ATE140006T1 - 1-(pyrido(3,4-b>-1,4-oxazinyl-4-yl)-1h-indole, zwischenprodukte und ein verfahren zu ihrer herstellung und ihre verwendung als arzneimittel - Google Patents

1-(pyrido(3,4-b>-1,4-oxazinyl-4-yl)-1h-indole, zwischenprodukte und ein verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Info

Publication number: ATE140006T1
Authority: AT; Austria
Prior art keywords: loweralkyl; hydrogen; chem; products; oxazinyl
Prior art date: 1991-04-15

Application number

AT92106160T

Other languages

English (en)

Inventor

Richard Charles Effland

Larry Davis

Gordon Edward Olsen

Original Assignee

Hoechst Roussel Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-04-15

Filing date

1992-04-09

Publication date

1996-07-15

1992-04-09 Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma

1996-07-15 Application granted granted Critical

1996-07-15 Publication of ATE140006T1 publication Critical patent/ATE140006T1/de

Links

239000013067 intermediate product Substances 0.000 title 1
229940126601 medicinal product Drugs 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 5
239000001257 hydrogen Substances 0.000 abstract 5
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
125000003118 aryl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
150000002431 hydrogen Chemical group 0.000 abstract 2
-1 nitro, amino, hydroxy Chemical group 0.000 abstract 2
208000024827 Alzheimer disease Diseases 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
230000001800 adrenalinergic effect Effects 0.000 abstract 1
125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
230000001713 cholinergic effect Effects 0.000 abstract 1
230000006735 deficit Effects 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
230000007074 memory dysfunction Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Psychiatry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT92106160T 1991-04-15 1992-04-09 1-(pyrido(3,4-b>-1,4-oxazinyl-4-yl)-1h-indole, zwischenprodukte und ein verfahren zu ihrer herstellung und ihre verwendung als arzneimittel ATE140006T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/684,758 US5214038A (en)	1991-04-15	1991-04-15	1-(pyrido[3,4-b]-1,4-oxazinyl-4-yl)-1H-indoles and intermediates for the preparation thereof

Publications (1)

Publication Number	Publication Date
ATE140006T1 true ATE140006T1 (de)	1996-07-15

Family

ID=24749434

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92106160T ATE140006T1 (de)	1991-04-15	1992-04-09	1-(pyrido(3,4-b>-1,4-oxazinyl-4-yl)-1h-indole, zwischenprodukte und ein verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Country Status (22)

Country	Link
US (3)	US5214038A (de)
EP (1)	EP0509400B1 (de)
JP (1)	JP2608359B2 (de)
KR (1)	KR100201509B1 (de)
AT (1)	ATE140006T1 (de)
AU (1)	AU643135B2 (de)
CA (1)	CA2065986C (de)
CZ (1)	CZ282054B6 (de)
DE (1)	DE69211892T2 (de)
DK (1)	DK0509400T3 (de)
ES (1)	ES2094840T3 (de)
FI (1)	FI97544C (de)
GR (1)	GR3020612T3 (de)
HU (1)	HUT62588A (de)
IE (1)	IE74907B1 (de)
IL (1)	IL101589A (de)
NO (1)	NO301765B1 (de)
NZ (2)	NZ242309A (de)
PL (1)	PL168671B1 (de)
RU (1)	RU2042680C1 (de)
TW (1)	TW211016B (de)
ZA (1)	ZA922721B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5360811A (en) *	1990-03-13	1994-11-01	Hoechst-Roussel Pharmaceuticals Incorporated	1-alkyl-, 1-alkenyl-, and 1-alkynylaryl-2-amino-1,3-propanediols and related compounds as anti-inflammatory agents
US5264442A (en) *	1990-08-13	1993-11-23	Hoechst-Roussel Pharmaceuticals Incorporated	Carbamoyl-1-(pyridinylalkyl)-1H-indoles, indolines and related analogs
GB9225859D0 (en) *	1992-12-11	1993-02-03	Smithkline Beecham Plc	Novel treatment
US5356910A (en) *	1993-07-19	1994-10-18	Hoechst-Roussel Pharmaceuticals Inc.	Use of N-(pyridinyl)-1H-indol-1-amines for the treatment of obsessive-compulsive disorder
GB9521680D0 (en) *	1995-10-23	1996-01-03	Orion Yhtymo Oy	New use of imidazole derivatives
GB0119435D0 (en) *	2001-02-15	2001-10-03	Aventis Pharm Prod Inc	Method of treating of demyelinating diseases or conditions
EP1424325A4 (de) *	2001-09-07	2005-12-21	Ono Pharmaceutical Co	Indolderivate, verfahren zu deren herstellung und arzneimittel, die diese als wirkstoff enthalten
GT200500063A (es) *	2004-04-01	2005-10-14		Metodo para tratar la esquizofrenia y/o anormalidades glucoregulatorias
CA2750086C (en)	2009-01-28	2018-01-02	Karus Therapeutics Limited	Scriptaid isosteres and their use in therapy
US9676765B2 (en)	2012-11-07	2017-06-13	Karus Therapeutics Limited	Histone deacetylase inhibitors and their use in therapy
SI2994465T1 (sl)	2013-05-10	2018-10-30	Karus Therapeutics Limited	Novi inhibitorji histon deacetilaze
GB201419228D0 (en)	2014-10-29	2014-12-10	Karus Therapeutics Ltd	Compounds
GB201419264D0 (en)	2014-10-29	2014-12-10	Karus Therapeutics Ltd	Compounds
MY210507A (en)	2018-08-13	2025-09-28	Hoffmann La Roche	New heterocyclic compounds as monoacylglycerol lipase inhibitors
WO2020104494A1 (en)	2018-11-22	2020-05-28	F. Hoffmann-La Roche Ag	New heterocyclic compounds
PH12022550339A1 (en)	2019-09-12	2023-03-13	Hoffmann La Roche	4,4a,5,7,8,8a-hexapyrido[4,3-b][1,4]oxazin-3-one compounds as magl inhibitors

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4029657A (en) *	1976-06-14	1977-06-14	The Dow Chemical Company	6,7-Dichloro-3,4-dihydro-2H-pyrazino(2,3-B)(1,4)oxazines
DE2726437A1 (de) *	1977-06-11	1978-12-21	Bayer Ag	Hydrazonfarbstoffe
US4880822A (en) *	1987-04-24	1989-11-14	Hoechst-Roussel Pharmaceuticals, Inc.	N-(pyridinyl)-1H-indol-1-amines
US5039811A (en) *	1987-04-24	1991-08-13	Hoechst-Roussel Pharmaceuticals Inc.	Preparation of N-(pyridinyl)-1H-indol-1-amines
US4970218A (en) *	1987-04-24	1990-11-13	Hoechst-Roussel Pharmaceuticals Inc.	N-(pyridinyl)-1H-indol-1-amines
DE3852335T2 (de) *	1987-04-24	1995-05-11	Hoechst Roussel Pharma	N-(Pyridinyl)-1H-indol-1-amine, Verfahren zu deren Herstellung und ihre Verwendung als Arzneimittel.
US4916135A (en) *	1989-05-08	1990-04-10	Hoechst Roussel Pharmaceuticals Inc.	N-heteroaryl-4-quinolinamines
US5006537A (en) *	1989-08-02	1991-04-09	Hoechst-Roussel Pharmaceuticals, Inc.	1,3-dihydro-1-(pyridinylamino)-2H-indol-2-ones
DK0415103T3 (da) *	1989-08-02	1995-06-19	Hoechst Roussel Pharma	2,3-Dihydro-1-(pyridinylamino)-indoler, en fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler
US4983608A (en) *	1989-09-05	1991-01-08	Hoechst-Roussell Pharmaceuticals, Inc.	N-substituted-4-pyrimidinamines and pyrimidinediamines

1991
- 1991-04-15 US US07/684,758 patent/US5214038A/en not_active Expired - Lifetime
1992
- 1992-04-09 DE DE69211892T patent/DE69211892T2/de not_active Expired - Fee Related
- 1992-04-09 EP EP92106160A patent/EP0509400B1/de not_active Expired - Lifetime
- 1992-04-09 DK DK92106160.2T patent/DK0509400T3/da active
- 1992-04-09 AT AT92106160T patent/ATE140006T1/de not_active IP Right Cessation
- 1992-04-09 ES ES92106160T patent/ES2094840T3/es not_active Expired - Lifetime
- 1992-04-10 NZ NZ242309A patent/NZ242309A/en unknown
- 1992-04-10 NZ NZ248131A patent/NZ248131A/en unknown
- 1992-04-11 TW TW081102816A patent/TW211016B/zh active
- 1992-04-13 KR KR1019920006109A patent/KR100201509B1/ko not_active Expired - Fee Related
- 1992-04-13 FI FI921641A patent/FI97544C/fi active
- 1992-04-14 AU AU14852/92A patent/AU643135B2/en not_active Ceased
- 1992-04-14 CA CA002065986A patent/CA2065986C/en not_active Expired - Fee Related
- 1992-04-14 ZA ZA922721A patent/ZA922721B/xx unknown
- 1992-04-14 JP JP4094177A patent/JP2608359B2/ja not_active Expired - Fee Related
- 1992-04-14 CZ CS921135A patent/CZ282054B6/cs not_active IP Right Cessation
- 1992-04-14 IE IE921190A patent/IE74907B1/en not_active IP Right Cessation
- 1992-04-14 RU SU925011168A patent/RU2042680C1/ru active
- 1992-04-14 NO NO921490A patent/NO301765B1/no unknown
- 1992-04-14 PL PL92294221A patent/PL168671B1/pl unknown
- 1992-04-14 IL IL10158992A patent/IL101589A/en not_active IP Right Cessation
- 1992-04-15 HU HU9201290A patent/HUT62588A/hu unknown
- 1992-11-16 US US07/976,778 patent/US5276156A/en not_active Expired - Lifetime
1993
- 1993-10-20 US US08/138,645 patent/US5519131A/en not_active Expired - Lifetime
1996
- 1996-07-24 GR GR960401978T patent/GR3020612T3/el unknown

