ATE124869T1 - Stabilisierung von calcitonin enthaltenden pharmazeutischen verbindungen. - Google Patents

Stabilisierung von calcitonin enthaltenden pharmazeutischen verbindungen.

Info

Publication number: ATE124869T1
Authority: AT; Austria
Prior art keywords: stabilization; compounds containing; pharmaceutical compounds; acid; hct
Prior art date: 1990-12-11

Application number

AT91311176T

Other languages

English (en)

Inventor

Turdor Arvinte

Katherine Diana Ryman

Original Assignee

Ciba Geigy Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-12-11

Filing date

1991-12-02

Publication date

1995-07-15

1990-12-11 Priority claimed from GB909026882A external-priority patent/GB9026882D0/en

1991-09-06 Priority claimed from GB919119048A external-priority patent/GB9119048D0/en

1991-12-02 Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag

1995-07-15 Application granted granted Critical

1995-07-15 Publication of ATE124869T1 publication Critical patent/ATE124869T1/de

Links

102000055006 Calcitonin Human genes 0.000 title 1
108060001064 Calcitonin Proteins 0.000 title 1
BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 title 1
229960004015 calcitonin Drugs 0.000 title 1
150000001875 compounds Chemical class 0.000 title 1
230000006641 stabilisation Effects 0.000 title 1
238000011105 stabilization Methods 0.000 title 1
101000741445 Homo sapiens Calcitonin Proteins 0.000 abstract 4
229940045644 human calcitonin Drugs 0.000 abstract 4
239000002253 acid Substances 0.000 abstract 3
239000007864 aqueous solution Substances 0.000 abstract 1
229920002678 cellulose Polymers 0.000 abstract 1
239000001913 cellulose Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/23—Calcitonins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Oil, Petroleum & Natural Gas (AREA)
Immunology (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Endocrinology (AREA)
Inorganic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Compounds Of Unknown Constitution (AREA)
External Artificial Organs (AREA)

AT91311176T 1990-12-11 1991-12-02 Stabilisierung von calcitonin enthaltenden pharmazeutischen verbindungen. ATE124869T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB909026882A GB9026882D0 (en)	1990-12-11	1990-12-11	Pharmaceutical compositions
GB919119048A GB9119048D0 (en)	1991-09-06	1991-09-06	Pharmaceutical compositions

Publications (1)

Publication Number	Publication Date
ATE124869T1 true ATE124869T1 (de)	1995-07-15

Family

ID=26298092

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91311176T ATE124869T1 (de)	1990-12-11	1991-12-02	Stabilisierung von calcitonin enthaltenden pharmazeutischen verbindungen.

Country Status (16)

