ATE130040T1 - Verfahren zur herstellung von (-)-(2r,3s)-2,3- epoxy-3-(4-methoxyphenyl)propionat-methylester. - Google Patents

Verfahren zur herstellung von (-)-(2r,3s)-2,3- epoxy-3-(4-methoxyphenyl)propionat-methylester.

Info

Publication number: ATE130040T1
Authority: AT; Austria
Prior art keywords: methoxyphenyl; epoxy; producing; methyl ester; propionate methyl
Prior art date: 1991-02-08

Application number

AT92400268T

Other languages

English (en)

Inventor

Lydia Zard

Arlette Tixidre

Guy Rossey

Alexander Wick

Original Assignee

Synthelabo

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-02-08

Filing date

1992-02-03

Publication date

1995-11-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9409484&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE130040(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1992-02-03 Application filed by Synthelabo filed Critical Synthelabo

1995-11-15 Application granted granted Critical

1995-11-15 Publication of ATE130040T1 publication Critical patent/ATE130040T1/de

Links

238000004519 manufacturing process Methods 0.000 title 1
CVZUMGUZDAWOGA-VHSXEESVSA-N methyl (2r,3s)-3-(4-methoxyphenyl)oxirane-2-carboxylate Chemical compound COC(=O)[C@@H]1O[C@H]1C1=CC=C(OC)C=C1 CVZUMGUZDAWOGA-VHSXEESVSA-N 0.000 title 1
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
102000004190 Enzymes Human genes 0.000 abstract 1
108090000790 Enzymes Proteins 0.000 abstract 1
XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
HSUGRBWQSSZJOP-RTWAWAEBSA-N diltiazem Chemical compound C1=CC(OC)=CC=C1[C@H]1[C@@H](OC(C)=O)C(=O)N(CCN(C)C)C2=CC=CC=C2S1 HSUGRBWQSSZJOP-RTWAWAEBSA-N 0.000 abstract 1
229960004166 diltiazem Drugs 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
238000005809 transesterification reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
- C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
Genetics & Genomics (AREA)
General Chemical & Material Sciences (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Analytical Chemistry (AREA)
Epoxy Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT92400268T 1991-02-08 1992-02-03 Verfahren zur herstellung von (-)-(2r,3s)-2,3- epoxy-3-(4-methoxyphenyl)propionat-methylester. ATE130040T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR919101427A FR2672600B1 (fr)	1991-02-08	1991-02-08	Procede de preparation du (-)-(2r,3s)-2,3-epoxy-3-(4-methoxyphenyl) propionate de methyle.

Publications (1)

Publication Number	Publication Date
ATE130040T1 true ATE130040T1 (de)	1995-11-15

Family

ID=9409484

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92400268T ATE130040T1 (de)	1991-02-08	1992-02-03	Verfahren zur herstellung von (-)-(2r,3s)-2,3- epoxy-3-(4-methoxyphenyl)propionat-methylester.

Country Status (9)

Country	Link
US (1)	US5169779A (de)
EP (1)	EP0498706B2 (de)
JP (1)	JP3126056B2 (de)
AT (1)	ATE130040T1 (de)
DE (1)	DE69205851T2 (de)
DK (1)	DK0498706T3 (de)
ES (1)	ES2082391T3 (de)
FR (1)	FR2672600B1 (de)
GR (1)	GR3018311T3 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1249777B (it) *	1990-05-17	1995-03-18	Zambon Spa	Processo per la preparazione di intermedi per la sintesi del diltiazem
AU4318293A (en) *	1992-06-08	1994-01-04	Laboratorios Menarini S.A.	A process for the preparation of s-(+)-2-(3-benzoylphenyl)propionic acid by enzyme-catalysed enantioselective transesterification in an organic solvent
ES2050067B1 (es) *	1992-06-08	1994-12-16	Menarini Lab	Proceso para la produccion de acido s-(+)-2-(3-benzoilfenil) propionico por transesterificacion enantioselectiva con un alcohol bifuncional catalizada enzimaticamente en medio organico.
ES2048653B1 (es) *	1992-06-08	1994-12-16	Menarini Lab	Proceso para la produccion de acido s-(+)-2-(3-benzoilfenil) propionico por transesterificacion enantioselectiva catalizada enzimaticamente en un disolvente organico.
NL9202208A (nl) *	1992-12-18	1994-07-18	Dsm Nv	Werkwijze voor de enzymatische bereiding van optisch aktieve glycidezure esters.
FI93741C (fi) *	1993-03-24	1995-05-26	Orion Yhtymae Oy	Menetelmä optisesti puhtaitten (2S,3S)- ja (2R,3R)-threo-alkyyli-2-hydroksi-3-(4-metoksifenyyli)-3-(2-X-fenyylitio)propionaattien tai vastaavien asyloitujen yhdisteiden valmistamiseksi
US5559229A (en) *	1995-06-01	1996-09-24	Acic (Canada) Inc.	Method for the manufacture of benzothiazepine
WO1998056762A2 (en) *	1997-06-11	1998-12-17	Tanabe Seiyaku Co., Ltd.	Process for preparing optically active phenyloxirane compounds
JP3658202B2 (ja)	1998-08-31	2005-06-08	キヤノン株式会社	現像カートリッジの組み立て方法
IT1302261B1 (it) *	1998-09-24	2000-09-05	Zambon Spa	Processo per la risoluzione cinetica enzimatica di 3-fenilglicidatiper transesterificazione con amminoalcoli
CN114874156A (zh) *	2022-06-20	2022-08-09	巨鑫生物制药股份有限公司	一种合成地尔硫卓中间体(2s)-顺-羟基内酰胺的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL8801311A (nl) *	1988-05-20	1989-12-18	Stamicarbon	Fenylglycidaatstereoisomeren, omzettingsprodukten daarvan met 2-nitrothiofenol en de bereiding van diltiazem.
IT1217765B (it) *	1988-06-02	1990-03-30	Montedison Spa	Processo per la risoluzione enzimatica degli isomeri ottici di derivati racemi esterei dell,acido 3 mercapto 2 alchilpropionico
FI95931C (fi) *	1988-09-02	1996-04-10	Tanabe Seiyaku Co	Menetelmä (2R,3S)-3-(4-metoksifenyyli)glysidiinihapon alemman alkyyliesterin valmistamiseksi

1991
- 1991-02-08 FR FR919101427A patent/FR2672600B1/fr not_active Expired - Fee Related
- 1991-02-13 US US07/654,518 patent/US5169779A/en not_active Expired - Lifetime
1992
- 1992-02-03 DE DE69205851T patent/DE69205851T2/de not_active Expired - Lifetime
- 1992-02-03 ES ES92400268T patent/ES2082391T3/es not_active Expired - Lifetime
- 1992-02-03 EP EP92400268A patent/EP0498706B2/de not_active Expired - Lifetime
- 1992-02-03 DK DK92400268.6T patent/DK0498706T3/da active
- 1992-02-03 AT AT92400268T patent/ATE130040T1/de not_active IP Right Cessation
- 1992-02-07 JP JP04022446A patent/JP3126056B2/ja not_active Expired - Lifetime
1995
- 1995-12-05 GR GR950403430T patent/GR3018311T3/el unknown

Also Published As

Publication number	Publication date
EP0498706A1 (de)	1992-08-12
DE69205851T2 (de)	1996-05-23
US5169779A (en)	1992-12-08
ES2082391T3 (es)	1996-03-16
DK0498706T3 (da)	1996-02-12
FR2672600A1 (fr)	1992-08-14
FR2672600B1 (fr)	1994-10-14
EP0498706B2 (de)	2000-05-31
EP0498706B1 (de)	1995-11-08
GR3018311T3 (en)	1996-03-31
DE69205851D1 (de)	1995-12-14
JPH0576389A (ja)	1993-03-30
JP3126056B2 (ja)	2001-01-22

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Legal Events

Date	Code	Title
1996-05-15	UEP	Publication of translation of european patent specification
2000-09-15	EEIH	Change in the person of patent owner
2001-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties