ATE121387T1 - Homologierte vitamin-d2-verbindungen und korrespondierende 1alpha-hydroxylierte verbindungen. - Google Patents

Homologierte vitamin-d2-verbindungen und korrespondierende 1alpha-hydroxylierte verbindungen.

Info

Publication number: ATE121387T1
Authority: AT; Austria
Prior art keywords: compounds; vitamin; hydroxylated; homologate; 1alpha
Prior art date: 1990-02-14

Application number

AT91905084T

Other languages

English (en)

Inventor

Hector Floyd Deluca

Heinrich Konstantine Schnoes

Kato Leonard Perlman

Original Assignee

Wisconsin Alumni Res Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-02-14

Filing date

1991-02-13

Publication date

1995-05-15

1991-02-13 Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found

1995-05-15 Application granted granted Critical

1995-05-15 Publication of ATE121387T1 publication Critical patent/ATE121387T1/de

Links

150000001875 compounds Chemical class 0.000 title abstract 2
MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical class C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 abstract 2
150000003703 vitamin D2 derivatives Chemical class 0.000 abstract 2
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
MECHNRXZTMCUDQ-UHFFFAOYSA-N Vitamin D2 Natural products C1CCC2(C)C(C(C)C=CC(C)C(C)C)CCC2C1=CC=C1CC(O)CCC1=C MECHNRXZTMCUDQ-UHFFFAOYSA-N 0.000 abstract 1
229910052791 calcium Inorganic materials 0.000 abstract 1
239000011575 calcium Substances 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
229960002061 ergocalciferol Drugs 0.000 abstract 1
BHEPBYXIRTUNPN-UHFFFAOYSA-N hydridophosphorus(.) (triplet) Chemical compound [PH] BHEPBYXIRTUNPN-UHFFFAOYSA-N 0.000 abstract 1
235000001892 vitamin D2 Nutrition 0.000 abstract 1
239000011653 vitamin D2 Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0036—Nitrogen-containing hetero ring
- C07J71/0042—Nitrogen only
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
- A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Hematology (AREA)
Obesity (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT91905084T 1990-02-14 1991-02-13 Homologierte vitamin-d2-verbindungen und korrespondierende 1alpha-hydroxylierte verbindungen. ATE121387T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/481,990 US5030772A (en)	1990-02-14	1990-02-14	Process for preparing vitamin D2 compounds and the corresponding 1 α-hydroxylated derivatives

Publications (1)

Publication Number	Publication Date
ATE121387T1 true ATE121387T1 (de)	1995-05-15

Family

ID=23914203

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91905084T ATE121387T1 (de)	1990-02-14	1991-02-13	Homologierte vitamin-d2-verbindungen und korrespondierende 1alpha-hydroxylierte verbindungen.

Country Status (7)

Country	Link
US (1)	US5030772A (de)
EP (1)	EP0468042B1 (de)
JP (1)	JP2731839B2 (de)
AT (1)	ATE121387T1 (de)
DE (1)	DE69109006T2 (de)
ES (1)	ES2071303T3 (de)
WO (1)	WO1991012239A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3933034A1 (de) *	1989-10-02	1991-04-11	Schering Ag	24-homo-vitamin-d-derivate, verfahren zu ihrer herstellung
AU656829B2 (en) *	1991-12-26	1995-02-16	Wisconsin Alumni Research Foundation	26, 27-dimethylene-1 alpha, 25-dihydroxyvitamin D2 and 26,27-dihydroxyvitamin D2 and methods for preparing same
US5716946A (en) *	1996-02-13	1998-02-10	Wisconsin Alumni Research Foundation	Multiple sclerosis treatment
JP2002516306A (ja) *	1998-05-29	2002-06-04	ボーンケアインターナショナルインコーポレイテッド	ヒドロキシ−２５−エン−ビタミンｄ化合物の製造方法
US6479474B2 (en)	1999-07-08	2002-11-12	Wisconsin Alumni Research Foundation	Dietary calcium as a supplement to vitamin D compound treatment of multiple sclerosis
US7094775B2 (en)	2004-06-30	2006-08-22	Bone Care International, Llc	Method of treating breast cancer using a combination of vitamin D analogues and other agents
US20060003950A1 (en) *	2004-06-30	2006-01-05	Bone Care International, Inc.	Method of treating prostatic diseases using a combination of vitamin D analogues and other agents
CA2586679A1 (en)	2004-11-12	2006-05-18	Bioxell Spa	Combined use of vitamin d derivatives and anti-proliferative agents for treating bladder cancer
US7745226B2 (en)	2005-04-06	2010-06-29	Quest Diagnostics Investments Incorporated	Methods for detecting vitamin D metabolites
US7972868B2 (en)	2007-11-28	2011-07-05	Quest Diagnostics Investments Incorporated	Methods for detecting dihydroxyvitamin D metabolites by mass spectrometry
SG173119A1 (en) *	2009-01-27	2011-08-29	Berg Biosystems Llc	Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy
MX366076B (es)	2009-08-14	2019-06-27	Berg Llc	Vitamina d3 y analogos de la misma para tratar alopecia.
US7977117B2 (en)	2009-12-03	2011-07-12	Quest Diagnostics Investments Incorprated	Vitamin D metabolite determination utilizing mass spectrometry following derivatization
CN102753964A (zh)	2009-12-11	2012-10-24	奎斯特诊断投资公司	非衍生的、非代谢的维生素d的质谱测定
JP5739903B2 (ja)	2009-12-11	2015-06-24	クエストダイアグノスティックスインヴェストメンツインコーポレイテッド	複合試料中のステロイド化合物の質量分析
SG10201709894RA (en)	2013-05-29	2018-01-30	Berg Llc	Preventing or mitigating chemotherapy induced alopecia using vitamin d

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3585221A (en) *	1969-03-24	1971-06-15	Wisconsin Alumni Res Found	25-hydroxyergocalciferol
US3880894A (en) *	1974-05-24	1975-04-29	Wisconsin Alumni Res Found	1,25-Dihydroxyergocalciferol
JPS51108046A (en) *	1975-03-17	1976-09-25	Teijin Ltd	1 arufua * 24 * r * *255 torihidorokishikorekarushifuerooruno seizoho
JPS51108048A (en) *	1975-03-17	1976-09-25	Teijin Ltd	1 arufua * 24 * s * *255 torihidokishikorekarushifuerooruno seizoho
JPS51108049A (en) *	1975-03-17	1976-09-25	Teijin Ltd	1 arufua * 24 * s * *255 torihidorokishikorekarushifuerooruno seizoho
US4260549A (en) *	1979-05-21	1981-04-07	Wisconsin Alumni Research Foundation	Process for preparing 1α-hydroxylated compounds
US4226787A (en) *	1978-07-26	1980-10-07	Wisconsin Alumni Research Foundation	Fluorovitamin D compounds and processes for their preparation
US4448721A (en) *	1982-09-20	1984-05-15	Wisconsin Alumni Research Foundation	Hydroxyvitamin D2 compounds and process for preparing same
FR2545824B1 (fr) *	1983-05-09	1987-11-20	Wisconsin Alumni Res Found	Derive 1a, 25-dihydroxyles de la vitamine d2 et produits intermediaires pour leur preparation et compositions pharmaceutiques renfermant ces derives
US4769181A (en) *	1983-11-07	1988-09-06	Wisconsin Alumni Research Foundation	1,25-dihydroxyvitamin D2 compounds
DE3590080C2 (de) *	1984-03-05	1992-08-06	Wisconsin Alumni Research Foundation, Madison, Wis., Us
US4588528A (en) *	1984-05-31	1986-05-13	Wisconsin Alumni Research Foundation	1,24-dihydroxy-Δ22 -vitamin D3 and process for preparing same
JPS62500301A (ja) *	1984-10-04	1987-02-05	ウイスコンシン　アラムナイ　リサ−チ　フオンデ−シヨン	２４―ホモビタミンｄ誘導体
US4554106A (en) *	1984-11-01	1985-11-19	Wisconsin Alumni Research Foundation	Method for preparing 1α-hydroxyvitamin D compounds
EP0211863B1 (de) *	1985-01-17	1992-12-30	Wisconsin Alumni Research Foundation	Vitamin-d-abkömmlinge und deren herstellungsverfahren
JPS62501505A (ja) *	1985-01-17	1987-06-18	ウイスコンシン　アラムナイ　リサ−チ　フオンデ−シヨン	ビタミンｄ誘導体
US5206229A (en) *	1988-04-21	1993-04-27	Leo Pharmaceutical Products Ltd	Vitamin d analogues
US4847012A (en) *	1988-04-29	1989-07-11	Wisconsin Alumni Research Foundation	Vitamin D related compounds and processes for their preparation
KR940003360B1 (ko) *	1988-04-29	1994-04-21	위스콘신 알럼나이 리써취 파운데이션	불포화 측쇄를 갖는 1α-히드록시비타민 D동족체
US4973584A (en) *	1989-03-09	1990-11-27	Deluca Hector F	Novel 1α-hydroxyvitamin D2 epimer and derivatives
DK0402982T3 (da) *	1989-06-15	1994-02-14	Duphar Int Res	Adductaldehyd og dets anvendelse til fremstilling af vitamin-D-forbindelser
GB8914963D0 (en) *	1989-06-29	1989-08-23	Leo Pharm Prod Ltd	Chemical compounds
DE3933034A1 (de) *	1989-10-02	1991-04-11	Schering Ag	24-homo-vitamin-d-derivate, verfahren zu ihrer herstellung

1990
- 1990-02-14 US US07/481,990 patent/US5030772A/en not_active Expired - Lifetime
1991
- 1991-02-13 DE DE69109006T patent/DE69109006T2/de not_active Expired - Fee Related
- 1991-02-13 AT AT91905084T patent/ATE121387T1/de active
- 1991-02-13 JP JP3505231A patent/JP2731839B2/ja not_active Expired - Lifetime
- 1991-02-13 EP EP91905084A patent/EP0468042B1/de not_active Expired - Lifetime
- 1991-02-13 ES ES91905084T patent/ES2071303T3/es not_active Expired - Lifetime
- 1991-02-13 WO PCT/US1991/000974 patent/WO1991012239A1/en not_active Ceased

Also Published As

Publication number	Publication date
EP0468042A1 (de)	1992-01-29
DE69109006D1 (de)	1995-05-24
JP2731839B2 (ja)	1998-03-25
JPH04505468A (ja)	1992-09-24
DE69109006T2 (de)	1995-08-31
EP0468042B1 (de)	1995-04-19
WO1991012239A1 (en)	1991-08-22
US5030772A (en)	1991-07-09
ES2071303T3 (es)	1995-06-16

Publication	Publication Date	Title
DE69109006D1 (de)	1995-05-24	HOMOLOGIERTE VITAMIN-D2-VERBINDUNGEN UND KORRESPONDIERENDE 1alpha-HYDROXYLIERTE VERBINDUNGEN.
MX9201419A (es)	1992-10-01	Derivados de benzo isoxazol-piperidina.
AU1808488A (en)	1988-12-06	Compounds for the treatment of alzheimer's disease
DK0651754T3 (da)	1997-10-27	K-252a-derivater
NO892762D0 (no)	1989-07-04	Fremgangsmaate for fremstilling av nye difosfonsyrederivater.
NO981800L (no)	1998-06-11	FremgangsmÕte for fremstilling av 1,1,1,3,3-pentafluorpentan
EE02979B1 (et)	1997-04-15	Formoterool ja tema ühendid ning nende valmistamise meetod
FI93117C (fi)	1995-02-27	Analogiamenetelmä terapeuttisesti käyttökelpoisten 9-aminotetrahydroakridiinijohdannaisten valmistamiseksi
NO903359L (no)	1991-02-01	Fremgangsmaate for fremstilling av 1,2,3,4-tetrahydro-9-akridinamin-derivater.
FI894078A0 (fi)	1989-08-31	Menetelmä teikoplaniiniyhdisteiden substituoitujen, antibioottisten alkyyliamidien valmistamiseksi
FI891986A0 (fi)	1989-04-26	Farmaceutiska sammansaettningar foer behandling av psoriasis.
DZ1777A1 (fr)	2002-02-17	Procédé de préparation de dérivés de type ester aminophosphonate azamacrocycliques ou acycliques.
NO20000771L (no)	2000-04-25	Anvendelse av fankinon for behandling av Alzheimers sykdom
NO932860L (no)	1994-02-14	Fremgangsmaate for fremstilling av kalsium-L-askorbat-2-fosfat
DZ1407A1 (fr)	2004-09-13	Dérivés d-substitués des n,n'-ditriméthoxybenzoylepipérazine ainsi que leur procédé de préparation.
EP0737672A3 (de)	1996-12-27	Verfahren zur Herstellung von Triazinderivate
NO180537C (no)	1997-05-07	Fremgangsmåte for fremstilling av vitamin D2-forbindelser og de tilsvarende <alfa>-hydroksylerte derivater
FR2648675B1 (fr)	1994-05-27	Compositions propres a influencer le developpement et la floraison de plantes, procede de traitement de plantes par ces compositions et plantes modifiees obtenues
DE69215588D1 (de)	1997-01-16	Inositol-Phosphat-Analog als kalzium-antagonistische Substanz
ES2089176T3 (es)	1996-10-01	Procedimiento para la preparacion de carboditioatos de piperidina fluorometil-sustituidos.
ES2067621T3 (es)	1995-04-01	Procedimiento para la preparacion de compuestos molusquicidas de 2,4,5-tribromopirrol-3-carbonitrilo.
FR2618781B2 (fr)	1990-05-04	Procede de preparation de derives de la 4,4-dimethyl tetrahydro pyr-2-one
FR2647450B1 (fr)	1994-10-21	Procede de preparation des derives de 2(prime), 3(prime)-dideshydro-2(prime),3(prime)-didesoxynucleoside
OA09202A (fr)	1992-06-30	Procédé de préparation des nouveaux dérivés de la thiéno-triazolo-diazépine.
DZ1415A1 (fr)	2004-09-13	Procédé de préparation de dérivés de la thiéno-triazolo-diazépine.