ATE121387T1 - Homologierte vitamin-d2-verbindungen und korrespondierende 1alpha-hydroxylierte verbindungen. - Google Patents

Homologierte vitamin-d2-verbindungen und korrespondierende 1alpha-hydroxylierte verbindungen.

Info

Publication number
ATE121387T1
ATE121387T1 AT91905084T AT91905084T ATE121387T1 AT E121387 T1 ATE121387 T1 AT E121387T1 AT 91905084 T AT91905084 T AT 91905084T AT 91905084 T AT91905084 T AT 91905084T AT E121387 T1 ATE121387 T1 AT E121387T1
Authority
AT
Austria
Prior art keywords
compounds
vitamin
hydroxylated
homologate
1alpha
Prior art date
Application number
AT91905084T
Other languages
English (en)
Inventor
Hector Floyd Deluca
Heinrich Konstantine Schnoes
Kato Leonard Perlman
Original Assignee
Wisconsin Alumni Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found
Application granted granted Critical
Publication of ATE121387T1 publication Critical patent/ATE121387T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT91905084T 1990-02-14 1991-02-13 Homologierte vitamin-d2-verbindungen und korrespondierende 1alpha-hydroxylierte verbindungen. ATE121387T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/481,990 US5030772A (en) 1990-02-14 1990-02-14 Process for preparing vitamin D2 compounds and the corresponding 1 α-hydroxylated derivatives

Publications (1)

Publication Number Publication Date
ATE121387T1 true ATE121387T1 (de) 1995-05-15

Family

ID=23914203

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91905084T ATE121387T1 (de) 1990-02-14 1991-02-13 Homologierte vitamin-d2-verbindungen und korrespondierende 1alpha-hydroxylierte verbindungen.

Country Status (7)

Country Link
US (1) US5030772A (de)
EP (1) EP0468042B1 (de)
JP (1) JP2731839B2 (de)
AT (1) ATE121387T1 (de)
DE (1) DE69109006T2 (de)
ES (1) ES2071303T3 (de)
WO (1) WO1991012239A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3933034A1 (de) * 1989-10-02 1991-04-11 Schering Ag 24-homo-vitamin-d-derivate, verfahren zu ihrer herstellung
ATE144250T1 (de) * 1991-12-26 1996-11-15 Wisconsin Alumni Res Found 26,27-dimethylen-1-alpha, 25-dihydroxyvitamin-d2 und 26,27-dihydroxyvitamin-d2 und verfahren zu ihrer herstellung
US5716946A (en) * 1996-02-13 1998-02-10 Wisconsin Alumni Research Foundation Multiple sclerosis treatment
EP1091936B1 (de) 1998-05-29 2003-07-30 Bone Care International, Inc. Verfahren zur herstellung von hydroxy-25-ene vitamin d verbindungen
US6479474B2 (en) * 1999-07-08 2002-11-12 Wisconsin Alumni Research Foundation Dietary calcium as a supplement to vitamin D compound treatment of multiple sclerosis
US7094775B2 (en) 2004-06-30 2006-08-22 Bone Care International, Llc Method of treating breast cancer using a combination of vitamin D analogues and other agents
US20060003950A1 (en) * 2004-06-30 2006-01-05 Bone Care International, Inc. Method of treating prostatic diseases using a combination of vitamin D analogues and other agents
CA2586679A1 (en) 2004-11-12 2006-05-18 Bioxell Spa Combined use of vitamin d derivatives and anti-proliferative agents for treating bladder cancer
US7745226B2 (en) 2005-04-06 2010-06-29 Quest Diagnostics Investments Incorporated Methods for detecting vitamin D metabolites
US7972868B2 (en) 2007-11-28 2011-07-05 Quest Diagnostics Investments Incorporated Methods for detecting dihydroxyvitamin D metabolites by mass spectrometry
CA2981549A1 (en) * 2009-01-27 2010-08-05 Berg Llc Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy
CN106265695B (zh) 2009-08-14 2021-05-07 博格有限责任公司 用于治疗脱发的维生素d3及其类似物
US7977117B2 (en) 2009-12-03 2011-07-12 Quest Diagnostics Investments Incorprated Vitamin D metabolite determination utilizing mass spectrometry following derivatization
US20110240840A1 (en) 2009-12-11 2011-10-06 Quest Diagnostics Investments Incorporated Mass spectrometric determination of cookson-derivatized, non-metabolized vitamin d
CA2783708C (en) 2009-12-11 2018-09-18 Quest Diagnostics Investments Incorporated Mass spectrometry of steroidal compounds in multiplex samples
CN112156097A (zh) 2013-05-29 2021-01-01 博格有限责任公司 使用维生素d预防或减轻化疗诱发的脱发

