc. High throughput screening assay systems in microscale fluidic devices
US5945345A (en) * 1996-08-27 1999-08-31 Metrika, Inc. Device for preventing assay interference using silver or lead to remove the interferant
US5832165A (en) 1996-08-28 1998-11-03 University Of Utah Research Foundation Composite waveguide for solid phase binding assays
CA2266930C (en) * 1996-09-24 2007-11-27 Case Western Reserve University Device for optical and electrochemical measurements in microliter size samples
US7153651B1 (en) * 1996-10-31 2006-12-26 Inverness Medical - Biostar, Inc. Flow-through optical assay devices providing laminar flow of fluid samples, and methods of construction thereof
US6703247B1 (en) 1996-12-23 2004-03-09 American Registry Of Pathology Apparatus and methods for efficient processing of biological samples on slides
US8293064B2 (en) * 1998-03-02 2012-10-23 Cepheid Method for fabricating a reaction vessel
EP0963545B1 (de) 1997-02-28 2011-05-11 Cepheid Chemischer reaktor mit wärmetauscher und optischem detektor, und reaktionsbehälter
WO1998039643A1 (en) * 1997-03-05 1998-09-11 Diametrics Method and apparatus for measurement of whole blood coagulation parameters
US6052224A (en) * 1997-03-21 2000-04-18 Northern Edge Associates Microscope slide system and method of use
US5910288A (en) * 1997-07-10 1999-06-08 Hewlett-Packard Company Method and apparatus for mixing a thin film of fluid
US6066243A (en) * 1997-07-22 2000-05-23 Diametrics Medical, Inc. Portable immediate response medical analyzer having multiple testing modules
US6061128A (en) * 1997-09-04 2000-05-09 Avocet Medical, Inc. Verification device for optical clinical assay systems
US6222619B1 (en) * 1997-09-18 2001-04-24 University Of Utah Research Foundation Diagnostic device and method
JP2001518624A (ja) * 1997-09-26 2001-10-16 ユニバーシティ・オブ・ワシントン 同時の粒子分離および化学反応
DE19753849A1 (de) * 1997-12-04 1999-06-10 Roche Diagnostics Gmbh Analytisches Testelement mit sich verjüngendem Kapillarkanal
US5908786A (en) * 1997-12-12 1999-06-01 Akzo Nobel, N.V. Blood coagulation monitoring device with liquid crystal and gradient heater
SE9800070D0 (sv) 1998-01-14 1998-01-14 Hemocue Ab Blandningsmetod
SE520341C2 (sv) * 1998-01-14 2003-06-24 Hemocue Ab Metod och förfarande för blandning i ett tunt vätskeskick
US5975153A (en) * 1998-02-13 1999-11-02 Roche Diagnostics Corporation Capillary fill test device with improved fluid delivery
SE9800590D0 (sv) * 1998-02-26 1998-02-26 Global Hemostasis Inst Mgr Ab Determination of polymerization/coagulation in a fluid
US6200531B1 (en) * 1998-05-11 2001-03-13 Igen International, Inc. Apparatus for carrying out electrochemiluminescence test measurements
US6312888B1 (en) 1998-06-10 2001-11-06 Abbott Laboratories Diagnostic assay for a sample of biological fluid
US6165795A (en) * 1998-06-25 2000-12-26 Cardiovascular Diagnostics, Inc. Methods for performing fibrinogen assays using dry chemical reagents containing ecarin and magnetic particles
US6830934B1 (en) 1999-06-15 2004-12-14 Lifescan, Inc. Microdroplet dispensing for a medical diagnostic device
US6084660A (en) * 1998-07-20 2000-07-04 Lifescan, Inc. Initiation of an analytical measurement in blood
US6521182B1 (en) * 1998-07-20 2003-02-18 Lifescan, Inc. Fluidic device for medical diagnostics
WO2000005587A2 (en) * 1998-07-21 2000-02-03 Arcturus Engineering, Inc. Fluidic extraction of microdissected samples
US6132685A (en) 1998-08-10 2000-10-17 Caliper Technologies Corporation High throughput microfluidic systems and methods
US6186659B1 (en) 1998-08-21 2001-02-13 Agilent Technologies Inc. Apparatus and method for mixing a film of fluid
US6482306B1 (en) 1998-09-22 2002-11-19 University Of Washington Meso- and microfluidic continuous flow and stopped flow electroösmotic mixer
US6498497B1 (en) * 1998-10-14 2002-12-24 Caliper Technologies Corp. Microfluidic controller and detector system with self-calibration
US20060216744A1 (en) * 1998-12-23 2006-09-28 American Registry Of Pathology Armed Forces Institute Of Pathology Apparatus and methods for efficient processing of biological samples on slides
WO2000038838A1 (en) * 1998-12-23 2000-07-06 American Registry Of Pathology Apparatus and methods for efficient processing of biological samples on slides
FR2792333B1 (fr) * 1999-04-14 2003-01-24 Labonord Dispositif de depot de cellules sur une plaque d'analyse
US20020019062A1 (en) * 1999-06-18 2002-02-14 Peter Lea Assay devices
US6258593B1 (en) 1999-06-30 2001-07-10 Agilent Technologies Inc. Apparatus for conducting chemical or biochemical reactions on a solid surface within an enclosed chamber
US6645359B1 (en) * 2000-10-06 2003-11-11 Roche Diagnostics Corporation Biosensor
WO2001026813A2 (en) 1999-10-08 2001-04-19 Micronics, Inc. Microfluidics without electrically of mechanically operated pumps
US6136549A (en) * 1999-10-15 2000-10-24 Feistel; Christopher C. systems and methods for performing magnetic chromatography assays
US6319719B1 (en) 1999-10-28 2001-11-20 Roche Diagnostics Corporation Capillary hematocrit separation structure and method
US6629057B2 (en) 1999-11-05 2003-09-30 Beckman Coulter, Inc. Comprehensive verification systems and methods for analyzer-read clinical assays
US6338969B1 (en) * 1999-11-15 2002-01-15 Bayer Corporation Assay test system for regulating temperature
US6458326B1 (en) 1999-11-24 2002-10-01 Home Diagnostics, Inc. Protective test strip platform
JP2001159618A (ja) * 1999-12-03 2001-06-12 Matsushita Electric Ind Co Ltd バイオセンサ
EP1240503B1 (de) 1999-12-24 2018-01-17 Roche Diabetes Care GmbH Teststreifen-analysesystem, medizinischer teststreifen, und verfahren zur analytischen untersuchung einer probe mit hilfe eines teststreifen-analysesystems
FR2803225B1 (fr) * 1999-12-29 2002-06-14 Biomerieux Sa Appareil d'analyse a compartiment reactionnel a geometrie variable, procede de mixage et de guidage de liquides
US6562210B1 (en) * 1999-12-30 2003-05-13 Roche Diagnostics Corporation Cell for electrochemical anaylsis of a sample
DE10002500A1 (de) * 2000-01-21 2001-07-26 Univ Albert Ludwigs Freiburg Kapillarkraftmischer
US6406672B1 (en) 2000-01-28 2002-06-18 Roche Diagnostics Plasma retention structure providing internal flow
US6451264B1 (en) * 2000-01-28 2002-09-17 Roche Diagnostics Corporation Fluid flow control in curved capillary channels
DE10005203A1 (de) * 2000-02-05 2001-08-16 Bayerische Motoren Werke Ag Vermessungsvorrichtung zum Abbilden und Aufzeichnen eines dreidimensionalen Objekts
US6323040B1 (en) * 2000-02-15 2001-11-27 Ryan S. Raz System for biological specimen preparation
US6402704B1 (en) * 2000-04-18 2002-06-11 Sonexxus Incorporated Prothrombin test apparatus for home use
AU2001261020A1 (en) * 2000-05-09 2001-11-20 Pharmanetics Incorporated Platelet function assay and reagent therefor
WO2001089691A2 (en) * 2000-05-24 2001-11-29 Micronics, Inc. Capillaries for fluid movement within microfluidic channels
HK1052219A1 (zh) * 2000-07-31 2003-09-05 Lifescan, Inc. 用於检测测试带上有无流体的方法和装置
WO2002033407A1 (en) * 2000-10-17 2002-04-25 Abbott Laboratories Diagnostic assay for a sample of biological fluid
GB0028647D0 (en) * 2000-11-24 2001-01-10 Nextgen Sciences Ltd Apparatus for chemical assays
US7144495B2 (en) * 2000-12-13 2006-12-05 Lifescan, Inc. Electrochemical test strip with an integrated micro-needle and associated methods
US6620310B1 (en) * 2000-12-13 2003-09-16 Lifescan, Inc. Electrochemical coagulation assay and device
DE60015590T2 (de) * 2000-12-28 2005-11-10 Roche Diagnostics Gmbh Verfahren zur Behandlung von Nukleinsaüreproben mittels Schwingung eines Teiles einer Kartuschenwandung, System und Kartusche zur Durchführung desselben
DE10101576B4 (de) * 2001-01-15 2016-02-18 Presens Precision Sensing Gmbh Optischer Sensor und Sensorfeld
US6525330B2 (en) 2001-02-28 2003-02-25 Home Diagnostics, Inc. Method of strip insertion detection
US6541266B2 (en) 2001-02-28 2003-04-01 Home Diagnostics, Inc. Method for determining concentration of an analyte in a test strip
US6562625B2 (en) 2001-02-28 2003-05-13 Home Diagnostics, Inc. Distinguishing test types through spectral analysis
JP4148778B2 (ja) * 2001-03-09 2008-09-10 バイオミクロ システムズ インコーポレイティッド アレイとのミクロ流体的インターフェース機器
WO2002084291A1 (en) * 2001-04-12 2002-10-24 Arkray, Inc. Specimen analyzing implement
US6759009B2 (en) * 2001-05-04 2004-07-06 Portascience Incorporated Method and device for clotting time assay
US20030211551A1 (en) * 2001-05-09 2003-11-13 Mahan Donald E Platelet function assay and reagent therefor
WO2002093169A1 (en) * 2001-05-17 2002-11-21 Bayer Healthcare Llc Assay test system for regulating temperature
US7473398B2 (en) 2001-05-25 2009-01-06 Roche Diagnostics Operations, Inc. Biosensor
EP1404218A4 (de) * 2001-06-12 2008-11-19 Pelikan Technologies Inc Thermischer sensor für die fluiddetektion
US7402282B2 (en) 2001-07-20 2008-07-22 Ortho-Clinical Diagnostics, Inc. Auxiliary sample supply for a clinical analyzer
EP1413880B1 (de) * 2001-07-27 2015-09-02 ARKRAY, Inc. Analysegerät
US6678542B2 (en) * 2001-08-16 2004-01-13 Optiscan Biomedical Corp. Calibrator configured for use with noninvasive analyte-concentration monitor and employing traditional measurements
DE10140699A1 (de) * 2001-08-24 2003-03-13 Roche Diagnostics Gmbh Anordnung und Verfahren zur Untersuchung der Fließfähigkeit einer physiologischen Flüssigprobe
US6902904B2 (en) 2001-08-27 2005-06-07 Pharmanetics Incorporated Coagulation assay reagents containing lanthanides
FR2829576B1 (fr) * 2001-09-12 2003-10-31 Bio Merieux Procede et dispositif d'isolement et/ou determination d'un analyte
JP2005504317A (ja) 2001-09-28 2005-02-10 イビディ ゲムベーハー フロー・チャンバー
DE10148210B4 (de) * 2001-09-28 2005-09-15 Ibidi Gmbh Flusskammer
DE10151778A1 (de) * 2001-10-19 2003-05-08 Philips Corp Intellectual Pty Verfahren zur Ermittlung der räumlichen Verteilung magnetischer Partikel
US6989891B2 (en) * 2001-11-08 2006-01-24 Optiscan Biomedical Corporation Device and method for in vitro determination of analyte concentrations within body fluids
US7050157B2 (en) * 2001-11-08 2006-05-23 Optiscan Biomedical Corp. Reagent-less whole-blood glucose meter
US6680177B2 (en) * 2001-12-07 2004-01-20 Cardiovascular Diagnostics, Inc. Low molecular weight heparin assay, system and reagent therefor
AU2002359130A1 (en) * 2001-12-21 2003-07-15 Biacore Ab Immobilization of binding agents
WO2003062791A2 (en) 2002-01-18 2003-07-31 University Of Utah Research Foundation Detection of single nucleotide polymorphisms using planar waveguides
US7004928B2 (en) 2002-02-08 2006-02-28 Rosedale Medical, Inc. Autonomous, ambulatory analyte monitor or drug delivery device
JP3892743B2 (ja) * 2002-03-01 2007-03-14 日本碍子株式会社 反応セルおよびその使用方法
US20060134713A1 (en) 2002-03-21 2006-06-22 Lifescan, Inc. Biosensor apparatus and methods of use
EP1495334A4 (de) 2002-03-25 2008-10-08 Farallon Medical Inc System zur durchführung von blutgerinnungstests und zur messung von blutgerinnungszeiten
US7524462B2 (en) * 2002-03-29 2009-04-28 Agilent Technologies, Inc. Capillary flow for a heterogenous assay in a micro-channel environment
ATE309544T1 (de) * 2002-04-09 2005-11-15 Cholestech Corp Verfahren und vorrichtung zur quantifizierung von lipoprotein-cholesterol hoher dichte
WO2003089938A1 (en) * 2002-04-17 2003-10-30 Biosafe Medical Technologies, Inc. Method and device for measurement of hematocrit
DE10219154A1 (de) * 2002-04-29 2003-11-20 Siemens Ag Verfahren zur Überwachung der Verfügbarkeit von Verbindungen in MPLS-Netzen
EP1975628B1 (de) * 2002-04-30 2012-01-25 ARKRAY, Inc. Analyseinstrument
WO2003093836A1 (fr) * 2002-04-30 2003-11-13 Arkray, Inc. Instrument d'analyse, procede d'analyse d'echantillon et dispositif d'analyse utilisant un tel instrument, procede de formation d'ouverture dans l'instrument
US7285425B2 (en) * 2002-05-14 2007-10-23 Siemens Medical Solutions Diagnostics Assay test system for regulating temperature
US6958132B2 (en) * 2002-05-31 2005-10-25 The Regents Of The University Of California Systems and methods for optical actuation of microfluidics based on opto-electrowetting
US7919308B2 (en) * 2002-06-14 2011-04-05 Agilent Technologies, Inc. Form in place gaskets for assays
KR20050013592A (ko) * 2002-06-20 2005-02-04 아이젠인터내셔널인코포레이티드 전기화학발광 유동 셀 및 유동 셀 성분
AUPS309002A0 (en) * 2002-06-20 2002-07-11 Vision Biosystems Limited A covertile for a substrate
US6939450B2 (en) * 2002-10-08 2005-09-06 Abbott Laboratories Device having a flow channel
JP3746756B2 (ja) * 2002-10-22 2006-02-15 株式会社日立製作所 溶液攪拌装置、溶液攪拌方法
US7126676B2 (en) * 2002-11-07 2006-10-24 Frank Anthony Greco Spectral analysis of light scattered from clotting blood
AU2003282351A1 (en) * 2002-11-12 2004-06-03 Inverness Medical Switzerland Gmbh Photometric determination of coagulation time in undiluted whole blood
EP1419818B1 (de) * 2002-11-14 2013-10-30 Boehringer Ingelheim microParts GmbH Vorrichtung zum schrittweisen Transport von Flüssigkeit unter Ausnutzung von Kapillarkräften
US20040101439A1 (en) * 2002-11-21 2004-05-27 Fusco Adam J Biological and chemical reaction devices and methods of manufacture
US7053783B2 (en) 2002-12-18 2006-05-30 Biovigilant Systems, Inc. Pathogen detector system and method
US20040132168A1 (en) * 2003-01-06 2004-07-08 Peter Rule Sample element for reagentless whole blood glucose meter
US6983177B2 (en) * 2003-01-06 2006-01-03 Optiscan Biomedical Corporation Layered spectroscopic sample element with microporous membrane
US20040131088A1 (en) * 2003-01-08 2004-07-08 Adtran, Inc. Shared T1/E1 signaling bit processor
ATE510605T1 (de) 2003-03-14 2011-06-15 Univ Columbia Systeme und verfahren für auf blut basierende therapien mit einer membranlosen mikrofluid- austauschvorrichtung
US20060076295A1 (en) 2004-03-15 2006-04-13 The Trustees Of Columbia University In The City Of New York Systems and methods of blood-based therapies having a microfluidic membraneless exchange device
CA2519628C (en) * 2003-03-24 2020-06-09 Intuity Medical, Inc. Analyte concentration detection devices and methods
AU2004231988B2 (en) * 2003-04-16 2010-04-15 Drexel University Acoustic blood analyzer for assessing blood properties
GB0313015D0 (en) * 2003-06-06 2003-07-09 Hall Effect Technologies Ltd Method and device for analysing a liquid
EP1666136B1 (de) * 2003-07-24 2008-10-15 AOGAKI, Ryoichi Mikroreaktor mit magnetischer barriere
USD530826S1 (en) * 2003-08-12 2006-10-24 Idexx Laboratories, Inc. Chemical reagent test slide
US7588733B2 (en) 2003-12-04 2009-09-15 Idexx Laboratories, Inc. Retaining clip for reagent test slides
KR100639776B1 (ko) * 2004-01-05 2006-10-27 바이오메드포토닉스 주식회사 측방 유동 정량 검정 방법 및 이를 위한 스트립과 레이저유발 표면형광 검출 장치 및 소형 스캐너
ES2614425T3 (es) 2004-01-08 2017-05-31 Dako Denmark A/S Aparato y métodos para el procesamiento de muestras biológicas y un depósito para los mismos
TWI258586B (en) * 2004-01-13 2006-07-21 Neupro Technology Co Ltd Immunochemical detection device
US7422905B2 (en) * 2004-02-27 2008-09-09 Medtronic, Inc. Blood coagulation test cartridge, system, and method
US7439069B2 (en) * 2004-02-27 2008-10-21 Nippoldt Douglas D Blood coagulation test cartridge, system, and method
ATE385572T1 (de) * 2004-03-05 2008-02-15 Egomedical Swiss Ag Analyttestsystem zur bestimmung der konzentration eines analyten in einer physiologischen flüssigkeit
US7399637B2 (en) * 2004-04-19 2008-07-15 Medtronic, Inc. Blood coagulation test cartridge, system, and method
WO2005103663A1 (ja) * 2004-04-23 2005-11-03 Arkray, Inc. 分析用具およびその製造方法
US20050264815A1 (en) * 2004-05-07 2005-12-01 Mark Wechsler Sample element with fringing-reduction capabilities
US20060001551A1 (en) * 2004-06-30 2006-01-05 Ulrich Kraft Analyte monitoring system with wireless alarm
US20060000710A1 (en) * 2004-06-30 2006-01-05 Klaus Peter Weidenhaupt Fluid handling methods
US20060000709A1 (en) * 2004-06-30 2006-01-05 Sebastian Bohm Methods for modulation of flow in a flow pathway
US20060002817A1 (en) * 2004-06-30 2006-01-05 Sebastian Bohm Flow modulation devices
US20060019406A1 (en) * 2004-07-23 2006-01-26 Ning Wei Lateral flow device for the detection of large pathogens
CN100595564C (zh) 2004-07-30 2010-03-24 百维吉伦特系统有限公司 病原体和粒子检测器系统和方法
PT1776464E (pt) 2004-08-13 2010-01-06 Egomedical Technologies Ag Sistema de teste de analitos para determinar a concentração de um analito num fluido fisiológico ou aquoso
DE502004004590D1 (de) * 2004-09-09 2007-09-20 Analyticon Biotechnologies Ag Lateralflussmessvorrichtung und Messverfahren für Analyten
US7550267B2 (en) * 2004-09-23 2009-06-23 University Of Washington Microscale diffusion immunoassay utilizing multivalent reactants
US20060068500A1 (en) * 2004-09-28 2006-03-30 Kimberly-Clark Worldwide, Inc. Detecting yeast infections using a lateral flow assay
US20060078471A1 (en) * 2004-10-12 2006-04-13 Witty Thomas R Apparatus and method for a precision flow assay
ATE391918T1 (de) * 2004-11-25 2008-04-15 Hoffmann La Roche Vorrichtung zum analysieren von proben
US20060134387A1 (en) * 2004-12-20 2006-06-22 William Gottermeier Multilayer article formed by adhesive ablation
AT502915B1 (de) * 2004-12-23 2008-01-15 Hoffmann La Roche Vorrichtung zur thermostatisierung einer messzelle in einem analysator und messzelle, welche in einen analysator austauschbar einsetzbar ist
US20070144976A1 (en) * 2004-12-24 2007-06-28 Matthias Franzreb Micro-reactor
US20070103678A1 (en) * 2005-02-14 2007-05-10 Sterling Bernhard B Analyte detection system with interferent identification and correction
US20060235348A1 (en) * 2005-02-14 2006-10-19 Callicoat David N Method of extracting and analyzing the composition of bodily fluids
US8936755B2 (en) 2005-03-02 2015-01-20 Optiscan Biomedical Corporation Bodily fluid composition analyzer with disposable cassette
