ATE123494T1 - Chinolon-derivate und deren salze, verfahren zu deren herstellung und diese enthaltende antibakterielle wirkstoffe. - Google Patents
Chinolon-derivate und deren salze, verfahren zu deren herstellung und diese enthaltende antibakterielle wirkstoffe.Info
- Publication number
- ATE123494T1 ATE123494T1 AT90106199T AT90106199T ATE123494T1 AT E123494 T1 ATE123494 T1 AT E123494T1 AT 90106199 T AT90106199 T AT 90106199T AT 90106199 T AT90106199 T AT 90106199T AT E123494 T1 ATE123494 T1 AT E123494T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- substituted
- hydrogen
- atom
- salts
- Prior art date
Links
- 230000000844 anti-bacterial effect Effects 0.000 title abstract 2
- 239000004480 active ingredient Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 150000007660 quinolones Chemical class 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical group C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1079523A JPH02258783A (ja) | 1989-03-30 | 1989-03-30 | キノロン誘導体及びその塩 |
| JP8232289 | 1989-03-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE123494T1 true ATE123494T1 (de) | 1995-06-15 |
Family
ID=26420539
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90106199T ATE123494T1 (de) | 1989-03-30 | 1990-03-30 | Chinolon-derivate und deren salze, verfahren zu deren herstellung und diese enthaltende antibakterielle wirkstoffe. |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US5153203A (de) |
| EP (1) | EP0390215B1 (de) |
| AT (1) | ATE123494T1 (de) |
| DE (1) | DE69019859T2 (de) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5407932A (en) * | 1989-03-31 | 1995-04-18 | Wakunaga Seiyaku Kabushiki Kaisha | Quinolone derivatives and antibacterial agents containing the same |
| US5696132A (en) * | 1991-05-28 | 1997-12-09 | Daiichi Pharmaceutical Co., Ltd. | Pyridonecarboxylic acid derivatives |
| GB9118183D0 (en) * | 1991-08-23 | 1991-10-09 | Solanki Kishor K | Imaging of infections |
| US5412098A (en) * | 1991-12-27 | 1995-05-02 | Wakunaga Seiyaku Kabushiki Kaisha | Quinolone derivative or salt thereof and antibacterial containing the same |
| TW252107B (de) * | 1993-08-27 | 1995-07-21 | Hokuriku Pharmacetical Co Ltd | |
| ES2256331T3 (es) * | 2000-12-21 | 2006-07-16 | PHARMACIA & UPJOHN COMPANY LLC | Derivados de quinolina antimicrobianos y uso de los mismos para tratar infecciones bacterianas. |
| ES2186550B2 (es) * | 2001-06-27 | 2003-11-16 | Vita Lab | Nuevos derivados de oxazolidinonas como antibacterianos. |
| WO2003031443A1 (de) | 2001-10-04 | 2003-04-17 | Morphochem Aktiengesellschaft für kombinatorische Chemie | Dual action antibiotics |
| WO2003031441A1 (en) * | 2001-10-04 | 2003-04-17 | Morphochen Aktiengesellschaft Für Kombinatorische Chemie | Multiple action compounds |
| JP4691988B2 (ja) * | 2002-10-03 | 2011-06-01 | 小野薬品工業株式会社 | Ｌｐａ受容体拮抗剤 |
| NZ543757A (en) | 2003-04-30 | 2009-02-28 | Morphochem Ag Komb Chemie | Use of oxazolidinone-quinoline hybrid antibiotics for the treatment of anthrax and other infections |
