ATE12791T1 - Kurzkettige oligosaccharide mit biologischen eigenschaften, verfahren zu ihrer herstellung und ihre verwendungen als arzneimittel. - Google Patents

Kurzkettige oligosaccharide mit biologischen eigenschaften, verfahren zu ihrer herstellung und ihre verwendungen als arzneimittel.

Info

Publication number
ATE12791T1
ATE12791T1 AT82400739T AT82400739T ATE12791T1 AT E12791 T1 ATE12791 T1 AT E12791T1 AT 82400739 T AT82400739 T AT 82400739T AT 82400739 T AT82400739 T AT 82400739T AT E12791 T1 ATE12791 T1 AT E12791T1
Authority
AT
Austria
Prior art keywords
octasaccharides
abreviation
see diagramm
denoted below
sequence
Prior art date
Application number
AT82400739T
Other languages
English (en)
Inventor
Jean-Claude Lormeau
Jean Choay
Maurice Petitou
Original Assignee
Choay Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Choay Sa filed Critical Choay Sa
Application granted granted Critical
Publication of ATE12791T1 publication Critical patent/ATE12791T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/02—Carbon-oxygen lyases (4.2) acting on polysaccharides (4.2.2)
    • C12Y402/02007—Heparin lyase (4.2.2.7), i.e. heparinase I

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Materials Engineering (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Polymers & Plastics (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
AT82400739T 1981-04-29 1982-04-26 Kurzkettige oligosaccharide mit biologischen eigenschaften, verfahren zu ihrer herstellung und ihre verwendungen als arzneimittel. ATE12791T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8108604A FR2504928A1 (fr) 1981-04-29 1981-04-29 Oligosaccharides a chaines courtes possedant des proprietes biologiques, leur preparation et leurs applications en tant que medicaments
EP82400739A EP0064452B1 (de) 1981-04-29 1982-04-26 Kurzkettige Oligosaccharide mit biologischen Eigenschaften, Verfahren zu ihrer Herstellung und ihre Verwendungen als Arzneimittel

Publications (1)

Publication Number Publication Date
ATE12791T1 true ATE12791T1 (de) 1985-05-15

Family

ID=9257922

Family Applications (1)

Application Number Title Priority Date Filing Date
AT82400739T ATE12791T1 (de) 1981-04-29 1982-04-26 Kurzkettige oligosaccharide mit biologischen eigenschaften, verfahren zu ihrer herstellung und ihre verwendungen als arzneimittel.

Country Status (9)

Country Link
EP (1) EP0064452B1 (de)
JP (1) JPS57190001A (de)
AT (1) ATE12791T1 (de)
CA (1) CA1180292A (de)
DE (1) DE3263083D1 (de)
DK (1) DK189982A (de)
ES (1) ES511470A0 (de)
FR (1) FR2504928A1 (de)
IE (1) IE52906B1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2584728B1 (fr) * 1985-07-12 1987-11-20 Choay Sa Procede de sulfatation de glycosaminoglycanes et de leurs fragments
EP0209924A1 (de) * 1985-07-12 1987-01-28 Akzo N.V. Antithrombotikum auf Basis von Glykosaminoglykan, Verfahren zu dessen Herstellung und pharmazeutische Zusammensetzung
US5106734A (en) * 1986-04-30 1992-04-21 Novo Nordisk A/S Process of using light absorption to control enzymatic depolymerization of heparin to produce low molecular weight heparin
US5707973A (en) * 1991-04-23 1998-01-13 Rhone-Poulenc Rorer S.A. Sulfated polysaccharids for treatment or prevention of thromboses
EP0861903A1 (de) * 1997-02-22 1998-09-02 Lansing, Manfred Verfahren zum reversiblen Immobilisieren von Oligo- oder Polysacchariden
US5985582A (en) * 1997-12-09 1999-11-16 Sigma-Aldrich Co. Thrombin-based assay for antithrombin III
FR2845686B1 (fr) * 2002-10-10 2013-08-30 Aventis Pharma Sa Melanges de polysaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant
FR2857971B1 (fr) * 2003-07-24 2005-08-26 Aventis Pharma Sa Melanges d'oligosaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant
EP1582531A1 (de) 2004-03-24 2005-10-05 Aventis Pharma S.A. Verfahren zur Oxydierung nicht-fraktionierten Heparins und die Detektion der Anwesenheit oder Abwesenheit von Glykoserin in Heparin und in von Heparin abgeleiteten Produkten
EP1792621B1 (de) 2005-11-30 2012-04-04 Istituto di Ricerche Chimiche e Biochimiche "G. Ronzoni" Oral verabreichbare Heparinderivate
WO2009155108A1 (en) 2008-05-30 2009-12-23 Momenta Pharmaceuticals, Inc. Saccharide structures and methods of making and using such structures
EP3398971A4 (de) * 2015-12-30 2019-09-25 Shenzhen Hepalink Pharmaceutical Group Co., Ltd. Sulfatiertes heparinoligosaccharid und herstellungsverfahren und anwendung davon
WO2022015794A1 (en) 2020-07-14 2022-01-20 Optimvia, Llc Methods for synthesizing non-anticoagulant heparan sulfate
JP2022540849A (ja) 2019-07-09 2022-09-20 オプティムヴィア、エルエルシー 抗凝固性多糖類の合成方法
JP7611465B2 (ja) * 2019-10-10 2025-01-10 ジェイ・アイ・サイエンス有限会社 溶離液性の利用フラクションコレクター

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3766167A (en) * 1971-03-26 1973-10-16 Research Corp Orally active anticoagulant
IL61201A (en) * 1979-10-05 1984-09-30 Choay Sa Oligosaccharides having no more than 8 saccharide moieties,their obtention from heparin and pharmaceutical compositions containing them
JPH0231721A (ja) * 1988-07-20 1990-02-01 Matsushita Electric Ind Co Ltd 充電式掃除機

Also Published As

Publication number Publication date
EP0064452A1 (de) 1982-11-10
ES8302094A1 (es) 1983-02-01
EP0064452B1 (de) 1985-04-17
CA1180292A (en) 1985-01-02
IE820741L (en) 1982-10-29
ES511470A0 (es) 1983-02-01
DE3263083D1 (en) 1985-05-23
FR2504928B1 (de) 1984-02-24
JPS57190001A (en) 1982-11-22
DK189982A (da) 1982-10-30
IE52906B1 (en) 1988-04-13
FR2504928A1 (fr) 1982-11-05

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