ATE125539T1 - 1,4-benzothiazedinderivat. - Google Patents

1,4-benzothiazedinderivat.

Info

Publication number
ATE125539T1
ATE125539T1 AT92901899T AT92901899T ATE125539T1 AT E125539 T1 ATE125539 T1 AT E125539T1 AT 92901899 T AT92901899 T AT 92901899T AT 92901899 T AT92901899 T AT 92901899T AT E125539 T1 ATE125539 T1 AT E125539T1
Authority
AT
Austria
Prior art keywords
lower alkoxy
benzothiazedine
derivative
phenyl
acyl
Prior art date
Application number
AT92901899T
Other languages
English (en)
Inventor
Noboru Kaneko
Tatsushi Oosawa
Teruyuki Sakai
Hideo Oota
Original Assignee
Noboru Kaneko
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Noboru Kaneko filed Critical Noboru Kaneko
Application granted granted Critical
Publication of ATE125539T1 publication Critical patent/ATE125539T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AT92901899T 1990-12-28 1991-12-27 1,4-benzothiazedinderivat. ATE125539T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2416066A JP2703408B2 (ja) 1990-12-28 1990-12-28 １，４‐ベンゾチアゼピン誘導体

Publications (1)

Publication Number Publication Date
ATE125539T1 true ATE125539T1 (de) 1995-08-15

Family

ID=18524314

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92901899T ATE125539T1 (de) 1990-12-28 1991-12-27 1,4-benzothiazedinderivat.

Country Status (13)

Country Link
US (1) US5416066A (de)
EP (1) EP0565721B1 (de)
JP (1) JP2703408B2 (de)
KR (1) KR0165131B1 (de)
CN (1) CN1028992C (de)
AT (1) ATE125539T1 (de)
AU (1) AU9107491A (de)
CA (1) CA2098495C (de)
DE (1) DE69111619T2 (de)
DK (1) DK0565721T3 (de)
RU (1) RU2089550C1 (de)
WO (1) WO1992012148A1 (de)
ZA (1) ZA9110166B (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2115650C1 (ru) * 1992-11-09 1998-07-20 Дзе Бутс Компани ПЛС 2,3,4,5-тетрагидро-1,4-бензотиазепины, их стереоизомеры или их фармацевтически приемлемые соли, способ их получения, фармацевтическая композиция, обладающая противосудорожным действием
US5608110A (en) * 1993-06-15 1997-03-04 Bracco International B.V. Heteroatom-bearing ligands and metal complexes thereof
US6083903A (en) 1994-10-28 2000-07-04 Leukosite, Inc. Boronic ester and acid compounds, synthesis and uses
EP1147772B1 (de) * 1998-12-28 2006-01-04 Noboru Kaneko verwendung von 1,4-benzothiazepinen zur Herstellung eines Medikaments ZUR BEHANDLUNG DER VORHOF-FIBRILLATION
EP1184037B1 (de) * 1999-05-19 2005-06-29 Noboru Kaneko Verwendung von 1,4-benzothiazepinderivaten als medikamente zur überwindung der toleranz für carcinostatika
WO2001047510A2 (en) * 1999-12-29 2001-07-05 Glaxo Group Limited Methods and compositions related to modulators of annexin and cartilage homeostasis
US7718644B2 (en) 2004-01-22 2010-05-18 The Trustees Of Columbia University In The City Of New York Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof
US7393652B2 (en) 2000-05-10 2008-07-01 The Trustees Of Columbia University In The City Of New York Methods for identifying a chemical compound that directly enhances binding of FKBP12.6 to PKA-phosphorylated type 2 ryanodine receptor (RyR2)
US20040229781A1 (en) * 2000-05-10 2004-11-18 Marks Andrew Robert Compounds and methods for treating and preventing exercise-induced cardiac arrhythmias
US6489125B1 (en) * 2000-05-10 2002-12-03 The Trustees Of Columbia University In The City Of New York Methods for identifying chemical compounds that inhibit dissociation of FKBP12.6 binding protein from type 2 ryanodine receptor
US20040048780A1 (en) * 2000-05-10 2004-03-11 The Trustees Of Columbia University In The City Of New York Method for treating and preventing cardiac arrhythmia
US7879840B2 (en) 2005-08-25 2011-02-01 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
US20060293266A1 (en) * 2000-05-10 2006-12-28 The Trustees Of Columbia Phosphodiesterase 4D in the ryanodine receptor complex protects against heart failure
US8022058B2 (en) 2000-05-10 2011-09-20 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
US7544678B2 (en) * 2002-11-05 2009-06-09 The Trustees Of Columbia University In The City Of New York Anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2)
JP2007525165A (ja) 2003-03-07 2007-09-06 トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク タイプ１ライアノジン受容体に基づく方法
US8710045B2 (en) * 2004-01-22 2014-04-29 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the ryanodine receptors
EP1743895A4 (de) * 2004-04-28 2010-06-16 Aetas Pharma Co Ltd Muskelrelaxationsbeschleuniger und therapeutisches mittel gegen muskelgewebekrankheiten wie muskelrelaxationsversagen
US7704990B2 (en) * 2005-08-25 2010-04-27 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
WO2009026444A1 (en) * 2007-08-22 2009-02-26 President And Fellows Of Harvard College Ryanodine channel binders and uses thereof
CA2717523C (en) 2008-03-03 2014-01-21 Armgo Pharma, Inc. Process for preparing benzothiazepines from .gamma.-aminoalkylbenzenes
KR101337244B1 (ko) 2009-02-25 2013-12-06 노보루 카네코 1,4-벤조티아제핀-1-옥사이드 유도체 및 이를 이용한 의약 조성물
US8933129B2 (en) 2009-04-15 2015-01-13 State Of Oregon By And Through The State Board Of Higher Education On Behalf Of Portland State University Compounds and methods for modulating activity of calcium release channels
CN106795148B (zh) 2014-07-30 2019-12-10 埃塔斯制药株式会社 1,4-苯并硫氮杂*-1-氧化物衍生物的光学异构体及使用它的医药组合物
ES2643856B1 (es) 2016-05-24 2018-08-03 Universidad Del Pais Vasco / Euskal Herriko Unibertsitatea Triazoles para la regulación de la homeostasis de calcio intracelular
US11426415B2 (en) 2017-03-06 2022-08-30 Washington University Treatment for Wolfram syndrome and other endoplasmic reticulum stress disorders
CN111447932A (zh) 2017-12-11 2020-07-24 埃塔斯制药株式会社 含有1,4-苯并硫氮杂*-1-氧化物衍生物的光学异构体的肾功能障碍的改善药

