ATE128113T1 - Calicheamicinon, dessen abkömmlinge und analogen und verfahren zu deren herstellung. - Google Patents

Calicheamicinon, dessen abkömmlinge und analogen und verfahren zu deren herstellung.

Info

Publication number: ATE128113T1
Authority: AT; Austria
Prior art keywords: derivatives; calichamicinone; analogues; production; calicheamicinone
Prior art date: 1990-04-27

Application number

AT91303818T

Other languages

English (en)

Inventor

Samuel J Danishefsky

John School Of Chemi Haseltine

Maria Paz Cabal

Nobuharu Iwasawa

Robert S Coleman

Original Assignee

Univ Yale

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-04-27

Filing date

1991-04-26

Publication date

1995-10-15

1991-04-26 Application filed by Univ Yale filed Critical Univ Yale

1995-10-15 Application granted granted Critical

1995-10-15 Publication of ATE128113T1 publication Critical patent/ATE128113T1/de

Links

TWCMVXMQHSVIOJ-UHFFFAOYSA-N Aglycone of yadanzioside D Natural products COC(=O)C12OCC34C(CC5C(=CC(O)C(O)C5(C)C3C(O)C1O)C)OC(=O)C(OC(=O)C)C24 TWCMVXMQHSVIOJ-UHFFFAOYSA-N 0.000 abstract 1
PLMKQQMDOMTZGG-UHFFFAOYSA-N Astrantiagenin E-methylester Natural products CC12CCC(O)C(C)(CO)C1CCC1(C)C2CC=C2C3CC(C)(C)CCC3(C(=O)OC)CCC21C PLMKQQMDOMTZGG-UHFFFAOYSA-N 0.000 abstract 1
HXCHCVDVKSCDHU-LULTVBGHSA-N calicheamicin Chemical compound C1[C@H](OC)[C@@H](NCC)CO[C@H]1O[C@H]1[C@H](O[C@@H]2C\3=C(NC(=O)OC)C(=O)C[C@](C/3=C/CSSSC)(O)C#C\C=C/C#C2)O[C@H](C)[C@@H](NO[C@@H]2O[C@H](C)[C@@H](SC(=O)C=3C(=C(OC)C(O[C@H]4[C@@H]([C@H](OC)[C@@H](O)[C@H](C)O4)O)=C(I)C=3C)OC)[C@@H](O)C2)[C@@H]1O HXCHCVDVKSCDHU-LULTVBGHSA-N 0.000 abstract 1
229930195731 calicheamicin Natural products 0.000 abstract 1
PFOARMALXZGCHY-UHFFFAOYSA-N homoegonol Natural products C1=C(OC)C(OC)=CC=C1C1=CC2=CC(CCCO)=CC(OC)=C2O1 PFOARMALXZGCHY-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/43—Y being a hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
- C07C49/743—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups having unsaturation outside the rings, e.g. humulones, lupulones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
- C07C49/747—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT91303818T 1990-04-27 1991-04-26 Calicheamicinon, dessen abkömmlinge und analogen und verfahren zu deren herstellung. ATE128113T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US51520990A	1990-04-27	1990-04-27

Publications (1)

Publication Number	Publication Date
ATE128113T1 true ATE128113T1 (de)	1995-10-15

Family

ID=24050400

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91303818T ATE128113T1 (de)	1990-04-27	1991-04-26	Calicheamicinon, dessen abkömmlinge und analogen und verfahren zu deren herstellung.

Country Status (8)

Country	Link
EP (1)	EP0454494B1 (de)
JP (1)	JPH04279544A (de)
AT (1)	ATE128113T1 (de)
CA (1)	CA2039789A1 (de)
DE (1)	DE69113102T2 (de)
DK (1)	DK0454494T3 (de)
ES (1)	ES2079569T3 (de)
GR (1)	GR3017912T3 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2564197A (en) *	1996-04-26	1997-11-19	University Of Alberta	Synthesis of (+/-) - calicheamicinone, precursors, intermediates and derivatives
PL229487B1 (pl)	2002-11-12	2018-07-31	Brigham & Womens Hospital Inc	Kompozycja zawierająca polimer β-1,6-glukozaminy, kompozycja zawierająca przeciwciało, kompozycja farmaceutyczna, sposób wytwarzania wyodrębnionego polisacharydu, sposób identyfikacji obecności deacetylowanej poli-N-acetyloglukozaminy (dPNAG) i/ lub poli-N-acetyloglukozaminy (PNAG), wyodrębniony polisacharyd do zastosowania w leczeniu lub profilaktyce zakażenia, wyodrębniony polisacharyd do zastosowania do wytwarzania przeciwciał, w tym przeciwciał monoklonalnych, wyodrębniony polisacharyd do zastosowania w identyfikacji przeciwciała monoklonalnego
CN102159540B (zh)	2008-07-21	2015-08-12	布赖汉姆妇女医院	与合成的β-1,6葡糖胺寡糖相关的方法和组合物
US12397014B2 (en)	2019-02-05	2025-08-26	The Brigham And Women's Hospital, Inc.	Polysaccharide compositions for use in treating filariasis

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL79519A0 (en) *	1985-08-27	1986-10-31	Bristol Myers Co	Bbm-1675c and d antitumor antibiotics
US4837206A (en) *	1987-04-29	1989-06-06	Bristol-Myers Company	Esperamicin derivatives

1991
- 1991-04-04 CA CA002039789A patent/CA2039789A1/en not_active Abandoned
- 1991-04-26 AT AT91303818T patent/ATE128113T1/de not_active IP Right Cessation
- 1991-04-26 DK DK91303818.8T patent/DK0454494T3/da active
- 1991-04-26 ES ES91303818T patent/ES2079569T3/es not_active Expired - Lifetime
- 1991-04-26 EP EP91303818A patent/EP0454494B1/de not_active Expired - Lifetime
- 1991-04-26 DE DE69113102T patent/DE69113102T2/de not_active Expired - Fee Related
- 1991-04-30 JP JP3099289A patent/JPH04279544A/ja active Pending
1995
- 1995-10-30 GR GR950403011T patent/GR3017912T3/el unknown

Also Published As

Publication number	Publication date
EP0454494A3 (en)	1993-05-26
EP0454494B1 (de)	1995-09-20
CA2039789A1 (en)	1991-10-28
GR3017912T3 (en)	1996-01-31
DE69113102T2 (de)	1996-03-28
JPH04279544A (ja)	1992-10-05
DE69113102D1 (de)	1995-10-26
EP0454494A2 (de)	1991-10-30
ES2079569T3 (es)	1996-01-16
DK0454494T3 (da)	1995-12-04

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Legal Events

Date	Code	Title	Description
1996-04-15	UEP	Publication of translation of european patent specification
1999-01-15	REN	Ceased due to non-payment of the annual fee