ATE124227T1 - Nadel mittels eines photosensibilisators mit verbesserter fluoreszenzbiopsie. - Google Patents

Nadel mittels eines photosensibilisators mit verbesserter fluoreszenzbiopsie.

Info

Publication number
ATE124227T1
ATE124227T1 AT92302907T AT92302907T ATE124227T1 AT E124227 T1 ATE124227 T1 AT E124227T1 AT 92302907 T AT92302907 T AT 92302907T AT 92302907 T AT92302907 T AT 92302907T AT E124227 T1 ATE124227 T1 AT E124227T1
Authority
AT
Austria
Prior art keywords
tissue
intensity ratio
biopsy
fluorescence
photosensitizer
Prior art date
Application number
AT92302907T
Other languages
English (en)
Inventor
Sandor George Vari
Theodore Papazoglou
Warren Scott Grundfest
Original Assignee
Cedars Sinai Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cedars Sinai Medical Center filed Critical Cedars Sinai Medical Center
Application granted granted Critical
Publication of ATE124227T1 publication Critical patent/ATE124227T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A61B18/22—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B10/0233—Pointed or sharp biopsy instruments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/414—Evaluating particular organs or parts of the immune or lymphatic systems
    • A61B5/415—Evaluating particular organs or parts of the immune or lymphatic systems the glands, e.g. tonsils, adenoids or thymus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/414—Evaluating particular organs or parts of the immune or lymphatic systems
    • A61B5/418—Evaluating particular organs or parts of the immune or lymphatic systems lymph vessels, ducts or nodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22082—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance
    • A61B2017/22087—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance photodynamic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/06—Measuring instruments not otherwise provided for
    • A61B2090/062—Measuring instruments not otherwise provided for penetration depth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/06—Measuring instruments not otherwise provided for
    • A61B2090/064—Measuring instruments not otherwise provided for for measuring force, pressure or mechanical tension

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Otolaryngology (AREA)
  • Electromagnetism (AREA)
  • Endocrinology (AREA)
  • Optics & Photonics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Luminescent Compositions (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Electrodes Of Semiconductors (AREA)
  • Surgical Instruments (AREA)
  • Dental Preparations (AREA)
AT92302907T 1991-04-03 1992-04-02 Nadel mittels eines photosensibilisators mit verbesserter fluoreszenzbiopsie. ATE124227T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/679,766 US5318023A (en) 1991-04-03 1991-04-03 Apparatus and method of use for a photosensitizer enhanced fluorescence based biopsy needle

Publications (1)

Publication Number Publication Date
ATE124227T1 true ATE124227T1 (de) 1995-07-15

Family

ID=24728271

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92302907T ATE124227T1 (de) 1991-04-03 1992-04-02 Nadel mittels eines photosensibilisators mit verbesserter fluoreszenzbiopsie.

Country Status (9)

Country Link
US (1) US5318023A (de)
EP (1) EP0513986B1 (de)
JP (1) JP3383301B2 (de)
AT (1) ATE124227T1 (de)
AU (1) AU1400892A (de)
CA (1) CA2063651A1 (de)
DE (1) DE69203153T2 (de)
GR (1) GR3017015T3 (de)
WO (1) WO1992017108A1 (de)