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3794639A (en) 1966-03-10 1974-02-26 Squibb & Sons Inc Benzoxazepines and benzothiazepines
ZA836994B (en) * 1982-09-30 1984-05-30 Robins Co Inc A H Fused aromatic oxazepinones and sulfur analogs thereof
EP0107930B1 (de) * 1982-09-30 1990-11-28 A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) Kondensierte aromatische Oxazepinone und Sulphuranaloge, ihrer Herstellung und Verwendung als Histamin-Antagonist
JPS6140651A (ja) * 1984-07-31 1986-02-26 Hitachi Ltd 記憶装置へのフアイル割当て方法および割当て決定装置
JP2871811B2 (ja) * 1990-02-28 1999-03-17 サントリー株式会社 縮合７員環系化合物
JP2935541B2 (ja) * 1990-06-28 1999-08-16 サントリー株式会社 縮合複素環化合物
US5250679A (en) * 1991-10-18 1993-10-05 Genentech, Inc. Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III.sub. receptor

Also Published As

Publication number Publication date
JP2703408B2 (ja) 1998-01-26
CA2098495A1 (en) 1992-06-29
WO1992012148A1 (en) 1992-07-23
EP0565721B1 (de) 1995-07-26
ZA9110166B (en) 1992-09-30
EP0565721A4 (en) 1994-06-01
JPH04230681A (ja) 1992-08-19
CA2098495C (en) 1999-11-30
DE69111619T2 (de) 1996-01-18
KR930703303A (ko) 1993-11-29
AU9107491A (en) 1992-08-17
US5416066A (en) 1995-05-16
CN1063491A (zh) 1992-08-12
RU2089550C1 (ru) 1997-09-10
DK0565721T3 (da) 1995-11-06
DE69111619D1 (de) 1995-08-31
KR0165131B1 (ko) 1999-02-18
EP0565721A1 (de) 1993-10-20
CN1028992C (zh) 1995-06-21

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time