DK0483077T3 - Fremgangsmåde til syntese af et kontraceptivt og menstruationscyklus-kontrollerende lægemiddel med onkostatiske, antikinetosiske, præventive og terapeutiske egenskaber til behandling af brysttumorer og melanomer - Google Patents

Fremgangsmåde til syntese af et kontraceptivt og menstruationscyklus-kontrollerende lægemiddel med onkostatiske, antikinetosiske, præventive og terapeutiske egenskaber til behandling af brysttumorer og melanomer

Info

Publication number: DK0483077T3
Authority: DK; Denmark
Prior art keywords: dose; bromomelatonin; iodomelatonin; per day; drug
Prior art date: 1990-09-28

Application number

DK91830402.3T

Other languages

English (en)

Inventor

Franco Fraschini

Ermanno Duranti

Bella Luigi Di

Bojidar Stankov

Aldo Laguzzi

Original Assignee

I F L O S A S Di Giorgio E Ald

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-09-28

Filing date

1991-09-27

Publication date

1996-04-15

1990-09-28 Priority claimed from IT02159690A external-priority patent/IT1243978B/it

1990-12-11 Priority claimed from IT2233890A external-priority patent/IT1251743B/it

1991-09-16 Priority claimed from ITMI912438A external-priority patent/IT1251204B/it

1991-09-27 Application filed by I F L O S A S Di Giorgio E Ald filed Critical I F L O S A S Di Giorgio E Ald

1996-04-15 Application granted granted Critical

1996-04-15 Publication of DK0483077T3 publication Critical patent/DK0483077T3/da

Links

229940079593 drug Drugs 0.000 title abstract 5
239000003814 drug Substances 0.000 title abstract 5
239000003433 contraceptive agent Substances 0.000 title abstract 2
230000002254 contraceptive effect Effects 0.000 title abstract 2
230000003449 preventive effect Effects 0.000 title abstract 2
230000001225 therapeutic effect Effects 0.000 title abstract 2
208000026310 Breast neoplasm Diseases 0.000 title 1
230000015572 biosynthetic process Effects 0.000 title 1
201000010893 malignant breast melanoma Diseases 0.000 title 1
238000000034 method Methods 0.000 title 1
230000000247 oncostatic effect Effects 0.000 title 1
230000027758 ovulation cycle Effects 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
FJDDSMSDZHURBJ-UHFFFAOYSA-N N-[2-(2-iodo-5-methoxy-1H-indol-3-yl)ethyl]acetamide Chemical compound COC1=CC=C2NC(I)=C(CCNC(C)=O)C2=C1 FJDDSMSDZHURBJ-UHFFFAOYSA-N 0.000 abstract 6
FNHLXIXCQDGUCQ-UHFFFAOYSA-N n-[2-(2-bromo-5-methoxy-1h-indol-3-yl)ethyl]acetamide Chemical compound COC1=CC=C2NC(Br)=C(CCNC(C)=O)C2=C1 FNHLXIXCQDGUCQ-UHFFFAOYSA-N 0.000 abstract 5
150000001875 compounds Chemical class 0.000 abstract 2
YJPIGAIKUZMOQA-UHFFFAOYSA-N Melatonin Natural products COC1=CC=C2N(C(C)=O)C=C(CCN)C2=C1 YJPIGAIKUZMOQA-UHFFFAOYSA-N 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 abstract 1
229930184178 coenzime Natural products 0.000 abstract 1
230000001276 controlling effect Effects 0.000 abstract 1
201000001441 melanoma Diseases 0.000 abstract 1
DRLFMBDRBRZALE-UHFFFAOYSA-N melatonin Chemical compound COC1=CC=C2NC=C(CCNC(C)=O)C2=C1 DRLFMBDRBRZALE-UHFFFAOYSA-N 0.000 abstract 1
229960003987 melatonin Drugs 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Steroid Compounds (AREA)
Orthopedics, Nursing, And Contraception (AREA)
Medicinal Preparation (AREA)

DK91830402.3T 1990-09-28 1991-09-27 Fremgangsmåde til syntese af et kontraceptivt og menstruationscyklus-kontrollerende lægemiddel med onkostatiske, antikinetosiske, præventive og terapeutiske egenskaber til behandling af brysttumorer og melanomer DK0483077T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
IT02159690A IT1243978B (it)	1990-09-28	1990-09-28	Farmaco per uso umano, ad azione contraccettiva ed oncostatica preventiva, nei tumori del seno, dell'utero e nel melanoma.
IT2233890A IT1251743B (it)	1990-12-11	1990-12-11	Farmaco per uso umano, ad azione contraccettiva ed oncostatica preventiva e terapeutica, nei tumori del seno, dell'utero e nel melanoma, ad azione anticinetosica a base di agonisti della melatonina ad alta affinita', in associazione con un progestinico
ITMI912438A IT1251204B (it)	1991-09-16	1991-09-16	Farmaco per uso umano, ad azione contraccettiva e regolatrice del ciclo mestruale, ad azione oncostatica preventiva e terapeutica, nei tumori mammari e nel melanoma, e ad azione anticinetosica e metodo di sintesi

Publications (1)

Publication Number	Publication Date
DK0483077T3 true DK0483077T3 (da)	1996-04-15

Family

ID=27273202

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91830402.3T DK0483077T3 (da)	1990-09-28	1991-09-27	Fremgangsmåde til syntese af et kontraceptivt og menstruationscyklus-kontrollerende lægemiddel med onkostatiske, antikinetosiske, præventive og terapeutiske egenskaber til behandling af brysttumorer og melanomer

Country Status (8)

Country	Link
US (1)	US5272141A (da)
EP (2)	EP0483077B1 (da)
JP (1)	JP2849692B2 (da)
AT (2)	ATE190490T1 (da)
DE (2)	DE69115221T2 (da)
DK (1)	DK0483077T3 (da)
ES (1)	ES2082959T3 (da)
GR (1)	GR3019175T3 (da)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1254995B (it) *	1992-06-24	1995-10-11		Farmaco contenente melatonina e/o agonisti, con somministrazione particolarmente efficace nelle patologie che interferiscono con i ritmi circandiani
IT1255199B (it) *	1992-07-01	1995-10-20	Franco Fraschini	Farmaco sintetizzato analogo della melatonina particolarmente efficacenelle patologie che interferiscono con i ritmi circadiani
JPH09511334A (ja) *	1994-03-30	1997-11-11	チバ−ガイギーアクチェンゲゼルシャフト	Ｒｚｒ受容体ファミリーを用いるスクリーニング方法
FR2737411B1 (fr) *	1995-08-01	1997-10-17	Theramex	Nouveaux medicaments hormonaux et leur utilisation pour la correction des carences estrogeniques
US6403631B1 (en)	1995-11-24	2002-06-11	Equitech Laboratories, Inc.	Method and compositions for enhancing pregnancy success in an animal
US5792785A (en) *	1995-11-24	1998-08-11	Equitech Laboratories, Inc.	Method for enhancing pregnancy success in an animal
US6133453A (en) *	1998-05-15	2000-10-17	Pharm-Eco Laboratories, Inc.	Method for making substituted indoles
US6355648B1 (en)	1999-05-04	2002-03-12	American Home Products Corporation	Thio-oxindole derivatives
US6380178B1 (en)	1999-05-04	2002-04-30	American Home Products Corporation	Cyclic regimens using cyclocarbamate and cyclic amide derivatives
US6369056B1 (en)	1999-05-04	2002-04-09	American Home Products Corporation	Cyclic urea and cyclic amide derivatives
US6417214B1 (en)	1999-05-04	2002-07-09	Wyeth	3,3-substituted indoline derivatives
US6444668B1 (en)	1999-05-04	2002-09-03	Wyeth	Combination regimens using progesterone receptor modulators
US6380235B1 (en)	1999-05-04	2002-04-30	American Home Products Corporation	Benzimidazolones and analogues
US6407101B1 (en)	1999-05-04	2002-06-18	American Home Products Corporation	Cyanopyrroles
US6358948B1 (en)	1999-05-04	2002-03-19	American Home Products Corporation	Quinazolinone and benzoxazine derivatives as progesterone receptor modulators
US6329416B1 (en) *	1999-05-04	2001-12-11	American Home Products Corporation	Combination regimens using 3,3-substituted indoline derivatives
US6462032B1 (en)	1999-05-04	2002-10-08	Wyeth	Cyclic regimens utilizing indoline derivatives
US6498154B1 (en)	1999-05-04	2002-12-24	Wyeth	Cyclic regimens using quinazolinone and benzoxazine derivatives
US6423699B1 (en)	1999-05-04	2002-07-23	American Home Products Corporation	Combination therapies using benzimidazolones
US6509334B1 (en)	1999-05-04	2003-01-21	American Home Products Corporation	Cyclocarbamate derivatives as progesterone receptor modulators
US6391907B1 (en)	1999-05-04	2002-05-21	American Home Products Corporation	Indoline derivatives
US6306851B1 (en)	1999-05-04	2001-10-23	American Home Products Corporation	Cyclocarbamate and cyclic amide derivatives
US6339098B1 (en)	1999-05-04	2002-01-15	American Home Products Corporation	2,1-benzisothiazoline 2,2-dioxides
US6319912B1 (en)	1999-05-04	2001-11-20	American Home Products Corporation	Cyclic regimens using 2,1-benzisothiazoline 2,2-dioxides
US6358947B1 (en)	1999-05-04	2002-03-19	American Home Products Corporation	Tetracyclic progesterone receptor modulator compounds and methods
US6399593B1 (en)	1999-05-04	2002-06-04	Wyeth	Cyclic regimens using cyclic urea and cyclic amide derivatives
UA73119C2 (en)	2000-04-19	2005-06-15	American Home Products Corpoir	Derivatives of cyclic thiocarbamates, pharmaceutical composition including noted derivatives of cyclic thiocarbamates and active ingredients of medicines as modulators of progesterone receptors
WO2005084664A1 (ja) *	2004-03-08	2005-09-15	Kanazawa University Technology Licensing Organization Ltd.	インドール誘導体及びその用途
JP3964417B2 (ja) *	2004-09-27	2007-08-22	国立大学法人金沢大学	インドール誘導体を有効成分とするα２受容体遮断剤及び血管拡張剤
CN113480467B (zh) *	2021-07-13	2022-12-30	河北维达康生物科技有限公司	一种放射性示踪剂2-碘褪黑素的合成工艺
US11977085B1 (en)	2023-09-05	2024-05-07	Elan Ehrlich	Date rape drug detection device and method of using same

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3920664A (en) *	1972-07-21	1975-11-18	Lilly Co Eli	D-2-halo-6-alkyl-8-substituted ergolines and related compounds
US4166182A (en) *	1978-02-08	1979-08-28	Eli Lilly And Company	6-n-propyl-8-methoxymethyl or methylmercaptomethylergolines and related compounds
JPS5686130A (en) *	1979-12-18	1981-07-13	Nissan Chem Ind Ltd	Alpha-halo m-benzoylphenyl acetic acid derivative
JPS6033820A (ja) *	1983-08-05	1985-02-21	Nippon Steel Corp	加熱手段を備えた熱間鋼材蓄積装置
US4614807A (en) *	1984-10-04	1986-09-30	Eli Lilly And Company	6,7-dihalomelatonins
JPS6256475A (ja) *	1985-09-05	1987-03-12	Daicel Chem Ind Ltd	５−ハロピリジン−３−カルボキサミド化合物
US4855305A (en) *	1987-03-23	1989-08-08	Applied Medical Research	Compositions and methods of effecting contraception utilizing melatonin
IT1251544B (it) *	1991-05-13	1995-05-17	Gabriele Biella	Composizioni farmaceutiche attive nella terapia dei disturbi del sonno comprendenti melatonina o un suo derivato in associazione con un derivato benzodiazepinico

1991
- 1991-09-27 EP EP91830402A patent/EP0483077B1/en not_active Expired - Lifetime
- 1991-09-27 AT AT94113848T patent/ATE190490T1/de active
- 1991-09-27 DE DE69115221T patent/DE69115221T2/de not_active Expired - Fee Related
- 1991-09-27 EP EP94113848A patent/EP0641565B1/en not_active Expired - Lifetime
- 1991-09-27 AT AT91830402T patent/ATE131058T1/de not_active IP Right Cessation
- 1991-09-27 ES ES91830402T patent/ES2082959T3/es not_active Expired - Lifetime
- 1991-09-27 DK DK91830402.3T patent/DK0483077T3/da active
- 1991-09-27 DE DE69132061T patent/DE69132061D1/de not_active Expired - Lifetime
- 1991-09-27 US US07/767,084 patent/US5272141A/en not_active Expired - Fee Related
- 1991-09-30 JP JP3251261A patent/JP2849692B2/ja not_active Expired - Lifetime
1996
- 1996-03-04 GR GR960400577T patent/GR3019175T3/el unknown

