ATE127231T1 - Verfahren zur bestimmung eines oder mehrerer analyte durch anwendung verschiedene typen von partikeln, welche durchflusszytometrisch unterschieden sind. - Google Patents

Verfahren zur bestimmung eines oder mehrerer analyte durch anwendung verschiedene typen von partikeln, welche durchflusszytometrisch unterschieden sind.

Info

Publication number
ATE127231T1
ATE127231T1 AT89905720T AT89905720T ATE127231T1 AT E127231 T1 ATE127231 T1 AT E127231T1 AT 89905720 T AT89905720 T AT 89905720T AT 89905720 T AT89905720 T AT 89905720T AT E127231 T1 ATE127231 T1 AT E127231T1
Authority
AT
Austria
Prior art keywords
particles
analyte
different
binding
flow cytometer
Prior art date
Application number
AT89905720T
Other languages
English (en)
Inventor
Tore Lindmo
Original Assignee
Sinvent As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sinvent As filed Critical Sinvent As
Application granted granted Critical
Publication of ATE127231T1 publication Critical patent/ATE127231T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/808—Optical sensing apparatus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/962—Prevention or removal of interfering materials or reactants or other treatment to enhance results, e.g. determining or preventing nonspecific binding
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/80—Fluorescent dyes, e.g. rhodamine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/805—Optical property

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
AT89905720T 1988-05-11 1989-05-10 Verfahren zur bestimmung eines oder mehrerer analyte durch anwendung verschiedene typen von partikeln, welche durchflusszytometrisch unterschieden sind. ATE127231T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NO882067A NO164622C (no) 1988-05-11 1988-05-11 Binaer immunometrisk partikkelbasert metode for maaling av spesifikke serum-antigener ved hjelp av vaeskestroemsmikrofotometri og et ferdigpreparert maaloppsett derav.

Publications (1)

Publication Number Publication Date
ATE127231T1 true ATE127231T1 (de) 1995-09-15

Family

ID=19890879

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89905720T ATE127231T1 (de) 1988-05-11 1989-05-10 Verfahren zur bestimmung eines oder mehrerer analyte durch anwendung verschiedene typen von partikeln, welche durchflusszytometrisch unterschieden sind.

Country Status (9)

Country Link
US (1) US5585241A (de)
EP (1) EP0413741B1 (de)
JP (1) JP2742953B2 (de)
AT (1) ATE127231T1 (de)
AU (1) AU3565889A (de)
CA (1) CA1335238C (de)
DE (1) DE68924064T2 (de)
NO (1) NO164622C (de)
WO (1) WO1989011101A1 (de)

Families Citing this family (121)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03225277A (ja) * 1990-01-31 1991-10-04 Fujirebio Inc 多項目の免疫化学的測定法
US5286452A (en) * 1991-05-20 1994-02-15 Sienna Biotech, Inc. Simultaneous multiple assays
US5329461A (en) * 1992-07-23 1994-07-12 Acrogen, Inc. Digital analyte detection system
US6200820B1 (en) * 1992-12-22 2001-03-13 Sienna Biotech, Inc. Light scatter-based immunoassay
TW239881B (de) * 1992-12-22 1995-02-01 Sienna Biotech Inc
US6401267B1 (en) 1993-09-27 2002-06-11 Radoje Drmanac Methods and compositions for efficient nucleic acid sequencing
GB9326238D0 (en) * 1993-12-23 1994-02-23 Sinvent As Method of assay
GB9326379D0 (en) * 1993-12-23 1994-02-23 Sinvent As Method of assay
GB2300914B (en) * 1995-04-28 1998-04-29 Tepnel Medical Ltd Analytical device
US5981180A (en) * 1995-10-11 1999-11-09 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
ATE496288T1 (de) 1995-10-11 2011-02-15 Luminex Corp Gleichzeitige mehrfachanalyse klinischer proben
US6387707B1 (en) 1996-04-25 2002-05-14 Bioarray Solutions Array Cytometry
US7144119B2 (en) 1996-04-25 2006-12-05 Bioarray Solutions Ltd. System and method for programmable illumination pattern generation
US6958245B2 (en) 1996-04-25 2005-10-25 Bioarray Solutions Ltd. Array cytometry
US7041510B2 (en) 1996-04-25 2006-05-09 Bioarray Solutions Ltd. System and method for programmable illumination pattern generation
US6251691B1 (en) 1996-04-25 2001-06-26 Bioarray Solutions, Llc Light-controlled electrokinetic assembly of particles near surfaces
US6586193B2 (en) 1996-04-25 2003-07-01 Genicon Sciences Corporation Analyte assay using particulate labels
CA2189486A1 (en) * 1996-11-04 1998-05-04 Yves St-Pierre Analysis of enzyme activity using immobilized fluorescence-labeled substrates
US20030027126A1 (en) 1997-03-14 2003-02-06 Walt David R. Methods for detecting target analytes and enzymatic reactions
US7622294B2 (en) 1997-03-14 2009-11-24 Trustees Of Tufts College Methods for detecting target analytes and enzymatic reactions
US6327410B1 (en) 1997-03-14 2001-12-04 The Trustees Of Tufts College Target analyte sensors utilizing Microspheres
US6023540A (en) 1997-03-14 2000-02-08 Trustees Of Tufts College Fiber optic sensor with encoded microspheres
US6406845B1 (en) 1997-05-05 2002-06-18 Trustees Of Tuft College Fiber optic biosensor for selectively detecting oligonucleotide species in a mixed fluid sample
EP0878552A1 (de) 1997-05-13 1998-11-18 Erasmus Universiteit Rotterdam Molekularer Nachweis von chromosomalen Veränderungen
US6686165B2 (en) * 1997-05-20 2004-02-03 Erasmus Universiteit Rotterdam Recognition of tumor-specific gene products in cancer
DE69838067T2 (de) 1997-05-23 2008-03-13 Bioarray Solutions Ltd. Farbkodierung und in situ abfrage von matrix-gekoppelten chemischen verbindungen
CA2244326C (en) 1997-08-11 2006-03-28 Shinichi Eda Microparticle enhanced light scattering agglutination assay and microparticle reagents therefor
EP1012335A4 (de) * 1997-08-15 2004-06-09 Hyseq Inc Erfahren und zusammensetzungen zur detektion oder quantifizierung von nukleinsäurespezies
US7115884B1 (en) 1997-10-06 2006-10-03 Trustees Of Tufts College Self-encoding fiber optic sensor
US7348181B2 (en) 1997-10-06 2008-03-25 Trustees Of Tufts College Self-encoding sensor with microspheres
US6180340B1 (en) 1997-10-31 2001-01-30 Gen-Probe Incorporated Extended dynamic range assays
WO1999026067A1 (en) 1997-11-18 1999-05-27 Bio-Rad Laboratories, Inc. Multiplex flow immunoassays with magnetic particles as solid phase
US6210910B1 (en) 1998-03-02 2001-04-03 Trustees Of Tufts College Optical fiber biosensor array comprising cell populations confined to microcavities
US6455263B2 (en) 1998-03-24 2002-09-24 Rigel Pharmaceuticals, Inc. Small molecule library screening using FACS
EP1078098A1 (de) 1998-05-04 2001-02-28 Dako A/S Verfahren und sonden zur detektion chromosomaler aberrationen
US7060431B2 (en) 1998-06-24 2006-06-13 Illumina, Inc. Method of making and decoding of array sensors with microspheres
US6284472B1 (en) * 1998-10-05 2001-09-04 Dade Behring Inc. Method for extending the range of an immunoassay
US7510841B2 (en) 1998-12-28 2009-03-31 Illumina, Inc. Methods of making and using composite arrays for the detection of a plurality of target analytes
US6429027B1 (en) 1998-12-28 2002-08-06 Illumina, Inc. Composite arrays utilizing microspheres
US6846460B1 (en) 1999-01-29 2005-01-25 Illumina, Inc. Apparatus and method for separation of liquid phases of different density and for fluorous phase organic syntheses
US20030096433A1 (en) * 1999-03-03 2003-05-22 Evotec Analytical Systems Gmbh Homogeneous fluorescence assay
US20060275782A1 (en) 1999-04-20 2006-12-07 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
US6355431B1 (en) 1999-04-20 2002-03-12 Illumina, Inc. Detection of nucleic acid amplification reactions using bead arrays
US6544732B1 (en) 1999-05-20 2003-04-08 Illumina, Inc. Encoding and decoding of array sensors utilizing nanocrystals
AU7569600A (en) 1999-05-20 2000-12-28 Illumina, Inc. Combinatorial decoding of random nucleic acid arrays
US8481268B2 (en) 1999-05-21 2013-07-09 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
US8080380B2 (en) 1999-05-21 2011-12-20 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
KR20000074881A (ko) * 1999-05-26 2000-12-15 황승용 마이크로웰을 이용한 디엔에이 돌연변이의 확인방법 및 키트
US6383740B2 (en) * 1999-07-30 2002-05-07 Bioergonomics, Inc. Methods for simultaneously detecting both members of a binding pair
ATE542916T1 (de) 1999-08-18 2012-02-15 Illumina Inc Methoden zur erzeugung von oligonukleotidlösungen
CA2382436C (en) 1999-08-30 2011-05-17 Illumina, Inc. Methods for improving signal detection from an array
JP2003521252A (ja) 2000-02-07 2003-07-15 イルミナ インコーポレイテッド ユニバーサルプライミングを用いる核酸検出方法
US7361488B2 (en) 2000-02-07 2008-04-22 Illumina, Inc. Nucleic acid detection methods using universal priming
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
US6913884B2 (en) 2001-08-16 2005-07-05 Illumina, Inc. Compositions and methods for repetitive use of genomic DNA
US7611869B2 (en) 2000-02-07 2009-11-03 Illumina, Inc. Multiplexed methylation detection methods
WO2001057268A2 (en) 2000-02-07 2001-08-09 Illumina, Inc. Nucleic acid detection methods using universal priming
US6770441B2 (en) 2000-02-10 2004-08-03 Illumina, Inc. Array compositions and methods of making same
EP1967595A3 (de) 2000-02-16 2008-12-03 Illumina, Inc. Paralleles Genotypisieren von mehreren Patientenproben
AU2001275475A1 (en) * 2000-06-12 2001-12-24 Genicon Sciences Corporation Assay for genetic polymorphisms using scattered light detectable labels
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
US7057704B2 (en) 2000-09-17 2006-06-06 Bioarray Solutions Ltd. System and method for programmable illumination pattern generation
WO2002028910A2 (en) * 2000-10-05 2002-04-11 Palti Yoram Prof Geometrically efficient particle agglutination, particularly to detect low affinity binding
US20030045005A1 (en) 2000-10-17 2003-03-06 Michael Seul Light-controlled electrokinetic assembly of particles near surfaces
US7361472B2 (en) 2001-02-23 2008-04-22 Invitrogen Corporation Methods for providing extended dynamic range in analyte assays
CA2441206A1 (en) 2001-03-19 2002-09-26 Gyros Ab Characterization of reaction variables
US7262063B2 (en) 2001-06-21 2007-08-28 Bio Array Solutions, Ltd. Directed assembly of functional heterostructures
US20030013083A1 (en) * 2001-07-16 2003-01-16 Tsai Tenlin S. Particle analysis as a detection system for particle-enhanced assays
US7479630B2 (en) 2004-03-25 2009-01-20 Bandura Dmitry R Method and apparatus for flow cytometry linked with elemental analysis
US7179658B2 (en) * 2001-09-06 2007-02-20 Beckman Coulter, Inc. Particle based homogeneous assays using capillary electrophoresis with laser-induced fluorescence detection
ATE437216T1 (de) 2001-09-06 2009-08-15 Genomic Profiling Systems Inc Schnellnachweis replizierender zellen
US8148171B2 (en) 2001-10-09 2012-04-03 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
US20050164261A1 (en) * 2001-10-09 2005-07-28 Chandler Don J. Multiplexed analysis of clinical specimens apparatus and methods
ES2712173T3 (es) 2001-10-15 2019-05-09 Bioarray Solutions Ltd Análisis multiplexado de loci polimórficos mediante consulta simultánea y detección mediada por enzimas
US6838289B2 (en) * 2001-11-14 2005-01-04 Beckman Coulter, Inc. Analyte detection system
US6551788B1 (en) * 2001-11-28 2003-04-22 Beckman Coulter, Inc. Particle-based ligand assay with extended dynamic range
WO2003048730A2 (en) 2001-12-03 2003-06-12 Abgenix, Inc. Identification of high affinity molecules by limited dilution screening
US7771951B2 (en) * 2001-12-03 2010-08-10 Amgen Fremont Inc. Antibody categorization based on binding characteristics
US20030175760A1 (en) * 2001-12-03 2003-09-18 Walker Wynn L. Discovery of therapeutic products
EP1616179A4 (de) * 2001-12-21 2006-07-12 Centocor Inc Neues screening-verfahren für molekulare antagonisten mittels durchflusszytometrie
CN1625689A (zh) 2002-01-31 2005-06-08 长冈实业株式会社 通过盘槽以及相关光分析盘触发的方法和系统
US20030153011A1 (en) * 2002-02-08 2003-08-14 Bell Michael L. Methods and reagents for conducting multiplexed assays of multiple analytes
AU2003215240A1 (en) 2002-02-14 2003-09-04 Illumina, Inc. Automated information processing in randomly ordered arrays
US7247489B2 (en) * 2002-03-11 2007-07-24 Auburn University Ion-detecting microspheres and methods of use thereof
EP1365240B1 (de) * 2002-05-22 2006-09-13 Sysmex Corporation Immunologische Verfahren, Vorrichtungen und Reagenzien
EP2204654B1 (de) * 2002-08-13 2012-12-12 N-Dia, Inc. Verwendung von Vorrichtungen und Verfahren zur Erkennung von Fruchtwasser in vaginalen Sekretionen
US20040038318A1 (en) * 2002-08-23 2004-02-26 Bell Michael L. Creatine kinase isoenzyme determination in multiplexed assays
WO2004047007A1 (en) 2002-11-15 2004-06-03 Bioarray Solutions, Ltd. Analysis, secure access to, and transmission of array images
JP4854506B2 (ja) * 2003-04-01 2012-01-18 ユニバーシティ オブ サザン カリフォルニア 疾患のリスクを予測および評価するためのう食リスク試験
PT1664722E (pt) 2003-09-22 2011-12-28 Bioarray Solutions Ltd Polielectrólito imobilizado à superfície com grupos funcionais múltiplos capazes de se ligarem covalentemente às biomoléculas
US7592187B2 (en) * 2003-10-15 2009-09-22 Reverse Proteomics Research Institute Co., Ltd. Method of calibrating ligand specificity
EP1692298A4 (de) 2003-10-28 2008-08-13 Bioarray Solutions Ltd Optimierung der genexpressionsanalyse unter verwendung immobilisierter fängersonden
US7410808B1 (en) * 2003-12-08 2008-08-12 Charm Sciences, Inc. Method and assay for detection of residues
US20050148005A1 (en) * 2003-12-12 2005-07-07 Pasha Emadi-Konjin Dye solubilization binding assay
DE102004023402A1 (de) * 2004-05-12 2005-12-08 Roche Diagnostics Gmbh Verfahren zur Erhöhung des dynamischen Messbereichs von auf spezifischen Bindereaktionen basierenden, insbesondere immunologischen Testelementen
US7848889B2 (en) 2004-08-02 2010-12-07 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
GB2420850A (en) * 2004-12-03 2006-06-07 Orion Diagnostica Oy Particle based binding assay
US7723127B2 (en) 2005-03-03 2010-05-25 Novx Systems Inc. Immunoassay with extended dynamic range
US20060240444A1 (en) * 2005-04-21 2006-10-26 Peiguo Chu Detection methods
US9057046B2 (en) 2005-09-26 2015-06-16 Rapid Micro Biosystems, Inc. Cassette containing growth medium
US8101368B2 (en) * 2006-02-13 2012-01-24 Dvs Sciences Inc. Quantitation of cellular DNA and cell numbers using element labeling
CA2668410C (en) * 2006-11-02 2017-05-16 Mitchell A. Winnik Particles containing detectable elemental code
CN102224410B (zh) 2008-09-24 2017-02-08 施特劳斯控股公司 用于测试分析物的成像分析仪
CA2784791A1 (en) * 2009-12-17 2011-07-14 Abaxis, Inc. Novel assays for detecting analytes in samples and kits and compositions related thereto
DK2566949T3 (da) 2010-05-06 2023-05-22 Charm Sciences Inc Læser-inkubatorindretning
WO2012049316A1 (en) 2010-10-15 2012-04-19 Olink Ab Dynamic range methods
WO2013070730A2 (en) 2011-11-07 2013-05-16 Rapid Micro Biosystems, Inc. Cassette for sterility testing
CA2804843C (en) 2012-02-06 2021-02-02 Ortho-Clinical Diagnostics, Inc. Multiple time windows for extending the range of an assay
JP6444859B2 (ja) 2012-04-16 2018-12-26 ラピッド マイクロ バイオシステムズ インコーポレイテッド 細胞培養デバイス
ES3057344T3 (en) 2013-01-02 2026-02-27 Qiagen Sciences Llc Methods for predicting time-to-delivery in pregnant women
US9157910B2 (en) * 2013-03-15 2015-10-13 Abbott Laboratories Assay with increased dynamic range
US9005901B2 (en) 2013-03-15 2015-04-14 Abbott Laboratories Assay with internal calibration
ES2884930T3 (es) * 2014-03-26 2021-12-13 Siemens Healthcare Diagnostics Inc Inmunoensayo de canalización de oxígeno luminiscente utilizando tres anticuerpos y métodos de producción y uso de los mismos
US11119102B1 (en) 2016-02-16 2021-09-14 Charm Sciences, Inc. Test device, method, and assembly
US10935555B2 (en) 2016-12-22 2021-03-02 Qiagen Sciences, Llc Determining candidate for induction of labor
US10656164B2 (en) 2016-12-22 2020-05-19 Qiagen Sciences, Llc Screening asymptomatic pregnant woman for preterm birth
US10520514B2 (en) * 2017-02-01 2019-12-31 Korea Institute Of Science And Technology Method for monitoring post-translational modification of protein
US12031985B2 (en) 2018-04-19 2024-07-09 First Light Diagnostics, Inc. Detection of targets
CA3115279A1 (en) 2018-10-04 2020-04-09 First Light Diagnostics, Inc. Analysis instrument
WO2020172496A1 (en) * 2019-02-21 2020-08-27 Ding Qinxue Method of removing non-specific binding signals using microparticles
CN113125731B (zh) * 2019-12-31 2025-09-16 科美博阳诊断技术(上海)有限公司 一种竞争性均相化学发光测定试剂盒及其应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0101228B1 (de) * 1982-08-06 1986-10-08 International Institute Of Cellular And Molecular Pathology (Icp) Bestimmung von Antigenen durch Teilchenagglutination
US4595661A (en) * 1983-11-18 1986-06-17 Beckman Instruments, Inc. Immunoassays and kits for use therein which include low affinity antibodies for reducing the hook effect
US4590169A (en) * 1983-11-18 1986-05-20 Beckman Instruments, Inc. Direct particle agglutination immunoassays avoiding false negatives at high antigen concentrations
US4665020A (en) * 1984-05-30 1987-05-12 United States Department Of Energy Flow cytometer measurement of binding assays
JPS60256057A (ja) * 1984-06-01 1985-12-17 Dai Ichi Pure Chem Co Ltd 免疫学的測定法
JPS61290362A (ja) * 1985-06-18 1986-12-20 Showa Denko Kk 微粒子測定法
US5047321A (en) * 1988-06-15 1991-09-10 Becton Dickinson & Co. Method for analysis of cellular components of a fluid

Also Published As

Publication number Publication date
NO164622B (no) 1990-07-16
AU3565889A (en) 1989-11-29
WO1989011101A1 (en) 1989-11-16
EP0413741A1 (de) 1991-02-27
NO882067D0 (no) 1988-05-11
EP0413741B1 (de) 1995-08-30
DE68924064T2 (de) 1996-02-08
NO164622C (no) 1990-10-24
US5585241A (en) 1996-12-17
JP2742953B2 (ja) 1998-04-22
DE68924064D1 (de) 1995-10-05
CA1335238C (en) 1995-04-18
NO882067L (no) 1989-11-13
JPH03504276A (ja) 1991-09-19

Similar Documents

Publication Publication Date Title
DE68924064D1 (de) Verfahren zur Bestimmung eines oder mehrerer Analyte durch Anwendung verschiedene Typen von Partikeln, welche durchflusszytometrisch unterschieden sind.
EP1075661B1 (de) Liganden-bindetest und kit mit einer abtrennzone für störende probenkomponenten
US5145784A (en) Double capture assay method employing a capillary flow device
EP0290921B1 (de) Testträger für die Analyse einer Probenflüssigkeit und Verfahren zu seiner Herstellung
JP3553601B2 (ja) 検定方法
DK164690D0 (da) Testmetode og reagenssaet dertil
TW326074B (en) Methods, kits and diagnostic systems for performing an affinity assay
DE68923907D1 (de) Verfahren zur immunochromatographischen Analyse.
JPH10111292A (ja) 検定用の試薬及び装置
JP3384805B2 (ja) 粒子の２つの判別可能な型を用いた検定方法
CA2480833A1 (en) Sensitive immunochromatographic assay
US4865997A (en) Assay for ligands by separating bound and free tracer from sample
JPS6447951A (en) Immunoassay method and kit for hapten detection by agglutination
ATE310956T1 (de) Festphasenverfahren und testsatz zur antigen- und antikörperprüfung in der blutgruppen-serologie
US5037736A (en) Process and test carrier for the determination of an analyte
EP0253581A1 (de) Analyseeinheit mit wasserlöslichen Polymeren und damit durchgeführte Bestimmungen
EP0413758A1 (de) Kapillarflussvorrichtung und doppelfixierungstestmethode
CA2021658A1 (en) Multiplex immunoassay system
KR890006828A (ko) 효소 분석법
JPS5647760A (en) Reverse passive antibody erythrocyte urokinase- detecting reagent for agglutination
ATE119670T1 (de) Nichtspezifische adsorptionsfreie methode zur bestimmung eines antikörpers und bestimmungsreagentien.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee