ATE121753T1 - Octapeptid oder heptapeptidderivate, verfahren zu deren herstellung sowie medikamente, die diese verbindungen enthalten und verwendung derselben. - Google Patents

Octapeptid oder heptapeptidderivate, verfahren zu deren herstellung sowie medikamente, die diese verbindungen enthalten und verwendung derselben.

Info

Publication number: ATE121753T1
Authority: AT; Austria
Prior art keywords: group; aminobenzoyl; aspartyl; amino acid; rest
Prior art date: 1991-01-25

Application number

AT92101196T

Other languages

English (en)

Inventor

Gyoergy Dr Keri

Imre Dr Mezoe

Aniko Dr Horvath

Zsolt Dr Vadasz

Istvan Dr Teplan

Agnes Balogh

Orsolya Dr Csuka

Gyoengyi Boekoenyi

Balazs Dr Szoeke

Judit Dr Horvath

Miklos Dr Idei

Janos Dr Seproedi

Original Assignee

Biosignal Kutato Fejlesztoe

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-01-25

Filing date

1992-01-27

Publication date

1995-05-15

1992-01-27 Application filed by Biosignal Kutato Fejlesztoe filed Critical Biosignal Kutato Fejlesztoe

1995-05-15 Application granted granted Critical

1995-05-15 Publication of ATE121753T1 publication Critical patent/ATE121753T1/de

Links

150000001875 compounds Chemical class 0.000 title 1
229940079593 drug Drugs 0.000 title 1
239000003814 drug Substances 0.000 title 1
-1 aromatic D-amino acid Chemical class 0.000 abstract 15
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
125000000217 alkyl group Chemical group 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000002237 D-aspartyl group Chemical group [H]OC(=O)[C@]([H])(N([H])[H])C([H])([H])C(*)=O 0.000 abstract 1
125000002716 D-tryptophyl group Chemical group N[C@@H](C(=O)*)CC1=CNC2=CC=CC=C12 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
150000001408 amides Chemical class 0.000 abstract 1
150000001412 amines Chemical class 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000002102 aryl alkyloxo group Chemical group 0.000 abstract 1
125000004104 aryloxy group Chemical group 0.000 abstract 1
125000003164 beta-aspartyl group Chemical group 0.000 abstract 1
125000000487 histidyl group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001239 threonyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Toxicology (AREA)
Zoology (AREA)
Endocrinology (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
Investigating Or Analysing Biological Materials (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT92101196T 1991-01-25 1992-01-27 Octapeptid oder heptapeptidderivate, verfahren zu deren herstellung sowie medikamente, die diese verbindungen enthalten und verwendung derselben. ATE121753T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
HU91272A HU207104B (en)	1991-01-25	1991-01-25	Process for producing new somatostatin analogs inhibiting tumour growth and pharmaceutical compositions comprising such compounds

Publications (1)

Publication Number	Publication Date
ATE121753T1 true ATE121753T1 (de)	1995-05-15

Family

ID=10948847

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92101196T ATE121753T1 (de)	1991-01-25	1992-01-27	Octapeptid oder heptapeptidderivate, verfahren zu deren herstellung sowie medikamente, die diese verbindungen enthalten und verwendung derselben.

Country Status (10)

Country	Link
US (1)	US5480870A (de)
EP (1)	EP0505680B1 (de)
JP (1)	JP2514518B2 (de)
KR (1)	KR920014828A (de)
AT (1)	ATE121753T1 (de)
CA (1)	CA2060034C (de)
DE (1)	DE69202182T2 (de)
ES (1)	ES2074294T3 (de)
FI (1)	FI105775B (de)
HU (1)	HU207104B (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5504069A (en) *	1993-02-11	1996-04-02	Biomeasure, Inc.	Inhibition of trauma-induced tumor growth
US5597894A (en) *	1995-06-05	1997-01-28	The Louisiana State University Medical Center Foundation	Multi-tyrosinated somatostatin analogs
IT1277391B1 (it) *	1995-07-28	1997-11-10	Romano Deghenghi	Peptidi ciclici analoghi della somatostatina ad attivita' inibitrice dell'ormone della crescita
US6355613B1 (en) *	1996-07-31	2002-03-12	Peptor Limited	Conformationally constrained backbone cyclized somatostatin analogs
WO1998008528A1 (en)	1996-08-30	1998-03-05	Biomeasure Incorporated	Method of inhibiting fibrosis with a somatostatin agonist
WO1998051330A1 (en)	1997-05-13	1998-11-19	Societe De Conseils De Recherches Et D'applications Scientifiques S.A. (S.C.R.A.S.)	Method and compositions for treating hyperlipidemia and other conditions
US6004928A (en) *	1997-05-13	1999-12-21	Biomeasure, Incorporated	Method of treating hyperlipidemia
AU7655098A (en)	1997-05-13	1998-12-08	Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.)	Somatostatin and somatostatin agonists for decreasing body weight
HU226567B1 (en) *	1998-04-27	2009-04-28	Biostatin Gyogyszerkutato Fejl	Use of phenylhydrazon derivates for the preparation of medicaments for the inhibition of neurogenic and non-neurogenic inflammations and for the alleviation of pain
US5968903A (en) *	1998-05-07	1999-10-19	Biomeasure, Incorporated	Inhibition of H. pylori proliferation
AU9436298A (en) *	1998-08-20	2000-03-14	Orpegen Pharma Gesellschaft Fur Biotechnologische Forschung, Entwicklung Und Produktion MBH	Method for producing biostatin (tt-232 triacetate) and the analogs thereof
CA2376506C (en) *	1999-06-04	2014-07-22	Dean Sadat-Aalaee	Neuromedin b and somatostatin receptor agonists
CN1367792A (zh) *	1999-06-25	2002-09-04	研究及应用科学协会股份有限公司	促生长素抑制素激动剂
US6864234B1 (en)	1999-06-25	2005-03-08	Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S.	Somatostatin agonists
BR0210915A (pt)	2001-06-08	2004-06-08	Sod Conseils Rech Applic	Análogos quiméricos de somatostatina-dopamina
US6987167B2 (en) *	2002-05-22	2006-01-17	Wockhardt Limited	Process for production of the somatostatin analog, octreotide
CN101791409A (zh)	2003-04-22	2010-08-04	研究及应用科学协会股份有限公司	肽载体
US7842662B2 (en)	2006-11-10	2010-11-30	Cara Therapeutics, Inc.	Synthetic peptide amide dimers
US8236766B2 (en)	2006-11-10	2012-08-07	Cara Therapeutics, Inc.	Uses of synthetic peptide amides
US7713937B2 (en)	2006-11-10	2010-05-11	Cara Therapeutics, Inc.	Synthetic peptide amides and dimeric forms thereof
RU2500685C2 (ru)	2006-11-10	2013-12-10	Кара Терапеутикс, Инк	Синтетические пептидные амиды
US8906859B2 (en)	2006-11-10	2014-12-09	Cera Therapeutics, Inc.	Uses of kappa opioid synthetic peptide amides
CA2727082C (en)	2008-06-12	2019-02-26	Syntaxin Limited	Fusion proteins for use in suppression of acromegaly
CN102083451A (zh)	2008-06-12	2011-06-01	赛恩泰新公司	癌症的抑制
GB0820970D0 (en)	2008-11-17	2008-12-24	Syntaxin Ltd	Suppression of cancer

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4725577A (en) *	1985-04-25	1988-02-16	Administrators Of The Tulane Educational Fund	Biologically active lysine containing octapeptides
US4650787A (en) *	1985-04-25	1987-03-17	Schally Andrew Victor	Biologically active octapeptides
JPH085913B2 (ja) *	1985-09-12	1996-01-24	ザ・アドミニストレ−タ−ズ・オブ・ザ・ツ−レイン・エデユケイシヨナル・フアンド	治療用ソマトスタチン同族体
JP2568228B2 (ja) *	1987-02-03	1996-12-25	ジ・アドミニストレーターズ・オブ・ザ・ツーレイン・エデュケイショナル・ファンド	治療用ソマトスタチンアナログ
JP2809403B2 (ja) *	1987-07-07	1998-10-08	ジ・アドミニストレーターズ・オブ・ザ・ツーレイン・エデュケイショナル・ファンド	治療用ソマトスタチンアナログ化合物
CA2012115C (en) *	1989-03-15	2001-07-03	Biomeasure, Inc.	Iodinated somatostatins
WO1991009056A1 (en) *	1989-12-08	1991-06-27	The Administrators Of The Tulane Educational Fund	Octapeptide analogs of somatostatin having threonine at the sixth position

1991
- 1991-01-25 HU HU91272A patent/HU207104B/hu not_active IP Right Cessation
1992
- 1992-01-22 KR KR1019920000840A patent/KR920014828A/ko not_active Withdrawn
- 1992-01-24 FI FI920340A patent/FI105775B/fi active
- 1992-01-24 CA CA002060034A patent/CA2060034C/en not_active Expired - Lifetime
- 1992-01-27 JP JP4033920A patent/JP2514518B2/ja not_active Expired - Fee Related
- 1992-01-27 AT AT92101196T patent/ATE121753T1/de not_active IP Right Cessation
- 1992-01-27 EP EP92101196A patent/EP0505680B1/de not_active Expired - Lifetime
- 1992-01-27 DE DE69202182T patent/DE69202182T2/de not_active Expired - Fee Related
- 1992-01-27 ES ES92101196T patent/ES2074294T3/es not_active Expired - Lifetime
1994
- 1994-04-26 US US08/233,558 patent/US5480870A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
FI105775B (fi)	2000-10-13
EP0505680A1 (de)	1992-09-30
JPH05163299A (ja)	1993-06-29
DE69202182D1 (de)	1995-06-01
KR920014828A (ko)	1992-08-25
JP2514518B2 (ja)	1996-07-10
FI920340A7 (fi)	1992-07-26
CA2060034C (en)	2002-10-29
HU207104B (en)	1993-03-01
HU910272D0 (en)	1991-08-28
CA2060034A1 (en)	1992-07-26
ES2074294T3 (es)	1995-09-01
HUT60752A (en)	1992-10-28
EP0505680B1 (de)	1995-04-26
US5480870A (en)	1996-01-02
FI920340A0 (fi)	1992-01-24
DE69202182T2 (de)	1995-08-31

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Legal Events

Date	Code	Title	Description
1996-02-15	UEP	Publication of translation of european patent specification
2010-10-15	REN	Ceased due to non-payment of the annual fee