JP4586130B2 (ja) * 2005-02-22 2010-11-24 丸石化成株式会社 検体液採取器具
WO2006098804A2 (en) * 2005-03-11 2006-09-21 Chembio Diagnostic Systems, Inc. Dual path immunoassay device
US7189522B2 (en) 2005-03-11 2007-03-13 Chembio Diagnostic Systems, Inc. Dual path immunoassay device
EP1866646A1 (de) * 2005-03-29 2007-12-19 Inverness Medical Switzerland GmbH Hybride vorrichtung
US20100245803A1 (en) * 2005-04-12 2010-09-30 Chromedx Inc. Blood sample holder for spectroscopic analysis
CA2507323A1 (en) * 2005-05-13 2006-11-13 Chromedx Inc. Diagnostic whole blood and plasma apparatus
US8206650B2 (en) * 2005-04-12 2012-06-26 Chromedx Inc. Joint-diagnostic spectroscopic and biosensor meter
US7740804B2 (en) * 2005-04-12 2010-06-22 Chromedx Inc. Spectroscopic sample holder
CA2517299A1 (en) * 2005-08-26 2007-02-26 Chromedx Inc. Hollow needle assembly
JP5590796B2 (ja) 2005-06-03 2014-09-17 ボード・オブ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・テキサス・システム 電気化学および単一ファラデー電極による電気化学発光
US20060281187A1 (en) 2005-06-13 2006-12-14 Rosedale Medical, Inc. Analyte detection devices and methods with hematocrit/volume correction and feedback control
US20080101991A1 (en) * 2005-06-23 2008-05-01 Arkray, Inc. Analysis Tool
EP1907818A4 (de) * 2005-07-15 2012-03-14 Biovigilant Systems Inc Pathogen- und partikeldetektorsystem und -verfahren
WO2007025558A1 (en) * 2005-08-31 2007-03-08 Egomedical Technologies Ag Analyte test system using non-enzymatic analyte recognition elements
AU2005336058A1 (en) * 2005-08-31 2007-03-08 Egomedical Technologies Ag Coagulation test system
US8801631B2 (en) 2005-09-30 2014-08-12 Intuity Medical, Inc. Devices and methods for facilitating fluid transport
WO2007041355A2 (en) 2005-09-30 2007-04-12 Intuity Medical, Inc. Catalysts for body fluid sample extraction
US9561001B2 (en) 2005-10-06 2017-02-07 Optiscan Biomedical Corporation Fluid handling cassette system for body fluid analyzer
US7344893B2 (en) * 2005-10-13 2008-03-18 Auric Enterprises, Llc Immuno-gold lateral flow assay
US8153444B2 (en) * 2005-10-13 2012-04-10 Auric Enterprises, Llc Immuno gold lateral flow assay
US8075852B2 (en) * 2005-11-02 2011-12-13 Affymetrix, Inc. System and method for bubble removal
US9056291B2 (en) 2005-11-30 2015-06-16 Micronics, Inc. Microfluidic reactor system
US7763453B2 (en) 2005-11-30 2010-07-27 Micronics, Inc. Microfluidic mixing and analytic apparatus
JP5175213B2 (ja) * 2005-12-22 2013-04-03 ハネウェル・インターナショナル・インコーポレーテッド 携帯用サンプル分析システム
JP5028804B2 (ja) * 2006-01-19 2012-09-19 ソニー株式会社 機能デバイス
GB2438669A (en) * 2006-03-07 2007-12-05 Inverness Medical Switzerland Sensing apparatus having a pair of coils and an oscillating member
WO2007103568A2 (en) * 2006-03-09 2007-09-13 Biosite, Inc. Methods and compositions for the diagnosis of diseases of the aorta
US20080261261A1 (en) * 2006-03-31 2008-10-23 Kmg2 Sensors Corporation System/unit and method employing a plurality of magnetoelastic sensor elements for automatically quantifying parameters of whole blood and platelet-rich plasma
US7837941B2 (en) 2006-04-07 2010-11-23 Agamatrix, Inc. Method and apparatus for monitoring alteration of flow characteristics in a liquid sample
CN101534917A (zh) 2006-05-22 2009-09-16 纽约市哥伦比亚大学理事会 采用萃取流体排出流过滤的微流无膜交换系统和方法
GB0611701D0 (en) * 2006-06-14 2006-07-26 Biochrom Ltd Analytical apparatus
AU2007265628B2 (en) 2006-06-23 2012-12-06 Revvity Health Sciences, Inc. Methods and devices for microfluidic point-of-care immunoassays
EP2034318B1 (de) 2006-06-26 2013-09-04 Nippon Telegraph and Telephone Corporation Durchflusszelle und verfahren zur herstellung davon
BRPI0714393A2 (pt) * 2006-07-17 2013-03-26 Universal Biosensors Pty Ltd detecÇço eletroquimica da mobilidade das partÍculas magnÉticas
US7749775B2 (en) * 2006-10-03 2010-07-06 Jonathan Scott Maher Immunoassay test device and method of use
US7384798B2 (en) * 2006-10-31 2008-06-10 Hewlett-Packard Development Company, L.P. Method of detecting analytes in a microfluidic sample and a system for performing the same
US20080101986A1 (en) * 2006-10-31 2008-05-01 Selwayan Saini Analytical test strip with electroluminescent module
US20080101987A1 (en) * 2006-10-31 2008-05-01 Selwayan Saini Analytical test strip with electroluminescent lamp
EP2092339B1 (de) * 2006-12-12 2012-05-16 Koninklijke Philips Electronics N.V. Mikroelektronische sensorvorrichtung zum nachweis markierter partikel
WO2008071218A1 (en) * 2006-12-14 2008-06-19 Egomedical Swiss Ag Monitoring device
EP2126587B1 (de) * 2007-01-09 2010-09-29 Cholestech Corporation Vorrichtung und verfahren zur messung des ldl-assoziierten cholesterols
WO2008092470A1 (en) * 2007-01-29 2008-08-07 Egomedical Swiss Ag Resealeable container for storing moisture sensitive test elements
DK2140275T3 (en) * 2007-05-02 2018-04-09 Siemens Healthcare Diagnostics Inc Piezo Dispensing of a Diagnostic Fluid in Microfluidic Devices
EP2140276A1 (de) * 2007-05-02 2010-01-06 Siemens Healthcare Diagnostics Inc. Piezoausgabe einer diagnoseflüssigkeit auf eine reagensoberfläche
US8597190B2 (en) 2007-05-18 2013-12-03 Optiscan Biomedical Corporation Monitoring systems and methods with fast initialization
AU2008293652B2 (en) * 2007-08-24 2013-02-21 Advanced Liquid Logic, Inc. Bead manipulations on a droplet actuator
US8529472B2 (en) * 2007-09-04 2013-09-10 Panasonic Corporation Blood analysis device and blood analysis system using the same
CN101842690B (zh) * 2007-10-29 2013-06-26 皇家飞利浦电子股份有限公司 受抑全内反射生物传感器盒
KR100886914B1 (ko) * 2007-11-01 2009-03-09 주식회사 아이센스 혈액 분석 장치용 카트리지 및 이를 이용한 혈액 분석 장치
WO2009060358A2 (en) * 2007-11-05 2009-05-14 Koninklijke Philips Electronics N. V. Method for detecting redispersion of beads
JP2011504591A (ja) * 2007-11-26 2011-02-10 アトノミックス アクティーゼルスカブ 信号対ノイズ比を増すための手段および方法を備える、統合型分離および検出カートリッジ
US8628976B2 (en) * 2007-12-03 2014-01-14 Azbil BioVigilant, Inc. Method for the detection of biologic particle contamination
EP2249899A4 (de) 2008-02-04 2011-05-11 Univ Columbia Fluidtrennvorrichtungen, -systeme und -verfahren
EP2260300B1 (de) * 2008-03-07 2013-09-25 Advanced Microdevices Pvt Ltd Verfahren und vorrichtung zur partikelentfernung und tröpfchenherstellung für die qualitative und quantitative bioanalyse
SE533103C2 (sv) * 2008-04-01 2010-06-29 Tommy Forsell Blodviskositetsanalys
US9833183B2 (en) 2008-05-30 2017-12-05 Intuity Medical, Inc. Body fluid sampling device—sampling site interface
EP3639744B1 (de) 2008-06-06 2021-11-24 Intuity Medical, Inc. Blutzucker messgerät und methode zur verwendung
WO2009148624A1 (en) 2008-06-06 2009-12-10 Intuity Medical, Inc. Detection meter and mode of operation
US20100022916A1 (en) 2008-07-24 2010-01-28 Javanbakhsh Esfandiari Method and Apparatus for Collecting and Preparing Biological Samples for Testing
JP5461556B2 (ja) * 2008-08-21 2014-04-02 シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレーテッド 尿残渣分析用多層スライド
CN102209898B (zh) * 2008-11-07 2014-08-27 霍夫曼-拉罗奇有限公司 光度反应膜的细粒填充剂
CN102257378B (zh) * 2008-12-18 2015-07-22 皇家飞利浦电子股份有限公司 用于感测流体的感测装置
US8042748B2 (en) 2008-12-19 2011-10-25 Zodiac Pool Systems, Inc. Surface disruptor for laminar jet fountain
US8177141B2 (en) * 2008-12-19 2012-05-15 Zodiac Pool Systems, Inc. Laminar deck jet
US8448499B2 (en) 2008-12-23 2013-05-28 C A Casyso Ag Cartridge device for a measuring system for measuring viscoelastic characteristics of a sample liquid, a corresponding measuring system, and a corresponding method
US8331751B2 (en) * 2009-03-02 2012-12-11 mBio Diagnositcs, Inc. Planar optical waveguide with core of low-index-of-refraction interrogation medium
US9658222B2 (en) 2009-03-02 2017-05-23 Mbio Diagnostics, Inc. Planar waveguide based cartridges and associated methods for detecting target analyte
US9212995B2 (en) 2009-03-02 2015-12-15 Mbio Diagnostics, Inc. System and method for detecting multiple molecules in one assay
US8586347B2 (en) 2010-09-15 2013-11-19 Mbio Diagnostics, Inc. System and method for detecting multiple molecules in one assay
US8300993B2 (en) * 2009-03-02 2012-10-30 Mbio Diagnostics, Inc. Waveguide with integrated lens
BRPI1014469A2 (pt) 2009-04-14 2017-06-27 Biocartis Sa cavitação induzida hifu com limiar de energia reduzido
KR20120030361A (ko) 2009-04-15 2012-03-28 비오까르띠 에스아 바이오분석 샘플 챔버의 보호
EP2419743B1 (de) 2009-04-15 2020-08-05 Biocartis NV OPTISCHES ERKENNUNGSSYSTEM ZUR ÜBERWACHUNG DER rtPCR-REAKTION
JP5816613B2 (ja) * 2009-04-23 2015-11-18 ダブリン シティ ユニバーシティ 凝固をモニタするための側方流動分析装置及びその方法
WO2010127464A1 (en) 2009-05-06 2010-11-11 Biocartis Sa Device for cutting a sample carrier
DE112010002222B4 (de) 2009-06-04 2024-01-25 Leidos Innovations Technology, Inc. (n.d.Ges.d. Staates Delaware) Mehr-Proben-Mikrofluidchip fur DNA-Analyse
US9554742B2 (en) 2009-07-20 2017-01-31 Optiscan Biomedical Corporation Fluid analysis system
US8731638B2 (en) 2009-07-20 2014-05-20 Optiscan Biomedical Corporation Adjustable connector and dead space reduction
US20120192952A1 (en) * 2009-07-20 2012-08-02 Monash University Three-dimensional microfluidic systems
JPWO2011049044A1 (ja) * 2009-10-19 2013-03-14 国立大学法人東京工業大学 磁性微粒子を用いるバイオセンサ
US9498791B2 (en) 2009-11-13 2016-11-22 Ventana Medical Systems, Inc. Opposables and automated specimen processing systems with opposables
US10746752B2 (en) 2009-11-13 2020-08-18 Ventana Medical Systems, Inc. Opposables and automated specimen processing systems with opposables
JP5611363B2 (ja) 2009-11-13 2014-10-22 ベンタナ メディカル システムズ, インコーポレイテッド 調整可能な体積を収容する薄膜処理装置
US8919605B2 (en) 2009-11-30 2014-12-30 Intuity Medical, Inc. Calibration material delivery devices and methods
EP2513637B1 (de) * 2009-12-18 2020-07-15 Koninklijke Philips N.V. Apparat zur bestimmung einer substanz
CA2786569C (en) 2010-01-29 2019-04-09 Perkinelmer Health Sciences, Inc. Sample-to-answer microfluidic cartridge
DK2555704T3 (da) 2010-04-08 2019-08-05 Hemosonics Llc Visning af hæmostatiske parametre
EP3156796A1 (de) 2010-06-09 2017-04-19 Optiscan Biomedical Corporation Messung von analyten in einer flüssigkeitsprobe aus einem patienten
US10330667B2 (en) 2010-06-25 2019-06-25 Intuity Medical, Inc. Analyte monitoring methods and systems
WO2012001127A1 (en) 2010-06-30 2012-01-05 Csem Centre Suisse D'electronique Et De Microtechnique Sa Recherche Et Developpement Pipette tip, pipette system and method for performing analysis with the pipette tip and system
WO2012004735A1 (en) * 2010-07-09 2012-01-12 Koninklijke Philips Electronics N.V. Cartridge with large-scale manufacturing design
US11402375B2 (en) 2010-08-05 2022-08-02 Abbott Point Of Care Inc. Magnetic immunosensor with trench configuration and method of use
WO2012019107A1 (en) 2010-08-05 2012-02-09 Abbott Point Of Care Inc. Magnetic immunosensor and method of use
CN103118785B (zh) 2010-08-05 2015-11-25 雅培医护站股份有限公司 使用易感磁微珠捕获的免疫测定方法和装置
WO2012019109A1 (en) * 2010-08-05 2012-02-09 Abbott Point Of Care Inc. Oscillating immunoassay method and device
GB201014316D0 (en) 2010-08-27 2010-10-13 Univ Dublin City A agglutination assay method and device
EP2624955A1 (de) * 2010-10-07 2013-08-14 BOEHRINGER INGELHEIM microParts GmbH Mikrofluidische plattform
GB2497501A (en) 2010-10-15 2013-06-12 Lockheed Corp Micro fluidic optic design
US9522396B2 (en) 2010-12-29 2016-12-20 S.D. Sight Diagnostics Ltd. Apparatus and method for automatic detection of pathogens
US8603835B2 (en) * 2011-02-10 2013-12-10 Chembio Diagnostic Systems, Inc. Reduced step dual path immunoassay device and method
BR112013020675B1 (pt) 2011-02-15 2022-01-25 Hemosonics, Llc Dispositivos e método para avaliação de hemostasia
JP6019485B2 (ja) * 2011-03-24 2016-11-02 ベーリンガー インゲルハイム マイクロパーツ ゲゼルシャフト ミット ベシュレンクテル ハフツングBoehringer Ingelheim microParts GmbH 血液濾過器具及び方法
WO2012159021A2 (en) 2011-05-19 2012-11-22 Hemosonics, Llc Portable hemostasis analyzer
MX2013014553A (es) * 2011-06-30 2014-02-19 Koninkl Philips Nv Examenes multiples de una muestra.
WO2013006716A1 (en) 2011-07-06 2013-01-10 Optiscan Biomedical Corporation Sample cell for fluid analysis system
USD698926S1 (en) * 2011-07-14 2014-02-04 Verathon Inc. Electrical connector tab
WO2013020103A1 (en) 2011-08-03 2013-02-07 Intuity Medical, Inc. Devices and methods for body fluid sampling and analysis
JP6190822B2 (ja) 2012-01-09 2017-08-30 マイクロニクス, インコーポレイテッド マイクロ流体リアクタシステム
US9588113B2 (en) 2012-02-22 2017-03-07 Church & Dwight Co., Inc. Methods for electronic analyte assaying
US9322054B2 (en) 2012-02-22 2016-04-26 Lockheed Martin Corporation Microfluidic cartridge
EP2926115B1 (de) 2012-11-30 2021-05-26 The University of North Carolina At Chapel Hill Verfahren und systeme zur bestimmung der physikalischer eigenschaften einer probe in einer tragbaren point-of-care-diagnosevorrichtung
JP6498125B2 (ja) 2012-12-21 2019-04-10 マイクロニクス, インコーポレイテッド 流体回路および関連する製造方法
KR20150096788A (ko) 2012-12-21 2015-08-25 마이크로닉스 인코포레이티드. 마이크로 유체공학 용도를 위한 저탄성 막
CN104919035B (zh) 2012-12-21 2017-08-11 精密公司 便携式荧光检测系统和微测定盒
US10802017B2 (en) 2013-02-22 2020-10-13 Hitachi High-Tech Corporation Bioanalysis device and biomolecule analyzer
USD728120S1 (en) 2013-03-15 2015-04-28 Ventana Medical Systems, Inc. Arcuate member for moving liquids along a microscope slide
EP2994543B1 (de) 2013-05-07 2018-08-15 Micronics, Inc. Vorrichtung zur herstellung und analyse von nukleinsäuren
WO2014182844A1 (en) 2013-05-07 2014-11-13 Micronics, Inc. Microfluidic devices and methods for performing serum separation and blood cross-matching
CA2911303C (en) 2013-05-07 2021-02-16 Micronics, Inc. Methods for preparation of nucleic acid-containing samples using clay minerals and alkaline solutions
EP2999988A4 (de) 2013-05-23 2017-01-11 S.D. Sight Diagnostics Ltd. Verfahren und system zur bildgebung einer zellprobe
US10729386B2 (en) 2013-06-21 2020-08-04 Intuity Medical, Inc. Analyte monitoring system with audible feedback
IL227276A0 (en) 2013-07-01 2014-03-06 Parasight Ltd A method and system for preparing a monolayer of cells, particularly suitable for diagnosis
US10082500B2 (en) 2013-08-22 2018-09-25 Franz Baudenbacher Device and method for detecting a target analyte
US10831013B2 (en) 2013-08-26 2020-11-10 S.D. Sight Diagnostics Ltd. Digital microscopy systems, methods and computer program products
KR20150039051A (ko) * 2013-10-01 2015-04-09 삼성전자주식회사 혈액으로부터 혈장 또는 혈청을 분리하는 혈액 필터 장치 및 그의 용도
WO2015095239A1 (en) 2013-12-18 2015-06-25 Optiscan Biomedical Corporation Systems and methods for detecting leaks
SG11201608278WA (en) 2014-04-02 2016-10-28 Chembio Diagnostic Systems Inc Immunoassay utilizing trapping conjugate
EP3594360B1 (de) 2014-04-24 2021-06-23 Lucira Health, Inc. Kolorimetrische detektion von nukleinsäureamplifikation
US10073091B2 (en) * 2014-08-08 2018-09-11 Ortho-Clinical Diagnostics, Inc. Lateral flow assay device
US10482595B2 (en) 2014-08-27 2019-11-19 S.D. Sight Diagnostics Ltd. System and method for calculating focus variation for a digital microscope
US10175225B2 (en) 2014-09-29 2019-01-08 C A Casyso Ag Blood testing system and method
US10539579B2 (en) 2014-09-29 2020-01-21 C A Casyso Gmbh Blood testing system and method
US10816559B2 (en) 2014-09-29 2020-10-27 Ca Casyso Ag Blood testing system and method
US20160116466A1 (en) 2014-10-27 2016-04-28 Chembio Diagnostic Systems, Inc. Rapid Screening Assay for Qualitative Detection of Multiple Febrile Illnesses
AU2016322966B2 (en) 2015-09-17 2021-10-14 S.D. Sight Diagnostics Ltd Methods and apparatus for detecting an entity in a bodily sample
CN105628747B (zh) * 2015-12-18 2019-03-22 上海奥普生物医药有限公司 凝血时间测试分析装置及其测试分析方法
CA3214851A1 (en) 2016-03-14 2017-09-21 Lucira Health, Inc. Devices and methods for biological assay sample preparation and delivery
EP3429752A4 (de) 2016-03-14 2019-10-30 Lucira Health, Inc. Systeme und verfahren zur durchführung von biologischen tests
DK3430378T3 (da) 2016-03-14 2022-10-24 Lucira Health Inc Indretninger og fremgangsmåder til modifikation af optiske egenskaber
EP4477316A3 (de) 2016-03-14 2025-02-19 Pfizer Inc. Selektiv belüftete biologische testvorrichtungen und zugehörige verfahren
US11733150B2 (en) 2016-03-30 2023-08-22 S.D. Sight Diagnostics Ltd. Distinguishing between blood sample components
US11307196B2 (en) 2016-05-11 2022-04-19 S.D. Sight Diagnostics Ltd. Sample carrier for optical measurements
EP3455626B1 (de) 2016-05-11 2025-08-06 S.D. Sight Diagnostics Ltd. Durchführung optischer messungen auf einer probe
KR101865055B1 (ko) * 2016-09-02 2018-06-08 (주)지엠에스바이오 혈당 측정용 스트립
US10172401B1 (en) * 2016-12-17 2019-01-08 Simple Texan Llc Backing plate for magnetic attachment
JP6941939B2 (ja) * 2016-12-22 2021-09-29 リンテック株式会社 検査部材、および検査部材の製造方法
US11080848B2 (en) 2017-04-06 2021-08-03 Lucira Health, Inc. Image-based disease diagnostics using a mobile device
JP7432500B2 (ja) 2017-04-20 2024-02-16 ヘモソニックス エル・エル・シー 止血機能の分析のための使い捨てシステム
CN113777011B (zh) 2017-09-14 2024-11-19 辉瑞公司 具有电子读出的复用生物测定装置
US10549275B2 (en) 2017-09-14 2020-02-04 Lucira Health, Inc. Multiplexed biological assay device with electronic readout
AU2018369859B2 (en) 2017-11-14 2024-01-25 S.D. Sight Diagnostics Ltd Sample carrier for optical measurements
GB2569344A (en) * 2017-12-14 2019-06-19 Randox Laboratories Ltd Fluidic card assembly
USD910200S1 (en) 2018-12-21 2021-02-09 Lucira Health, Inc. Test tube