Also Published As

Publication number	Publication date
EP0483077A3 (en)	1992-09-23
DE69115221D1 (de)	1996-01-18
EP0641565B1 (en)	2000-03-15
JPH06263635A (ja)	1994-09-20
ES2082959T3 (es)	1996-04-01
GR3019175T3 (en)	1996-06-30
EP0483077B1 (en)	1995-12-06
EP0641565A1 (en)	1995-03-08
US5272141A (en)	1993-12-21
JP2849692B2 (ja)	1999-01-20
EP0483077A2 (en)	1992-04-29
DE69115221T2 (de)	1996-08-22
ATE131058T1 (de)	1995-12-15
ATE190490T1 (de)	2000-04-15
DE69132061D1 (de)	2000-04-20

Publication	Publication Date	Title
GR3019175T3 (en)	1996-06-30	A method for carrying out the synthesis of a contraceptive and menstrual cycle controlling drug having oncostatic, antikinetosic, preventive and therapeutic properties for treatment of mammary tumours and melanomas.
MX171191B (es)	1993-10-06	Composiciones farmaceuticas de glipizida
NO306377B1 (no)	1999-11-01	Doseform for avgivelse av et medikament
PT90049A (pt)	1989-11-10	Forma de dosagem para administrar um medicamento para terapia humana
NO924209D0 (no)	1992-11-02	Doseringsform for tilfoersel av et antiparkinsonmiddel
IT8419266A1 (it)	1985-07-20	Dispositivo per generare calore in tessuti" del corpo umano e procedimento di cenerazione di calore, particolarmente per la cura di tumori
GEP20043269B (en)	2004-06-25	Purine Derivatives, Method for Their Production and Composition Containing the Same
IT1196564B (it)	1988-11-16	Impiego di acetil l-carnitina nel trattamento terapeutico delle neuropatie periferiche
NO172344C (no)	1993-07-07	Analogifremgangsmaate for fremstilling av terapeutisk aktive substituerte flavonoidforbindelser og salter
EA200300544A1 (ru)	2003-08-28	Эффективные противоопухолевые лекарственные средства
DE69202441D1 (de)	1995-06-14	Melatoninderivate und Kombinationen mit Antiestrogenen zur Behandlung von Brustkarzinoma.
NO932570D0 (no)	1993-07-15	Behandling av neoplastisk sykdom med interleukin-10
ES2033021T3 (es)	1996-07-16	Agente con efecto destructivo a tumores malignos, procedimiento para su obtencion y preparacion para la aplicacion en la terapia de enfermos de cancer.
SE8404283D0 (sv)	1984-08-28	Anvendning av ett specifikt tumorassocierat antigen, nemligen sialosyllaktotetraos, for diagnostiska och terapeutiska forfaranden vid cancersjukdomar
BR0009380A (pt)	2001-12-26	Tratamento de câncer melhorado comtemozolomida
MX9203361A (es)	1992-07-01	Composiciones farmaceuticas que contienen cloruro de galio.
MX9304365A (es)	1994-07-29	Una forma de dosis osmotica para administrar tandospirona.
KR890000108A (ko)	1989-03-11	종양 치료용 약제학적 조성물
ATE183088T1 (de)	1999-08-15	Arzneimittel zur behandlung von hauterkrankungen
KR927002224A (ko)	1992-09-03	항종양효과증강제 및 항종양제
IT1251204B (it)	1995-05-04	Farmaco per uso umano, ad azione contraccettiva e regolatrice del ciclo mestruale, ad azione oncostatica preventiva e terapeutica, nei tumori mammari e nel melanoma, e ad azione anticinetosica e metodo di sintesi
Maruyama	1983	Work in progress: californium-252 brachytherapy plus fractionated irradiation for advanced tonsillar carcinoma.
SU1517164A1 (ru)	1996-05-20	Способ лечения злокачественных опухолей печени
ATE84418T1 (de)	1993-01-15	2,6-diamino-3-phenyl-azo-pyridin enthaltendes tier- und humanarzneimittel mit antiviraler und antitumoraler aktivitaet.
DK0455769T3 (da)	1996-02-05	Anvendelse af 7-OH-1,2-benzopyron til fremstilling af et lægemiddel til behandling af magline tumore r hos mennesker