Families Citing this family (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5873821A (en) * 1992-05-18 1999-02-23 Non-Invasive Technology, Inc. Lateralization spectrophotometer
US6549795B1 (en) 1991-05-16 2003-04-15 Non-Invasive Technology, Inc. Spectrophotometer for tissue examination
US5769792A (en) * 1991-07-03 1998-06-23 Xillix Technologies Corp. Endoscopic imaging system for diseased tissue
US6785568B2 (en) * 1992-05-18 2004-08-31 Non-Invasive Technology Inc. Transcranial examination of the brain
US5954053A (en) * 1995-06-06 1999-09-21 Non-Invasive Technology, Inc. Detection of brain hematoma
CA2097280A1 (en) * 1992-06-01 1993-12-02 Sandor G. Vari Apparatus and method of use for a photosensitizer enhanced fluorescence based bipsy needle
US5762609A (en) 1992-09-14 1998-06-09 Sextant Medical Corporation Device and method for analysis of surgical tissue interventions
US5460182A (en) * 1992-09-14 1995-10-24 Sextant Medical Corporation Tissue penetrating apparatus and methods
US5772597A (en) 1992-09-14 1998-06-30 Sextant Medical Corporation Surgical tool end effector
US5987346A (en) 1993-02-26 1999-11-16 Benaron; David A. Device and method for classification of tissue
US5349954A (en) * 1993-07-23 1994-09-27 General Electric Company Tumor tissue characterization apparatus and method
US5590660A (en) * 1994-03-28 1997-01-07 Xillix Technologies Corp. Apparatus and method for imaging diseased tissue using integrated autofluorescence
US5515864A (en) * 1994-04-21 1996-05-14 Zuckerman; Ralph Method and apparatus for the in vivo measurement of oxygen concentration levels by the indirect determination of fluoescence lifetime
US5712165A (en) * 1994-08-22 1998-01-27 Beth Israel Hospital Administration Method and apparatus for detecting hydrocarbon oxidation
US5572996A (en) * 1994-09-19 1996-11-12 Pdt Systems, Inc. In vivo pharmacokinetics of photosensitive drugs and method
US5660181A (en) * 1994-12-12 1997-08-26 Physical Optics Corporation Hybrid neural network and multiple fiber probe for in-depth 3-D mapping
US6258576B1 (en) 1996-06-19 2001-07-10 Board Of Regents, The University Of Texas System Diagnostic method and apparatus for cervical squamous intraepithelial lesions in vitro and in vivo using fluorescence spectroscopy
US5991653A (en) * 1995-03-14 1999-11-23 Board Of Regents, The University Of Texas System Near-infrared raman spectroscopy for in vitro and in vivo detection of cervical precancers
US5697373A (en) * 1995-03-14 1997-12-16 Board Of Regents, The University Of Texas System Optical method and apparatus for the diagnosis of cervical precancers using raman and fluorescence spectroscopies
US6174424B1 (en) 1995-11-20 2001-01-16 Cirrex Corp. Couplers for optical fibers
US5953477A (en) * 1995-11-20 1999-09-14 Visionex, Inc. Method and apparatus for improved fiber optic light management
US5647368A (en) * 1996-02-28 1997-07-15 Xillix Technologies Corp. Imaging system for detecting diseased tissue using native fluorsecence in the gastrointestinal and respiratory tract
US5762613A (en) * 1996-05-07 1998-06-09 Spectrascience, Inc. Optical biopsy forceps
US5843000A (en) * 1996-05-07 1998-12-01 The General Hospital Corporation Optical biopsy forceps and method of diagnosing tissue
US5842995A (en) * 1996-06-28 1998-12-01 Board Of Regents, The Univerisity Of Texas System Spectroscopic probe for in vivo measurement of raman signals
DE19780856D2 (de) * 1996-08-16 1999-09-23 Roche Diagnostics Gmbh Kontrollsystem für die Überwachung der regelmäßigen Einnahme eines Medikamentes
US6208783B1 (en) 1997-03-13 2001-03-27 Cirrex Corp. Optical filtering device
CA2283949A1 (en) 1997-03-13 1998-09-17 Haishan Zeng Methods and apparatus for detecting the rejection of transplanted tissue
US6937885B1 (en) 1997-10-30 2005-08-30 Hypermed, Inc. Multispectral/hyperspectral medical instrument
US6055451A (en) 1997-12-12 2000-04-25 Spectrx, Inc. Apparatus and method for determining tissue characteristics
US6174291B1 (en) 1998-03-09 2001-01-16 Spectrascience, Inc. Optical biopsy system and methods for tissue diagnosis
