DK504889A - N-heterocykliske forbindelser - Google Patents

N-heterocykliske forbindelser

Info

Publication number: DK504889A
Authority: DK; Denmark
Prior art keywords: sulphur; nitrogen; chem; oxygen; group
Prior art date: 1988-10-13

Application number

DK504889A

Other languages

English (en)

Other versions

DK504889D0 (da

Inventor

Barry Sidney Orlek

Richard Eric Faulkner

Original Assignee

Beecham Group Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-10-13

Filing date

1989-10-11

Publication date

1990-04-14

1988-10-13 Priority claimed from GB888824071A external-priority patent/GB8824071D0/en

1988-12-23 Priority claimed from GB888830223A external-priority patent/GB8830223D0/en

1989-09-18 Priority claimed from GB898920660A external-priority patent/GB8920660D0/en

1989-10-11 Application filed by Beecham Group Plc filed Critical Beecham Group Plc

1989-10-11 Publication of DK504889D0 publication Critical patent/DK504889D0/da

1990-04-14 Publication of DK504889A publication Critical patent/DK504889A/da

Links

IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 6
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 4
239000005864 Sulphur Chemical group 0.000 abstract 4
125000000217 alkyl group Chemical group 0.000 abstract 3
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
229910052757 nitrogen Inorganic materials 0.000 abstract 3
229910052760 oxygen Inorganic materials 0.000 abstract 3
239000001301 oxygen Substances 0.000 abstract 3
125000003118 aryl group Chemical group 0.000 abstract 2
125000005842 heteroatom Chemical group 0.000 abstract 2
125000006656 (C2-C4) alkenyl group Chemical group 0.000 abstract 1
125000006650 (C2-C4) alkynyl group Chemical group 0.000 abstract 1
101100294115 Caenorhabditis elegans nhr-4 gene Proteins 0.000 abstract 1
101100295741 Gallus gallus COR4 gene Proteins 0.000 abstract 1
101100134922 Gallus gallus COR5 gene Proteins 0.000 abstract 1
OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
150000001721 carbon Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000000717 hydrazino group Chemical group [H]N([*])N([H])[H] 0.000 abstract 1
150000002431 hydrogen Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Furan Compounds (AREA)
Hydrogenated Pyridines (AREA)
Pyrrole Compounds (AREA)
Photoreceptors In Electrophotography (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Mechanical Treatment Of Semiconductor (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK504889A 1988-10-13 1989-10-11 N-heterocykliske forbindelser DK504889A (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB888824071A GB8824071D0 (en)	1988-10-13	1988-10-13	Novel compounds
GB888830223A GB8830223D0 (en)	1988-12-23	1988-12-23	Novel compounds
GB898920660A GB8920660D0 (en)	1989-09-18	1989-09-18	Novel compounds

Publications (2)

Publication Number	Publication Date
DK504889D0 DK504889D0 (da)	1989-10-11
DK504889A true DK504889A (da)	1990-04-14

Family

ID=27264121

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK504889A DK504889A (da)	1988-10-13	1989-10-11	N-heterocykliske forbindelser

Country Status (9)

