ATE125818T1 - Verfahren zur naturation von somatotropin. - Google Patents

Verfahren zur naturation von somatotropin.

Info

Publication number: ATE125818T1
Authority: AT; Austria
Prior art keywords: protein; naturation; somatotropin; refractile bodies; surfactant
Prior art date: 1990-09-12

Application number

AT91870142T

Other languages

English (en)

Inventor

Sa Van Ho

Original Assignee

Monsanto Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-09-12

Filing date

1991-09-09

Publication date

1995-08-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24324383&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE125818(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1991-09-09 Application filed by Monsanto Co filed Critical Monsanto Co

1995-08-15 Application granted granted Critical

1995-08-15 Publication of ATE125818T1 publication Critical patent/ATE125818T1/de

Links

238000000034 method Methods 0.000 title abstract 2
102000004169 proteins and genes Human genes 0.000 abstract 3
108090000623 proteins and genes Proteins 0.000 abstract 3
102000018997 Growth Hormone Human genes 0.000 abstract 2
108010051696 Growth Hormone Proteins 0.000 abstract 2
239000004094 surface-active agent Substances 0.000 abstract 2
DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 abstract 1
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 1
239000007864 aqueous solution Substances 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
239000004202 carbamide Substances 0.000 abstract 1
230000003196 chaotropic effect Effects 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
239000000539 dimer Substances 0.000 abstract 1
229960000789 guanidine hydrochloride Drugs 0.000 abstract 1
PJJJBBJSCAKJQF-UHFFFAOYSA-N guanidinium chloride Chemical compound [Cl-].NC(N)=[NH2+] PJJJBBJSCAKJQF-UHFFFAOYSA-N 0.000 abstract 1
230000003647 oxidation Effects 0.000 abstract 1
238000007254 oxidation reaction Methods 0.000 abstract 1
229940083575 sodium dodecyl sulfate Drugs 0.000 abstract 1
235000019333 sodium laurylsulphate Nutrition 0.000 abstract 1
230000007928 solubilization Effects 0.000 abstract 1
238000005063 solubilization Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/823—Lower fungi, e.g. mold
- Y10S530/824—Yeasts
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/825—Bacteria

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
General Chemical & Material Sciences (AREA)
Analytical Chemistry (AREA)
Endocrinology (AREA)
Toxicology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Beans For Foods Or Fodder (AREA)
Cosmetics (AREA)

AT91870142T 1990-09-12 1991-09-09 Verfahren zur naturation von somatotropin. ATE125818T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/581,233 US5023323A (en)	1990-09-12	1990-09-12	Method of somatotropin naturation

Publications (1)

Publication Number	Publication Date
ATE125818T1 true ATE125818T1 (de)	1995-08-15

Family

ID=24324383

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91870142T ATE125818T1 (de)	1990-09-12	1991-09-09	Verfahren zur naturation von somatotropin.

Country Status (4)

Country	Link
US (1)	US5023323A (de)
EP (1)	EP0475927B1 (de)
AT (1)	ATE125818T1 (de)
DE (1)	DE69111726D1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3685424D1 (de) *	1985-06-26	1992-06-25	Upjohn Co	Solubilisation und oxidation von somatotropin aus transformierten mikroorganismen.
US5109117A (en) *	1990-06-26	1992-04-28	Monsanto Company	Method of somatotropin naturation using urea and a soluble organic alcohol
ZA9711733B (en) *	1996-12-31	1998-07-01	Monsanto Co	Method for solubilization and naturation of somatotropins
ATE349460T1 (de) *	1998-07-09	2007-01-15	Barofold Inc	Rückfaltung von protein-aggregaten und einschlussteilchen durch hohen druck
DE19836559A1 (de)	1998-08-12	2000-03-23	Antigen Gmbh	Gefäß zur Entnahme von Blut
CA2434045A1 (en) *	2000-10-31	2002-08-15	The Regents Of The University Of Colorado, A Body Corporate	Improved protein disaggregation and refolding using high pressure
CA2663416A1 (en) *	2006-09-15	2008-03-20	Barofold, Inc.	High pressure treatment of proteins for reduced immunogenicity
BR102013026129A2 (pt) *	2013-10-10	2016-05-24	Ouro Fino Participações E Empreendimentos S A	processo para a produção de somatotropina bovina recombinate ativa e produto obtido

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4315919A (en) *	1980-10-06	1982-02-16	Edward Shanbrom	Depyrogenation process
GR79124B (de) *	1982-12-22	1984-10-02	Genentech Inc
US4511502A (en) *	1982-12-22	1985-04-16	Genentech, Inc.	Purification and activity assurance of precipitated heterologous proteins
US4518526A (en) *	1982-12-22	1985-05-21	Genentech, Inc.	Purification and activity assurance of precipitated heterologous proteins
US4530787A (en) *	1984-03-28	1985-07-23	Cetus Corporation	Controlled oxidation of microbially produced cysteine-containing proteins
JPS6148719A (ja) *	1984-08-16	1986-03-10	Fanuc Ltd	光学式ロ−タリ−エンコ−ダ
ES8800957A1 (es) *	1985-02-22	1987-12-01	Monsanto Co	Un metodo para la solubilizacion y renaturalizacion de proteina somatotropina
US4652630A (en) *	1985-02-22	1987-03-24	Monsanto Company	Method of somatotropin naturation
US4731440A (en) *	1985-02-22	1988-03-15	Monsanto Company	Method of somatotropin solubilization using dimethylsulfone and naturation
DE3685424D1 (de) *	1985-06-26	1992-06-25	Upjohn Co	Solubilisation und oxidation von somatotropin aus transformierten mikroorganismen.
US4766224A (en) *	1985-08-19	1988-08-23	International Minerals & Chemical Corp.	Purification and activation of proteins from insoluble inclusion bodies
DE3611817A1 (de) *	1986-04-08	1987-10-15	Boehringer Mannheim Gmbh	Verfahren zur renaturierung von proteinen
US4841023A (en) *	1986-06-25	1989-06-20	New York Blood Center, Inc.	Inactivation of viruses in labile protein-containing compositions using fatty acids
US4888416A (en) *	1987-03-30	1989-12-19	International Minerals & Chemical Corp.	Method for stabilizing somatotropins
US4801691A (en) *	1987-05-15	1989-01-31	International Minerals & Chemical Corp.	Method for removing sodium dodecyl sulfate from sodium dodecyl sulfate solubilized protein solutions

1990
- 1990-09-12 US US07/581,233 patent/US5023323A/en not_active Expired - Fee Related
1991
- 1991-09-09 AT AT91870142T patent/ATE125818T1/de not_active IP Right Cessation
- 1991-09-09 EP EP91870142A patent/EP0475927B1/de not_active Expired - Lifetime
- 1991-09-09 DE DE69111726T patent/DE69111726D1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP0475927A2 (de)	1992-03-18
EP0475927B1 (de)	1995-08-02
DE69111726D1 (de)	1995-09-07
US5023323A (en)	1991-06-11
EP0475927A3 (en)	1992-12-09

Legal Events

Date	Code	Title	Description
1996-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69111726D1 (de)	1995-09-07	Verfahren zur Naturation von Somatotropin.
ATE107356T1 (de)	1994-07-15	Verfahren zur herstellung eines proteins.
DE69934585D1 (de)	2007-02-08	Rückfaltung von protein-aggregaten und einschlussteilchen durch hohen druck
ES552233A0 (es)	1987-12-01	Un metodo para la solubilizacion y renaturalizacion de proteina somatotropina
ATE136309T1 (de)	1996-04-15	Verfahren zum lösen und renaturieren von somatotropin
AU583723B2 (en)	1989-05-04	Process for renaturing of proteins
DE3784555D1 (de)	1993-04-15	Isolierung von bioaktivem, monomerem wachstumshormon.
DE3887889D1 (de)	1994-03-24	Verfahren zur Gewinnung von mikrobiell hergestelltem Beta-Interferon.
ES2032383T3 (es)	1993-02-16	Solubilizacion y oxidacion de somatotropina desde microorganismos transformados.
US5109117A (en)	1992-04-28	Method of somatotropin naturation using urea and a soluble organic alcohol
DE69631906T2 (de)	2005-01-20	Verfahren zur herstellung von richtig gefaltetem, biologisch aktivem, rekombinantem protein
ATE158586T1 (de)	1997-10-15	Verfahren zur stabilisierung von proteinen
ATE113060T1 (de)	1994-11-15	Methode zur auflösung und naturation von somatotropin unter verwendung von einer niedrigen harnstoffkonzentration.
DE3675382D1 (de)	1990-12-06	Erhoehte biowirkung von saeugetier-somatotropin durch selektive deamidierung.
KR900000384A (ko)	1990-01-30	효모에서 발현된 인체 γ-인터페론의 정제방법
KR960034217A (ko)	1996-10-22	재조합 인간 인터페론 베타의 정제방법
KR940014780A (ko)	1994-07-19	성장호르몬의 봉입체로부터 활성형태의 성장호르몬을 제조하는 방법
ATE46361T1 (de)	1989-09-15	Verfahren zur herstellung eines proteins.