ATE123057T1 - Trombolytischer wirkstoff mit modifikation der domäne der kringle. - Google Patents

Trombolytischer wirkstoff mit modifikation der domäne der kringle.

Info

Publication number
ATE123057T1
ATE123057T1 AT89912186T AT89912186T ATE123057T1 AT E123057 T1 ATE123057 T1 AT E123057T1 AT 89912186 T AT89912186 T AT 89912186T AT 89912186 T AT89912186 T AT 89912186T AT E123057 T1 ATE123057 T1 AT E123057T1
Authority
AT
Austria
Prior art keywords
kringle
kringle domain
trombolytic
modification
active substance
Prior art date
Application number
AT89912186T
Other languages
English (en)
Inventor
Nicole T Hatzenbuhler
Keith R Marotti
Edward F Rehberg
Johan H Verheijen
Original Assignee
Tno
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tno filed Critical Tno
Application granted granted Critical
Publication of ATE123057T1 publication Critical patent/ATE123057T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
AT89912186T 1988-10-27 1989-10-04 Trombolytischer wirkstoff mit modifikation der domäne der kringle. ATE123057T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US26367388A 1988-10-27 1988-10-27

Publications (1)

Publication Number Publication Date
ATE123057T1 true ATE123057T1 (de) 1995-06-15

Family

ID=23002781

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89912186T ATE123057T1 (de) 1988-10-27 1989-10-04 Trombolytischer wirkstoff mit modifikation der domäne der kringle.

Country Status (8)

Country Link
US (1) US5275946A (de)
EP (1) EP0440709B1 (de)
JP (1) JPH04506897A (de)
AT (1) ATE123057T1 (de)
AU (1) AU4502589A (de)
CA (1) CA2001343A1 (de)
DE (1) DE68922859T2 (de)
WO (1) WO1990004635A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6825328B1 (en) * 1998-07-20 2004-11-30 Stephen W. Scherer Lafora's disease gene
US20050136458A1 (en) * 1998-12-31 2005-06-23 Oligos, Etc, Inc. Method for nucleic acid preparation
US9274765B2 (en) * 2005-05-12 2016-03-01 Drawing Management, Inc. Spatial graphical user interface and method for using the same
US7615061B2 (en) * 2006-02-28 2009-11-10 Arthrocare Corporation Bone anchor suture-loading system, method and apparatus
ES2823998T3 (es) * 2011-09-08 2021-05-11 Inst Nat Sante Rech Med Nuevos activadores de plasminógeno tisular mutados y usos de los mismos
USD658588S1 (en) 2011-09-27 2012-05-01 Paul Justice Recessed outlet cover
US11613744B2 (en) 2018-12-28 2023-03-28 Vertex Pharmaceuticals Incorporated Modified urokinase-type plasminogen activator polypeptides and methods of use
CA3123872A1 (en) 2018-12-28 2020-07-02 Catalyst Biosciences, Inc. Modified urokinase-type plasminogen activator polypeptides and methods of use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0289508A1 (de) * 1985-12-20 1988-11-09 The Upjohn Company Analoge des gewebespezifischen plasminogenaktivators
EP0234051B1 (de) * 1986-02-17 1991-12-11 Stichting Centraal Laboratorium van de Bloedtransfusiedienst van het Nederlandse Rode Kruis Gewebeplasminogen-Aktivator-Mutant, dafür kodierende rekombinante genetische Information und Verfahren zur Herstellung dieser Mutanten, deren Verwendung und pharmazeutische Zusammensetzungen
PT84588B (en) * 1986-04-02 1989-05-09 Beecham Group Plc Process for preparing a fibrinolytic enzyme
FI100106B (fi) * 1986-12-05 1997-09-30 Novartis Ag Menetelmä plasminogeenin yksisäikeisen yhdistelmäaktivaattorin valmist amiseksi
WO1988005081A2 (en) * 1986-12-30 1988-07-14 Cetus Corporation Novel plasminogen activator

Also Published As

Publication number Publication date
WO1990004635A1 (en) 1990-05-03
AU4502589A (en) 1990-05-14
DE68922859T2 (de) 1995-09-21
DE68922859D1 (de) 1995-06-29
EP0440709A1 (de) 1991-08-14
EP0440709B1 (de) 1995-05-24
JPH04506897A (ja) 1992-12-03
US5275946A (en) 1994-01-04
CA2001343A1 (en) 1990-04-27

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee