DK0454494T3 - Calicheamicinoner, derivater deraf og analoge dertil og fremgangsmåde til fremstilling af disse - Google Patents
Calicheamicinoner, derivater deraf og analoge dertil og fremgangsmåde til fremstilling af disseInfo
- Publication number
- DK0454494T3 DK0454494T3 DK91303818.8T DK91303818T DK0454494T3 DK 0454494 T3 DK0454494 T3 DK 0454494T3 DK 91303818 T DK91303818 T DK 91303818T DK 0454494 T3 DK0454494 T3 DK 0454494T3
- Authority
- DK
- Denmark
- Prior art keywords
- derivatives
- calicheamicinones
- analogues
- preparation
- calicheamicinone
- Prior art date
Links
- TWCMVXMQHSVIOJ-UHFFFAOYSA-N Aglycone of yadanzioside D Natural products COC(=O)C12OCC34C(CC5C(=CC(O)C(O)C5(C)C3C(O)C1O)C)OC(=O)C(OC(=O)C)C24 TWCMVXMQHSVIOJ-UHFFFAOYSA-N 0.000 abstract 1
- PLMKQQMDOMTZGG-UHFFFAOYSA-N Astrantiagenin E-methylester Natural products CC12CCC(O)C(C)(CO)C1CCC1(C)C2CC=C2C3CC(C)(C)CCC3(C(=O)OC)CCC21C PLMKQQMDOMTZGG-UHFFFAOYSA-N 0.000 abstract 1
- HXCHCVDVKSCDHU-LULTVBGHSA-N calicheamicin Chemical compound C1[C@H](OC)[C@@H](NCC)CO[C@H]1O[C@H]1[C@H](O[C@@H]2C\3=C(NC(=O)OC)C(=O)C[C@](C/3=C/CSSSC)(O)C#C\C=C/C#C2)O[C@H](C)[C@@H](NO[C@@H]2O[C@H](C)[C@@H](SC(=O)C=3C(=C(OC)C(O[C@H]4[C@@H]([C@H](OC)[C@@H](O)[C@H](C)O4)O)=C(I)C=3C)OC)[C@@H](O)C2)[C@@H]1O HXCHCVDVKSCDHU-LULTVBGHSA-N 0.000 abstract 1
- 229930195731 calicheamicin Natural products 0.000 abstract 1
- PFOARMALXZGCHY-UHFFFAOYSA-N homoegonol Natural products C1=C(OC)C(OC)=CC=C1C1=CC2=CC(CCCO)=CC(OC)=C2O1 PFOARMALXZGCHY-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/43—Y being a hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
- C07C49/743—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups having unsaturation outside the rings, e.g. humulones, lupulones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
- C07C49/747—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51520990A | 1990-04-27 | 1990-04-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0454494T3 true DK0454494T3 (da) | 1995-12-04 |
Family
ID=24050400
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK91303818.8T DK0454494T3 (da) | 1990-04-27 | 1991-04-26 | Calicheamicinoner, derivater deraf og analoge dertil og fremgangsmåde til fremstilling af disse |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0454494B1 (da) |
| JP (1) | JPH04279544A (da) |
| AT (1) | ATE128113T1 (da) |
| CA (1) | CA2039789A1 (da) |
| DE (1) | DE69113102T2 (da) |
| DK (1) | DK0454494T3 (da) |
| ES (1) | ES2079569T3 (da) |
| GR (1) | GR3017912T3 (da) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2564197A (en) * | 1996-04-26 | 1997-11-19 | University Of Alberta | Synthesis of (+/-) - calicheamicinone, precursors, intermediates and derivatives |
| PL229487B1 (pl) | 2002-11-12 | 2018-07-31 | Brigham & Womens Hospital Inc | Kompozycja zawierająca polimer β-1,6-glukozaminy, kompozycja zawierająca przeciwciało, kompozycja farmaceutyczna, sposób wytwarzania wyodrębnionego polisacharydu, sposób identyfikacji obecności deacetylowanej poli-N-acetyloglukozaminy (dPNAG) i/ lub poli-N-acetyloglukozaminy (PNAG), wyodrębniony polisacharyd do zastosowania w leczeniu lub profilaktyce zakażenia, wyodrębniony polisacharyd do zastosowania do wytwarzania przeciwciał, w tym przeciwciał monoklonalnych, wyodrębniony polisacharyd do zastosowania w identyfikacji przeciwciała monoklonalnego |
| CN102159540B (zh) | 2008-07-21 | 2015-08-12 | 布赖汉姆妇女医院 | 与合成的β-1,6葡糖胺寡糖相关的方法和组合物 |
| US12397014B2 (en) | 2019-02-05 | 2025-08-26 | The Brigham And Women's Hospital, Inc. | Polysaccharide compositions for use in treating filariasis |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL79519A0 (en) * | 1985-08-27 | 1986-10-31 | Bristol Myers Co | Bbm-1675c and d antitumor antibiotics |
| US4837206A (en) * | 1987-04-29 | 1989-06-06 | Bristol-Myers Company | Esperamicin derivatives |
-
1991
- 1991-04-04 CA CA002039789A patent/CA2039789A1/en not_active Abandoned
- 1991-04-26 AT AT91303818T patent/ATE128113T1/de not_active IP Right Cessation
- 1991-04-26 DK DK91303818.8T patent/DK0454494T3/da active
- 1991-04-26 ES ES91303818T patent/ES2079569T3/es not_active Expired - Lifetime
- 1991-04-26 EP EP91303818A patent/EP0454494B1/en not_active Expired - Lifetime
- 1991-04-26 DE DE69113102T patent/DE69113102T2/de not_active Expired - Fee Related
- 1991-04-30 JP JP3099289A patent/JPH04279544A/ja active Pending
-
1995
- 1995-10-30 GR GR950403011T patent/GR3017912T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0454494A3 (en) | 1993-05-26 |
| EP0454494B1 (en) | 1995-09-20 |
| CA2039789A1 (en) | 1991-10-28 |
| GR3017912T3 (en) | 1996-01-31 |
| DE69113102T2 (de) | 1996-03-28 |
| JPH04279544A (ja) | 1992-10-05 |
| DE69113102D1 (de) | 1995-10-26 |
| EP0454494A2 (en) | 1991-10-30 |
| ES2079569T3 (es) | 1996-01-16 |
| ATE128113T1 (de) | 1995-10-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FI980347L (fi) | Menetelmä merkkien tuottamiseksi timantteihin | |
| DK0454386T3 (da) | Fremgangsmåde til fremstilling af saccharose-6-ester | |
| DK146489D0 (da) | Fremgangsmaade til fremstilling af 2',3'-dideoxy-2',3'-didehydronucleosider | |
| DK0429760T4 (da) | Fremgangsmåde til fremstilling af et aromatiseringsmiddel | |
| DK0458150T3 (da) | Fremgangsmåde til fremstilling af formede genstande | |
| FI892534A7 (fi) | Menetelmä 1,3-diolien valmistamiseksi epoksideista | |
| DE3850162D1 (de) | Rahmensynchronisierungsapparat. | |
| FI903726A7 (fi) | Korrelaatioon perustuva synkronointimenetelmä | |
| DK54090A (da) | Fremgangsmaade og apparat til fremstilling af krumme formstofboejler, isaer busteholderboejler | |
| DK0454494T3 (da) | Calicheamicinoner, derivater deraf og analoge dertil og fremgangsmåde til fremstilling af disse | |
| MX9204520A (es) | Proceso para la preparacion de natamicina por fermentacion (caso ch 2074). | |
| DE68912809D1 (de) | Verfahren zur Herstellung von Bis(2,2,6,6-tetramethyl-4-piperidyl)amin. | |
| FI910967A7 (fi) | Menetelmä bisfenoli A:n valmistamiseksi | |
| DK154207C (da) | Fremgangsmaade til fremstilling af 1,8-dihydroxy-10-acyl-9-anthroner | |
| DK113483A (da) | Fremgangsmaade til fremstilling af 3,4-diphenyl-5-methylpyrazolderivater | |
| FI960332A7 (fi) | Menetelmä substituoitujan 4,6-diamino-5-syanopyrinidiinien valmistamiseksi | |
| KR910014338A (ko) | 알파-불포화 아민의 제조방법 | |
| DK0465373T3 (da) | Fremgangsmåde til fremstilling af kappa-carragenaner | |
| FI906009A7 (fi) | Menetelmä des(64,65)-proinsuliinin valmistamiseksi | |
| DK417787A (da) | Fremgangsmaade til fremstilling af 7-oxo-4-thia-1-azabicyclo-(3,2,0)hept-2-en-derivater | |
| DK152131C (da) | Fremgangsmaade til fremstilling af 5,6,7,7a-tetrahydro-4h-thieno(3,2-c)-pyridin-2-on-derivater | |
| DK389484D0 (da) | Fremgangsmaade til fremstilling af 2,3-dihydrobenzopyranonderivater | |
| FI911633A7 (fi) | Menetelmä alkaanisulfoanilidijohdosten valmistamiseksi | |
| FI900205A0 (fi) | Menetelmä uuden antibiootin N-asetyylibenanomisiini B:n valmistamiseksi | |
| FI890658A7 (fi) | Menetelmä 1,2-disulfoniyhdisteiden valmistamiseksi |