ATE128132T1 - N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2h-benzopyran oder dihydrobenzodioxin)- carboxamid-derivate. - Google Patents

N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2h-benzopyran oder dihydrobenzodioxin)- carboxamid-derivate.

Info

Publication number: ATE128132T1
Authority: AT; Austria
Prior art keywords: alk; dihydrobenzodioxin; dihydrobenzofuran; benzopyran; piperidinyl
Prior art date: 1989-03-22

Application number

AT90200589T

Other languages

English (en)

Inventor

Daele Georges Henri Paul Van

Den Keybus Frans Maria Alf Van

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-03-22

Filing date

1990-03-13

Publication date

1995-10-15

1990-03-13 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

1995-10-15 Application granted granted Critical

1995-10-15 Publication of ATE128132T1 publication Critical patent/ATE128132T1/de

Links

HBEDSQVIWPRPAY-UHFFFAOYSA-N 2,3-dihydrobenzofuran Chemical compound C1=CC=C2OCCC2=C1 HBEDSQVIWPRPAY-UHFFFAOYSA-N 0.000 title abstract 4
229940053202 antiepileptics carboxamide derivative Drugs 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
150000002431 hydrogen Chemical class 0.000 abstract 2
239000008194 pharmaceutical composition Substances 0.000 abstract 2
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 abstract 1
125000006619 (C1-C6) dialkylamino group Chemical group 0.000 abstract 1
125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
150000001204 N-oxides Chemical class 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
230000002496 gastric effect Effects 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
230000004936 stimulating effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Nutrition Science (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pyrane Compounds (AREA)

AT90200589T 1989-03-22 1990-03-13 N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2h-benzopyran oder dihydrobenzodioxin)- carboxamid-derivate. ATE128132T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US32694189A	1989-03-22	1989-03-22

Publications (1)

Publication Number	Publication Date
ATE128132T1 true ATE128132T1 (de)	1995-10-15

Family

ID=23274437

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90200589T ATE128132T1 (de)	1989-03-22	1990-03-13	N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2h-benzopyran oder dihydrobenzodioxin)- carboxamid-derivate.

Country Status (30)

Country	Link
US (12)	US5374637A (de)
EP (1)	EP0389037B1 (de)
JP (1)	JP2845341B2 (de)
KR (1)	KR0163587B1 (de)
CN (1)	CN1034502C (de)
AT (1)	ATE128132T1 (de)
AU (1)	AU616838B2 (de)
CA (1)	CA2012432C (de)
CY (1)	CY1921A (de)
DE (1)	DE69022453T2 (de)
DK (1)	DK0389037T3 (de)
DZ (1)	DZ1405A1 (de)
ES (1)	ES2081340T3 (de)
FI (1)	FI101624B1 (de)
GR (1)	GR3017992T3 (de)
HK (1)	HK131596A (de)
HU (2)	HU221621B1 (de)
IE (1)	IE67184B1 (de)
IL (1)	IL93817A (de)
JO (1)	JO1613B1 (de)
MA (1)	MA21778A1 (de)
MY (2)	MY106407A (de)
NO (1)	NO176101C (de)
NZ (1)	NZ232964A (de)
PT (1)	PT93531B (de)
RU (2)	RU2037492C1 (de)
TN (1)	TNSN90032A1 (de)
ZA (1)	ZA902188B (de)
ZM (1)	ZM1290A1 (de)
ZW (1)	ZW3390A1 (de)

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JPS59186969A (ja) *	1983-04-08	1984-10-23	Yoshitomi Pharmaceut Ind Ltd	ベンゾフラン−およびベンゾピランカルボキサミド誘導体
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SE8503055D0 (sv) *	1985-06-19	1985-06-19	Astra Laekemedel Ab	Piperonylcarboxamido derivatives
GB8519707D0 (en) *	1985-08-06	1985-09-11	Fordonal Sa	Chemical compounds
FR2586018B1 (fr) *	1985-08-12	1988-03-25	Ile De France	Nouveau benzodioxepanne, son procede de synthese et ses applications en therapeutique
JPS6299375A (ja) *	1985-10-25	1987-05-08	Kowa Co	ベンゾジオキソ−ル誘導体
GB8527052D0 (en) *	1985-11-02	1985-12-04	Beecham Group Plc	Compounds
FR2593504B1 (fr) *	1986-01-30	1988-12-09	Ile De France	Nouveaux derives de dihydrobenzofuranne - et de chromane - carboxamides, leurs procedes de preparation et leur utilisation comme neuroleptiques
JPS62234083A (ja) *	1986-02-28	1987-10-14	アーバモント　インク　ディビーエイ　アドリヤ　ラボラトリーズ	鎮吐薬または精神病治療薬として有用なカルボキサミド類
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TW294595B (de) *	1992-11-20	1997-01-01	Janssen Pharmaceutica Nv

1990
- 1990-03-06 US US07/489,419 patent/US5374637A/en not_active Expired - Lifetime
- 1990-03-13 EP EP90200589A patent/EP0389037B1/de not_active Expired - Lifetime
- 1990-03-13 ES ES90200589T patent/ES2081340T3/es not_active Expired - Lifetime
- 1990-03-13 AT AT90200589T patent/ATE128132T1/de not_active IP Right Cessation
- 1990-03-13 DE DE69022453T patent/DE69022453T2/de not_active Expired - Fee Related
- 1990-03-13 DK DK90200589.1T patent/DK0389037T3/da active
- 1990-03-16 CA CA002012432A patent/CA2012432C/en not_active Expired - Fee Related
- 1990-03-16 NZ NZ232964A patent/NZ232964A/en unknown
- 1990-03-19 JO JO19901613A patent/JO1613B1/en active
- 1990-03-20 DZ DZ900052A patent/DZ1405A1/fr active
- 1990-03-20 MA MA22042A patent/MA21778A1/fr unknown
- 1990-03-20 MY MYPI90000431A patent/MY106407A/en unknown
- 1990-03-20 IL IL9381790A patent/IL93817A/en unknown
- 1990-03-20 ZW ZW33/90A patent/ZW3390A1/xx unknown
- 1990-03-20 JP JP2068541A patent/JP2845341B2/ja not_active Expired - Fee Related
- 1990-03-20 MY MYPI94003195A patent/MY131911A/en unknown
- 1990-03-21 ZM ZM12/90A patent/ZM1290A1/xx unknown
- 1990-03-21 RU SU904743491A patent/RU2037492C1/ru not_active IP Right Cessation
- 1990-03-21 ZA ZA902188A patent/ZA902188B/xx unknown
- 1990-03-21 AU AU52091/90A patent/AU616838B2/en not_active Ceased
- 1990-03-21 IE IE104090A patent/IE67184B1/en not_active IP Right Cessation
- 1990-03-21 FI FI901421A patent/FI101624B1/fi not_active IP Right Cessation
- 1990-03-21 PT PT93531A patent/PT93531B/pt not_active IP Right Cessation
- 1990-03-21 CN CN90101524A patent/CN1034502C/zh not_active Expired - Fee Related
- 1990-03-21 HU HU9001627A patent/HU221621B1/hu not_active IP Right Cessation
- 1990-03-21 KR KR1019900003782A patent/KR0163587B1/ko not_active Expired - Fee Related
- 1990-03-21 NO NO901306A patent/NO176101C/no not_active IP Right Cessation
- 1990-03-22 TN TNTNSN90032A patent/TNSN90032A1/fr unknown
1993
- 1993-11-02 RU RU93050009A patent/RU2108332C1/ru not_active IP Right Cessation
1994
- 1994-09-07 US US08/301,825 patent/US5552553A/en not_active Expired - Fee Related
1995
- 1995-03-31 US US08/414,673 patent/US5616738A/en not_active Expired - Fee Related
- 1995-03-31 US US08/414,676 patent/US5521314A/en not_active Expired - Fee Related
- 1995-04-03 US US08/415,888 patent/US5554772A/en not_active Expired - Fee Related
- 1995-04-03 US US08/415,885 patent/US5576448A/en not_active Expired - Fee Related
- 1995-04-03 US US08/415,953 patent/US5565582A/en not_active Expired - Fee Related
- 1995-04-13 US US08/421,658 patent/US5616583A/en not_active Expired - Fee Related
- 1995-04-13 US US08/421,728 patent/US5610157A/en not_active Expired - Fee Related
- 1995-04-13 US US08/421,727 patent/US5602129A/en not_active Expired - Fee Related
- 1995-04-13 US US08/421,826 patent/US5739134A/en not_active Expired - Fee Related
- 1995-04-13 US US08/421,659 patent/US5536733A/en not_active Expired - Fee Related
- 1995-06-21 HU HU95P/P00311P patent/HU211171A9/hu unknown
- 1995-11-08 GR GR950403101T patent/GR3017992T3/el unknown
1996
- 1996-07-18 HK HK131596A patent/HK131596A/en not_active IP Right Cessation
1997
- 1997-03-07 CY CY192197A patent/CY1921A/xx unknown

Also Published As

Publication number	Publication date
US5576448A (en)	1996-11-19
JP2845341B2 (ja)	1999-01-13
FI101624B (fi)	1998-07-31
MY131911A (en)	2007-09-28
GR3017992T3 (en)	1996-02-29
DE69022453D1 (de)	1995-10-26
FI101624B1 (fi)	1998-07-31
EP0389037B1 (de)	1995-09-20
KR900014371A (ko)	1990-10-23
CA2012432A1 (en)	1990-09-22
US5602129A (en)	1997-02-11
ES2081340T3 (es)	1996-03-01
ZM1290A1 (en)	1992-07-31
ZW3390A1 (en)	1991-10-23
CN1045781A (zh)	1990-10-03
NO176101B (no)	1994-10-24
NO901306L (no)	1990-09-24
EP0389037A1 (de)	1990-09-26
NO901306D0 (no)	1990-03-21
AU5209190A (en)	1990-09-27
DZ1405A1 (fr)	2004-09-13
IL93817A0 (en)	1990-12-23
US5521314A (en)	1996-05-28
US5565582A (en)	1996-10-15
PT93531B (pt)	1998-01-30
PT93531A (pt)	1990-11-07
NZ232964A (en)	1991-07-26
RU2108332C1 (ru)	1998-04-10
MA21778A1 (fr)	1990-10-01
US5739134A (en)	1998-04-14
ZA902188B (en)	1991-11-27
JPH02289566A (ja)	1990-11-29
IE67184B1 (en)	1996-03-06
DE69022453T2 (de)	1996-03-28
FI901421A0 (fi)	1990-03-21
IL93817A (en)	1995-03-30
KR0163587B1 (ko)	1998-12-01
DK0389037T3 (da)	1995-10-16
JO1613B1 (en)	1990-07-01
US5554772A (en)	1996-09-10
HU221621B1 (hu)	2002-12-28
NO176101C (no)	1995-02-01
US5536733A (en)	1996-07-16
IE901040L (en)	1990-09-22
HU901627D0 (en)	1990-06-28
HK131596A (en)	1996-07-26
CA2012432C (en)	2000-11-14
US5610157A (en)	1997-03-11
CY1921A (en)	1997-03-07
MY106407A (en)	1995-05-30
US5616583A (en)	1997-04-01
US5374637A (en)	1994-12-20
HUT58322A (en)	1992-02-28
AU616838B2 (en)	1991-11-07
US5616738A (en)	1997-04-01
TNSN90032A1 (fr)	1991-03-05
US5552553A (en)	1996-09-03
HU211171A9 (en)	1995-11-28
CN1034502C (zh)	1997-04-09
RU2037492C1 (ru)	1995-06-19

Legal Events

Date	Code	Title	Description
1996-03-15	UEP	Publication of translation of european patent specification
2005-12-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE128132T1 (de)	1995-10-15	N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2h-benzopyran oder dihydrobenzodioxin)- carboxamid-derivate.
MA21381A1 (fr)	1989-04-01	Nouveau n-(1 alkyl-3-hydroxy-4-piperidyl)
ATE122348T1 (de)	1995-05-15	Antipsychotische 3-piperazinylbenzazolderivate.
DE68923231D1 (de)	1995-08-03	Antihypertensive 3-Piperidinylindazol-Derivate.