ATE121406T1 - Trizyklische lactamderivate und pharmazeutische zusammensetzungen, die sie enthalten. - Google Patents

Trizyklische lactamderivate und pharmazeutische zusammensetzungen, die sie enthalten.

Info

Publication number: ATE121406T1
Authority: AT; Austria
Prior art keywords: group; hydrogen atom; phenylc1; 4alkyl; 6alkyl
Prior art date: 1989-02-28

Application number

AT90302076T

Other languages

English (en)

Inventor

Ian Harold Coates

Alexander William Oxford

Paul John Beswick

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-02-28

Filing date

1990-02-27

Publication date

1995-05-15

1990-02-27 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

1995-05-15 Application granted granted Critical

1995-05-15 Publication of ATE121406T1 publication Critical patent/ATE121406T1/de

Links

150000003951 lactams Chemical class 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 6
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 3
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
-1 phenylC1-3alkyl Chemical group 0.000 abstract 3
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
125000005843 halogen group Chemical group 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 abstract 2
102000035037 5-HT3 receptors Human genes 0.000 abstract 1
108091005477 5-HT3 receptors Proteins 0.000 abstract 1
208000019901 Anxiety disease Diseases 0.000 abstract 1
208000028017 Psychotic disease Diseases 0.000 abstract 1
206010047700 Vomiting Diseases 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
230000036506 anxiety Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
HRDXJKGNWSUIBT-UHFFFAOYSA-N methoxybenzene Chemical group [CH2]OC1=CC=CC=C1 HRDXJKGNWSUIBT-UHFFFAOYSA-N 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Otolaryngology (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Hydrogenated Pyridines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT90302076T 1989-02-28 1990-02-27 Trizyklische lactamderivate und pharmazeutische zusammensetzungen, die sie enthalten. ATE121406T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB898904551A GB8904551D0 (en)	1989-02-28	1989-02-28	Chemical compounds

Publications (1)

Publication Number	Publication Date
ATE121406T1 true ATE121406T1 (de)	1995-05-15

Family

ID=10652455

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90302076T ATE121406T1 (de)	1989-02-28	1990-02-27	Trizyklische lactamderivate und pharmazeutische zusammensetzungen, die sie enthalten.

Country Status (6)

Country	Link
US (1)	US5013733A (de)
EP (1)	EP0385722B1 (de)
JP (1)	JPH03200786A (de)
AT (1)	ATE121406T1 (de)
DE (1)	DE69018678T2 (de)
GB (1)	GB8904551D0 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5229517A (en) *	1990-09-27	1993-07-20	Hoechst-Roussel Pharmaceuticals Incorporated	2-(4-Piperindinyl)-1H-pyrido[4,3-B]indol-1-ones and related compounds
US5102889B1 (en) *	1990-09-27	1993-05-11		2-(4-piperidinyl)-1h-pyrido(4,3-b)indol-1-ones and related compounds
US5189041A (en) *	1990-11-16	1993-02-23	Syntex (U.S.A.) Inc.	Tricyclic 5-ht3 receptor antagonists
HU211081B (en) *	1990-12-18	1995-10-30	Sandoz Ag	Process for producing indole derivatives as serotonin antagonists and pharmaceutical compositions containing the same
GB9214184D0 (en) *	1992-07-03	1992-08-12	Smithkline Beecham Plc	Pharmaceuticals
GB9721139D0 (en)	1997-10-07	1997-12-03	Glaxo Group Ltd	Medicaments
CA2335336A1 (en) *	1998-06-19	1999-12-23	James Edmund Audia	Inhibition of serotonin reuptake
WO2002041889A2 (en) *	2000-11-24	2002-05-30	Smithkline Beecham P.L.C.	Indolsulfonyl compounds useful in the treatment of cns disorders
US20030212105A1 (en) *	2000-12-07	2003-11-13	Agrawal Shyam Sunder	Novel anti-fertility agent
WO2003014118A1 (en) *	2001-08-08	2003-02-20	Pharmacia & Upjohn Company	THERAPEUTIC 1H-PYRIDO[4,3-b]INDOLES
BRPI0907122B8 (pt)	2008-01-11	2021-05-25	Albany Molecular Res Inc	compostos de piridoindóis (1-azinona) substituídos, composição farmacêutica compreendendo os referidos compostos, e usos dos mesmos
WO2011003012A1 (en) *	2009-07-01	2011-01-06	Albany Molecular Research, Inc.	Azinone-substituted azapolycycle mch-1 antagonists, methods of making, and use thereof
WO2011003007A1 (en) *	2009-07-01	2011-01-06	Albany Molecular Research, Inc.	Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof
US8637501B2 (en) *	2009-07-01	2014-01-28	Albany Molecular Research, Inc.	Azinone-substituted azepino[b]indole and pyrido-pyrrolo-azepine MCH-1 antagonists, methods of making, and use thereof
US9073925B2 (en) *	2009-07-01	2015-07-07	Albany Molecular Research, Inc.	Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof
WO2012088124A2 (en)	2010-12-21	2012-06-28	Albany Molecular Research, Inc.	Tetrahydro-azacarboline mch-1 antagonists, methods of making, and uses thereof
WO2012088038A2 (en)	2010-12-21	2012-06-28	Albany Molecular Research, Inc.	Piperazinone-substituted tetrahydro-carboline mch-1 antagonists, methods of making, and uses thereof
WO2024006734A1 (en)	2022-06-27	2024-01-04	10X Genomics, Inc.	Methods for preparing and using mhc multimer reagents compositions
WO2024015856A1 (en)	2022-07-13	2024-01-18	10X Genomics, Inc.	Compositions and methods for characterizing binding characteristics of antigen binding molecules from single cells
WO2024050299A1 (en)	2022-08-29	2024-03-07	10X Genomics, Inc.	Improved methods and compositions for characterization of antigen-binding molecules from single cells

