ATE126798T1 - Chinoline derivate, nützlich als angiotensin-ii- antagonisten. - Google Patents

Chinoline derivate, nützlich als angiotensin-ii- antagonisten.

Info

Publication number: ATE126798T1
Authority: AT; Austria
Prior art keywords: group; alkoxy; aryl; independently; angiotensin
Prior art date: 1991-10-28

Application number

AT92402879T

Other languages

English (en)

Inventor

Gerard Cremer

Pascale Goberville

Jean-Claude Muller

Original Assignee

Synthelabo

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-10-28

Filing date

1992-10-22

Publication date

1995-09-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9418349&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE126798(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1992-10-22 Application filed by Synthelabo filed Critical Synthelabo

1995-09-15 Application granted granted Critical

1995-09-15 Publication of ATE126798T1 publication Critical patent/ATE126798T1/de

Links

229940123413 Angiotensin II antagonist Drugs 0.000 title 1
SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical class N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 title 1
239000002333 angiotensin II receptor antagonist Substances 0.000 title 1
229940027991 antiseptic and disinfectant quinoline derivative Drugs 0.000 title 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 3
125000003118 aryl group Chemical group 0.000 abstract 3
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
125000000753 cycloalkyl group Chemical group 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
125000006656 (C2-C4) alkenyl group Chemical group 0.000 abstract 1
-1 1H-tetrazol-5-yl group Chemical group 0.000 abstract 1
125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Quinoline Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
Communication Cables (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicinal Preparation (AREA)

AT92402879T 1991-10-28 1992-10-22 Chinoline derivate, nützlich als angiotensin-ii- antagonisten. ATE126798T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9113240A FR2683819B1 (fr)	1991-10-28	1991-10-28	Derives de quinoleine, leur procede de preparation et leur application en therapeutique.

Publications (1)

Publication Number	Publication Date
ATE126798T1 true ATE126798T1 (de)	1995-09-15

Family

ID=9418349

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92402879T ATE126798T1 (de)	1991-10-28	1992-10-22	Chinoline derivate, nützlich als angiotensin-ii- antagonisten.

Country Status (18)

Country	Link
EP (1)	EP0540400B1 (de)
JP (1)	JPH05239053A (de)
KR (1)	KR930007935A (de)
CN (1)	CN1073171A (de)
AT (1)	ATE126798T1 (de)
AU (1)	AU651740B2 (de)
CA (1)	CA2081537A1 (de)
CZ (1)	CZ324292A3 (de)
DE (1)	DE69204252T2 (de)
FI (1)	FI924869L (de)
FR (1)	FR2683819B1 (de)
HU (1)	HUT62883A (de)
IL (1)	IL103568A0 (de)
MX (1)	MX9206169A (de)
NO (1)	NO924138L (de)
NZ (1)	NZ244892A (de)
PL (1)	PL296369A1 (de)
ZA (1)	ZA928297B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5478832A (en) *	1992-05-08	1995-12-26	The Green Cross Corporation	Quinoline compounds
IT1255461B (it) *	1992-07-28	1995-11-02	Luso Farmaco Inst	Eteri di imidazoli ad attivita' a ii antagonista
FR2699174B1 (fr) *	1992-12-14	1995-01-20	Synthelabo	Dérivés de 3-(quinoléin-6-yl-méthyl)-4H-imidazol-4-one, leur préparation et leur application en thérapeutique.
FR2710914B1 (fr) *	1993-10-04	1995-11-24	Synthelabo	Dérivés de 2-[2-(tétrazol-5-yl)phényl]-1,2-dihydroquinoléine, leur préparation et leur utilisation comme intermédiaires de synthèse.
FR2716196B1 (fr) *	1994-02-16	1996-04-05	Synthelabo	Dérivés de 8-[2-(1H-tétrazol-5-yl) phényl] quinoléine, leur préparation et leur application en thérapeutique.
JPH09202774A (ja)	1996-01-25	1997-08-05	Green Cross Corp:The	２−アリールキノリン類およびその製造方法
DE19706161A1 (de) *	1997-02-17	1998-08-20	Oswald Hartmut Prof Dr Med	Verwendung von Cyaninen, Isocyaninen und Pseudoisocyaninen als Diuretika
KR100744826B1 (ko) *	2006-04-05	2007-08-01	한국화학연구원	이미다졸기가 치환된 퀴놀리논 유도체
US8969514B2 (en)	2007-06-04	2015-03-03	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
EP2527360B1 (de)	2007-06-04	2015-10-28	Synergy Pharmaceuticals Inc.	Für die Behandlung von gastrointestinalen Erkrankungen, Entzündungen, Krebs und anderen Erkrankungen geeignete Agonisten von Guanylatcyclase
EP2810951B1 (de)	2008-06-04	2017-03-15	Synergy Pharmaceuticals Inc.	Für die Behandlung von gastrointestinalen Erkrankungen, Entzündungen, Krebs und anderen Erkrankungen geeignete Agonisten von Guanylatcyclase
EP3241839B1 (de)	2008-07-16	2019-09-04	Bausch Health Ireland Limited	Zur behandlung von erkrankungen des magen-darm-trakts, entzündlichen erkrankungen, krebs und anderen erkrankungen geeignete agonisten von guanylatcyclase
US9616097B2 (en)	2010-09-15	2017-04-11	Synergy Pharmaceuticals, Inc.	Formulations of guanylate cyclase C agonists and methods of use
CN103804349A (zh) *	2012-11-01	2014-05-21	杨子娇	一类治疗青光眼的化合物及其用途
CA2905435A1 (en)	2013-03-15	2014-09-25	Synergy Pharmaceuticals Inc.	Compositions useful for the treatment of gastrointestinal disorders
CA2905438A1 (en)	2013-03-15	2014-09-25	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase and their uses
SI3004138T1 (sl)	2013-06-05	2024-07-31	Bausch Health Ireland Limited	Ultra čisti agonisti gvanilat ciklaze C, postopek za njihovo pripravo in uporabo
CN108558750B (zh) *	2018-07-11	2021-01-05	武汉工程大学	无溶剂法合成3-硝基喹啉衍生物的工艺

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL94390A (en) *	1989-05-30	1996-03-31	Merck & Co Inc	The 6-membered trans-nitrogen-containing heterocycles are compressed with imidazo and pharmaceutical preparations containing them
MX9200299A (es) *	1991-02-07	1992-12-01	Roussel Uclaf	Nuevos derivados biciclicos nitrogenados, su procedimiento de preparacion los nuevos compuestos intermedios obtenidos su aplicacion como medicamentos y las composiciones farmaceuticas que los contienen.
DE4117750A1 (de) *	1991-05-30	1992-12-24	Bayer Ag	Neue 2-amino-5-cyano-1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
ATE152718T1 (de) *	1991-08-15	1997-05-15	Ciba Geigy Ag	N-acyl-n-heterocyclyl- oder naphthylalkyl- aminosäuren als angiotensin ii antagonisten

1991
- 1991-10-28 FR FR9113240A patent/FR2683819B1/fr not_active Expired - Fee Related
1992
- 1992-10-22 AT AT92402879T patent/ATE126798T1/de active
- 1992-10-22 EP EP92402879A patent/EP0540400B1/de not_active Revoked
- 1992-10-22 DE DE69204252T patent/DE69204252T2/de not_active Revoked
- 1992-10-27 CA CA002081537A patent/CA2081537A1/en not_active Abandoned
- 1992-10-27 MX MX9206169A patent/MX9206169A/es unknown
- 1992-10-27 ZA ZA928297A patent/ZA928297B/xx unknown
- 1992-10-27 NO NO92924138A patent/NO924138L/no unknown
- 1992-10-27 AU AU27348/92A patent/AU651740B2/en not_active Ceased
- 1992-10-27 CZ CS923242A patent/CZ324292A3/cs unknown
- 1992-10-27 CN CN92113784A patent/CN1073171A/zh active Pending
- 1992-10-27 IL IL103568A patent/IL103568A0/xx unknown
- 1992-10-27 JP JP4288458A patent/JPH05239053A/ja active Pending
- 1992-10-27 KR KR1019920019802A patent/KR930007935A/ko not_active Withdrawn
- 1992-10-27 HU HU9203374A patent/HUT62883A/hu unknown
- 1992-10-27 PL PL29636992A patent/PL296369A1/xx unknown
- 1992-10-27 FI FI924869A patent/FI924869L/fi not_active Application Discontinuation
- 1992-10-27 NZ NZ244892A patent/NZ244892A/xx unknown

Also Published As

Publication number	Publication date
FI924869A7 (fi)	1993-04-29
HUT62883A (en)	1993-06-28
EP0540400B1 (de)	1995-08-23
JPH05239053A (ja)	1993-09-17
ZA928297B (en)	1993-05-07
AU651740B2 (en)	1994-07-28
CZ324292A3 (en)	1993-09-15
FR2683819B1 (fr)	1994-02-11
NO924138L (no)	1993-04-29
IL103568A0 (en)	1993-03-15
PL296369A1 (en)	1993-05-31
EP0540400A1 (de)	1993-05-05
FI924869A0 (fi)	1992-10-27
FI924869L (fi)	1993-04-29
HU9203374D0 (en)	1993-01-28
FR2683819A1 (fr)	1993-05-21
DE69204252T2 (de)	1996-04-18
MX9206169A (es)	1993-07-01
KR930007935A (ko)	1993-05-20
DE69204252D1 (de)	1995-09-28
CN1073171A (zh)	1993-06-16
CA2081537A1 (en)	1993-04-29
NO924138D0 (no)	1992-10-27
AU2734892A (en)	1993-04-29
NZ244892A (en)	1994-06-27

Publication	Publication Date	Title
ATE126798T1 (de)	1995-09-15	Chinoline derivate, nützlich als angiotensin-ii- antagonisten.
ATE174917T1 (de)	1999-01-15	Pyrazolo(1,5-a>pyrimidinderivate und sie enthaltende antiinflammatorische mittel
ES2076827T3 (es)	1995-11-01	Azaindoles, procedimientos de preparacion y medicamentos que los contienen.
NZ336302A (en)	2000-08-25	Quinoline and quinazoline compounds useful in therapy, particularly in the treatment of benign prostatic hyperplasia
ATE143019T1 (de)	1996-10-15	Xanthin derivate
EP0640080A1 (de)	1995-03-01	Substituierte indole und azaindole als angiotensin ii antagonisten.
ATE125808T1 (de)	1995-08-15	Indolederivate und ihre verwendung als serotonin- antagoniste.
DE69410509D1 (de)	1998-07-02	Benzoxazinderivate, deren Herstellung und deren Verwendung in Therapie
CO5251439A1 (es)	2003-02-28	Compuestos calciliticos
DK0500409T3 (da)	1996-07-15	Derivater af 4-pyrimidinoler, deres fremstilling og anvendelse i therapien
DE69116930D1 (de)	1996-03-21	Fluorierte Bis(hydroxymethyl)cyclobutylpurine und -pyrimidine
KR930021638A (ko)	1993-11-22	이미다조피리딘
GB2110669B (en)	1985-04-11	Imidazolidinones
DK599486D0 (da)	1986-12-12	1,4-dihydropyridiner, deres fremstilling af anvendelse som laegemidler
ATE148462T1 (de)	1997-02-15	Isoxazole derivate als lichtschutzmittel
ATE170187T1 (de)	1998-09-15	Pyrrolothienopyrazin-verbindungen als 5ht3- rezeptoren-antagonisten
ATE207879T1 (de)	2001-11-15	Alkynylaminosäure derivate und ihre verwendung als pharmazeutische verbindungen
DE60000556D1 (de)	2002-11-14	Tetrazolylalkyl-Indolderivate als entzündungshemmende und analgetische Mittel