ATE124697T1 - Azabicyclische derivate mit affinität am muskarine rezeptor. - Google Patents

Azabicyclische derivate mit affinität am muskarine rezeptor.

Info

Publication number: ATE124697T1
Authority: AT; Austria
Prior art keywords: nitrogen; group; sulphur; chem; oxygen
Prior art date: 1989-08-05

Application number

AT90308500T

Other languages

English (en)

Inventor

Harry John Smithklin Wadsworth

Coldharbour Ro Pharmaceuticals

Paul Adrian Smithkline B Wyman

Steven Smithkline Beecha Dabbs

Road Coldharbour

Sarah Margaret Smithkl Jenkins

Original Assignee

Beecham Group Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-08-05

Filing date

1990-08-01

Publication date

1995-07-15

1990-08-01 Application filed by Beecham Group Plc filed Critical Beecham Group Plc

1995-07-15 Application granted granted Critical

1995-07-15 Publication of ATE124697T1 publication Critical patent/ATE124697T1/de

Links

IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 3
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 3
239000005864 Sulphur Chemical group 0.000 abstract 3
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 3
229910052760 oxygen Inorganic materials 0.000 abstract 3
239000001301 oxygen Substances 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
229910052757 nitrogen Inorganic materials 0.000 abstract 2
125000006592 (C2-C3) alkenyl group Chemical group 0.000 abstract 1
125000006593 (C2-C3) alkynyl group Chemical group 0.000 abstract 1
125000001494 2-propynyl group Chemical group [H]C#CC([H])([H])* 0.000 abstract 1
OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 abstract 1
-1 N(R4)2 Chemical group 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
150000001721 carbon Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 1
239000003937 drug carrier Chemical group 0.000 abstract 1
125000001153 fluoro group Chemical group F* 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical group 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
150000002431 hydrogen Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Hospice & Palliative Care (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Psychiatry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT90308500T 1989-08-05 1990-08-01 Azabicyclische derivate mit affinität am muskarine rezeptor. ATE124697T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB898917957A GB8917957D0 (en)	1989-08-05	1989-08-05	Novel compounds

Publications (1)

Publication Number	Publication Date
ATE124697T1 true ATE124697T1 (de)	1995-07-15

Family

ID=10661237

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90308500T ATE124697T1 (de)	1989-08-05	1990-08-01	Azabicyclische derivate mit affinität am muskarine rezeptor.

Country Status (12)

Country	Link
US (1)	US5470859A (de)
EP (1)	EP0414394B1 (de)
JP (1)	JP2958655B2 (de)
KR (1)	KR910004616A (de)
AT (1)	ATE124697T1 (de)
AU (1)	AU629668B2 (de)
CA (1)	CA2022633A1 (de)
DE (1)	DE69020661T2 (de)
GB (1)	GB8917957D0 (de)
IE (1)	IE902818A1 (de)
PT (1)	PT94910A (de)
ZA (1)	ZA906127B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1993008191A1 (en) *	1991-10-15	1993-04-29	Warner-Lambert Company	Azabicyclo oxime and amine cholinergic agents and methods of treatment
JPH06239861A (ja) *	1993-02-17	1994-08-30	Kanegafuchi Chem Ind Co Ltd	二環式含チッ素化合物
US6271229B1 (en) *	1993-08-19	2001-08-07	Novo Nordisk A/S	Method of treating gastrointestinal motility disorders
JPH11500113A (ja) *	1995-02-17	1999-01-06	ノボノルディスクアクティーゼルスカブ	ヘテロ環化合物類の使用
WO1997001556A1 (en) *	1995-06-29	1997-01-16	Novo Nordisk A/S	Novel substituted azacyclic or azabicyclic compounds
JPH11508541A (ja) *	1995-06-29	1999-07-27	ノボノルディスクアクティーゼルスカブ	新規な置換アザ二環式化合物
US5936088A (en) *	1995-09-22	1999-08-10	Novo Nordisk A/S	Substituted azacyclic or azabicyclic compounds with affinity and selectivity for nicotinic cholinergic receptors
JPH11512443A (ja) *	1995-09-22	1999-10-26	ノボノルディスクアクティーゼルスカブ	新規な置換アザ環式またはアザ二環式化合物
EP1236727A1 (de) *	2001-03-01	2002-09-04	Bayer CropScience GmbH	Azabicycloverbindungen als Pestizide
EP1480977A2 (de) *	2002-02-15	2004-12-01	PHARMACIA & UPJOHN COMPANY	Substituierte arylverbindungen zur behandlung von krankheiten