Country	Link
US (1)	US5166357A (da)
EP (1)	EP0366304B1 (da)
JP (1)	JP2934743B2 (da)
AT (1)	ATE165095T1 (da)
AU (1)	AU4278289A (da)
CA (1)	CA2000041A1 (da)
DE (1)	DE68928644T2 (da)
DK (1)	DK504889A (da)
PT (1)	PT91956B (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ227684A (en) *	1988-01-30	1991-07-26	Merck Sharp & Dohme	Pyrazine, pyridazine, and pyrimidine derivatives and pharmaceutical compositions
EP0402056A3 (en) *	1989-06-06	1991-09-04	Beecham Group p.l.c.	Azabicyclic compounds, process for their preparation and pharmaceutical compositions containing them
EP0413545B1 (en) *	1989-08-16	1997-05-14	Beecham Group Plc	Azabicyclic compounds
ATE136031T1 (de) *	1989-10-07	1996-04-15	Beecham Group Plc	Azabizyklische verbindungen, verfahren und zwischenprodukte zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen
JPH06502616A (ja) *	1990-12-21	1994-03-24	メルク　シヤープ　エンド　ドーム　リミテツド	治療用化合物
US5936088A (en) *	1995-09-22	1999-08-10	Novo Nordisk A/S	Substituted azacyclic or azabicyclic compounds with affinity and selectivity for nicotinic cholinergic receptors
US5733912A (en) *	1997-02-19	1998-03-31	Abbott Laboratories	7A-heterocycle substituted hexahydro-1H-pyrrolizine compounds useful in controlling chemical synaptic transmission
AU3889900A (en)	1999-03-30	2000-10-16	E.I. Du Pont De Nemours And Company	Process for the preparation of alpha-methylene lactones
DE60015944T2 (de) *	1999-03-30	2005-11-03	E.I. Du Pont De Nemours And Co., Wilmington	Verfahren zur herstellung von alpha-methylenelactonen und alpha-substitutierten hydrocarbyliden-lactonen
US6362346B1 (en)	1999-11-12	2002-03-26	E. I. Du Pont De Nemours And Company	Process for the preparation of α-methylene-γ-butyrolactone and α-acetoxymethyl-γ-butyrolactone
US6642346B2 (en)	2000-02-28	2003-11-04	E. I. Du Pont De Nemours And Company	Coating compositions containing substituted and unsubstituted exomethylene lactone or lactam monomers
US6531616B2 (en)	2000-12-22	2003-03-11	E. I. Du Pont De Nemours And Company	Process for the preparation of a-methylenelactones and a-substituted hydrocarbylidene lactones
KR100428408B1 (ko) *	2001-12-14	2004-04-28	학교법인 성균관대학	α-메틸렌-γ-부티로락톤의 제조방법
DE60301127T2 (de)	2002-01-07	2006-04-20	E.I. Du Pont De Nemours And Co., Wilmington	Methylenlacton synthese in superkritischen flüssigkeiten
US7314942B2 (en)	2002-01-07	2008-01-01	E. I. Dupont De Nemours & Co.	Methylenelactones syntheses in supercritical fluids
EP2258357A3 (en)	2005-08-26	2011-04-06	Braincells, Inc.	Neurogenesis with acetylcholinesterase inhibitor
EP2275096A3 (en)	2005-08-26	2011-07-13	Braincells, Inc.	Neurogenesis via modulation of the muscarinic receptors
WO2008030651A1 (en) *	2006-09-08	2008-03-13	Braincells, Inc.	Combinations containing a 4-acylaminopyridine derivative
CN102276559B (zh) *	2011-08-12	2014-05-28	河北威远生化农药有限公司	3-羟甲基四氢呋喃的合成方法
CN118660972A (zh)	2022-02-11	2024-09-17	汉高股份有限及两合公司	用于合成α-亚甲基-γ-丁内酯的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ219646A (en) *	1986-03-27	1990-10-26	Merck Sharp & Dohme	Oxadiazole derivatives of azacyclics for treating cns disorders
EP0261763B1 (en) *	1986-06-27	1994-02-09	Beecham Group Plc	Novel bridged bicyclic N-heterocycles
GB8615785D0 (en) *	1986-06-27	1986-08-06	Beecham Group Plc	Compounds
ATE133415T1 (de) *	1987-04-15	1996-02-15	Beecham Group Plc	Am brückenkopf substituierte azabicyclenderivate
NZ225999A (en) *	1987-09-10	1992-04-28	Merck Sharp & Dohme	Azacyclic- or azabicyclic-substituted thiadiazole derivatives and pharmaceutical compositions
DE3877470T2 (de) *	1987-09-10	1993-06-24	Merck Sharp & Dohme	Oxazole und thiazole zur behandlung seniler demenz.
IL88156A (en) *	1987-11-13	1997-02-18	Novo Nordisk As	Azacyclic compounds their preparation and pharmaceutical compositions containing them
EP0322182A3 (en) *	1987-12-22	1992-01-02	Beecham Group Plc	Azabicyclic compounds, process for their preparation and pharmaceutical compositions containing them

1989
- 1989-10-02 CA CA002000041A patent/CA2000041A1/en not_active Abandoned
- 1989-10-10 US US07/418,649 patent/US5166357A/en not_active Expired - Fee Related
- 1989-10-11 DK DK504889A patent/DK504889A/da not_active Application Discontinuation
- 1989-10-11 DE DE68928644T patent/DE68928644T2/de not_active Expired - Fee Related
- 1989-10-11 PT PT91956A patent/PT91956B/pt not_active IP Right Cessation
- 1989-10-11 AT AT89310406T patent/ATE165095T1/de not_active IP Right Cessation
- 1989-10-11 AU AU42782/89A patent/AU4278289A/en not_active Abandoned
- 1989-10-11 EP EP89310406A patent/EP0366304B1/en not_active Expired - Lifetime
- 1989-10-12 JP JP1264089A patent/JP2934743B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
ATE165095T1 (de)	1998-05-15
EP0366304B1 (en)	1998-04-15
EP0366304A2 (en)	1990-05-02
DE68928644D1 (de)	1998-05-20
DE68928644T2 (de)	1998-08-27
DK504889D0 (da)	1989-10-11
PT91956A (pt)	1990-04-30
CA2000041A1 (en)	1990-04-13
PT91956B (pt)	1995-05-31
JP2934743B2 (ja)	1999-08-16
EP0366304A3 (en)	1991-09-11
AU4278289A (en)	1990-04-26
JPH02134380A (ja)	1990-05-23
US5166357A (en)	1992-11-24

Legal Events

Date	Code	Title	Description
1995-04-10	AHS	Application shelved for other reasons than non-payment

Publication	Publication Date	Title
DK504889D0 (da)	1989-10-11	Hidtil ukendte forbindelser
DE3854932D1 (de)	1996-03-07	Am Brückenkopf substituierte Azabicyclenderivate
NO951813L (no)	1995-05-09	Bicyklisk heterocyklisk sulfonamid og sulfonester-derivater
NO308739B1 (no)	2000-10-23	Imidazolderivater samt medisinsk sammensetning og anti-HIV- sammensetning omfattende samme
DK584886D0 (da)	1986-12-05	Vanduoplaeselige, mono- og disubstituerede derivater af rapamycin og farmaceutisk acceptable salte deraf
DK1113011T3 (da)	2006-11-27	Aminotetrazol-derivater, der er anvendelige som nitrogenoxidsynthaseinhibitorer
ES2103931T3 (es)	1997-10-01	Imidazoacridinas y su uso antineoplasico.
BE1003256A5 (fr)	1992-02-11	Derives de la butynylamine.
YU48136B (sh)	1997-05-28	Morfolinil derivati doksorubicina i postupak za njihovo dobijanje
PT90572A (pt)	1989-11-30	Processo para a preparacao de derivados de 6-fenil-3-piperazinilalquil-1h,3h-2,4-pirimidinadiona
ES2013035A6 (es)	1990-04-16	Un metodo para preparar derivados de acilfenol.
AU629668B2 (en)	1992-10-08	Heterocyclic substituted azabicyclic compounds for pharmaceutical use
GR3005961T3 (da)	1993-06-07
DE69415314D1 (de)	1999-01-28	Neue bisoxadiazolidinderivate
ATE113030T1 (de)	1994-11-15	Hydroxyalkancarbonsäure-derivate und deren verwendung.
AU6382390A (en)	1991-04-11	Azabicyclo compounds
ATE302199T1 (de)	2005-09-15	Quinalozinon-derivate
DE69416683D1 (de)	1999-04-01	Benzolactam-derivate
DE69708198D1 (de)	2001-12-20	Muscarinische Rezeptor-Agonisten
ATE153024T1 (de)	1997-05-15	Azabicyclische verbindungen
GR3018346T3 (en)	1996-03-31	Benzoxazine derivatives, benzothiazine derivatives and herbicides comprising the same.
ATE180386T1 (de)	1999-06-15	Molluskizide