ATE130612T1 - Verfahren für die herstellung von bizyklischen beta-laktamen. - Google Patents

Verfahren für die herstellung von bizyklischen beta-laktamen.

Info

Publication number: ATE130612T1
Authority: AT; Austria
Prior art keywords: beta; lactams; alkoxy; bizyclic; production
Prior art date: 1990-06-06

Application number

AT91304975T

Other languages

English (en)

Inventor

Marvin Joseph Miller

Matthew Alan Williams

Original Assignee

Univ Notre Dame Du Lac

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-06-06

Filing date

1991-06-03

Publication date

1995-12-15

1991-06-03 Application filed by Univ Notre Dame Du Lac filed Critical Univ Notre Dame Du Lac

1995-12-15 Application granted granted Critical

1995-12-15 Publication of ATE130612T1 publication Critical patent/ATE130612T1/de

Links

238000000034 method Methods 0.000 title abstract 3
150000003952 β-lactams Chemical class 0.000 title abstract 2
150000002148 esters Chemical class 0.000 abstract 3
JKHLDFUXVIYLJV-HODUVHNASA-N (5r)-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid Chemical compound C1C(=O)C(C(=O)O)N2C(=O)C[C@H]21 JKHLDFUXVIYLJV-HODUVHNASA-N 0.000 abstract 1
HIBRBHXOSQFCNJ-SCSAIBSYSA-N (6R)-3-hydroxy-8-oxo-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Chemical compound OC=1CC[C@H]2N(C=1C(=O)O)C(C2)=O HIBRBHXOSQFCNJ-SCSAIBSYSA-N 0.000 abstract 1
239000003242 anti bacterial agent Substances 0.000 abstract 1
229940088710 antibiotic agent Drugs 0.000 abstract 1
125000002619 bicyclic group Chemical group 0.000 abstract 1
150000007942 carboxylates Chemical class 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
239000003960 organic solvent Substances 0.000 abstract 1
229910052703 rhodium Inorganic materials 0.000 abstract 1
239000010948 rhodium Substances 0.000 abstract 1
MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 abstract 1
238000007363 ring formation reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/02—Preparation
- C07D477/04—Preparation by forming the ring or condensed ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D463/02—Preparation
- C07D463/04—Preparation by forming the ring or condensed ring systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Cephalosporin Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Plural Heterocyclic Compounds (AREA)

AT91304975T 1990-06-06 1991-06-03 Verfahren für die herstellung von bizyklischen beta-laktamen. ATE130612T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/534,073 US5051502A (en)	1990-06-06	1990-06-06	Rhodium catalyzed cyclization process for bicyclic β-lactams

Publications (1)

Publication Number	Publication Date
ATE130612T1 true ATE130612T1 (de)	1995-12-15

Family

ID=24128598

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91304975T ATE130612T1 (de)	1990-06-06	1991-06-03	Verfahren für die herstellung von bizyklischen beta-laktamen.

Country Status (14)

Country	Link
US (2)	US5051502A (de)
EP (1)	EP0460881B1 (de)
JP (1)	JPH04330075A (de)
KR (1)	KR920000760A (de)
AT (1)	ATE130612T1 (de)
CA (1)	CA2043939A1 (de)
DE (1)	DE69114765T2 (de)
DK (1)	DK0460881T3 (de)
ES (1)	ES2081434T3 (de)
GR (1)	GR3018615T3 (de)
HK (1)	HK43696A (de)
HU (1)	HU212569B (de)
IE (1)	IE911918A1 (de)
IL (1)	IL98350A (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5189158A (en) *	1991-03-20	1993-02-23	American Cyanamid Company	4-substituted azetidinones as precursors to 2-substituted-3-carboxy carbapenem antibiotics and a method of producing them
US5493018A (en) *	1994-01-25	1996-02-20	Merck & Co., Inc.	Process for synthesizing carbapenem intermediates using a rhodium catalyst and lewis acid
KR100661081B1 (ko) *	2000-06-10	2006-12-26	동화약품공업주식회사	항바이러스제로 유용한 6-메틸니코틴아미드 유도체
HUP0401006A2 (hu) *	2001-07-06	2004-08-30	Teva Pharmaceutical Industries Ltd.	Eljárás 7-amino-szin-3,5-dihidroxi-heptánsav-származékok előállítására, ezek köztitermékei és módszerek az előállításukra

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4174316A (en) *	1978-08-14	1979-11-13	Merck & Co., Inc.	4-Iodomethylazetidin-2-one
US4275207A (en) *	1978-08-14	1981-06-23	Merck & Co., Inc.	Process for preparing 7-(1-hydroxyethyl)-3-(2-aminoethylthio)-1-carbadethiaceph-3-em-3-carboxylic acid and intermediate therefor
DE3509769A1 (de) *	1985-03-19	1986-09-25	Bayer Ag, 5090 Leverkusen	Verfahren zur herstellung von carbapenemzwischenprodukten
US4665171A (en) *	1985-07-17	1987-05-12	Harvard University	Process and intermediates for β-lactam antibiotics

1990
- 1990-06-06 US US07/534,073 patent/US5051502A/en not_active Expired - Fee Related
1991
- 1991-06-03 DK DK91304975.5T patent/DK0460881T3/da active
- 1991-06-03 DE DE69114765T patent/DE69114765T2/de not_active Expired - Fee Related
- 1991-06-03 EP EP91304975A patent/EP0460881B1/de not_active Expired - Lifetime
- 1991-06-03 AT AT91304975T patent/ATE130612T1/de not_active IP Right Cessation
- 1991-06-03 IL IL9835091A patent/IL98350A/en not_active IP Right Cessation
- 1991-06-03 ES ES91304975T patent/ES2081434T3/es not_active Expired - Lifetime
- 1991-06-04 KR KR1019910009207A patent/KR920000760A/ko not_active Abandoned
- 1991-06-05 CA CA002043939A patent/CA2043939A1/en not_active Abandoned
- 1991-06-05 JP JP3134117A patent/JPH04330075A/ja active Pending
- 1991-06-05 HU HU911885A patent/HU212569B/hu not_active IP Right Cessation
- 1991-06-05 IE IE191891A patent/IE911918A1/en unknown
- 1991-07-22 US US07/733,895 patent/US5106968A/en not_active Expired - Fee Related
1996
- 1996-01-09 GR GR960400031T patent/GR3018615T3/el unknown
- 1996-03-14 HK HK43696A patent/HK43696A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
IL98350A (en)	1995-07-31
EP0460881A1 (de)	1991-12-11
HK43696A (en)	1996-03-22
HU911885D0 (en)	1991-12-30
JPH04330075A (ja)	1992-11-18
IE911918A1 (en)	1991-12-18
DE69114765D1 (de)	1996-01-04
US5051502A (en)	1991-09-24
CA2043939A1 (en)	1991-12-07
US5106968A (en)	1992-04-21
KR920000760A (ko)	1992-01-29
DE69114765T2 (de)	1996-05-02
ES2081434T3 (es)	1996-03-16
EP0460881B1 (de)	1995-11-22
HUT58096A (en)	1992-01-28
HU212569B (en)	1996-08-29
IL98350A0 (en)	1992-07-15
DK0460881T3 (da)	1995-12-18
GR3018615T3 (en)	1996-04-30

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Legal Events

Date	Code	Title	Description
1996-06-15	UEP	Publication of translation of european patent specification
1998-03-15	REN	Ceased due to non-payment of the annual fee