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3585221A (en) * 1969-03-24 1971-06-15 Wisconsin Alumni Res Found 25-hydroxyergocalciferol
US3880894A (en) * 1974-05-24 1975-04-29 Wisconsin Alumni Res Found 1,25-Dihydroxyergocalciferol
JPS51108048A (en) * 1975-03-17 1976-09-25 Teijin Ltd 1 arufua * 24 * s * *255 torihidokishikorekarushifuerooruno seizoho
JPS51108049A (en) * 1975-03-17 1976-09-25 Teijin Ltd 1 arufua * 24 * s * *255 torihidorokishikorekarushifuerooruno seizoho
JPS51108046A (en) * 1975-03-17 1976-09-25 Teijin Ltd 1 arufua * 24 * r * *255 torihidorokishikorekarushifuerooruno seizoho
US4260549A (en) * 1979-05-21 1981-04-07 Wisconsin Alumni Research Foundation Process for preparing 1α-hydroxylated compounds
US4226787A (en) * 1978-07-26 1980-10-07 Wisconsin Alumni Research Foundation Fluorovitamin D compounds and processes for their preparation
US4448721A (en) * 1982-09-20 1984-05-15 Wisconsin Alumni Research Foundation Hydroxyvitamin D2 compounds and process for preparing same
GB2139627B (en) * 1983-05-09 1987-02-04 Wisconsin Alumni Res Found 1 25-dihydroxylated vitamin d2 compounds and intermediates in the preparation thereof
US4769181A (en) * 1983-11-07 1988-09-06 Wisconsin Alumni Research Foundation 1,25-dihydroxyvitamin D2 compounds
AU584071B2 (en) * 1984-03-05 1989-05-18 Wisconsin Alumni Research Foundation 1a-hydroxyvitamin d2 analogs and process for preparing same
US4588528A (en) * 1984-05-31 1986-05-13 Wisconsin Alumni Research Foundation 1,24-dihydroxy-Δ22 -vitamin D3 and process for preparing same
DE3590488C2 (de) * 1984-10-04 1992-10-01 Wisconsin Alumni Research Foundation, Madison, Wis., Us
US4554106A (en) * 1984-11-01 1985-11-19 Wisconsin Alumni Research Foundation Method for preparing 1α-hydroxyvitamin D compounds
KR910004337B1 (ko) * 1985-01-17 1991-06-26 위스콘신 알럼니 리서치 화운데이션 비타민 d 유도체 및 이를 함유하는 약제
JPS62501505A (ja) * 1985-01-17 1987-06-18 ウイスコンシン　アラムナイ　リサ−チ　フオンデ−シヨン ビタミンｄ誘導体
KR0144358B1 (ko) * 1988-04-21 1998-07-15 피. 라이달 크리스텐슨 비타민 d 동족체
NL8920392A (nl) * 1988-04-29 1990-04-02 Wisconsin Alumni Res Found 1alfa-hydroxyvitamine d-homologen met onverzadigde zijketen.
US4847012A (en) * 1988-04-29 1989-07-11 Wisconsin Alumni Research Foundation Vitamin D related compounds and processes for their preparation
US4973584A (en) * 1989-03-09 1990-11-27 Deluca Hector F Novel 1α-hydroxyvitamin D2 epimer and derivatives
DK0402982T3 (da) * 1989-06-15 1994-02-14 Duphar Int Res Adductaldehyd og dets anvendelse til fremstilling af vitamin-D-forbindelser
GB8914963D0 (en) * 1989-06-29 1989-08-23 Leo Pharm Prod Ltd Chemical compounds
DE3933034A1 (de) * 1989-10-02 1991-04-11 Schering Ag 24-homo-vitamin-d-derivate, verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
JP2731839B2 (ja) 1998-03-25
US5030772A (en) 1991-07-09
EP0468042A1 (de) 1992-01-29
ES2071303T3 (es) 1995-06-16
DE69109006T2 (de) 1995-08-31
JPH04505468A (ja) 1992-09-24
WO1991012239A1 (en) 1991-08-22
DE69109006D1 (de) 1995-05-24
EP0468042B1 (de) 1995-04-19

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