ATE124399T1 - 3-phenyl-5,6-dihydro(c)-acridin-7-carboxylsäure und verwandte verbindungen als chemotherapeutische wirkstoffe gegen krebs. - Google Patents

3-phenyl-5,6-dihydro(c)-acridin-7-carboxylsäure und verwandte verbindungen als chemotherapeutische wirkstoffe gegen krebs.

Info

Publication number: ATE124399T1
Authority: AT; Austria
Prior art keywords: carboxylic acid; acridine; dihydro; phenyl; chemotherapeutic agents
Prior art date: 1989-01-25

Application number

AT90101253T

Other languages

English (en)

Inventor

Carl Henry Behrens

Original Assignee

Du Pont Merck Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-01-25

Filing date

1990-01-23

Publication date

1995-07-15

1990-01-23 Application filed by Du Pont Merck Pharma filed Critical Du Pont Merck Pharma

1995-07-15 Application granted granted Critical

1995-07-15 Publication of ATE124399T1 publication Critical patent/ATE124399T1/de

Links

150000001875 compounds Chemical class 0.000 title abstract 3
206010028980 Neoplasm Diseases 0.000 title abstract 2
239000002246 antineoplastic agent Substances 0.000 title 1
201000011510 cancer Diseases 0.000 title 1
229940127089 cytotoxic agent Drugs 0.000 title 1
OOGYVVYCCYJADG-UHFFFAOYSA-N acridine-1-carboxylic acid Chemical class C1=CC=C2C=C3C(C(=O)O)=CC=CC3=NC2=C1 OOGYVVYCCYJADG-UHFFFAOYSA-N 0.000 abstract 2
241000124008 Mammalia Species 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/02—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with only hydrogen, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/18—Ring systems of four or more rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT90101253T 1989-01-25 1990-01-23 3-phenyl-5,6-dihydro(c)-acridin-7-carboxylsäure und verwandte verbindungen als chemotherapeutische wirkstoffe gegen krebs. ATE124399T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/301,379 US4918077A (en)	1989-01-25	1989-01-25	3-phenyl-5,6-dihydrobenz(c)acridine-7-carboxylic acids and related compounds as cancer chemotherapeutic agents

Publications (1)

Publication Number	Publication Date
ATE124399T1 true ATE124399T1 (de)	1995-07-15

Family

ID=23163099

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90101253T ATE124399T1 (de)	1989-01-25	1990-01-23	3-phenyl-5,6-dihydro(c)-acridin-7-carboxylsäure und verwandte verbindungen als chemotherapeutische wirkstoffe gegen krebs.

Country Status (21)

Country	Link
US (2)	US4918077A (de)
EP (1)	EP0380038B1 (de)
JP (1)	JPH0662572B2 (de)
KR (1)	KR910006985B1 (de)
AT (1)	ATE124399T1 (de)
AU (1)	AU623481B2 (de)
CA (1)	CA2007529A1 (de)
DE (1)	DE69020368T2 (de)
DK (1)	DK0380038T3 (de)
ES (1)	ES2075074T3 (de)
FI (1)	FI95374C (de)
GR (1)	GR3016979T3 (de)
HU (1)	HU205743B (de)
IE (1)	IE68761B1 (de)
IL (1)	IL93161A0 (de)
MY (1)	MY104829A (de)
NO (1)	NO176961C (de)
NZ (1)	NZ232207A (de)
PT (1)	PT92952B (de)
RU (1)	RU1779247C (de)
ZA (1)	ZA90545B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5135934A (en) *	1990-07-06	1992-08-04	Du Pont Merck Pharmaceutical Company	3-phenyl-5,6-dihydrobenz(c) acridine-7-carboxylic acids and related compounds as immunosuppressive agents
CA2111955C (en) *	1992-04-24	2002-03-05	Fumio Suzuki	Novel tetracyclic compound
US5807549A (en) *	1993-05-21	1998-09-15	Research Corporation Technologies, Inc.	Lymphocyte chemoattractant factor and uses thereof
US5428040A (en) *	1993-08-31	1995-06-27	The Du Pont Merck Pharmaceutical Company	Carbocyclic fused-ring quinolinecarboxylic acids useful as immunosuppressive agents
ES2177583T3 (es) *	1993-09-28	2002-12-16	Kyowa Hakko Kogyo Kk	Nuevo compuesto tetraciclico.
GB9400585D0 (en) *	1994-01-13	1994-03-09	Guest John D	Improvements in or relating to tube couplings
JP3141148B2 (ja) *	1995-08-08	2001-03-05	大鵬薬品工業株式会社	縮合インダン誘導体及びその塩
WO1997042953A1 (en) *	1996-05-10	1997-11-20	Novartis Ag	Use of brequinar and derivatives in chronic rejection of allografts and xenotransplantation
US7847125B2 (en) *	2007-11-16	2010-12-07	Chemtura Corporation	Acridan derivatives as antioxidants
CN102351870B (zh) *	2011-08-25	2014-03-12	中山大学	一种苯并吖啶衍生物的制备方法及其作为抗癌药物的用途
US20160287549A1 (en)	2013-11-22	2016-10-06	Genzyme Corporation	Novel methods for treating neurodegenerative diseases

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE502610A (de) *	1950-04-18
US4680299A (en) *	1984-04-30	1987-07-14	E.I. Du Pont De Nemours And Company	2-phenyl-4-quinolinecarboxylic acids and pharmaceutical compositions thereof
CA1288436C (en) *	1983-07-22	1991-09-03	David Paul Hesson	Phenylquinolinecarboxylic acids and derivatives as antitumor agents
US4847381A (en) *	1987-08-31	1989-07-11	American Cyanamid Company	2-Phenyl-4-quinoline carboxylic acids

1989
- 1989-01-25 US US07/301,379 patent/US4918077A/en not_active Expired - Lifetime
1990
- 1990-01-10 CA CA002007529A patent/CA2007529A1/en not_active Abandoned
- 1990-01-23 NZ NZ232207A patent/NZ232207A/xx unknown
- 1990-01-23 DK DK90101253.4T patent/DK0380038T3/da active
- 1990-01-23 AT AT90101253T patent/ATE124399T1/de not_active IP Right Cessation
- 1990-01-23 EP EP90101253A patent/EP0380038B1/de not_active Expired - Lifetime
- 1990-01-23 DE DE69020368T patent/DE69020368T2/de not_active Expired - Fee Related
- 1990-01-23 ES ES90101253T patent/ES2075074T3/es not_active Expired - Lifetime
- 1990-01-24 PT PT92952A patent/PT92952B/pt not_active IP Right Cessation
- 1990-01-24 IL IL93161A patent/IL93161A0/xx not_active IP Right Cessation
- 1990-01-24 KR KR1019900000801A patent/KR910006985B1/ko not_active Expired
- 1990-01-24 HU HU90255A patent/HU205743B/hu not_active IP Right Cessation
- 1990-01-24 FI FI900365A patent/FI95374C/fi not_active IP Right Cessation
- 1990-01-24 RU SU904742891A patent/RU1779247C/ru active
- 1990-01-24 JP JP2012772A patent/JPH0662572B2/ja not_active Expired - Lifetime
- 1990-01-24 IE IE26790A patent/IE68761B1/en not_active IP Right Cessation
- 1990-01-24 NO NO900342A patent/NO176961C/no unknown
- 1990-01-25 MY MYPI90000135A patent/MY104829A/en unknown
- 1990-01-25 AU AU48745/90A patent/AU623481B2/en not_active Ceased
- 1990-01-25 ZA ZA90545A patent/ZA90545B/xx unknown
- 1990-02-01 US US07/473,507 patent/US5002954A/en not_active Expired - Fee Related
1995
- 1995-08-02 GR GR950402095T patent/GR3016979T3/el unknown

Also Published As

Publication number	Publication date
CA2007529A1 (en)	1990-07-25
ES2075074T3 (es)	1995-10-01
ZA90545B (en)	1991-09-25
PT92952A (pt)	1990-07-31
EP0380038A2 (de)	1990-08-01
NZ232207A (en)	1991-08-27
PT92952B (pt)	1995-12-29
FI900365A0 (fi)	1990-01-24
AU623481B2 (en)	1992-05-14
DE69020368T2 (de)	1995-11-09
NO176961C (no)	1995-06-28
MY104829A (en)	1994-06-30
EP0380038A3 (de)	1991-11-13
NO900342D0 (no)	1990-01-24
US4918077A (en)	1990-04-17
US5002954A (en)	1991-03-26
HU205743B (en)	1992-06-29
JPH0662572B2 (ja)	1994-08-17
AU4874590A (en)	1990-08-02
HU900255D0 (en)	1990-03-28
FI95374B (fi)	1995-10-13
DK0380038T3 (da)	1995-08-28
IE900267L (en)	1990-07-25
NO900342L (no)	1990-07-26
HUT53880A (en)	1990-12-28
FI95374C (fi)	1996-01-25
JPH02233661A (ja)	1990-09-17
DE69020368D1 (de)	1995-08-03
EP0380038B1 (de)	1995-06-28
KR900011735A (ko)	1990-08-02
RU1779247C (ru)	1992-11-30
IL93161A0 (en)	1990-11-05
IE68761B1 (en)	1996-07-10
GR3016979T3 (en)	1995-11-30
NO176961B (no)	1995-03-20
KR910006985B1 (ko)	1991-09-14

Legal Events

Date	Code	Title
1995-12-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties
1996-03-15	EEK	Proclamation as to paragraph 128 patent law
1996-08-15	UEP	Publication of translation of european patent specification
2000-10-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
GR3023219T3 (en)	1997-07-30	Pyrazolopyridine compounds and processes for preparation thereof
FI103047B (fi)	1999-04-15	Menetelmä uusien terapeuttisesti käyttökelpoisten bentso£de\|pyrano£3', 4':6,7\|indolitsino£1,2-b\|kinoliinijohdannaisten valmistamiseksi
CA2258548A1 (en)	1997-12-31	Phenylamino-substituted tricyclic derivatives for treatment of hyperproliferative diseases
BR9805734A (pt)	2000-05-16	Derivados de imidazolin-4-ona úteis como agentes anticancerìgenos.
DE69020368D1 (de)	1995-08-03	3-Phenyl-5,6-dihydro(C)-acridin-7-carboxylsäure und verwandte Verbindungen als chemotherapeutische Wirkstoffe gegen Krebs.
DE69429591D1 (de)	2002-02-14	Therapeutisch wirksame Verbindungen
IL114785A0 (en)	1995-11-27	Pyrrolocarbazoles their preparation and pharmaceutical compositions containing them
FI935800A0 (fi)	1993-12-22	Antidepressiva och mot Parkisons sjukdom verksamma foereningar
PT87277A (pt)	1988-05-01	Process for the preparation of new bicyclic compounds and pharmaceutical compositions comprising same
AU672644B2 (en)	1996-10-10	Aryl substituted heterocyclic compounds
MX15697A (es)	1993-12-01	Derivados heterotetraciclicos de lactama y procesopara su preparacion
FR2781482B1 (fr)	2001-08-31	Nouveaux derives de 8h-thieno-[2,3-b]pyrrolizine-8-one, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
DE69011174D1 (de)	1994-09-08	Catecholaminester.