ATE194624T1 - Mutanten von menschlichem antithrombin iii - Google Patents

Mutanten von menschlichem antithrombin iii

Info

Publication number: ATE194624T1
Authority: AT; Austria
Prior art keywords: iii; mutant; mutants; antithrombin iii; amino acids
Prior art date: 1992-04-10

Application number

AT93105829T

Other languages

English (en)

Inventor

Hiroyuki Kato

Shinji Yoshitake

Suguru Suzuki

Noboru Suzuki

Toshio Seto

Naoko Nagaoka

Yoshiharu Mizui

Original Assignee

Eisai Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-04-10

Filing date

1993-04-08

Publication date

2000-07-15

1993-04-08 Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd

2000-07-15 Application granted granted Critical

2000-07-15 Publication of ATE194624T1 publication Critical patent/ATE194624T1/de

Links

101000757319 Homo sapiens Antithrombin-III Proteins 0.000 title abstract 2
102000052834 human SERPINC1 Human genes 0.000 title abstract 2
229960004336 human antithrombin iii Drugs 0.000 title abstract 2
HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract 2
150000001413 amino acids Chemical class 0.000 abstract 2
229960002897 heparin Drugs 0.000 abstract 2
229920000669 heparin Polymers 0.000 abstract 2
108020004414 DNA Proteins 0.000 abstract 1
108020004511 Recombinant DNA Proteins 0.000 abstract 1
208000007536 Thrombosis Diseases 0.000 abstract 1
239000003146 anticoagulant agent Substances 0.000 abstract 1
229940127219 anticoagulant drug Drugs 0.000 abstract 1
239000004019 antithrombin Substances 0.000 abstract 1
239000002299 complementary DNA Substances 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
239000013604 expression vector Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8121—Serpins
- C07K14/8128—Antithrombin III
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Hematology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Diabetes (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Enzymes And Modification Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT93105829T 1992-04-10 1993-04-08 Mutanten von menschlichem antithrombin iii ATE194624T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP9048892		1992-04-10
JP03185593A JP3479539B2 (ja)	1992-04-10	1993-02-22	ヒトアンチトロンビンｉｉｉ変異体

Publications (1)

Publication Number	Publication Date
ATE194624T1 true ATE194624T1 (de)	2000-07-15

Family

ID=26370368

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93105829T ATE194624T1 (de)	1992-04-10	1993-04-08	Mutanten von menschlichem antithrombin iii

Country Status (9)

Country	Link
US (1)	US5420252A (de)
EP (1)	EP0568833B1 (de)
JP (1)	JP3479539B2 (de)
AT (1)	ATE194624T1 (de)
AU (1)	AU655723B2 (de)
CA (1)	CA2093575A1 (de)
DE (1)	DE69328992T2 (de)
DK (1)	DK0568833T3 (de)
ES (1)	ES2149788T3 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU3479495A (en) *	1994-09-30	1996-04-26	Ppl Therapeutics (Scotland) Ltd	Alpha-1-antitrypsin and antithrombine-iii variants
KR20010052345A (ko) *	1998-05-12	2001-06-25	수잔 씨 복	인간 항트롬빈 3 및 그에 관련된 방법
WO2000020026A2 (en)	1998-10-08	2000-04-13	Children's Hospital	Compositions and methods for inhibiting angiogenesis
JP4339962B2 (ja)	1999-06-23	2009-10-07	武比古小出	ヒトアンチトロンビン変異体
EP1530629B1 (de)	2002-05-31	2011-08-31	The University of Utah Research Foundation	Varianten von antithrombin iii
AU2005206806A1 (en) *	2004-01-09	2005-08-04	University Of Utah Research Foundation	Methods of using high affinity ATIII variants
DK2175877T3 (da) *	2007-07-20	2012-04-16	Univ Paris Sud Xi	Anvendelse af muterede antitrombiner til behandling eller forebyggelse af koagulationssygdomme
WO2010081878A1 (en) *	2009-01-16	2010-07-22	Universite Paris-Sud Xi	Mutated antithrombins, a process for preparing the same and their use as drugs
PT2496246T (pt)	2009-11-03	2018-07-31	Grifols Therapeutics Llc	Composição, método e kit para o inibidor da alfa-1 protease
RU2540480C2 (ru)	2009-11-24	2015-02-10	Грифольс Терапьютикс Инк.	Способы, композиции и наборы для лиофилизации
ES2374054B1 (es) *	2010-07-03	2012-12-26	Instituto De Salud Carlos Iii	Nuevo inhibidor de serina proteasa y su uso.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5185431A (en)	1988-08-31	1993-02-09	Eisai Co., Ltd.	Recombinant natural killer cell activator
DE3901917A1 (de)	1989-01-24	1990-07-26	Behringwerke Ag	Mutanten von humanem antithrombin iii
IE902276A1 (en)	1989-06-26	1991-01-16	Akzo Nv	Serpin variants
US5102995A (en) *	1989-10-20	1992-04-07	Washington University	Dna encoding modified heparin cofactor ii

1993
- 1993-02-22 JP JP03185593A patent/JP3479539B2/ja not_active Expired - Lifetime
- 1993-04-06 AU AU36761/93A patent/AU655723B2/en not_active Ceased
- 1993-04-07 CA CA002093575A patent/CA2093575A1/en not_active Abandoned
- 1993-04-08 ES ES93105829T patent/ES2149788T3/es not_active Expired - Lifetime
- 1993-04-08 AT AT93105829T patent/ATE194624T1/de not_active IP Right Cessation
- 1993-04-08 DK DK93105829T patent/DK0568833T3/da active
- 1993-04-08 DE DE69328992T patent/DE69328992T2/de not_active Expired - Lifetime
- 1993-04-08 EP EP93105829A patent/EP0568833B1/de not_active Expired - Lifetime
- 1993-04-09 US US08/046,431 patent/US5420252A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
ES2149788T3 (es)	2000-11-16
DE69328992T2 (de)	2000-12-07
JPH05339292A (ja)	1993-12-21
AU655723B2 (en)	1995-01-05
US5420252A (en)	1995-05-30
EP0568833B1 (de)	2000-07-12
CA2093575A1 (en)	1993-10-11
DE69328992D1 (de)	2000-08-17
DK0568833T3 (da)	2000-09-18
JP3479539B2 (ja)	2003-12-15
EP0568833A1 (de)	1993-11-10
AU3676193A (en)	1993-10-14

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Legal Events

Date	Code	Title	Description
2000-10-15	UEP	Publication of translation of european patent specification
2004-01-15	REN	Ceased due to non-payment of the annual fee