ES2081434T3 - Procedimiento para beta-lactamas biciclicas. - Google Patents

Procedimiento para beta-lactamas biciclicas.

Info

Publication number
ES2081434T3
ES2081434T3 ES91304975T ES91304975T ES2081434T3 ES 2081434 T3 ES2081434 T3 ES 2081434T3 ES 91304975 T ES91304975 T ES 91304975T ES 91304975 T ES91304975 T ES 91304975T ES 2081434 T3 ES2081434 T3 ES 2081434T3
Authority
ES
Spain
Prior art keywords
beta
lactams
alkoxy
bicycle
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91304975T
Other languages
English (en)
Inventor
Marvin Joseph Miller
Matthew Alan Williams
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Notre Dame
Original Assignee
University of Notre Dame
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Notre Dame filed Critical University of Notre Dame
Application granted granted Critical
Publication of ES2081434T3 publication Critical patent/ES2081434T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C07D477/04—Preparation by forming the ring or condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/02—Preparation
    • C07D463/04—Preparation by forming the ring or condensed ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

SE PROPORCIONAN 1-CARBAPENAM-2-UNO-3-ACIDO CARBOXILICO Y 1-CABA-3HIDROXI-3-CEFEM-4-ACIDO CARBOXILICO Y ESTERES MEDIANTE UN PROCESO QUE COMPRENDE UNA CICLIZACION CATALIZADORA DE CARBOXILATO C SUB 2 1-ALKOXIAZO-(BETA)-KETOBUTIRICO Y UN ESTER DE UN ACIDO 5(1-ALKOXI -SUSTITUIDO ALKOXI-2-OXO-4-AZETIDINILO)-(ALFA)-DIAZO-(BETA)KETOVALERICO RESPECTIVAMENTE. EL PROCESO SE LLEVA A CABO EN UN DISOLVENTE ORGANICO INERTE A UNA TEMPERATURA ENTRE 15 C A 85 C. LOS 1-CARBA BICICLICOS (BETA)-LACTAMS SON INTERMEDIOS PARA LA PREPARACION DE ANTIBIOTICOS.
ES91304975T 1990-06-06 1991-06-03 Procedimiento para beta-lactamas biciclicas. Expired - Lifetime ES2081434T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/534,073 US5051502A (en) 1990-06-06 1990-06-06 Rhodium catalyzed cyclization process for bicyclic β-lactams

Publications (1)

Publication Number Publication Date
ES2081434T3 true ES2081434T3 (es) 1996-03-16

Family

ID=24128598

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91304975T Expired - Lifetime ES2081434T3 (es) 1990-06-06 1991-06-03 Procedimiento para beta-lactamas biciclicas.

Country Status (14)

Country Link
US (2) US5051502A (es)
EP (1) EP0460881B1 (es)
JP (1) JPH04330075A (es)
KR (1) KR920000760A (es)
AT (1) ATE130612T1 (es)
CA (1) CA2043939A1 (es)
DE (1) DE69114765T2 (es)
DK (1) DK0460881T3 (es)
ES (1) ES2081434T3 (es)
GR (1) GR3018615T3 (es)
HK (1) HK43696A (es)
HU (1) HU212569B (es)
IE (1) IE911918A1 (es)
IL (1) IL98350A (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5189158A (en) * 1991-03-20 1993-02-23 American Cyanamid Company 4-substituted azetidinones as precursors to 2-substituted-3-carboxy carbapenem antibiotics and a method of producing them
US5493018A (en) * 1994-01-25 1996-02-20 Merck & Co., Inc. Process for synthesizing carbapenem intermediates using a rhodium catalyst and lewis acid
KR100661081B1 (ko) * 2000-06-10 2006-12-26 동화약품공업주식회사 항바이러스제로 유용한 6-메틸니코틴아미드 유도체
IL159718A0 (en) * 2001-07-06 2004-06-20 Teva Pharma Synthesis of intermediates for preparation of stating derivatives

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4174316A (en) * 1978-08-14 1979-11-13 Merck & Co., Inc. 4-Iodomethylazetidin-2-one
US4275207A (en) * 1978-08-14 1981-06-23 Merck & Co., Inc. Process for preparing 7-(1-hydroxyethyl)-3-(2-aminoethylthio)-1-carbadethiaceph-3-em-3-carboxylic acid and intermediate therefor
DE3509769A1 (de) * 1985-03-19 1986-09-25 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von carbapenemzwischenprodukten
US4665171A (en) * 1985-07-17 1987-05-12 Harvard University Process and intermediates for β-lactam antibiotics

Also Published As

Publication number Publication date
DE69114765D1 (de) 1996-01-04
GR3018615T3 (en) 1996-04-30
HUT58096A (en) 1992-01-28
EP0460881A1 (en) 1991-12-11
US5106968A (en) 1992-04-21
CA2043939A1 (en) 1991-12-07
HU212569B (en) 1996-08-29
US5051502A (en) 1991-09-24
DK0460881T3 (da) 1995-12-18
ATE130612T1 (de) 1995-12-15
HU911885D0 (en) 1991-12-30
EP0460881B1 (en) 1995-11-22
KR920000760A (ko) 1992-01-29
DE69114765T2 (de) 1996-05-02
HK43696A (en) 1996-03-22
IL98350A (en) 1995-07-31
IL98350A0 (en) 1992-07-15
IE911918A1 (en) 1991-12-18
JPH04330075A (ja) 1992-11-18

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