Also Published As

Publication number	Publication date
JPH05112572A (ja)	1993-05-07
NZ248131A (en)	1995-07-26
AU643135B2 (en)	1993-11-04
JP2608359B2 (ja)	1997-05-07
DE69211892T2 (de)	1996-12-19
CZ282054B6 (cs)	1997-05-14
KR100201509B1 (ko)	1999-06-15
NO921490L (no)	1992-10-16
CS113592A3 (en)	1992-11-18
US5519131A (en)	1996-05-21
PL294221A1 (en)	1993-08-09
KR920019796A (ko)	1992-11-20
HUT62588A (en)	1993-05-28
ZA922721B (en)	1992-11-25
FI921641A7 (fi)	1992-10-16
CA2065986A1 (en)	1992-10-16
FI921641A0 (fi)	1992-04-13
NO301765B1 (no)	1997-12-08
FI97544C (fi)	1997-01-10
AU1485292A (en)	1992-10-22
TW211016B (de)	1993-08-11
CA2065986C (en)	2006-02-21
IE74907B1 (en)	1997-08-13
RU2042680C1 (ru)	1995-08-27
EP0509400B1 (de)	1996-07-03
DE69211892D1 (de)	1996-08-08
GR3020612T3 (en)	1996-10-31
IL101589A (en)	1996-10-31
US5276156A (en)	1994-01-04
NZ242309A (en)	1995-07-26
PL168671B1 (pl)	1996-03-29
HU9201290D0 (en)	1992-07-28
EP0509400A1 (de)	1992-10-21
ES2094840T3 (es)	1997-02-01
US5214038A (en)	1993-05-25
NO921490D0 (no)	1992-04-14
IE921190A1 (en)	1992-10-21
IL101589A0 (en)	1992-12-30
FI97544B (fi)	1996-09-30
DK0509400T3 (da)	1996-10-28

Legal Events

Date	Code	Title	Description
1997-01-15	UEP	Publication of translation of european patent specification
2011-01-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE3772905D1 (de)	1991-10-17	Alpha-alkyl-4-amino-3-chinolin-methanole und 1-(4-aralkylamino-3-chinolyl)alkanone, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
DE69211892D1 (de)	1996-08-08	1-(Pyrido[3,4-b]-1,4-oxazinyl-4-yl)-1H-Indole, Zwischenprodukte und ein Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE69025941D1 (de)	1996-04-18	Dem Physostigmin verwandte 4- und 6-Carbamate, ein Verfahren und Zwischenprodukte zu ihrer Herstellung und ihre Verwendung als Arzneimittel
ATE163012T1 (de)	1998-02-15	N-substituierte 4-pyrimidinamine und - pyrimidindiamine, verfahren zu ihrer herstellung und ihre anwendung als arzneimittel
DE69016530D1 (de)	1995-03-16	1,3-Dihydro-1-(pyridinylamino)-2H-indol-2-one, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel.
ATE171176T1 (de)	1998-10-15	1-(substituierte pyridinylamino)-1h-indol-5-yl substituierte carbamate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE69206889D1 (de)	1996-02-01	Arylalkylpiperidine-4-yl)methyl]-2-alpha-3,4,5-tetrahydro-1-(2H)-acenaphthylene-1-Onederivate, ein Verfahren für ihre Herstellung und ihre Verwendung als Medikamente
DE3780015D1 (de)	1992-07-30	Kondensierte heterocyclische tetrahydroaminochinolinole und verwandte verbindungen, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
DE68918402D1 (de)	1994-10-27	1,2,3,4-Tetrahydro-1,9-Acridindiamine, ein Verfahren zu ihrer Herstellung und ihre Verwendung als Medikamente.
DE69011013D1 (de)	1994-09-01	1-(Pyridinylamino)-2-pyrrolidinone, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel.
DE69016531D1 (de)	1995-03-16	2,3-Dihydro-1-(pyridinylamino)-indole, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel.
ATE104298T1 (de)	1994-04-15	Kondensierte heterocyclische derivate von 1,2,3,4-tetrahydroacridin, verfahren zu ihrer herstellung und ihre verwendung als medikament.
DE3671017D1 (de)	1990-06-13	Benzo(c)-1,5-naphthyridine, ein verfahren und zwischenprodukte zu ihrer herstellung und ihre verwendung als arzneimittel.
DE68906647D1 (de)	1993-06-24	Hydroxy-1,2,3,4-tetrahydroaminoacridine, verfahren fuer ihre herstellung und ihre verwendung als arzneimittel.
ATE183746T1 (de)	1999-09-15	Pyrido(3,4-b>pyrrolo(1,2-e>(1,4,5>oxadiazepine und verwandte analoge, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel