ATE124086T1 - Herstellung von proteinen. - Google Patents

Herstellung von proteinen.

Info

Publication number: ATE124086T1
Authority: AT; Austria
Prior art keywords: production; proteins; yeast strains; transformed; methods
Prior art date: 1988-05-04

Application number

AT89810335T

Other languages

English (en)

Inventor

Hansjoerg Dr Treichler

Kenji Dr Takabayashi

Dieter Heinrich Prof Dr Wolf

Jutta Dr Heim

Original Assignee

Ciba Geigy Ag

Ucp Gen Pharma Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-05-04

Filing date

1989-05-01

Publication date

1995-07-15

1988-05-04 Priority claimed from GB888810524A external-priority patent/GB8810524D0/en

1988-05-27 Priority claimed from GB888812627A external-priority patent/GB8812627D0/en

1989-03-29 Priority claimed from GB898907110A external-priority patent/GB8907110D0/en

1989-05-01 Application filed by Ciba Geigy Ag, Ucp Gen Pharma Ag filed Critical Ciba Geigy Ag

1995-07-15 Application granted granted Critical

1995-07-15 Publication of ATE124086T1 publication Critical patent/ATE124086T1/de

Links

102000004169 proteins and genes Human genes 0.000 title abstract 2
108090000623 proteins and genes Proteins 0.000 title abstract 2
240000004808 Saccharomyces cerevisiae Species 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
108091005804 Peptidases Proteins 0.000 abstract 1
239000004365 Protease Substances 0.000 abstract 1
102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 1
230000002950 deficient Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion

Landscapes

Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Biomedical Technology (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
General Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Physics & Mathematics (AREA)
Microbiology (AREA)
Plant Pathology (AREA)
Mycology (AREA)
Medicinal Chemistry (AREA)
Gastroenterology & Hepatology (AREA)
Tropical Medicine & Parasitology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Enzymes And Modification Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Liquid Crystal Substances (AREA)

AT89810335T 1988-05-04 1989-05-01 Herstellung von proteinen. ATE124086T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB888810524A GB8810524D0 (en)	1988-05-04	1988-05-04	Improvements in production of polypeptides
GB888812627A GB8812627D0 (en)	1988-05-27	1988-05-27	Improvements in production of polypeptides
GB898907110A GB8907110D0 (en)	1988-05-04	1989-03-29	Improvements in the production of polypeptides

Publications (1)

Publication Number	Publication Date
ATE124086T1 true ATE124086T1 (de)	1995-07-15

Family

ID=27263890

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT89810335T ATE124086T1 (de)	1988-05-04	1989-05-01	Herstellung von proteinen.

Country Status (16)

Country	Link
EP (1)	EP0341215B1 (de)
JP (1)	JPH0824565B2 (de)
AT (1)	ATE124086T1 (de)
AU (1)	AU614121B2 (de)
CA (1)	CA1340016C (de)
DE (1)	DE68923123T2 (de)
DK (1)	DK175701B1 (de)
ES (1)	ES2072918T3 (de)
FI (1)	FI103129B1 (de)
HU (1)	HU218731B (de)
IE (1)	IE66044B1 (de)
IL (1)	IL90170A (de)
MX (1)	MX169508B (de)
NO (1)	NO180593C (de)
NZ (1)	NZ228955A (de)
PT (1)	PT90436B (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8809860D0 (en) *	1988-04-26	1988-06-02	Ciba Geigy Ag	Process for production of polypeptides
FR2645175B1 (fr) *	1989-03-31	1994-02-18	Transgene Sa	Souche de saccharomyces cerevisiaeproductrice d'une proteine heterologue et procede de preparation de ladite proteine heterologue par fermentation de ladite souche
FR2645174B1 (fr) *	1989-03-31	1994-01-07	Transgene Sa	Souches de levure ameliorees pour la production de proteines heterologues matures en particulier d'hirudine et procede de preparation d'hirudine correspondant
US5879926A (en) *	1989-03-31	1999-03-09	Transgene S.A.	Yeast strains for the production of mature heterologous proteins, especially hirudin
WO1991008229A1 (de) *	1989-12-01	1991-06-13	Basf Aktiengesellschaft	Hirudinpolyalkylenglykolkonjugate
US5580734A (en) *	1990-07-13	1996-12-03	Transkaryotic Therapies, Inc.	Method of producing a physical map contigous DNA sequences
DE69114500T2 (de) *	1990-07-13	1996-06-13	Transkaryotic Therapies Inc	Verfahren zum absuchen einer bibliothek.
US5612198A (en) *	1990-09-04	1997-03-18	The Salk Institute	Production of insulin-like growth factor-1 in methylotrophic yeast cells
EP0548267A4 (en) *	1990-09-04	1994-11-23	Salk Inst Biotech Ind	Production of insulin-like growth factor-1 in methylotrophic yeast cells
DK0687731T3 (da)	1990-11-08	1999-09-20	Japan Energy Corp	Sekretionsvektor, transformerede mikroorganismer indeholdende vektoren og fremstilling af produkter fra denne mikroorganism
SG84484A1 (en) *	1991-02-25	2001-11-20	Ciba Geigy Ag	Improved yeast vectors
ATE220105T1 (de) *	1991-04-01	2002-07-15	Merck & Co Inc	Gene, die die proteolytische aktivitaet von pichia beeinflussen und deren verwendung
HU214698B (hu) *	1992-04-09	1998-06-29	Gyógyszerkutató Intézet Kft.	Eljárás rekombináns deszulfátó-hirudin HV-1 peptidek előállítására
SG49859A1 (en) *	1992-09-04	2002-03-19	Ucp Gen Pharma Ag	Process for the production of protease inhibitors
TW282490B (de) *	1992-12-15	1996-08-01	Ciba Geigy Ag
AU685835B2 (en) *	1993-08-04	1998-01-29	Novartis Ag	High molecular weight desulphatohirudin
DE4404168A1 (de) *	1994-02-10	1995-08-17	Hoechst Ag	Hirudinderivate und Verfahren zu deren Herstellung
US5981227A (en) *	1995-02-09	1999-11-09	Movartis Ag	Process for the production of proteins
ES2281079T3 (es) *	1995-03-20	2007-09-16	Novozymes A/S	Celula huesped que expresa niveles reducidos de metaloproteasa y metodos de utilizacion de la celula huesped para la produccion de proteinas.
DE19529997C1 (de)	1995-08-16	1997-04-10	Hoechst Ag	Verfahren zur Inaktivierung von Carboxypeptidase Y in hirudinhaltigen Kulturbrühen
AU7112796A (en) *	1995-09-27	1997-04-17	Chiron Corporation	Method of making a protease deficient host
DE69625623T2 (de)	1996-01-31	2003-11-06	Sumitomo Bakelite Co. Ltd., Tokio/Tokyo	Verfahren zur Herstellung von in Epoxyharz eingekapselter Halbleitervorrichtung
FR2768743B1 (fr) *	1997-09-23	2001-09-14	Bio Merieux	Procede de lyse de micro-organisme
GB2338236B (en) *	1998-06-13	2003-04-09	Aea Technology Plc	Microbiological cell processing
US7795205B2 (en)	2004-04-12	2010-09-14	Canyon Pharmaceuticals, Inc.	Methods for effecting regression of tumor mass and size in a metastasized pancreatic tumor
US8815541B2 (en)	2009-11-25	2014-08-26	Novo Nordisk A/S	Method for making polypeptides
AU2018348518B2 (en)	2017-10-10	2024-05-16	Ajinomoto Co., Inc.	Method for manufacturing protein
EP4166647A4 (de)	2020-06-11	2025-01-01	Ajinomoto Co., Inc.	Verfahren zur herstellung von protein

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3342139A1 (de) *	1983-11-22	1985-05-30	Ciba-Geigy Ag, Basel	Desulfatohirudine, verfahren zu ihrer herstellung und pharmazeutische mittel
JPS62224284A (ja) *	1986-03-25	1987-10-02	Agency Of Ind Science & Technol	微生物
GB8809860D0 (en) *	1988-04-26	1988-06-02	Ciba Geigy Ag	Process for production of polypeptides
GB8817160D0 (en) *	1988-07-19	1988-08-24	Ciba Geigy Ag	Novel proteins
GB8817161D0 (en) *	1988-07-19	1988-08-24	Ciba Geigy Ag	Modified proteins