Country	Link
EP (1)	EP0490549B1 (de)
JP (1)	JP3179538B2 (de)
KR (1)	KR100253862B1 (de)
AT (1)	ATE124869T1 (de)
AU (1)	AU653371B2 (de)
CA (1)	CA2057291C (de)
DE (1)	DE69111205T2 (de)
DK (1)	DK0490549T3 (de)
ES (1)	ES2074236T3 (de)
HU (1)	HU213204B (de)
IE (1)	IE66398B1 (de)
IL (1)	IL100239A (de)
MX (1)	MX9102446A (de)
NZ (1)	NZ240901A (de)
PH (1)	PH30776A (de)
PT (1)	PT99727B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5541155A (en) *	1994-04-22	1996-07-30	Emisphere Technologies, Inc.	Acids and acid salts and their use in delivery systems
US5578323A (en)	1992-06-15	1996-11-26	Emisphere Technologies, Inc.	Proteinoid carriers and methods for preparation and use thereof
US5714167A (en)	1992-06-15	1998-02-03	Emisphere Technologies, Inc.	Active agent transport systems
US5629020A (en) *	1994-04-22	1997-05-13	Emisphere Technologies, Inc.	Modified amino acids for drug delivery
US5397479A (en) *	1993-04-26	1995-03-14	International Remote Imaging Systems, Inc.	Composition and method for enrichment of white blood cells from whole human blood
EP0726075A1 (de) *	1995-02-08	1996-08-14	Therapicon Srl	Nicht-inorganische pharmazeutische salzige Lösungen zur endonasale Verabreichung
US6001347A (en)	1995-03-31	1999-12-14	Emisphere Technologies, Inc.	Compounds and compositions for delivering active agents
US5750147A (en)	1995-06-07	1998-05-12	Emisphere Technologies, Inc.	Method of solubilizing and encapsulating itraconazole
IL126318A (en)	1996-03-29	2004-09-27	Emisphere Tech Inc	Compounds and compositions for delivering active agents and some novel carrier compounds
CA2258264A1 (en)	1996-06-14	1997-12-18	Emisphere Technologies, Inc.	Microencapsulated fragrances and method for preparation
US5726154A (en) *	1996-06-28	1998-03-10	University Of Utah Research Foundation	Stabilization and oral delivery of calcitonin
US6358504B1 (en)	1997-02-07	2002-03-19	Emisphere Technologies, Inc.	Compounds and compositions for delivering active agents
US6502208B1 (en)	1997-03-31	2002-12-31	International Business Machines Corporation	Method and system for check stop error handling
KR100611559B1 (ko) *	1998-05-08	2007-04-25	동아제약주식회사	칼시토닌을 함유한 비강투여용 약제학적 조성물
AU6875900A (en)	1999-09-08	2001-04-10	Chugai Seiyaku Kabushiki Kaisha	Protein solution preparation and method of stabilizing the same
JP3498041B2 (ja) *	2000-05-29	2004-02-16	科研製薬株式会社	プラルモレリン含有点鼻用製剤
BRPI0611901A2 (pt)	2005-06-14	2012-08-28	Amgen, Inc	composição, liofilizado, kit, e, processo para preparar uma composição
EP2471554A1 (de) *	2010-12-28	2012-07-04	Hexal AG	Pharmazeutische Formulierung mit biopharmazeutischem Arzneimittel
SE536091C2 (sv) *	2011-04-14	2013-04-30	Pep Tonic Medical Ab	Farmaceutisk komposition innehållande oxytocin eller fragment eller varianter därav och åtminstone en icke-jonisk cellulosaeter
PT3528787T (pt)	2016-10-21	2026-03-11	Amgen Inc	Formulações farmacêuticas e métodos para produzir as mesmas

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH657858A5 (de) *	1983-06-27	1986-09-30	Ciba Geigy Ag	Substanz aus der gruppe der calcitonine.
JPS61194034A (ja) *	1985-02-25	1986-08-28	Teijin Ltd	経鼻投与用粉末状組成物
MY102411A (en) *	1986-12-23	1992-06-17	Ciba Geigy Ag	Nasal solutions
US5059587A (en) *	1987-08-03	1991-10-22	Toyo Jozo Company, Ltd.	Physiologically active peptide composition for nasal administration
CA1338839C (en) *	1988-01-29	1997-01-14	Yoshio Sasaki	Controlled release formulation
US5026825A (en) *	1988-09-08	1991-06-25	Rhone-Poulenc Rorer Pharmaceuticals Inc.	Intranasal calcitonin formulations
JPH02174726A (ja) *	1988-12-23	1990-07-06	Toyo Jozo Co Ltd	エルカトニン水溶液組成物の安定化法
JP2514249B2 (ja) *	1989-05-23	1996-07-10	帝人株式会社	安定化されたカルシトニン類医薬組成物

1991
- 1991-11-22 JP JP30789591A patent/JP3179538B2/ja not_active Expired - Fee Related
- 1991-12-02 DE DE69111205T patent/DE69111205T2/de not_active Expired - Fee Related
- 1991-12-02 ES ES91311176T patent/ES2074236T3/es not_active Expired - Lifetime
- 1991-12-02 DK DK91311176.1T patent/DK0490549T3/da active
- 1991-12-02 AT AT91311176T patent/ATE124869T1/de not_active IP Right Cessation
- 1991-12-02 EP EP91311176A patent/EP0490549B1/de not_active Expired - Lifetime
- 1991-12-04 IL IL10023991A patent/IL100239A/en not_active IP Right Cessation
- 1991-12-06 AU AU88898/91A patent/AU653371B2/en not_active Ceased
- 1991-12-06 PH PH43606A patent/PH30776A/en unknown
- 1991-12-09 PT PT99727A patent/PT99727B/pt not_active IP Right Cessation
- 1991-12-09 NZ NZ240901A patent/NZ240901A/xx not_active IP Right Cessation
- 1991-12-09 CA CA002057291A patent/CA2057291C/en not_active Expired - Fee Related
- 1991-12-09 MX MX9102446A patent/MX9102446A/es unknown
- 1991-12-10 IE IE429491A patent/IE66398B1/en not_active IP Right Cessation
- 1991-12-10 HU HU913887A patent/HU213204B/hu not_active IP Right Cessation
- 1991-12-10 KR KR1019910022557A patent/KR100253862B1/ko not_active Expired - Fee Related

Also Published As

Publication number	Publication date
PT99727B (pt)	1999-05-31
DE69111205T2 (de)	1996-01-04
NZ240901A (en)	1993-03-26
JPH06340547A (ja)	1994-12-13
CA2057291C (en)	2003-09-09
KR920011516A (ko)	1992-07-24
PT99727A (pt)	1992-10-30
IL100239A0 (en)	1992-09-06
IL100239A (en)	1996-06-18
PH30776A (en)	1997-10-17
KR100253862B1 (ko)	2000-09-01
EP0490549A1 (de)	1992-06-17
IE914294A1 (en)	1992-06-17
JP3179538B2 (ja)	2001-06-25
DK0490549T3 (da)	1995-08-21
EP0490549B1 (de)	1995-07-12
HUT59832A (en)	1992-07-28
ES2074236T3 (es)	1995-09-01
DE69111205D1 (de)	1995-08-17
HU913887D0 (en)	1992-02-28
IE66398B1 (en)	1995-12-27
MX9102446A (es)	1992-07-01
HU213204B (en)	1997-03-28
CA2057291A1 (en)	1992-06-12
AU8889891A (en)	1992-06-18
AU653371B2 (en)	1994-09-29

Legal Events

Date	Code	Title	Description
1995-12-15	UEP	Publication of translation of european patent specification
2010-09-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE124869T1 (de)	1995-07-15	Stabilisierung von calcitonin enthaltenden pharmazeutischen verbindungen.
DE69531314D1 (de)	2003-08-21	Verwendung von metallionen chelatoren zur stabilisierung von interferon-enthaltenden pharmazeutischen zubereitungen
DK358384A (da)	1985-01-23	Farmaceutiske midler til bekaempelse af diabetes mellitus
KR920019371A (ko)	1992-11-19	안정화된 인자 ⅷ 제제
DE3871434D1 (de)	1992-07-02	Stabilisierte wasserstoffperoxidloesung.
MX9100230A (es)	1992-02-28	Solucion de celulosa en agua y n-metilmorfolina-n-oxido
ATE95063T1 (de)	1993-10-15	Kalzitonin enthaltende emulsion zur nasalen verabreichung.
ATE65401T1 (de)	1991-08-15	Stabile, injizierbare loesungen von salzen von vincristin.
DK534087D0 (da)	1987-10-13	Desinfektionsmiddel indeholdende en stabiliseret hydrogenperoxidopl oesning til desinfektion af bloede kontaktlinser
NO875055L (no)	1988-06-06	Injiserbare, bruksferdige opploesninger inneholdende et antitumor-antracyklin glykosid.
FI902276A0 (fi)	1990-05-07	Menetelmä 8-N-(dietyyliaminoetyyli)rebekkamysiinin stabiilin vesiliuoksen valmistamiseksi
DK443988A (da)	1989-02-11	Injektionspraeparat indeholdende modificeret tpa
DE3667472D1 (de)	1990-01-18	Analoge von hypokalzemischen polypeptiden, welche den kalziumgehalt des koerpers schonen, deren herstellung, deren verwendung als arznei und diese enthaltende zusammensetzungen.
KR920004334A (ko)	1992-03-27	광학적 활성 알라닌아닐리드 화합물의 산부가염 및 그것을 함유하는 약학적조성물
ATE78402T1 (de)	1992-08-15	Waesserige loesungen von doxorubicin.
DE69026098D1 (de)	1996-04-25	Organogermaniumderivate enthaltende Zubereitungen zur therapeutischen Verwendung
IT1247752B (it)	1994-12-30	Composizioni farmaceutiche aventi come principio attivo calcitonina da somministrarsi per via intranasale.