US6066102A (en) 1998-03-09 2000-05-23 Spectrascience, Inc. Optical biopsy forceps system and method of diagnosing tissue
US6721582B2 (en) 1999-04-06 2004-04-13 Argose, Inc. Non-invasive tissue glucose level monitoring
US20020091324A1 (en) * 1998-04-06 2002-07-11 Nikiforos Kollias Non-invasive tissue glucose level monitoring
US7899518B2 (en) * 1998-04-06 2011-03-01 Masimo Laboratories, Inc. Non-invasive tissue glucose level monitoring
US6505059B1 (en) 1998-04-06 2003-01-07 The General Hospital Corporation Non-invasive tissue glucose level monitoring
US6728560B2 (en) 1998-04-06 2004-04-27 The General Hospital Corporation Non-invasive tissue glucose level monitoring
US6258577B1 (en) 1998-07-21 2001-07-10 Gambro, Inc. Method and apparatus for inactivation of biological contaminants using endogenous alloxazine or isoalloxazine photosensitizers
US7498156B2 (en) 1998-07-21 2009-03-03 Caridianbct Biotechnologies, Llc Use of visible light at wavelengths of 500 to 550 nm to reduce the number of pathogens in blood and blood components
US7049110B2 (en) 1998-07-21 2006-05-23 Gambro, Inc. Inactivation of West Nile virus and malaria using photosensitizers
AU6139199A (en) * 1998-09-11 2000-04-03 Spectrx, Inc. Multi-modal optical tissue diagnostic system
US6377842B1 (en) 1998-09-22 2002-04-23 Aurora Optics, Inc. Method for quantitative measurement of fluorescent and phosphorescent drugs within tissue utilizing a fiber optic probe
US6074383A (en) * 1998-09-30 2000-06-13 Becton Dickinson And Company Laser lancet tip
US6580935B1 (en) 1999-03-12 2003-06-17 Cirrex Corp. Method and system for stabilizing reflected light
DE19925210C2 (de) * 1999-06-01 2001-12-20 Alexander Hohla Fasersonde
US6697666B1 (en) 1999-06-22 2004-02-24 Board Of Regents, The University Of Texas System Apparatus for the characterization of tissue of epithelial lined viscus
US7094378B1 (en) 2000-06-15 2006-08-22 Gambro, Inc. Method and apparatus for inactivation of biological contaminants using photosensitizers
US7220747B2 (en) 1999-07-20 2007-05-22 Gambro, Inc. Method for preventing damage to or rejuvenating a cellular blood component using mitochondrial enhancer
US7904139B2 (en) * 1999-08-26 2011-03-08 Non-Invasive Technology Inc. Optical examination of biological tissue using non-contact irradiation and detection
US7840257B2 (en) * 2003-01-04 2010-11-23 Non Invasive Technology, Inc. Examination of biological tissue using non-contact optical probes
US6268120B1 (en) 1999-10-19 2001-07-31 Gambro, Inc. Isoalloxazine derivatives to neutralize biological contaminants
US6291795B1 (en) * 1999-11-09 2001-09-18 The United States Of America As Represented By The United States Department Of Energy Unfocused laser beam delivery system
AU2001251134B2 (en) 2000-03-31 2006-02-02 Angiodynamics, Inc. Tissue biopsy and treatment apparatus and method
US7985588B2 (en) 2000-06-02 2011-07-26 Caridianbct Biotechnologies, Llc Induction of and maintenance of nucleic acid damage in pathogens using riboflavin and light
TW590780B (en) 2000-06-02 2004-06-11 Gambro Inc Additive solutions containing riboflavin
US7648699B2 (en) 2000-06-02 2010-01-19 Caridianbct Biotechnologies, Llc Preventing transfusion related complications in a recipient of a blood transfusion
US9044523B2 (en) 2000-06-15 2015-06-02 Terumo Bct, Inc. Reduction of contaminants in blood and blood products using photosensitizers and peak wavelengths of light
JP3981328B2 (ja) * 2000-11-09 2007-09-26 サイセル・テクノロジーズ，インコーポレイテッド 蛍光タグを使用した生体分子濃縮物をインビボで検出するための方法、回路、および物質の組成物
US7557353B2 (en) 2001-11-30 2009-07-07 Sicel Technologies, Inc. Single-use external dosimeters for use in radiation therapies
US20040064053A1 (en) * 2002-09-30 2004-04-01 Chang Sung K. Diagnostic fluorescence and reflectance
WO2004075032A2 (en) * 2003-02-19 2004-09-02 Sicel Technologies Inc. In vivo fluorescence sensors, systems, and related methods operating in conjunction with fluorescent analytes
WO2005037329A2 (en) * 2003-10-17 2005-04-28 Tyco Healthcare Group, Lp Surgical stapling device with independent tip rotation
US8055321B2 (en) 2005-03-14 2011-11-08 Peter Bernreuter Tissue oximetry apparatus and method
US7865223B1 (en) * 2005-03-14 2011-01-04 Peter Bernreuter In vivo blood spectrometry
EP1868485B1 (de) 2005-04-15 2016-06-08 Surgisense Corporation Chirurgische instrumente mit sensoren zur erkennung von gewebeeigenschaften sowie systeme zur verwendung solcher instrumente
WO2006119431A2 (en) * 2005-04-29 2006-11-09 The Regents Of The University Of Colorado, A Body Corporate Electromagnetic characterization of tissue
US20070122344A1 (en) 2005-09-02 2007-05-31 University Of Rochester Medical Center Office Of Technology Transfer Intraoperative determination of nerve location
US8129105B2 (en) 2006-04-13 2012-03-06 Ralph Zuckerman Method and apparatus for the non-invasive measurement of tissue function and metabolism by determination of steady-state fluorescence anisotropy
US20080161744A1 (en) 2006-09-07 2008-07-03 University Of Rochester Medical Center Pre-And Intra-Operative Localization of Penile Sentinel Nodes
EP2091416A1 (de) * 2006-12-06 2009-08-26 Koninklijke Philips Electronics N.V. Gewinnung von optischen gewebeeigenschaften
US7669883B2 (en) * 2007-03-29 2010-03-02 Newfrey Llc Air bag bracket/fastener
US9901362B2 (en) 2007-07-16 2018-02-27 Dune Medical Devices Ltd. Medical device and method for use in tissue characterization and treatment
WO2009010960A2 (en) * 2007-07-16 2009-01-22 Dune Medical Devices Ltd. Medical device and method for use in tissue characterization and treatment
US9999353B2 (en) 2007-07-16 2018-06-19 Dune Medical Devices Ltd. Medical device and method for use in tissue characterization and treatment
US9757098B2 (en) 2007-07-16 2017-09-12 Dune Medical Devices Ltd. Medical device and method for use in tissue characterization and treatment
US8406860B2 (en) 2008-01-25 2013-03-26 Novadaq Technologies Inc. Method for evaluating blush in myocardial tissue
EP2259716B1 (de) 2008-03-03 2014-07-02 Koninklijke Philips N.V. Biopsie-führung mithilfe eines bildbasierten röntgenführungssystems und einer photonischen nadel
EP2249737B1 (de) * 2008-03-03 2020-07-01 Koninklijke Philips N.V. Biopsie-führung mithilfe elektromagnetischer verfolgung und einer photonischen nadel
US10219742B2 (en) 2008-04-14 2019-03-05 Novadaq Technologies ULC Locating and analyzing perforator flaps for plastic and reconstructive surgery
EP3372250B1 (de) 2008-05-02 2019-12-25 Novadaq Technologies ULC Verfahren zur herstellung und verwendung substanzbeladener erythrozyten zur beobachtung und behandlung von mikrovaskulärer hämodynamik
WO2010056973A1 (en) 2008-11-14 2010-05-20 Nonin Medical, Inc. Optical sensor path selection
US10492671B2 (en) 2009-05-08 2019-12-03 Novadaq Technologies ULC Near infra red fluorescence imaging for visualization of blood vessels during endoscopic harvest
FR2948007B1 (fr) 2009-07-20 2012-06-08 Chab Lama Al Sonde a aiguille fibree tranchante pour le diagnostic optique en profondeur de tumeurs.
US8818733B2 (en) * 2010-04-20 2014-08-26 Mayo Foundation For Medical Education And Research Determination of photodynamic therapy (PDT) treatment parameters
EP3574835A1 (de) 2012-05-21 2019-12-04 The Regents of the University of Colorado, a body corporate Dreidimensionale abbildung von prostatakrebs
JP6028096B2 (ja) 2012-06-21 2016-11-16 ノバダック テクノロジーズ インコーポレイテッド 血管造影及びかん流の定量化並びに解析手法
JP2014025774A (ja) * 2012-07-26 2014-02-06 Sony Corp 光線力学診断装置、光線力学診断方法及びデバイス
CN103536355A (zh) * 2013-08-21 2014-01-29 熊力 肿瘤靶向无损弱激光多功能手术刀系统
CN103815964A (zh) * 2014-03-20 2014-05-28 熊力 一种多功能手术刀
EP3128892A4 (de) 2014-04-05 2018-05-09 Surgisense Corporation Vorrichtung, systeme und verfahren zur abbildung von sauerstoffanreicherung von gewebe
CN107209118B (zh) 2014-09-29 2021-05-28 史赛克欧洲运营有限公司 在自体荧光存在下生物材料中目标荧光团的成像
EP3203902B1 (de) 2014-10-09 2021-07-07 Novadaq Technologies ULC Quantifizierung des absoluten blutströmung in gewebe mittels fluoreszenzvermittelter photoplethysmographie
WO2016161496A1 (en) 2015-04-08 2016-10-13 Synaptive Medical (Barbados) Inc. Systems, devices and methods for tissue removal and analysis
CA3049922A1 (en) 2017-02-10 2018-08-16 Novadaq Technologies ULC Open-field handheld fluorescence imaging systems and methods
KR102113648B1 (ko) * 2018-06-07 2020-05-22 임성빈 의료용 광역학 치료 장치

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4194513A (en) * 1977-05-05 1980-03-25 Indiana University Foundation Antenatal cell extracting device and method
US4140109A (en) * 1977-10-17 1979-02-20 Savic Michael I Impedance-based method and apparatus for monitoring cryodestruction in controlled cryosurgery
US4273127A (en) * 1978-10-12 1981-06-16 Research Corporation Method for cutting and coagulating tissue
JPS5940830A (ja) * 1982-08-31 1984-03-06 浜松ホトニクス株式会社 レ−ザ光パルスを用いた癌の診断装置
US4887600A (en) * 1986-04-22 1989-12-19 The General Hospital Corporation Use of lasers to break down objects
US5042494A (en) * 1985-11-13 1991-08-27 Alfano Robert R Method and apparatus for detecting cancerous tissue using luminescence excitation spectra
US4930516B1 (en) * 1985-11-13 1998-08-04 Laser Diagnostic Instr Inc Method for detecting cancerous tissue using visible native luminescence
JPS63255072A (ja) * 1987-03-23 1988-10-21 イーストマン・コダック・カンパニー 二つのレーザーを用いる治療および診断装置
US5111821A (en) * 1988-11-08 1992-05-12 Health Research, Inc. Fluorometric method for detecting abnormal tissue using dual long-wavelength excitation
JP2779825B2 (ja) * 1989-02-15 1998-07-23 則雄 大工園 レーザ光出射装置
US5131398A (en) * 1990-01-22 1992-07-21 Mediscience Technology Corp. Method and apparatus for distinguishing cancerous tissue from benign tumor tissue, benign tissue or normal tissue using native fluorescence
US5074306A (en) * 1990-02-22 1991-12-24 The General Hospital Corporation Measurement of burn depth in skin
US5071417A (en) * 1990-06-15 1991-12-10 Rare Earth Medical Lasers, Inc. Laser fusion of biological materials

Also Published As

Publication number Publication date
JPH05508097A (ja) 1993-11-18
DE69203153D1 (de) 1995-08-03
DE69203153T2 (de) 1995-11-02
GR3017015T3 (en) 1995-11-30
EP0513986B1 (de) 1995-06-28
AU1400892A (en) 1992-10-08
WO1992017108A1 (en) 1992-10-15
JP3383301B2 (ja) 2003-03-04
EP0513986A1 (de) 1992-11-19
CA2063651A1 (en) 1992-10-04
US5318023A (en) 1994-06-07

Similar Documents

Publication Publication Date Title
DE69203153D1 (de) Nadel mittels eines Photosensibilisators mit verbesserter Fluoreszenzbiopsie.
Yang et al. A multispectral fluorescence imaging system: Design and initial clinical tests in intra‐operative Photofrin‐photodynamic therapy of brain tumors
Manoharan et al. Raman spectroscopy and fluorescence photon migration for breast cancer diagnosis and imaging
US6317624B1 (en) Apparatus and method for demarcating tumors
Mayinger et al. Light-induced autofluorescence spectroscopy for the endoscopic detection of esophageal cancer
Andersson‐Engels et al. Preliminary evaluation of two fluorescence imaging methods for the detection and the delineation of basal cell carcinomas of the skin
AU654914B2 (en) Apparatus and method of use for a photosensitiser enhanced fluorescence based biopsy needle
EP1372483A2 (de) Fluoreszenz-lifetime-spektrometer (fls) und verfahren zum nachweis von krankem gewebe
Cubeddu et al. Fluorescence lifetime imaging: an application to the detection of skin tumors
Andersson-Engels et al. Fluorescence characteristics of atherosclerotic plaque and malignant tumors
Braichotte et al. Clinical pharmacokinetic studies of tetra (meta‐hydroxyphenyl) chlorin in squamous cell carcinoma by fluorescence spectroscopy at 2 wavelengths
Mayinger et al. Light-induced autofluorescence spectroscopy for tissue diagnosis of GI lesions
Hibst et al. New approach on fluorescence spectroscopy for caries detection
EP0588994A1 (de) Fluoreszenzdiagnostik von krebs mit hilfe von -g(d)-amino lävulinsäure
EP0573264A2 (de) Gerät und Verfahren zum Gebrauch einer für die durch Photosensibilator verbesserte Fluoreszenzbiopsie
Katz et al. Optical biopsy-detecting cancer with light
Alfano et al. Noninvasive fluorescence-based instrumentation for cancer and precancer detection and screening
Zeng et al. Fluorescence spectroscopy and imaging for skin cancer detection and evaluation
Andersson-Engels et al. Fluorescence imaging in medical diagnostics
Wang et al. In-vitro laser-induced fluorescence studies of breast tumors following low-dose injection of Photofrin
Braichotte et al. Endoscopic tissue autofluorescence measurements in the upper aerodigestive tract and the bronchi
Baumgartner et al. Delta-ALA-assisted fluorescence detection of cancer in the urinary bladder
Bigio et al. Elastic scattering spectroscopy for detection of prostate cancer: preliminary feasibility study
Vladimirov et al. Delta-ALA-mediated fluorescence spectroscopy of gastrointestinal tumors: comparison of in vivo and in vitro results
Alfano et al. Photonic Pathology: Fluorescence and Raman Spectroscopy for Tissue Diagnosis and Characterization

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee