ATE95063T1 - Kalzitonin enthaltende emulsion zur nasalen verabreichung. - Google Patents

Kalzitonin enthaltende emulsion zur nasalen verabreichung.

Info

Publication number: ATE95063T1
Authority: AT; Austria
Prior art keywords: nasal administration; calcitonin; emulsion containing; containing calcitonin; preparations
Prior art date: 1990-08-16

Application number

AT91402231T

Other languages

English (en)

Inventor

Nakayuki Yamamoto

Michihiko Sugimoto

Hideo Sakakibara

Masaru Saita

Yuji Shimozono

Takafumi Manako

Original Assignee

Asahi Chemical Ind

Hisamitsu Pharmaceutical Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-08-16

Filing date

1991-08-12

Publication date

1993-10-15

1991-08-12 Application filed by Asahi Chemical Ind, Hisamitsu Pharmaceutical Co filed Critical Asahi Chemical Ind

1993-10-15 Application granted granted Critical

1993-10-15 Publication of ATE95063T1 publication Critical patent/ATE95063T1/de

Links

239000000839 emulsion Substances 0.000 title abstract 3
102000055006 Calcitonin Human genes 0.000 title abstract 2
108060001064 Calcitonin Proteins 0.000 title abstract 2
BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 title abstract 2
229960004015 calcitonin Drugs 0.000 title abstract 2
VDPRSOCKHVPZRS-UHFFFAOYSA-N 1-(2-decylsulfanylethyl)pyrrolidin-2-one Chemical compound CCCCCCCCCCSCCN1CCCC1=O VDPRSOCKHVPZRS-UHFFFAOYSA-N 0.000 abstract 1
VTAJIXDZFCRWBR-UHFFFAOYSA-N Licoricesaponin B2 Natural products C1C(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2)C(O)=O)C)(C)CC2)(C)C2C(C)(C)CC1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O VTAJIXDZFCRWBR-UHFFFAOYSA-N 0.000 abstract 1
238000010521 absorption reaction Methods 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
150000003976 azacycloalkanes Chemical class 0.000 abstract 1
229940037448 calcitonin preparations Drugs 0.000 abstract 1
LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 abstract 1
229960004949 glycyrrhizic acid Drugs 0.000 abstract 1
UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 abstract 1
239000001685 glycyrrhizic acid Substances 0.000 abstract 1
235000019410 glycyrrhizin Nutrition 0.000 abstract 1
LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/23—Calcitonins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Endocrinology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Chemical & Material Sciences (AREA)
Immunology (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Biophysics (AREA)
Otolaryngology (AREA)
Molecular Biology (AREA)
Dispersion Chemistry (AREA)
Oil, Petroleum & Natural Gas (AREA)
Organic Chemistry (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)

AT91402231T 1990-08-16 1991-08-12 Kalzitonin enthaltende emulsion zur nasalen verabreichung. ATE95063T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP2215044A JPH078806B2 (ja)	1990-08-16	1990-08-16	カルシトニン類含有経鼻投与用乳剤

Publications (1)

Publication Number	Publication Date
ATE95063T1 true ATE95063T1 (de)	1993-10-15

Family

ID=16665828

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91402231T ATE95063T1 (de)	1990-08-16	1991-08-12	Kalzitonin enthaltende emulsion zur nasalen verabreichung.

Country Status (13)

Country	Link
US (1)	US5281580A (de)
EP (1)	EP0471618B1 (de)
JP (1)	JPH078806B2 (de)
KR (1)	KR950000770B1 (de)
AT (1)	ATE95063T1 (de)
AU (1)	AU629758B2 (de)
CA (1)	CA2047903C (de)
DE (1)	DE69100436T2 (de)
DK (1)	DK0471618T3 (de)
ES (1)	ES2060329T3 (de)
IE (1)	IE65630B1 (de)
NZ (1)	NZ239166A (de)
PT (1)	PT98692B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP3090353B2 (ja) *	1991-09-17	2000-09-18	旭化成工業株式会社	パラチロイドホルモン類含有経鼻投与用乳剤
IT1251685B (it) *	1991-10-11	1995-05-19	Isf Spa	Composizioni farmaceutiche contenenti una calcitonina
CA2160681A1 (en) *	1993-04-19	1994-10-27	Masao Takahashi	Microemulsion preparation containing a slightly absorbable substance
EP0726075A1 (de) *	1995-02-08	1996-08-14	Therapicon Srl	Nicht-inorganische pharmazeutische salzige Lösungen zur endonasale Verabreichung
DE29723959U1 (de) *	1997-07-22	1999-07-22	Zellner, Gerhard, Dr., 83435 Bad Reichenhall	Nasenspray-Flüssigkeit
TWI243687B (en) *	1998-04-21	2005-11-21	Teijin Ltd	Pharmaceutical composition for application to mucosa
JP2000247911A (ja) *	1999-02-26	2000-09-12	Hisamitsu Pharmaceut Co Inc	大腸用吸収促進剤
AR026073A1 (es)	1999-10-20	2002-12-26	Nycomed Gmbh	Composicion farmaceutica acuosa que contiene ciclesonida
AU783952B2 (en)	2000-02-04	2006-01-05	Unigene Laboratories, Inc.	Nasal calcitonin formulations
US7244703B2 (en) *	2001-06-22	2007-07-17	Bentley Pharmaceuticals, Inc.	Pharmaceutical compositions and methods for peptide treatment
WO2004084859A2 (en) *	2003-03-21	2004-10-07	Nastech Pharmaceutical Company Inc.	Nasal calcitonin formulations containing chlorobutanol
CN101829319A (zh)	2003-12-08	2010-09-15	Cpex药品公司	用于胰岛素治疗的药用组合物及方法
GB2423711B (en) *	2005-10-24	2007-02-14	Fortune Apex Dev Ltd	Method for preparing a pharmaceutical composition with enhanced mucoadhesion
WO2008007214A2 (en) *	2006-07-07	2008-01-17	Avestha Gengraine Technologies Pvt. Ltd.	Glycyrrhiza glabra plant extracts for treating osteoporosis and the extraction process thereof
CN102727870B (zh)	2006-09-27	2014-04-30	旭化成制药株式会社	鲑降钙素的应用
KR101686271B1 (ko)	2009-11-18	2016-12-13	아사히 가세이 파마 가부시키가이샤	인간 변형성 슬관절증의 예방제 및/또는 치료제 및/또는 악화 억제제
US20190210394A1 (en) *	2018-01-05	2019-07-11	Beatrice A. Darby	Reading staff book system

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2212062A (en) *	1938-04-16	1940-08-20	Harry O Duerr	Waste destructor and garbage reclamation unit
GB2127689B (en) *	1982-10-05	1986-07-09	Sandoz Ltd	Calcitonin inhalation compositions
AU572815B2 (en) *	1982-12-29	1988-05-19	Armour Pharmaceutical Company	Pharmaceutical calcitonin compositions for intranasal application
JPS61267528A (ja) *	1984-11-26	1986-11-27	Yamanouchi Pharmaceut Co Ltd	吸収促進剤を含有するカルシトニン経鼻剤
US4690852A (en) *	1985-06-11	1987-09-01	Paul Gach	Foil for stained glass assembly
EP0234745B1 (de) *	1986-01-29	1991-06-12	Dyson Refractories Limited	Katalysatoren
JPH0643390B2 (ja) *	1986-04-08	1994-06-08	久光製薬株式会社	アザシクロアルカン誘導体
ES2061688T3 (es) *	1987-11-13	1994-12-16	Smithkline Beecham Farma	Composiciones farmaceuticas que comprenden una calcitonina y un glicirricinato como mejorador de la absorcion.
US5026825A (en) *	1988-09-08	1991-06-25	Rhone-Poulenc Rorer Pharmaceuticals Inc.	Intranasal calcitonin formulations
JPH0669956B2 (ja) *	1988-09-30	1994-09-07	旭化成工業株式会社	ポリペプタイド類の吸着防止剤

1990
- 1990-08-16 JP JP2215044A patent/JPH078806B2/ja not_active Expired - Fee Related
1991
- 1991-07-23 US US07/734,637 patent/US5281580A/en not_active Expired - Fee Related
- 1991-07-24 IE IE261491A patent/IE65630B1/en not_active IP Right Cessation
- 1991-07-25 CA CA002047903A patent/CA2047903C/en not_active Expired - Fee Related
- 1991-07-29 NZ NZ239166A patent/NZ239166A/xx not_active IP Right Cessation
- 1991-08-12 DK DK91402231.4T patent/DK0471618T3/da active
- 1991-08-12 DE DE91402231T patent/DE69100436T2/de not_active Expired - Fee Related
- 1991-08-12 EP EP91402231A patent/EP0471618B1/de not_active Expired - Lifetime
- 1991-08-12 AT AT91402231T patent/ATE95063T1/de not_active IP Right Cessation
- 1991-08-12 ES ES91402231T patent/ES2060329T3/es not_active Expired - Lifetime
- 1991-08-14 KR KR1019910014060A patent/KR950000770B1/ko not_active Expired - Fee Related
- 1991-08-15 AU AU82445/91A patent/AU629758B2/en not_active Ceased
- 1991-08-16 PT PT98692A patent/PT98692B/pt not_active IP Right Cessation

Also Published As

Publication number	Publication date
KR950000770B1 (ko)	1995-02-02
DE69100436D1 (de)	1993-11-04
DE69100436T2 (de)	1994-01-20
IE912614A1 (en)	1992-02-26
JPH0499729A (ja)	1992-03-31
NZ239166A (en)	1992-11-25
CA2047903C (en)	1995-12-05
ES2060329T3 (es)	1994-11-16
PT98692A (pt)	1992-07-31
AU629758B2 (en)	1992-10-08
CA2047903A1 (en)	1992-02-17
KR920003991A (ko)	1992-03-27
IE65630B1 (en)	1995-11-01
PT98692B (pt)	1999-01-29
AU8244591A (en)	1992-02-20
DK0471618T3 (da)	1993-11-29
EP0471618A1 (de)	1992-02-19
EP0471618B1 (de)	1993-09-29
US5281580A (en)	1994-01-25
JPH078806B2 (ja)	1995-02-01

Legal Events

Date	Code	Title
1994-06-15	UEP	Publication of translation of european patent specification
2004-11-15	EEIH	Change in the person of patent owner
2006-05-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE95063T1 (de)	1993-10-15	Kalzitonin enthaltende emulsion zur nasalen verabreichung.
DK358384A (da)	1985-01-23	Farmaceutiske midler til bekaempelse af diabetes mellitus
BR9408343A (pt)	1997-08-19	Derivados 5-(2-imidazolinil amino) benzimidazol sua preparação e seu uso como agonistas alfa-2 adrenoceptor
IL98089A0 (en)	1992-06-21	Pharmaceutical preparations for administration of biologically active substance to a mammal via a mucosal membrane
ATE204178T1 (de)	2001-09-15	Methode zur behandlung und vorbeugung von typ-1 diabetis durch orale verabreichung von insulin
NO166448C (no)	1991-07-24	Analogifremgangsmaate for fremstilling av terapeutisk aktive tiazolidindioner.
SE8804629D0 (sv)	1988-12-22	New therapeutically active compounds
MY102565A (en)	1992-07-31	Novel derivatives of guanine
WO1996024370B1 (en)	1996-09-19	Pharmaceutical non inorganic saline solutions for endonasal administration of a calcitonin
ATE191719T1 (de)	2000-04-15	Analoge des calcitonin aus lachs, ihre herstellung und ihre verwendung als medizin und als analytische reagentien
ZA874812B (en)	1988-10-26	Drug
DE69226370D1 (de)	1998-08-27	Parathyroidhormon enthaltene emulsion zur nasalen verabreichung
ES2074236T3 (es)	1995-09-01	Composiciones farmaceuticas que comprenden calcitonina.
DE69122364D1 (de)	1996-10-31	Verwendung von (S)-Isofluran und (S)-Desfluran zur Anästhesie sowie entsprechende Arzneimittelzubereitungen
ATE284697T1 (de)	2005-01-15	Pharmazeutische zubereitung auf der basis von rhamnolipid gegen dermatologische erkrankungen
EP0353821A3 (de)	1991-07-17	Antipsychotische 3-Piperazinylbenzazolderivate
KR900009606A (ko)	1990-07-05	불소-함유 2-니트로 이미다졸 유도체 및 그를 함유하는 방사선 증감제
DK178883D0 (da)	1983-04-22	2-(2'-hydroxy-3'-(1,1-dimethylpropylamino)-propoxy)-beta-phenylpropiophenon, syreadditionssalte deraf, fremgangsmade til fremstilling deraf samt farmaceutiske praeparater med indhold deraf
FI913034A0 (fi)	1991-06-20	Foerening med magsyrainhiberande effekt och foerfarande foer dess framstaellning.
BR9712033A (pt)	2000-01-18	Composição farmacêutica para tratamento de doenças virais.
ATE82850T1 (de)	1992-12-15	Verwendung von 2-pyrimidinyl-1-piperazinderivaten.
NO950177D0 (no)	1995-01-17	Farmakologisk aktive erivater
EA199800177A1 (ru)	1998-10-29	Способ снижения количества экзогенного инсулина, вводимого пациенту с инсулиннезависимым сахарным диабетом
SE8204670D0 (sv)	1982-08-12	Ny forening med antiulcerogen aktivitet, forfarande for dess framstellning och farmaceutisk beredning innehallande densamma
NO933521D0 (no)	1993-10-01	Acylsulfonamido- og sulfonamidopyridin-2-karboksylsyreester samt deres pyridin-n-oksyder, fremgangsmaater for deres fremstilling og deres anvendelse som legemiddel