CN112834763B (zh) * 2019-11-22 2025-03-25 京东方科技集团股份有限公司 检测芯片及检测系统
CN110681297B (zh) * 2019-11-25 2023-05-30 徐州蓝湖信息科技有限公司 一种化工试剂制备扩散加速器
WO2021195120A1 (en) * 2020-03-24 2021-09-30 In Diagnostics, Inc. Clinical spectrophotometer for general chemistry, immuno-assay and nucleic acid detection
WO2021216764A1 (en) * 2020-04-24 2021-10-28 Leavitt Medical, Inc. D/B/A Lumea Focal plane spacers for microscope slides and related systems and methods
USD953561S1 (en) 2020-05-05 2022-05-31 Lucira Health, Inc. Diagnostic device with LED display
USD962470S1 (en) 2020-06-03 2022-08-30 Lucira Health, Inc. Assay device with LCD display
US11554371B2 (en) * 2020-12-30 2023-01-17 International Business Machines Corporation Precise fluid input control for point-of-care devices
WO2022202262A1 (ja) * 2021-03-24 2022-09-29 富士フイルム株式会社 カートリッジ及びイムノクロマトグラフ検査装置
KR102674118B1 (ko) * 2021-07-08 2024-06-12 (주)옵토레인 Pcr 모듈
GB2622895B (en) * 2022-12-23 2025-01-22 Flexotronix Ltd Housing

Family Cites Families (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US27866A (en) * 1860-04-10 Improved mode of securing metal hoops on cotton-bales
US2616796A (en) * 1950-11-25 1952-11-04 Fred J Schilling Apparatus for determining a coagulation factor of blood samples
US3233975A (en) * 1962-03-05 1966-02-08 Ames Lab Tek Inc Prothrombin reaction chamber
GB1088421A (en) * 1964-01-07 1967-10-25 Harshaw Chemicals Ltd A method and apparatus for depositing a coating on the internal walls of capillary or smallbore tubes
US3395210A (en) * 1964-02-07 1968-07-30 Warner Lambert Pharmaceutical Lyophilized diagnostic reagent for the determination of blood coagulation factors
DE1617732C2 (de) * 1966-03-01 1972-12-21 Promoveo-Sobioda & Cie, Seyssinet (Frankreich) Vorrichtung zur Untersuchung lebender Zellen von Mikroorganismen
US3450501A (en) * 1966-03-28 1969-06-17 Bruce J Oberhardt Prothrombin time determination
US3520659A (en) * 1967-10-20 1970-07-14 Xerox Corp Method and apparatus for use in determining prothrombin time of a blood sample
US3635678A (en) * 1969-06-13 1972-01-18 Baxter Laboratories Inc Clot-timing system and method
BE759811A (fr) * 1969-12-04 1971-06-03 Technicon Instr Appareil de determination automatique des vitesses de coagulation, agglutination ou floculation de liquides, et agent renforcateur de reactionutilisable avec cet appareil
US3695842A (en) * 1970-03-12 1972-10-03 Intern Technidyne Corp Method and system for analyzing a liquid
US3691017A (en) * 1970-05-06 1972-09-12 Worthington Bio Chem Corp Means and method for chemical analysis
US3672351A (en) * 1970-08-17 1972-06-27 Richard W Ubersax Disposable blood test device
BE792113A (fr) * 1971-12-13 1973-05-30 Technicon Instr Melangeur de liquides contenant des particules magnetiques
US3861197A (en) * 1973-06-29 1975-01-21 Technicon Instr Method and apparatus for determining the viscosity of a liquid sample
US3880714A (en) * 1973-07-18 1975-04-29 Warner Lambert Co Diagnostic reagent
SE380100B (de) * 1974-02-07 1975-10-27 Monega Anstalt
US3918908A (en) * 1974-05-17 1975-11-11 Geomet Method for prothrombin testing
SE399768B (sv) * 1975-09-29 1978-02-27 Lilja Jan E Kyvett for provtagning, blandning av, provet med ett reagensmedel och direkt utforande av, serskilt optisk, analys av det med reagensmedlet blandade provet
US4097237A (en) * 1977-03-04 1978-06-27 Technicon Instruments Corporation Determination of cells in blood
US4176973A (en) * 1977-07-29 1979-12-04 Gregory Stephen A Stenotype tape marking attachment
JPS5469497A (en) * 1977-11-12 1979-06-04 Kyoto Daiichi Kagaku Kk Method and device for measuring blood solidification time
US4344438A (en) * 1978-08-02 1982-08-17 The United States Of America As Represented By The Department Of Health, Education And Welfare Optical sensor of plasma constituents
US4233029A (en) * 1978-10-25 1980-11-11 Eastman Kodak Company Liquid transport device and method
US4302313A (en) * 1979-07-23 1981-11-24 Eastman Kodak Company Electrode-containing device with capillary transport between electrodes
US4310399A (en) * 1979-07-23 1982-01-12 Eastman Kodak Company Liquid transport device containing means for delaying capillary flow
US4321057A (en) * 1979-09-20 1982-03-23 Buckles Richard G Method for quantitative analysis using optical fibers
US4323536A (en) * 1980-02-06 1982-04-06 Eastman Kodak Company Multi-analyte test device
US4413407A (en) * 1980-03-10 1983-11-08 Eastman Kodak Company Method for forming an electrode-containing device with capillary transport between electrodes
DE3029579C2 (de) * 1980-08-05 1985-12-12 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren und Mittel zur Abtrennung von Plasma oder Serum aus Vollblut
US4366241A (en) * 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
US4426451A (en) * 1981-01-28 1984-01-17 Eastman Kodak Company Multi-zoned reaction vessel having pressure-actuatable control means between zones
US4391905A (en) * 1981-02-12 1983-07-05 Miles Laboratories, Inc. System for the determination of glucose in fluids
US4340669A (en) * 1981-02-12 1982-07-20 Miles Laboratories, Inc. System for the determination of glucose in fluids
US4391906A (en) * 1981-02-12 1983-07-05 Miles Laboratories, Inc. System for the determination of glucose in fluids
US4473457A (en) * 1982-03-29 1984-09-25 Eastman Kodak Company Liquid transport device providing diversion of capillary flow into a non-vented second zone
DE3233809A1 (de) * 1982-09-11 1984-03-15 Boehringer Mannheim Gmbh, 6800 Mannheim Kuevette zur bestimmung chemischer verbindungen in fluessigkeiten
DE3247608A1 (de) * 1982-12-23 1984-07-05 Boehringer Mannheim Gmbh, 6800 Mannheim Teststreifen
US4558014A (en) * 1983-06-13 1985-12-10 Myron J. Block Assay apparatus and methods
CA1237074A (en) * 1983-12-02 1988-05-24 Vertrik Bioteknik Ab Device for chemical analyses and use thereof
US4654127A (en) * 1984-04-11 1987-03-31 Sentech Medical Corporation Self-calibrating single-use sensing device for clinical chemistry and method of use
AU588245B2 (en) * 1984-06-13 1989-09-14 Inverness Medical Switzerland Gmbh Devices for use in chemical test procedures
US4596695A (en) * 1984-09-10 1986-06-24 Cottingham Hugh V Agglutinographic reaction chamber
US4826759A (en) * 1984-10-04 1989-05-02 Bio-Metric Systems, Inc. Field assay for ligands
US4678757A (en) * 1985-04-11 1987-07-07 Smithkline Diagnostics, Inc. Device and method for whole blood separation and analysis
FR2580407B1 (fr) * 1985-04-11 1987-06-26 Vieillard Didier Procede et appareil pour la mesure de la coagulation du plasma sanguin
DE3523439A1 (de) * 1985-06-29 1987-01-08 Boehringer Mannheim Gmbh Testtraeger
DE3523969A1 (de) * 1985-07-04 1987-01-08 Boehringer Mannheim Gmbh Gerinnungsneutrale, hydrophile glasfasern
US4756884A (en) * 1985-08-05 1988-07-12 Biotrack, Inc. Capillary flow device
US4963498A (en) * 1985-08-05 1990-10-16 Biotrack Capillary flow device
US4682895A (en) * 1985-08-06 1987-07-28 Texas A&M University Fiber optic probe for quantification of colorimetric reactions
US4761381A (en) * 1985-09-18 1988-08-02 Miles Inc. Volume metering capillary gap device for applying a liquid sample onto a reactive surface
US4712460A (en) * 1985-11-18 1987-12-15 Biotrack, Inc. Integrated drug dosage form and metering system
DE3616496A1 (de) * 1986-05-16 1987-11-19 Boehringer Mannheim Gmbh Analyseelement zur bestimmung von gerinnungsparametern
US4731330A (en) * 1986-07-01 1988-03-15 Biotrack, Inc. Whole blood control sample
US4753776A (en) * 1986-10-29 1988-06-28 Biotrack, Inc. Blood separation device comprising a filter and a capillary flow pathway exiting the filter
US4789629A (en) * 1986-11-24 1988-12-06 Smithkline Beckman Corporation Method and device for collecting and testing for fecal occult blood
US4849340A (en) * 1987-04-03 1989-07-18 Cardiovascular Diagnostics, Inc. Reaction system element and method for performing prothrombin time assay
US4912034A (en) * 1987-09-21 1990-03-27 Biogenex Laboratories Immunoassay test device and method
US4999163A (en) * 1987-10-29 1991-03-12 Hygeia Sciences, Inc. Disposable, pre-packaged device for conducting immunoassay procedures
US4818677A (en) * 1987-12-03 1989-04-04 Monoclonal Antibodies, Inc. Membrane assay using focused sample application

Also Published As

Publication number Publication date
DE3853457D1 (de) 1995-05-04
EP0308494A1 (de) 1989-03-29
JP2736091B2 (ja) 1998-04-02
EP0308494B1 (de) 1995-03-29
US20020119486A1 (en) 2002-08-29
CA1310566C (en) 1992-11-24
DE3853457T2 (de) 1995-10-26
AU613623B2 (en) 1991-08-08
WO1988007666A1 (en) 1988-10-06
US6197494B1 (en) 2001-03-06
EP0308494A4 (de) 1990-07-04
AU1591888A (en) 1988-11-02
US4849340A (en) 1989-07-18
US5658723A (en) 1997-08-19
JPH01502797A (ja) 1989-09-28

Similar Documents

Publication Publication Date Title
ATE120543T1 (de) Vorrichtung und verfahren zur genauen, schnellen und einfachen durchführung eines prothrombin tests.
IT1068124B (it) Vaschetta di campionatura per analisi chimiche
DE69507019D1 (de) Speicheltestverfahren und vorrichtung
ES433418A1 (es) Un sistema de ensayos para la determinacion de constituyen-tes quimicos en un fluido.
ATE31822T1 (de) Testvorrichtung.
DE69429770D1 (de) Verfahren und analytisches system zur genauen schnellen und einfachen ausführung von fibrinogen-assays
ATE55833T1 (de) Vorrichtung zum analysieren einer fluessigen probe.
GB1494232A (en) Method of preparing measuring liquids
ES2128321T3 (es) Ensayos de fibrinogeno que usan reactivos quimicos que contienen particulas magneticas.
DE60112017D1 (de) Verfahren, Reagenz, Messkartusche und Vorrichtung zur Fibrinogenbestimmung
ATE75041T1 (de) Verfahren und vorrichtung zur messung des reaktionsgrades zwischen antigenen und zellleukozytenantik¯rpern.
JPS5748658A (en) Immunologic measuring method and reagent for measurement
ES540545A0 (es) Un metodo para la preparacion de un instrumento de ensayo para determinar la presencia de un ion en una muestra acuosaa ensayar
ES481441A1 (es) Un metodo de una sola inmersion, para la preparacion de un dispositivo de ensayo, para determinar la presencia de urobilinogeno.
FR2303290A1 (fr) Detecteur a reactif, son procede de preparation et son application a l'analyse chimique et biochimique
FR2319903A1 (fr) Procede et appareillage pour effectuer des analyses chimiques et cliniques
NL7512875A (en) Rapid measurement of coagulation rates - using uniform bore reaction tube contg. lyophilised reagents to which blood sample is added
IT1086777B (it) Procedimento per la preparazione di soluzioni titolate

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties