ATE121395T1 - Cumarinderivate, ihre herstellung und ihre verwendung zur behandlung von zerebrovaskulären störungen. - Google Patents

Cumarinderivate, ihre herstellung und ihre verwendung zur behandlung von zerebrovaskulären störungen.

Info

Publication number
ATE121395T1
ATE121395T1 AT90308441T AT90308441T ATE121395T1 AT E121395 T1 ATE121395 T1 AT E121395T1 AT 90308441 T AT90308441 T AT 90308441T AT 90308441 T AT90308441 T AT 90308441T AT E121395 T1 ATE121395 T1 AT E121395T1
Authority
AT
Austria
Prior art keywords
treatment
preparation
hydrogen
lower alkyl
cerebrovascular disorders
Prior art date
Application number
AT90308441T
Other languages
English (en)
Inventor
Hiroaki C O Sankyo Yanagisawa
Koichi C O Sankyo Com Fujimoto
Yasuo C O Sankyo Compa Shimoji
Takuro C O Sankyo Com Kanazaki
Nobuyoshi C O Sankyo Com Iwata
Yoshiko C O Sankyo Compan Kubo
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Application granted granted Critical
Publication of ATE121395T1 publication Critical patent/ATE121395T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/18—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted otherwise than in position 3 or 7

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
AT90308441T 1989-07-31 1990-07-31 Cumarinderivate, ihre herstellung und ihre verwendung zur behandlung von zerebrovaskulären störungen. ATE121395T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP19881789 1989-07-31
JP30955889 1989-11-28

Publications (1)

Publication Number Publication Date
ATE121395T1 true ATE121395T1 (de) 1995-05-15

Family

ID=26511193

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90308441T ATE121395T1 (de) 1989-07-31 1990-07-31 Cumarinderivate, ihre herstellung und ihre verwendung zur behandlung von zerebrovaskulären störungen.

Country Status (9)

Country Link
EP (1) EP0411912B1 (de)
KR (1) KR910002846A (de)
CN (2) CN1028527C (de)
AT (1) ATE121395T1 (de)
CA (1) CA2022236A1 (de)
DE (1) DE69018726D1 (de)
HU (1) HU207510B (de)
IE (1) IE902750A1 (de)
PT (1) PT94866A (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2190708A1 (en) * 1995-12-08 1997-06-09 Johannes Aebi Aminoalkyl substituted benzo-heterocyclic compounds
TR200000764T2 (tr) * 1997-09-24 2001-03-21 Orion Corporation Fosfolamban inhibitörleri olarak, 1-okza, aza ve tiyanaftalin-2-on'ların biseterleri.
AU2003267245C1 (en) 2002-09-20 2008-05-29 Promega Corporation Luminescence-based methods and probes for measuring cytochrome P450 activity
CN100358519C (zh) * 2003-05-15 2008-01-02 中国科学院上海有机化学研究所 香豆素类化合物作为制备抗真菌药物的应用
EP2272973B1 (de) 2005-05-31 2015-05-27 Promega Corporation Luminogene und fluorogene Verbindungen und Verfahren für den Nachweis von Molekülen oder Leiden
US8288559B2 (en) 2008-08-18 2012-10-16 Promega Corporation Luminogenic compounds and methods to detect cytochrome P450 3A enzymes
CN103788044B (zh) * 2008-11-28 2016-09-14 中国医学科学院药物研究所 硝克柳胺化合物晶i型、其制法和其药物组合物与用途
WO2015116867A1 (en) 2014-01-29 2015-08-06 Promega Corporation Quinone-masked probes as labeling reagents for cell uptake measurements
CN105524034B (zh) * 2015-03-27 2018-08-17 北京大学 香豆素衍生物的制备、药理作用及治疗脑缺血的应用
EP3831820A1 (de) * 2019-12-05 2021-06-09 ETH Zurich Verbindungen und verfahren zur aminoxidasebildgebung
CN114920722B (zh) * 2021-06-02 2024-03-08 何黎琴 一种7-羟基-3-乙酰基香豆素肟类化合物、其制备方法及医药用途
CN113292526A (zh) * 2021-06-16 2021-08-24 锦州九泰药业有限责任公司 一种高收率延通心原料药的合成方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6013788A (ja) * 1983-07-05 1985-01-24 Yamanouchi Pharmaceut Co Ltd 新規なクマリン誘導体
DE3427985A1 (de) * 1984-07-28 1986-01-30 Boehringer Mannheim Gmbh, 6800 Mannheim Neue 2h-l-benzopyran-2-on-derivate, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten
US4701456A (en) * 1984-09-19 1987-10-20 Warner-Lambert Company Aminoalkoxybenzopyranones as antipsychotic and anxiolytic agents

Also Published As

Publication number Publication date
CA2022236A1 (en) 1991-02-01
HUT54362A (en) 1991-02-28
KR910002846A (ko) 1991-02-26
CN1107151A (zh) 1995-08-23
DE69018726D1 (de) 1995-05-24
EP0411912B1 (de) 1995-04-19
CN1049662A (zh) 1991-03-06
EP0411912A3 (en) 1991-09-11
HU207510B (en) 1993-04-28
EP0411912A2 (de) 1991-02-06
PT94866A (pt) 1991-03-20
CN1028527C (zh) 1995-05-24
IE902750A1 (en) 1991-02-27

Similar Documents

Publication Publication Date Title
CA2124680A1 (en) Piperazine derivatives as 5-ht1a antagonists
ATE108774T1 (de) Isoindolonderivate, ihre herstellung und ihre verwendung als zwischenprodukte zur herstellung von substanz-p-antagonisten.
DE69418243D1 (de) N-Heteroaryl-N'-Phenylharnstoffderivate, ihre Herstellung und Verwendung
ATE50763T1 (de) Tetralin-derivate, ihre herstellung und verwendung.
ATE121744T1 (de) Neue triazolopyrimidin- und pyrazolopyrimidinderivate zur behandlung von kachexie.
DE19675020I2 (de) Morpholinoethylester von Mycophenolsaeure und ihre Derivate ihre Herstellung und Verwendung in pharmazeutische Zusammensetzungen
ATE117681T1 (de) Chinolinderivate, ihre herstellung und verwendung.
ATE26263T1 (de) 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepine, verfahren zur herstellung derselben und ihre verwendung als heilmittel.
DE69018726D1 (de) Cumarinderivate, ihre Herstellung und ihre Verwendung zur Behandlung von zerebrovaskulären Störungen.
DE3689848D1 (de) Zyklopenta[D]pyrimidinderivate, ihre Herstellung und Verwendung.
DE3888340D1 (de) Verwendung von 1,4-disubstituierten-Piperidinyl-Verbindungen zur Herstellung eines Arzneimittels zur Behandlung von Schlaflosigkeit.
DE69104314D1 (de) Verwendung von 1-[3-(Dimethylamino)propyl]-1-phenylphthalenen zur Behandlung zerebrovaskulärer Störungen.
ATE79257T1 (de) Verwendung von tetrahydrobenz(c,d>indol-6carboxamiden zur herstellung von arzneimitteln zur behandlung von angstzustaenden.
FI893901A0 (fi) Menetelmä tetrasyklisten masennuslääkkeiden valmistamiseksi
DE58905079D1 (de) Neue alpha-aminocarbonsaeure-derivate, ihre herstellung und verwendung.
ES528365A0 (es) Compuestos de cromano
ATE41659T1 (de) Benzothiazepinderivate, verfahren zur herstellung und pharmazeutische zusammensetzungen.
ES2035915T3 (es) Agentes antiarritmicos n-fenetil-aminoalquil-benzamida.
ATE43575T1 (de) (4.2.0>-bicyclooctanderivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen.
ATE46156T1 (de) 1,3-benzoxathiol-derivate, deren verwendung und deren herstellung.
DE69023045D1 (de) Carboxamidderivate.
DE69105865D1 (de) Biphenyl-5,5'-bis-Alkansäurederivate, deren Herstellung und Verwendung.
DE69106008D1 (de) Behandlung von Schlaf-Apnoea mit Azapironderivaten.
ATE53205T1 (de) Methioninsubstituierte 1,4-dihydropyridine, verfahren zur herstellung und ihre verwendung.
ATE66671T1 (de) Gamma-l-glutanyl-4-nitoanilid-derivate und verfahren zur bestimmung von gamma-gtp-aktivitaet unter verwendung dieser derivate.