ATE122047T1 - 4,5,5a,6-tetrahydro-3h-isoxyzolo(5,4,3- k1)acridinderivate, ein verfahren zu ihrer herstellung und ihre verwendung als medikamente. - Google Patents

4,5,5a,6-tetrahydro-3h-isoxyzolo(5,4,3- k1)acridinderivate, ein verfahren zu ihrer herstellung und ihre verwendung als medikamente.

Info

Publication number: ATE122047T1
Authority: AT; Austria
Prior art keywords: chem; loweralkyl; isoxyzolo; medications; tetrahydro
Prior art date: 1989-06-09

Application number

AT90110684T

Other languages

English (en)

Inventor

Gregory Michael Shutske

Original Assignee

Hoechst Roussel Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-06-09

Filing date

1990-06-06

Publication date

1995-05-15

1990-06-06 Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma

1995-05-15 Application granted granted Critical

1995-05-15 Publication of ATE122047T1 publication Critical patent/ATE122047T1/de

Links

DZBUGLKDJFMEHC-UHFFFAOYSA-N acridine Chemical class C1=CC=CC2=CC3=CC=CC=C3N=C21 DZBUGLKDJFMEHC-UHFFFAOYSA-N 0.000 title 1
229940027998 antiseptic and disinfectant acridine derivative Drugs 0.000 title 1
229940079593 drug Drugs 0.000 title 1
239000003814 drug Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
150000002431 hydrogen Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
208000024827 Alzheimer disease Diseases 0.000 abstract 1
239000000730 antalgic agent Substances 0.000 abstract 1
230000006949 cholinergic function Effects 0.000 abstract 1
230000003247 decreasing effect Effects 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
-1 loweralkyl Chemical group 0.000 abstract 1
230000007074 memory dysfunction Effects 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/06—Peri-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Liquid Crystal Substances (AREA)
Steroid Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT90110684T 1989-06-09 1990-06-06 4,5,5a,6-tetrahydro-3h-isoxyzolo(5,4,3- k1)acridinderivate, ein verfahren zu ihrer herstellung und ihre verwendung als medikamente. ATE122047T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/364,420 US4920117A (en)	1989-06-09	1989-06-09	4,5,5a,6-tetrahydro-3H-isoxazolo(5,4,3-kl)acridines, pharmaceutical compositions and use

Publications (1)

Publication Number	Publication Date
ATE122047T1 true ATE122047T1 (de)	1995-05-15

Family

ID=23434459

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90110684T ATE122047T1 (de)	1989-06-09	1990-06-06	4,5,5a,6-tetrahydro-3h-isoxyzolo(5,4,3- k1)acridinderivate, ein verfahren zu ihrer herstellung und ihre verwendung als medikamente.

Country Status (17)

Country	Link
US (1)	US4920117A (de)
EP (1)	EP0401779B1 (de)
JP (1)	JPH089624B2 (de)
KR (1)	KR0148365B1 (de)
AT (1)	ATE122047T1 (de)
AU (1)	AU619985B2 (de)
CA (1)	CA2018564C (de)
DE (1)	DE69019066T2 (de)
DK (1)	DK0401779T3 (de)
ES (1)	ES2072334T3 (de)
FI (1)	FI902851A7 (de)
IE (1)	IE67074B1 (de)
IL (1)	IL94664A (de)
NO (1)	NO902556L (de)
NZ (1)	NZ233971A (de)
PT (1)	PT94298B (de)
ZA (1)	ZA904442B (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4927820A (en) *	1988-11-25	1990-05-22	Hoechst Roussel Pharmaceuticals Inc.	Fused heterocyclic derivatives of 1,2,3,4-tetrahydroacridine
US5236930A (en) *	1989-11-13	1993-08-17	Mitbushi Gas Chemical Company, Inc.	Oxazopyrroloquinolines and use of oxazopyrroloquinolines
WO2003076419A1 (en) *	2002-03-08	2003-09-18	Japan Science And Technology Agency	Isoxazole derivatives and process for producing the same

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8314391D0 (en) *	1983-05-24	1983-06-29	Kefalas As	Heterocyclic compounds
FR2566407B1 (fr) *	1984-06-25	1986-09-26	Roussel Uclaf	Nouveaux derives de l'isoxazoloquinoleine, procede de preparation, application a titre de medicaments, et compositions les renfermant
US4927820A (en) *	1988-11-25	1990-05-22	Hoechst Roussel Pharmaceuticals Inc.	Fused heterocyclic derivatives of 1,2,3,4-tetrahydroacridine

1989
- 1989-06-09 US US07/364,420 patent/US4920117A/en not_active Expired - Fee Related
1990
- 1990-06-06 DK DK90110684.9T patent/DK0401779T3/da active
- 1990-06-06 DE DE69019066T patent/DE69019066T2/de not_active Expired - Fee Related
- 1990-06-06 AT AT90110684T patent/ATE122047T1/de not_active IP Right Cessation
- 1990-06-06 EP EP90110684A patent/EP0401779B1/de not_active Expired - Lifetime
- 1990-06-06 ES ES90110684T patent/ES2072334T3/es not_active Expired - Lifetime
- 1990-06-07 IL IL9466490A patent/IL94664A/en not_active IP Right Cessation
- 1990-06-07 PT PT94298A patent/PT94298B/pt not_active IP Right Cessation
- 1990-06-07 NZ NZ233971A patent/NZ233971A/en unknown
- 1990-06-07 FI FI902851A patent/FI902851A7/fi not_active Application Discontinuation
- 1990-06-08 ZA ZA904442A patent/ZA904442B/xx unknown
- 1990-06-08 CA CA002018564A patent/CA2018564C/en not_active Expired - Fee Related
- 1990-06-08 IE IE207890A patent/IE67074B1/en not_active IP Right Cessation
- 1990-06-08 JP JP2148885A patent/JPH089624B2/ja not_active Expired - Fee Related
- 1990-06-08 NO NO90902556A patent/NO902556L/no unknown
- 1990-06-08 AU AU56917/90A patent/AU619985B2/en not_active Ceased
- 1990-06-08 KR KR1019900008392A patent/KR0148365B1/ko not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CA2018564C (en)	2002-11-12
DE69019066D1 (de)	1995-06-08
NO902556L (no)	1990-12-10
IL94664A (en)	1994-11-11
IE67074B1 (en)	1996-02-21
FI902851A0 (fi)	1990-06-07
ZA904442B (en)	1991-03-27
PT94298B (pt)	1997-01-31
IE902078L (en)	1990-12-09
JPH089624B2 (ja)	1996-01-31
EP0401779B1 (de)	1995-05-03
IL94664A0 (en)	1991-04-15
AU619985B2 (en)	1992-02-06
DE69019066T2 (de)	1995-10-19
DK0401779T3 (da)	1995-10-16
EP0401779A1 (de)	1990-12-12
PT94298A (pt)	1991-02-08
ES2072334T3 (es)	1995-07-16
NZ233971A (en)	1992-11-25
CA2018564A1 (en)	1990-12-09
NO902556D0 (no)	1990-06-08
US4920117A (en)	1990-04-24
KR910000744A (ko)	1991-01-30
JPH0324085A (ja)	1991-02-01
AU5691790A (en)	1990-12-13
KR0148365B1 (ko)	1998-11-02
FI902851A7 (fi)	1990-12-10

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Legal Events

Date	Code	Title	Description
1995-10-15	UEP	Publication of translation of european patent specification
2005-03-15	REN	Ceased due to non-payment of the annual fee