1989
- 1989-04-28 AU AU33828/89A patent/AU614121B2/en not_active Expired
- 1989-05-01 AT AT89810335T patent/ATE124086T1/de not_active IP Right Cessation
- 1989-05-01 DE DE68923123T patent/DE68923123T2/de not_active Expired - Lifetime
- 1989-05-01 ES ES89810335T patent/ES2072918T3/es not_active Expired - Lifetime
- 1989-05-01 EP EP89810335A patent/EP0341215B1/de not_active Expired - Lifetime
- 1989-05-02 PT PT90436A patent/PT90436B/pt not_active IP Right Cessation
- 1989-05-02 JP JP1112294A patent/JPH0824565B2/ja not_active Expired - Lifetime
- 1989-05-02 CA CA000598488A patent/CA1340016C/en not_active Expired - Lifetime
- 1989-05-02 MX MX015887A patent/MX169508B/es unknown
- 1989-05-02 NZ NZ228955A patent/NZ228955A/en unknown
- 1989-05-03 IL IL9017089A patent/IL90170A/en active IP Right Grant
- 1989-05-03 NO NO891837A patent/NO180593C/no not_active IP Right Cessation
- 1989-05-03 DK DK198902175A patent/DK175701B1/da not_active IP Right Cessation
- 1989-05-03 IE IE145189A patent/IE66044B1/en not_active IP Right Cessation
- 1989-05-03 FI FI892114A patent/FI103129B1/fi not_active IP Right Cessation
- 1989-05-03 HU HU077/89A patent/HU218731B/hu unknown

Also Published As

Publication number	Publication date
MX169508B (es)	1993-07-08
CA1340016C (en)	1998-08-25
ES2072918T3 (es)	1995-08-01
DK217589D0 (da)	1989-05-03
AU3382889A (en)	1989-11-09
IL90170A (en)	1995-12-31
JPH02104279A (ja)	1990-04-17
JPH0824565B2 (ja)	1996-03-13
NZ228955A (en)	1991-06-25
IE66044B1 (en)	1995-12-13
FI892114L (fi)	1989-11-05
FI892114A0 (fi)	1989-05-03
PT90436A (pt)	1989-11-30
EP0341215A2 (de)	1989-11-08
IL90170A0 (en)	1989-12-15
NO180593C (no)	1997-05-14
AU614121B2 (en)	1991-08-22
NO891837D0 (no)	1989-05-03
EP0341215A3 (de)	1992-01-15
DE68923123T2 (de)	1995-11-30
EP0341215B1 (de)	1995-06-21
HU218731B (hu)	2000-11-28
DK217589A (da)	1989-11-05
IE891451L (en)	1989-11-04
FI103129B (fi)	1999-04-30
DK175701B1 (da)	2005-01-24
DE68923123D1 (de)	1995-07-27
PT90436B (pt)	1994-11-30
NO891837L (no)	1989-11-06
NO180593B (no)	1997-02-03
HUT54210A (en)	1991-01-28
FI103129B1 (fi)	1999-04-30

Legal Events

Date	Code	Title	Description
2009-08-15	EELA	Cancelled due to lapse of time

Publication	Publication Date	Title
ATE124086T1 (de)	1995-07-15	Herstellung von proteinen.
ATE112802T1 (de)	1994-10-15	Herstellung von funktionellen menschlichen urokinasepolypeptiden.
AU3120689A (en)	1989-09-14	CKS method of protein synthesis
ES2061682T3 (es)	1994-12-16	Cisteina proteinasas, produccion y uso.
ATE118547T1 (de)	1995-03-15	Produktion von kallikrein.
ATE71658T1 (de)	1992-02-15	Verfahren zur herstellung von humanlysozym.
FI931634A0 (fi)	1993-04-08	Nytt svampproteas
NO944181D0 (no)	1994-11-02	Proteaser for sopp
FI99211B (fi)	1997-07-15	Menetelmä hirudiinivariantin valmistamiseksi
DE69028890D1 (de)	1996-11-21	Ergiebige Herstellung von Protease-Mutanten
AU591305B2 (en)	1989-11-30	Improved process for preparing 5,6-substitued-2,4- quinazolinediamines and novel intermediates
DE69329540D1 (de)	2000-11-16	Verfahren zur Herstellung von Proteaseinhibitoren
DE68908843D1 (de)	1993-10-07	Verfahren zur Herstellung von 4,6-Dimethyl-7-hydroxynonan-3-on.
DK196489A (da)	1989-10-26	Carbamatderivater samt en fremgangsmaade til fremstilling heraf