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2100259B (en) *	1981-06-13	1984-10-31	Merrell Toraude & Co	Treatment of migraine with tropyl benzoate derivatives
IE56226B1 (en) *	1982-04-14	1991-05-22	Beecham Group Plc	Substituted azabicyclo compounds,process for their preparation and pharmaceutical compositions containing them
FR2531083B1 (fr) *	1982-06-29	1986-11-28	Sandoz Sa	Nouveaux derives de la piperidine, leur preparation et leur utilisation comme medicaments
FR2529548A1 (fr) *	1982-07-02	1984-01-06	Delalande Sa	Nouveaux derives de l'amino-3 quinuclidine, leur procede et leur application en therapeutique
DE3650772T2 (de) *	1985-04-27	2003-04-03	F. Hoffmann-La Roche Ag, Basel	Derivate von Indazole-3-carboxamide und -3-carboxylsäure
HU895334D0 (en) *	1986-07-30	1990-01-28	Sandoz Ag	Process for the preparation of nasal pharmaceutical compositions
GR871809B (en) *	1986-11-28	1988-03-07	Glaxo Group Ltd	Process for the preparation of tricyclic ketones
NZ226032A (en) *	1987-09-03	1991-12-23	Glaxo Group Ltd	2-(imidazolylmethyl)-pyrido or-azepino(4,3-b)indole-1(2h)-one derivatives; preparatory processes and pharmaceutical compositions
EP0339959A3 (de) *	1988-04-27	1991-03-20	Glaxo Group Limited	Laktam-Derivate
EP0350130A3 (de) *	1988-07-07	1991-07-10	Duphar International Research B.V	Substituierte 1,7-annelierte 1H-Indazole
AU631131B2 (en) *	1988-08-02	1992-11-19	Glaxo Group Limited	Lactam derivatives
JPH02167280A (ja) *	1988-08-15	1990-06-27	Glaxo Group Ltd	ラクタム誘導体

1989
- 1989-02-28 GB GB898904551A patent/GB8904551D0/en active Pending
1990
- 1990-02-27 JP JP2047077A patent/JPH03200786A/ja active Pending
- 1990-02-27 US US07/485,532 patent/US5013733A/en not_active Expired - Fee Related
- 1990-02-27 DE DE69018678T patent/DE69018678T2/de not_active Expired - Fee Related
- 1990-02-27 EP EP90302076A patent/EP0385722B1/de not_active Expired - Lifetime
- 1990-02-27 AT AT90302076T patent/ATE121406T1/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE69018678T2 (de)	1995-08-17
US5013733A (en)	1991-05-07
DE69018678D1 (de)	1995-05-24
EP0385722A2 (de)	1990-09-05
JPH03200786A (ja)	1991-09-02
GB8904551D0 (en)	1989-04-12
EP0385722B1 (de)	1995-04-19
EP0385722A3 (de)	1991-09-25

Legal Events

Date	Code	Title	Description
1995-11-15	UEP	Publication of translation of european patent specification
1997-05-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69018678D1 (de)	1995-05-24	Trizyklische Lactamderivate und pharmazeutische Zusammensetzungen, die sie enthalten.
IL87658A0 (en)	1989-02-28	Lactam derivatives,their preparation and pharmaceutical compositions containing them
NZ230154A (en)	1991-10-25	Imidazolyl-substituted 6- or 7-membered ring lactam derivatives and pharmaceutical composition
ES2173074T3 (es)	2002-10-16	Derivados de xantina, procedimiento para su preparacion y su uso farmaceutico.
ATE78254T1 (de)	1992-08-15	Indol-derivate.
DK0552712T3 (da)	1999-08-09	8-(1-aminocycloalkyl)1,3-dialkylxanthinderivater som antagonister for adenosinreceptorer
ZA892861B (en)	1989-12-27	Heterotetracyclic lactam derivatives
NO872982D0 (no)	1987-07-16	Nye tetracykliske indolderivater.
FI892415A0 (fi)	1989-05-19	Tricykliska ketoner.
FI884049A7 (fi)	1989-03-04	Laktamderivat.