ATE126828T1 - Mutanten des menschlichen plasminogenaktivator- inhibitors 1 (pai-1), ihre herstellung und verwendung. - Google Patents

Mutanten des menschlichen plasminogenaktivator- inhibitors 1 (pai-1), ihre herstellung und verwendung.

Info

Publication number
ATE126828T1
ATE126828T1 AT90914972T AT90914972T ATE126828T1 AT E126828 T1 ATE126828 T1 AT E126828T1 AT 90914972 T AT90914972 T AT 90914972T AT 90914972 T AT90914972 T AT 90914972T AT E126828 T1 ATE126828 T1 AT E126828T1
Authority
AT
Austria
Prior art keywords
pai
mutants
plasminogen activator
activator inhibitor
human plasminogen
Prior art date
Application number
AT90914972T
Other languages
English (en)
Inventor
Hans Pannekoek
Original Assignee
Stichting Centraal Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stichting Centraal Lab filed Critical Stichting Centraal Lab
Application granted granted Critical
Publication of ATE126828T1 publication Critical patent/ATE126828T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8132—Plasminogen activator inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
AT90914972T 1989-10-03 1990-10-03 Mutanten des menschlichen plasminogenaktivator- inhibitors 1 (pai-1), ihre herstellung und verwendung. ATE126828T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL8902454A NL8902454A (nl) 1989-10-03 1989-10-03 Mutanten van de humane plasminogeen activator inhibitor 1 (pai-1), hun bereiding en toepassing, en recombinante polynucleotiden die voor deze mutanten coderende genetische informatie omvatten.

Publications (1)

Publication Number Publication Date
ATE126828T1 true ATE126828T1 (de) 1995-09-15

Family

ID=19855387

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90914972T ATE126828T1 (de) 1989-10-03 1990-10-03 Mutanten des menschlichen plasminogenaktivator- inhibitors 1 (pai-1), ihre herstellung und verwendung.

Country Status (8)

Country Link
EP (1) EP0494929B1 (de)
JP (1) JPH05503211A (de)
AT (1) ATE126828T1 (de)
DE (1) DE69021885T2 (de)
DK (1) DK0494929T3 (de)
ES (1) ES2078979T3 (de)
NL (1) NL8902454A (de)
WO (1) WO1991005048A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3742997A1 (de) * 1987-12-18 1989-06-29 Behringwerke Ag Peptide, verfahren zu ihrer herstellung, ihre verwendung zur gewinnung von antikoerpern sowie deren verwendung zur blockierung der pai-1-aktivitaet menschlichen blutes
US5610148A (en) * 1991-01-18 1997-03-11 University College London Macroscopically oriented cell adhesion protein for wound treatment
US5629287A (en) * 1991-01-18 1997-05-13 University College London Depot formulations
DE4242655A1 (de) * 1992-12-17 1994-06-23 Behringwerke Ag Verwendung von Thrombin-Inhibitoren zur Inhibition okularer Fibrinbildung
US5910481A (en) * 1995-11-13 1999-06-08 Immuno Ag Hybrid proteins with modified activity
US6750201B1 (en) * 1997-10-17 2004-06-15 The Trustees Of The University Of Pennsylvania Compositions and methods for promoting internalization and degradation of urokinase-type plasminogen activator
JP2001520200A (ja) * 1997-10-17 2001-10-30 ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア ウロキナーゼタイプのプラスミノーゲン活性化因子の内在化および分解を促進するための組成物および方法
DE10153601A1 (de) 2001-11-02 2003-05-22 Paion Gmbh DSPA zur Behandlung von Schlaganfall
WO2003046006A1 (en) * 2001-11-27 2003-06-05 Bayer Healthcare Ag Polynucleotides encoding nexin-related serine protease inhibitor
US7939304B2 (en) 2002-10-02 2011-05-10 Catalyst Biosciences, Inc. Mutant MT-SP1 proteases with altered substrate specificity or activity
BRPI0409865A (pt) * 2003-05-02 2006-05-16 Paion Deutschland Gmbh injeção intravenosa de ativadores de plasminogênio não neurotóxicos para o tratamento do ataque de apoplexia
WO2004096267A1 (de) * 2003-05-02 2004-11-11 Paion Gmbh Intravenöse injektion nicht-neurotoxischer plasminogen-aktivatoren zur behandlung von schlaganfall
WO2005110453A2 (en) 2004-04-12 2005-11-24 Catalyst Biosciences, Inc. Cleavage of vegf and vegf receptor by wildtype and mutant mt-sp1
ATE530644T1 (de) 2006-07-05 2011-11-15 Catalyst Biosciences Inc Protease-screening-verfahren und dadurch identifizierte proteasen
ES2324192B1 (es) * 2008-01-30 2010-06-17 PUIG BEAUTY & FASHION GROUP, S.L. Derivados peptidicos utiles en el tratamiento, cuidado o limpieza de la piel, mucosa, cuero cabelludo o uñas.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3521226A1 (de) * 1985-02-08 1986-08-14 Hoechst Ag, 6230 Frankfurt Gene fuer biologisch aktive proteine
NL8602307A (nl) * 1986-09-12 1988-04-05 Stichting Centraal Lab Recombinant dna molekuul; werkwijze voor het bereiden van humane endotheliale plasminogeen activator remmer (pai) of een mutant daarvan; farmaceutisch preparaat; getransformeerde gastheercellen.
JPH01191687A (ja) * 1988-01-28 1989-08-01 Hoechst Japan Kk ヒトα↓２−プラスミンインヒビターまたはそれと類似の蛋白質から誘導される新規蛋白質

Also Published As

Publication number Publication date
DE69021885T2 (de) 1996-05-02
EP0494929B1 (de) 1995-08-23
ES2078979T3 (es) 1996-01-01
JPH05503211A (ja) 1993-06-03
WO1991005048A1 (en) 1991-04-18
EP0494929A1 (de) 1992-07-22
DK0494929T3 (da) 1996-01-29
DE69021885D1 (de) 1995-09-28
NL8902454A (nl) 1991-05-01

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Legal Events

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UEP Publication of translation of european patent specification
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