| DE10340485B4 (de) | 2003-09-03 | 2015-05-13 | Morphochem AG Aktiengesellschaft für kombinatorische Chemie | Verfahren zur Herstellung von Oxazolidinon-Chinolon Hybriden |
| US8158797B2 (en) | 2003-12-18 | 2012-04-17 | Morphochem Aktiengesellschaft Fur Kombinatorische Chemie | Oxazolidinone-quinolone hybrid antibiotics |
| AU2004299278C9 (en) | 2003-12-18 | 2013-10-24 | Morphochem Aktiengesellschaft Fuer Kombinatorische Chemie | Oxazolidinone-quinolone hybrid antibiotics |
| US7246755B2 (en) * | 2003-12-18 | 2007-07-24 | Cepia, Llc | Power sprayer |
| US7498341B2 (en) * | 2004-01-31 | 2009-03-03 | Sanofi Aventis Deutschland Gmbh | Heterocyclically substituted 7-amino-4-quinolone-3-carboxylic acid derivatives, process for their preparation and their use as medicaments |
| AU2007225088B2 (en) * | 2006-03-13 | 2012-09-13 | Kyorin Pharmaceutical Co., Ltd | Aminoquinolones as GSK-3 inhibitors |
| WO2009035634A2 (en) * | 2007-09-11 | 2009-03-19 | Activx Biosciences, Inc. | Cyanoaminoquinolones and tetrazoloaminoquinolones as gsk-3 inhibitors |
| CN102344457B (zh) | 2007-09-12 | 2015-07-22 | 杏林制药株式会社 | 作为 gsk-3 抑制剂的螺环状氨基喹诺酮 |
| BRPI1008974A2 (pt) | 2009-03-11 | 2017-06-06 | Kyorin Seiyaku Kk | composto, composição farmacêutica, e, método para tratar, prevenir ou melhorar uma doença mediada com gsk-3 |
| CN104402902B (zh) * | 2014-12-15 | 2016-05-18 | 河南大学 | 手性7-(哌嗪取代的吡唑醛缩异烟肼腙)氟喹诺酮羧酸衍生物及其制备方法和应用 |
| CA3027827A1 (en) | 2016-06-15 | 2017-12-21 | Wakunaga Pharmaceutical Co., Ltd. | Novel pyridonecarboxylic acid derivative or salt thereof |
| CN109912504B (zh) * | 2019-04-04 | 2020-11-10 | 山东省联合农药工业有限公司 | 一种喹啉羧酸类化合物及其制备方法与用途 |
| CN114163452A (zh) * | 2021-12-24 | 2022-03-11 | 广东医科大学 | 一种1,3-恶嗪并1,3-恶唑衍生物的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4473568A (en) * | 1983-03-01 | 1984-09-25 | Warner Lambert Company | Antibacterial thiazolidine or thiomorpholine substituted quinolines |
| DE3705621C2 (de) * | 1986-02-25 | 1997-01-09 | Otsuka Pharma Co Ltd | Heterocyclisch substituierte Chinoloncarbonsäurederivate |
| DE3811341A1 (de) * | 1987-10-09 | 1989-04-27 | Bayer Ag | In 7-stellung c-verknuepfte chinolon- und 1,8-naphthyridin-4-on-carbonsaeure und ein verfahren zu ihrer herstellung |
| EP0339406A1 (de) * | 1988-04-19 | 1989-11-02 | Hokuriku Pharmaceutical Co.,Ltd | Derivate der Chinolin-3-carbonsäure, Verfahren zu ihrer Herstellung und diese Derivate enthaltende antibakterielle Zusammensetzung |
-
1990
- 1990-03-30 DE DE69019859T patent/DE69019859T2/de not_active Expired - Fee Related
- 1990-03-30 EP EP90106199A patent/EP0390215B1/de not_active Expired - Lifetime
- 1990-03-30 US US07/501,720 patent/US5153203A/en not_active Expired - Fee Related
- 1990-03-30 AT AT90106199T patent/ATE123494T1/de active
Also Published As
| Publication number | Publication date |
|---|---|
| DE69019859T2 (de) | 1995-10-05 |
| EP0390215A2 (de) | 1990-10-03 |
| US5153203A (en) | 1992-10-06 |
| EP0390215B1 (de) | 1995-06-07 |
| DE69019859D1 (de) | 1995-07-13 |
| EP0390215A3 (de) | 1991-07-24 |
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