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB239309A (en) *	1924-06-18	1925-09-10	George William Hale	Improvements in radiotelephonic and other radio-frequency signalling systems
GB261763A (en) *	1925-11-18	1927-09-08	British Thomson Houston Co Ltd	Improvements in and relating to vapour electric devices
GB287356A (en) *	1927-06-02	1928-03-22	John Harris	Improvements in or relating to mechanical ore roasting furnaces
GB307141A (en) *	1927-12-23	1929-03-07	British Dyestuffs Corp Ltd	Improvements in detergent, cleansing and polishing compositions
GB307142A (en) *	1927-12-23	1929-03-07	Erik Schirm	Improvements in or relating to organs, harmoniums and like musical instruments
GB316718A (en) *	1928-05-23	1929-08-08	Howden James & Co Ltd	Improvements in or relating to air heaters
GB322182A (en) *	1928-05-24	1929-11-25	Tiefbau Und Kalteindustrie A G	A process for the solidification of sandy masses permeable by water
GB323864A (en) *	1928-11-16	1930-01-16	Daniel Tyrer	Improved process for obtaining a mixture of hydrogen and carbon monoxide by the decomposition of hydrocarbon gases or vapours in the presence of steam
GB339834A (en) *	1929-01-21	1930-12-18	Goodrich Co B F	Improvements in or relating to methods of preserving rubber and to age-resisting rubber products produced thereby
GB366304A (en) *	1930-06-04	1932-02-04	Nicolaas Van Der Willik	Moulded articles such as tiles, plates, floor-and wall-coverings and process for their manufacture
GB363085A (en) *	1930-11-11	1931-12-17	Edward Barker	Improvements in conveyors
GB375450A (en) *	1931-04-01	1932-06-30	Robert Constantine Graseby	Improvements in or relating to electric signalling systems and apparatus
GB402056A (en) *	1932-04-11	1933-11-13	Joseph Stephens	Improvements in jet pumps and the like
GB398616A (en) *	1932-06-17	1933-09-21	Gen Electric Co Ltd	Improvements in or relating to systems for the distribution of music, speech or the like over line wires
GB398617A (en) *	1932-06-21	1933-09-21	Gordon Fraser	Improvements in or relating to sliver balling machines
ES2061502T3 (es) *	1986-06-27	1994-12-16	Beecham Group Plc	Nuevos n-heterociclos biciclicos puenteados.
AU614513B2 (en) *	1987-04-15	1991-09-05	Beecham Group Plc	1-azabicyclic compounds
EP0322182A3 (de) *	1987-12-22	1992-01-02	Beecham Group Plc	Azabicyclische-Verbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
EP0363085A3 (de) *	1988-10-03	1991-03-27	Beecham Group Plc	Chemische Verbindungen
EP0402056A3 (de) *	1989-06-06	1991-09-04	Beecham Group p.l.c.	Azabicyclische Verbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen

1989
- 1989-08-05 GB GB898917957A patent/GB8917957D0/en active Pending
1990
- 1990-08-01 DE DE69020661T patent/DE69020661T2/de not_active Expired - Fee Related
- 1990-08-01 AT AT90308500T patent/ATE124697T1/de not_active IP Right Cessation
- 1990-08-01 EP EP90308500A patent/EP0414394B1/de not_active Expired - Lifetime
- 1990-08-02 US US07/561,974 patent/US5470859A/en not_active Expired - Fee Related
- 1990-08-03 IE IE281890A patent/IE902818A1/en unknown
- 1990-08-03 PT PT94910A patent/PT94910A/pt not_active Application Discontinuation
- 1990-08-03 AU AU60130/90A patent/AU629668B2/en not_active Ceased
- 1990-08-03 JP JP2205283A patent/JP2958655B2/ja not_active Expired - Lifetime
- 1990-08-03 CA CA002022633A patent/CA2022633A1/en not_active Abandoned
- 1990-08-03 ZA ZA906127A patent/ZA906127B/xx unknown
- 1990-08-04 KR KR1019900011975A patent/KR910004616A/ko not_active Withdrawn

Also Published As

Publication number	Publication date
AU6013090A (en)	1991-02-07
JPH03178976A (ja)	1991-08-02
JP2958655B2 (ja)	1999-10-06
CA2022633A1 (en)	1991-02-06
EP0414394B1 (de)	1995-07-05
DE69020661T2 (de)	1996-01-11
KR910004616A (ko)	1991-03-29
ZA906127B (en)	1991-06-26
GB8917957D0 (en)	1989-09-20
AU629668B2 (en)	1992-10-08
EP0414394A3 (en)	1991-05-08
US5470859A (en)	1995-11-28
EP0414394A2 (de)	1991-02-27
PT94910A (pt)	1991-04-18
IE902818A1 (en)	1991-02-27
DE69020661D1 (de)	1995-08-10

Legal Events

Date	Code	Title	Description
1996-01-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE133415T1 (de)	1996-02-15	Am brückenkopf substituierte azabicyclenderivate
DK0625977T3 (da)	1998-05-04	Piperazinderivater som 5-1A-antagonister
FI933357A0 (fi)	1993-07-27	Foerfarande foer framstaellning av benzamider
ATE404539T1 (de)	2008-08-15	Kondensierte pyridinderivate
DE3781080D1 (de)	1992-09-17	2-substituierte-e-kondensierte(1,2,4)triazolo-(1,5-c)pyrimidine, pharmazeutische zubereitungen und ihre verwendung.
DK504889A (da)	1990-04-14	N-heterocykliske forbindelser
ATE124697T1 (de)	1995-07-15	Azabicyclische derivate mit affinität am muskarine rezeptor.
CA2305612A1 (en)	1999-04-22	Halogen substituted tetracyclic tetrahydrofuran derivatives
EP1070715A4 (de)	2002-10-17	Arylpiperidine und ihre verwendung
ATE153024T1 (de)	1997-05-15	Azabicyclische verbindungen
NO891608D0 (no)	1989-04-19	Heterotetracykliske laktamderivater.
DE60239324D1 (de)	2011-04-14	Phenyl- und pyridyl-piperidine mit tnf-wirkung
DE69116302D1 (de)	1996-02-22	4-[4- oder 6-(Trifluormethyl-2-pyridinyl)]-1-piperazinyl-alkyl substituierte Laktame
DK210387A (da)	1987-10-29	Heterocykliske forbindelser og fremgangsmaade til deres fremstilling samt farmaceutiske midler indeholdende disse