ATE131058T1 - Methode zur synthese eines präparats zur regulation der empfängnis und des menstruationszyklus mit onkostatischen antikinetosischen, preventiven und therapeutischen eigenschaften zur behandlung von brustkrebs und melanomen. - Google Patents

Methode zur synthese eines präparats zur regulation der empfängnis und des menstruationszyklus mit onkostatischen antikinetosischen, preventiven und therapeutischen eigenschaften zur behandlung von brustkrebs und melanomen.

Info

Publication number: ATE131058T1
Authority: AT; Austria
Prior art keywords: dose; bromomelatonin; iodomelatonin; per day; preventive
Prior art date: 1990-09-28

Application number

AT91830402T

Other languages

English (en)

Inventor

Franco I F L O S A S Fraschini

Ermanno I F L O S A S Duranti

Bella Luigi I F L O S A S Di

Bojidar I F L O S A S Stankov

Aldo I F L O S A S Laguzzi

Original Assignee

I F L O S A S Di Giorgio E Ald

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-09-28

Filing date

1991-09-27

Publication date

1995-12-15

1990-09-28 Priority claimed from IT02159690A external-priority patent/IT1243978B/it

1990-12-11 Priority claimed from IT2233890A external-priority patent/IT1251743B/it

1991-09-16 Priority claimed from ITMI912438A external-priority patent/IT1251204B/it

1991-09-27 Application filed by I F L O S A S Di Giorgio E Ald filed Critical I F L O S A S Di Giorgio E Ald

1995-12-15 Application granted granted Critical

1995-12-15 Publication of ATE131058T1 publication Critical patent/ATE131058T1/de

Links

230000003449 preventive effect Effects 0.000 title abstract 2
230000001225 therapeutic effect Effects 0.000 title abstract 2
206010006187 Breast cancer Diseases 0.000 title 1
208000026310 Breast neoplasm Diseases 0.000 title 1
230000015572 biosynthetic process Effects 0.000 title 1
201000010893 malignant breast melanoma Diseases 0.000 title 1
238000000034 method Methods 0.000 title 1
230000000247 oncostatic effect Effects 0.000 title 1
230000027758 ovulation cycle Effects 0.000 title 1
238000002360 preparation method Methods 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
FJDDSMSDZHURBJ-UHFFFAOYSA-N N-[2-(2-iodo-5-methoxy-1H-indol-3-yl)ethyl]acetamide Chemical compound COC1=CC=C2NC(I)=C(CCNC(C)=O)C2=C1 FJDDSMSDZHURBJ-UHFFFAOYSA-N 0.000 abstract 6
FNHLXIXCQDGUCQ-UHFFFAOYSA-N n-[2-(2-bromo-5-methoxy-1h-indol-3-yl)ethyl]acetamide Chemical compound COC1=CC=C2NC(Br)=C(CCNC(C)=O)C2=C1 FNHLXIXCQDGUCQ-UHFFFAOYSA-N 0.000 abstract 5
229940079593 drug Drugs 0.000 abstract 4
239000003814 drug Substances 0.000 abstract 4
150000001875 compounds Chemical class 0.000 abstract 2
YJPIGAIKUZMOQA-UHFFFAOYSA-N Melatonin Natural products COC1=CC=C2N(C(C)=O)C=C(CCN)C2=C1 YJPIGAIKUZMOQA-UHFFFAOYSA-N 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 abstract 1
229930184178 coenzime Natural products 0.000 abstract 1
239000003433 contraceptive agent Substances 0.000 abstract 1
230000002254 contraceptive effect Effects 0.000 abstract 1
230000001276 controlling effect Effects 0.000 abstract 1
201000001441 melanoma Diseases 0.000 abstract 1
DRLFMBDRBRZALE-UHFFFAOYSA-N melatonin Chemical compound COC1=CC=C2NC=C(CCNC(C)=O)C2=C1 DRLFMBDRBRZALE-UHFFFAOYSA-N 0.000 abstract 1
229960003987 melatonin Drugs 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Steroid Compounds (AREA)
Medicinal Preparation (AREA)
Orthopedics, Nursing, And Contraception (AREA)

AT91830402T 1990-09-28 1991-09-27 Methode zur synthese eines präparats zur regulation der empfängnis und des menstruationszyklus mit onkostatischen antikinetosischen, preventiven und therapeutischen eigenschaften zur behandlung von brustkrebs und melanomen. ATE131058T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
IT02159690A IT1243978B (it)	1990-09-28	1990-09-28	Farmaco per uso umano, ad azione contraccettiva ed oncostatica preventiva, nei tumori del seno, dell'utero e nel melanoma.
IT2233890A IT1251743B (it)	1990-12-11	1990-12-11	Farmaco per uso umano, ad azione contraccettiva ed oncostatica preventiva e terapeutica, nei tumori del seno, dell'utero e nel melanoma, ad azione anticinetosica a base di agonisti della melatonina ad alta affinita', in associazione con un progestinico
ITMI912438A IT1251204B (it)	1991-09-16	1991-09-16	Farmaco per uso umano, ad azione contraccettiva e regolatrice del ciclo mestruale, ad azione oncostatica preventiva e terapeutica, nei tumori mammari e nel melanoma, e ad azione anticinetosica e metodo di sintesi

Publications (1)

Publication Number	Publication Date
ATE131058T1 true ATE131058T1 (de)	1995-12-15

Family

ID=27273202

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT94113848T ATE190490T1 (de)	1990-09-28	1991-09-27	Kontrazeptives und menstruationszyklus regulierendes präparat mit onkostatischen eigenschaften
AT91830402T ATE131058T1 (de)	1990-09-28	1991-09-27	Methode zur synthese eines präparats zur regulation der empfängnis und des menstruationszyklus mit onkostatischen antikinetosischen, preventiven und therapeutischen eigenschaften zur behandlung von brustkrebs und melanomen.

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT94113848T ATE190490T1 (de)	1990-09-28	1991-09-27	Kontrazeptives und menstruationszyklus regulierendes präparat mit onkostatischen eigenschaften

Country Status (8)

Country	Link
US (1)	US5272141A (de)
EP (2)	EP0641565B1 (de)
JP (1)	JP2849692B2 (de)
AT (2)	ATE190490T1 (de)
DE (2)	DE69115221T2 (de)
DK (1)	DK0483077T3 (de)
ES (1)	ES2082959T3 (de)
GR (1)	GR3019175T3 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1254995B (it) *	1992-06-24	1995-10-11		Farmaco contenente melatonina e/o agonisti, con somministrazione particolarmente efficace nelle patologie che interferiscono con i ritmi circandiani
IT1255199B (it) *	1992-07-01	1995-10-20	Franco Fraschini	Farmaco sintetizzato analogo della melatonina particolarmente efficacenelle patologie che interferiscono con i ritmi circadiani
AU2109695A (en)	1994-03-30	1995-10-23	Novartis Ag	Screening method using the rzr receptor family
FR2737411B1 (fr) *	1995-08-01	1997-10-17	Theramex	Nouveaux medicaments hormonaux et leur utilisation pour la correction des carences estrogeniques
US5792785A (en) *	1995-11-24	1998-08-11	Equitech Laboratories, Inc.	Method for enhancing pregnancy success in an animal
US6403631B1 (en)	1995-11-24	2002-06-11	Equitech Laboratories, Inc.	Method and compositions for enhancing pregnancy success in an animal
US6133453A (en) *	1998-05-15	2000-10-17	Pharm-Eco Laboratories, Inc.	Method for making substituted indoles
US6355648B1 (en)	1999-05-04	2002-03-12	American Home Products Corporation	Thio-oxindole derivatives
US6358948B1 (en)	1999-05-04	2002-03-19	American Home Products Corporation	Quinazolinone and benzoxazine derivatives as progesterone receptor modulators
US6358947B1 (en)	1999-05-04	2002-03-19	American Home Products Corporation	Tetracyclic progesterone receptor modulator compounds and methods
US6380178B1 (en)	1999-05-04	2002-04-30	American Home Products Corporation	Cyclic regimens using cyclocarbamate and cyclic amide derivatives
US6509334B1 (en)	1999-05-04	2003-01-21	American Home Products Corporation	Cyclocarbamate derivatives as progesterone receptor modulators
US6417214B1 (en)	1999-05-04	2002-07-09	Wyeth	3,3-substituted indoline derivatives
US6391907B1 (en)	1999-05-04	2002-05-21	American Home Products Corporation	Indoline derivatives
US6462032B1 (en)	1999-05-04	2002-10-08	Wyeth	Cyclic regimens utilizing indoline derivatives
US6380235B1 (en)	1999-05-04	2002-04-30	American Home Products Corporation	Benzimidazolones and analogues
US6339098B1 (en)	1999-05-04	2002-01-15	American Home Products Corporation	2,1-benzisothiazoline 2,2-dioxides
US6498154B1 (en)	1999-05-04	2002-12-24	Wyeth	Cyclic regimens using quinazolinone and benzoxazine derivatives
US6306851B1 (en)	1999-05-04	2001-10-23	American Home Products Corporation	Cyclocarbamate and cyclic amide derivatives
US6399593B1 (en)	1999-05-04	2002-06-04	Wyeth	Cyclic regimens using cyclic urea and cyclic amide derivatives
US6319912B1 (en)	1999-05-04	2001-11-20	American Home Products Corporation	Cyclic regimens using 2,1-benzisothiazoline 2,2-dioxides
US6407101B1 (en)	1999-05-04	2002-06-18	American Home Products Corporation	Cyanopyrroles
US6423699B1 (en)	1999-05-04	2002-07-23	American Home Products Corporation	Combination therapies using benzimidazolones
US6329416B1 (en)	1999-05-04	2001-12-11	American Home Products Corporation	Combination regimens using 3,3-substituted indoline derivatives
US6369056B1 (en)	1999-05-04	2002-04-09	American Home Products Corporation	Cyclic urea and cyclic amide derivatives
US6444668B1 (en)	1999-05-04	2002-09-03	Wyeth	Combination regimens using progesterone receptor modulators
UA73119C2 (en)	2000-04-19	2005-06-15	American Home Products Corpoir	Derivatives of cyclic thiocarbamates, pharmaceutical composition including noted derivatives of cyclic thiocarbamates and active ingredients of medicines as modulators of progesterone receptors
WO2005084664A1 (ja) *	2004-03-08	2005-09-15	Kanazawa University Technology Licensing Organization Ltd.	インドール誘導体及びその用途
JP3964417B2 (ja) *	2004-09-27	2007-08-22	国立大学法人金沢大学	インドール誘導体を有効成分とするα２受容体遮断剤及び血管拡張剤
CN113480467B (zh) *	2021-07-13	2022-12-30	河北维达康生物科技有限公司	一种放射性示踪剂2-碘褪黑素的合成工艺
US11977085B1 (en)	2023-09-05	2024-05-07	Elan Ehrlich	Date rape drug detection device and method of using same

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3920664A (en) *	1972-07-21	1975-11-18	Lilly Co Eli	D-2-halo-6-alkyl-8-substituted ergolines and related compounds
US4166182A (en) *	1978-02-08	1979-08-28	Eli Lilly And Company	6-n-propyl-8-methoxymethyl or methylmercaptomethylergolines and related compounds
JPS5686130A (en) *	1979-12-18	1981-07-13	Nissan Chem Ind Ltd	Alpha-halo m-benzoylphenyl acetic acid derivative
JPS6033820A (ja) *	1983-08-05	1985-02-21	Nippon Steel Corp	加熱手段を備えた熱間鋼材蓄積装置
US4614807A (en) *	1984-10-04	1986-09-30	Eli Lilly And Company	6,7-dihalomelatonins
JPS6256475A (ja) *	1985-09-05	1987-03-12	Daicel Chem Ind Ltd	５−ハロピリジン−３−カルボキサミド化合物
US4855305A (en) *	1987-03-23	1989-08-08	Applied Medical Research	Compositions and methods of effecting contraception utilizing melatonin
IT1251544B (it) *	1991-05-13	1995-05-17	Gabriele Biella	Composizioni farmaceutiche attive nella terapia dei disturbi del sonno comprendenti melatonina o un suo derivato in associazione con un derivato benzodiazepinico

1991
- 1991-09-27 DE DE69115221T patent/DE69115221T2/de not_active Expired - Fee Related
- 1991-09-27 DK DK91830402.3T patent/DK0483077T3/da active
- 1991-09-27 US US07/767,084 patent/US5272141A/en not_active Expired - Fee Related
- 1991-09-27 DE DE69132061T patent/DE69132061D1/de not_active Expired - Lifetime
- 1991-09-27 AT AT94113848T patent/ATE190490T1/de active
- 1991-09-27 ES ES91830402T patent/ES2082959T3/es not_active Expired - Lifetime
- 1991-09-27 EP EP94113848A patent/EP0641565B1/de not_active Expired - Lifetime
- 1991-09-27 EP EP91830402A patent/EP0483077B1/de not_active Expired - Lifetime
- 1991-09-27 AT AT91830402T patent/ATE131058T1/de not_active IP Right Cessation
- 1991-09-30 JP JP3251261A patent/JP2849692B2/ja not_active Expired - Lifetime
1996
- 1996-03-04 GR GR960400577T patent/GR3019175T3/el unknown

Also Published As

Publication number	Publication date
EP0483077A3 (en)	1992-09-23
ATE190490T1 (de)	2000-04-15
JPH06263635A (ja)	1994-09-20
US5272141A (en)	1993-12-21
ES2082959T3 (es)	1996-04-01
EP0641565A1 (de)	1995-03-08
DK0483077T3 (da)	1996-04-15
GR3019175T3 (en)	1996-06-30
JP2849692B2 (ja)	1999-01-20
EP0641565B1 (de)	2000-03-15
EP0483077A2 (de)	1992-04-29
DE69115221D1 (de)	1996-01-18
EP0483077B1 (de)	1995-12-06
DE69132061D1 (de)	2000-04-20
DE69115221T2 (de)	1996-08-22

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Legal Events

Date	Code	Title	Description
1996-07-15	UEP	Publication of translation of european patent specification
2001-06-15	REN	Ceased due to non-payment of the annual fee